Author: Jessica.F

Search for β-Secretase Inhibitors from Natural Spices was written by Matsumura, Shinichi;Murata, Kazuya;Yoshioka, Yuri;Matsuda, Hideaki. And the article was included in Natural Product Communications in 2016.Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The growing number of Alzheimer’s disease (AD) patients prompted us to seek effective natural resources for the prevention of AD. We focused on the inhibition of β-secretase, which is known to catalyze the production of senile plaque. Sixteen spices used in Asian countries were selected for the screening. Among the extracts tested, hexane extracts obtained from turmeric, cardamom, long pepper, cinnamon, Sichuan pepper, betel, white turmeric and aromatic ginger showed potent inhibitory activities. Their active principles were identified as sesquiterpenoids, monoterpenoids, fatty acid derivatives and phenylpropanoids using GC-MS analyses. The chem. structures and IC₅₀ values of the compounds are disclosed. The results suggest that long-term consumption of aromatic compounds from spices could be effective in the prevention of AD. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Preparation of bioactive amide compounds from black pepper by countercurrent chromatography and preparative HPLC was written by Jin, Yongyang;Qian, Dengyong;Du, Qizhen. And the article was included in Industrial Crops and Products in 2013.SDS of cas: 18836-52-7 The following contents are mentioned in the article:

Amide compounds are the major bioactive substances in black pepper. Black pepper extracts were fractionated by high-speed countercurrent chromatog. resulting in three compounds: dehydropipernonaline, piperine and (2E,4E,12Z)-N-isobutyl-octadecatrienamide, and four fractions which were separated by preparative HPLC to yield ten purified compounds: retrofractamide-A, (2E,4E)-N-isobutyl-decadienamide, retrofractamide-C, piperoleine A, dehydropiperoleine A, retrofractamide-B, piperoleine B, pipernonaline, pipercyclobutanamides A and (2E,4E,14Z)-N-isobutyleicosa-2,4,14-trienamide as identified by ESI-MS and NMR anal. The results of the present study indicated that HSCCC is an effective technique for the preparation of bioactive amide compounds from black pepper. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7SDS of cas: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effects of Combined Treatment with Compounds Affecting Mitochondria on Physiological Parameters in Old Monkey. was written by Klots, I N;Gvozdik, T E;Shamsutdinova, O A;Mukhametzyanova, E I;Keburiya, V V;Gvaramiya, I A;Karal-Ogly, D D. And the article was included in Bulletin of experimental biology and medicine in 2022.Computed Properties of C11H15N2O8P The following contents are mentioned in the article:

Correction of mitochondrial function is a promising direction for modulating aging processes. The effect of NAD⁺ (in the form of its precursor nicotinamide mononucleotide, NMN) and antioxidant MitoQ specifically affecting mitochondria was studied on male rhesus monkeys (Macaca mulatta). The first group of animals initially received only NMN, the second group received only MitoQ, and then both groups received both drugs simultaneously. The above treatment did not lead to changes in the body weight and body temperature, hemostasis, and ECG. The use of MitoQ, but not NMN improved some hematological and biochemical parameters, shifting them to the values of young animals. Changes in these parameters depended on animal age, so the use of MitoQ can only be effective until a certain age. Combined use of the two drugs had no clear advantages over MitoQ alone. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Computed Properties of C11H15N2O8P).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C11H15N2O8P

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A Bridge Too Far: Testing the Limits of Polypyridyl Ligands in Bridging Soluble Subunits of a Coordination Polymer was written by Beddoe, Samuel V. F.;Fitzpatrick, Anthony J.;Price, Jason R.;Mallo, Neil;Beves, Jonathon E.;Morgan, Grace G.;Kitchen, Jonathan A.;Keene, Tony D.. And the article was included in Crystal Growth & Design in 2017.HPLC of Formula: 53118-43-7 The following contents are mentioned in the article:

Starting with a coordination polymer, {[Cu(L)]₂}_n (1 where H₂L = salicylidene-2-aminophenol), the authors have explored the ability of polypyridyl ligands (P) to bridge the monomer complex to form nine {[Cu(L)]₂(P)} complexes. The identity and solution stability of the [Cu(L)] units was studied through a novel combined UV-visible/EPR experiment and it is a stable supramol. building unit for the construction of discrete complexes and coordination polymers. The reorganization of [Cu(L)] units to a new coordination polymer on addition of 4,4′-bipyridine markedly changes the connectivity of the structure and the magnitude of the antiferromagnetic interactions through reorientation of the Cu(II) orbitals. The authors also present the structure of 1, 80 years after its synthesis was first reported. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7HPLC of Formula: 53118-43-7).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.HPLC of Formula: 53118-43-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Metal-free C-H methylation and acetylation of heteroarenes with PEG-400 was written by Kudale, Vishal Suresh;Wang, Jeh-Jeng. And the article was included in Green Chemistry in 2020.Electric Literature of C13H11BrN2O The following contents are mentioned in the article:

A novel and an efficient route for synthesis of methyl-arylquinazolinones I [R = H, 8-Me, 7-Cl; R¹ = Ph, 4-MeOC₆H₄, 2-ClC₆H₄, etc.] and acetylated heteroarenes II [Ar = 2-quinolyl, 3-CN-2-pyridyl, 1,3-benzothiazol-2-yl, etc.] via methylation and acetylation of aza-heteroarenes using PEG-400 under O₂ and TsOH·H₂O for the first time by tuning the reaction conditions using a different set of starting materials was described. The key features of current protocol were oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance and a broad substrate scope. The potential applicability of designed methodol. was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug mols. by a one-pot strategy. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Electric Literature of C13H11BrN2O).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Electric Literature of C13H11BrN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Piper longum Linn.-a fruit contains potential inhibitors of COVID-19 main protease based on molecular docking was written by Sivaraj, S.;Rangaraj, S.;Suguna, A.. And the article was included in World Journal of Pharmaceutical Research in 2020.Formula: C14H25NO The following contents are mentioned in the article:

A new coronavirus (nCoV) identified as the etiol. agent responsible for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan. Currently there is no clin. approved antiviral drug or vaccine available and effective treatment options remain very limited. Here, we have studied the virtual interaction between COVID-19 main protease (Mpro-PDB ID: 6LU7) and ten bioactive compounds of Piper longum by mol. docking using Autodock 4.2. It was identified that Piperundecalidine, a phytoconstituent present in fruit of Piper longum as potential inhibitor of COVID-19 Mpro which shows higher binding affinity (-9.54 kcal/mol) than the lead tideglusib (-8.48 kcal/mol). However, these data need further in vitro and in vivo evaluation to use against 2019-nCoV. This was the first report on phytoconstituents of Piper longum as potential inhibitor of COVID-19 Mpro using mol. docking studies. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Formula: C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

NAD supplementation improves mitochondrial performance of cardiolipin mutants was written by Ji, Jiajia;Damschroder, Deena;Bessert, Denise;Lazcano, Pablo;Wessells, Robert;Reynolds, Christian A.;Greenberg, Miriam L.. And the article was included in Biochimica et Biophysica Acta, Molecular and Cell Biology of Lipids in 2022.Recommanded Product: 1094-61-7 The following contents are mentioned in the article:

Cardiolipin (CL) deficiency causes mitochondrial dysfunction and aberrant metabolism that are associated in humans with the severe disease Barth syndrome (BTHS). Several metabolic abnormalities are observed in BTHS patients and model systems, including decreased oxidative phosphorylation, reduced tricarboxylic acid (TCA) cycle flux, and accumulated lactate and D-β-hydroxybutyrate, which strongly suggests that NAD (NAD) redox metabolism may be altered in CL-deficient cells. In this study, we identified abnormal NAD+ metabolism in multiple BTHS model systems and demonstrate that supplementation of NAD+ precursors such as NMN (NMN) improves mitochondrial function. Improved mitochondrial function in the Drosophila model was associated with restored exercise endurance, which suggests a potential therapeutic benefit of NAD+ precursor supplementation in the management of BTHS patients. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Recommanded Product: 1094-61-7).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 1094-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

NAD supplementation improves mitochondrial performance of cardiolipin mutants was written by Ji, Jiajia;Damschroder, Deena;Bessert, Denise;Lazcano, Pablo;Wessells, Robert;Reynolds, Christian A.;Greenberg, Miriam L.. And the article was included in Biochimica et Biophysica Acta, Molecular and Cell Biology of Lipids in 2022.Electric Literature of C11H15N2O8P The following contents are mentioned in the article:

Cardiolipin (CL) deficiency causes mitochondrial dysfunction and aberrant metabolism that are associated in humans with the severe disease Barth syndrome (BTHS). Several metabolic abnormalities are observed in BTHS patients and model systems, including decreased oxidative phosphorylation, reduced tricarboxylic acid (TCA) cycle flux, and accumulated lactate and D-β-hydroxybutyrate, which strongly suggests that NAD (NAD) redox metabolism may be altered in CL-deficient cells. In this study, we identified abnormal NAD+ metabolism in multiple BTHS model systems and demonstrate that supplementation of NAD+ precursors such as NMN (NMN) improves mitochondrial function. Improved mitochondrial function in the Drosophila model was associated with restored exercise endurance, which suggests a potential therapeutic benefit of NAD+ precursor supplementation in the management of BTHS patients. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Electric Literature of C11H15N2O8P).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Electric Literature of C11H15N2O8P

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Structural characterization and preventive effect on non-alcoholic fatty liver disease of oligosaccharides from Bletilla striata was written by Hu, Baifei;Yang, Huabing;Chen, Guangming;Sun, Xiongjie;Zou, Xiaojuan;Ma, Jun;Yao, Xiaowei;Liang, Qiong;Liu, Hongtao. And the article was included in Food & Function in 2022.Safety of ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate The following contents are mentioned in the article:

In this study, Bletilla striata polysaccharides were degraded into oligosaccharides. The structural features were analyzed by HPLC, HPLC-MS, FT-IR, and NMR spectroscopy. The results indicated that Bletilla striata oligosaccharides (BOs) were composed of mannose and glucose with a molar ratio of 5.2 : 1, and the main backbones of BOs contained (1→4)-linked-α-D-Man, (1→2)-linked-α-D-Man, and (1→2)-linked-α-D-Glc. By using a high-fat diet (HFD)-induced mouse model, we demonstrated that BOs had an improving effect on non-alc. fatty liver disease (NAFLD). Using the metabolomics assay, we found that BOs significantly regulated the hepatic metabolism of fatty acids, arachidonic acid, and other related metabolites in HFD-fed mice, accompanied by the reduction of lipid accumulation and fibrosis in liver tissues. In summary, BOs displayed high potential for the treatment of NAFLD as a functional food. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Safety of ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Safety of ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Structural characterization and preventive effect on non-alcoholic fatty liver disease of oligosaccharides from Bletilla striata was written by Hu, Baifei;Yang, Huabing;Chen, Guangming;Sun, Xiongjie;Zou, Xiaojuan;Ma, Jun;Yao, Xiaowei;Liang, Qiong;Liu, Hongtao. And the article was included in Food & Function in 2022.Formula: C11H15N2O8P The following contents are mentioned in the article:

In this study, Bletilla striata polysaccharides were degraded into oligosaccharides. The structural features were analyzed by HPLC, HPLC-MS, FT-IR, and NMR spectroscopy. The results indicated that Bletilla striata oligosaccharides (BOs) were composed of mannose and glucose with a molar ratio of 5.2 : 1, and the main backbones of BOs contained (1→4)-linked-α-D-Man, (1→2)-linked-α-D-Man, and (1→2)-linked-α-D-Glc. By using a high-fat diet (HFD)-induced mouse model, we demonstrated that BOs had an improving effect on non-alc. fatty liver disease (NAFLD). Using the metabolomics assay, we found that BOs significantly regulated the hepatic metabolism of fatty acids, arachidonic acid, and other related metabolites in HFD-fed mice, accompanied by the reduction of lipid accumulation and fibrosis in liver tissues. In summary, BOs displayed high potential for the treatment of NAFLD as a functional food. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Formula: C11H15N2O8P).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Formula: C11H15N2O8P

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics