Author: Jessica.F

Identification and simultaneous quantification of five alkaloids in Piper longum L. by HPLC-ESI-MSⁿ and UFLC-ESI-MS/MS and their application to Piper nigrum L. was written by Liu, Hao-Long;Luo, Rong;Chen, Xiao-Qing;Ba, Yin-Ying;Zheng, Li;Guo, Wei-Wei;Wu, Xia. And the article was included in Food Chemistry in 2015.Reference of 18836-52-7 The following contents are mentioned in the article:

A simple, effective and suitable UFLC-ESI-MS/MS method was developed for simultaneous determination of 5 characteristic alkaloids (piperine, piperlonguminine, Δα,β-dihydropiperlonguminine, pellitorine, piperanine) in Piper longum and Piper nigrum. The MS detection was carried out in multiple reaction monitoring scan mode. The method had good specificity, linearity (R² >0.995), stability (RSD <2.53%), repeatability (RSD <2.58%), and recovery (90.0-103.5%). The limits of detection and quantification of the 5 alkaloids ranged 0.02-0.03 and 0.05-0.10 ng/mL, resp. The intra-day and inter-day precision was less than 9.30 and 9.55%, resp. The validation results confirmed that the method could simultaneously determine the target alkaloids in the samples. The alkaloid identities were verified by HPLC-ESI-MS/MS. Compared with P. nigrum, P. longum had lower piperine content but was richer in the other four alkaloids. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Reference of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Reference of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of Nicotinamide Mononucleotide from Xylose via Coupling Engineered Escherichia coli and a Biocatalytic Cascade was written by Ngivprom, Utumporn;Lasin, Praphapan;Khunnonkwao, Panwana;Worakaensai, Suphanida;Jantama, Kaemwich;Kamkaew, Anyanee;Lai, Rung-Yi. And the article was included in ChemBioChem in 2022.Electric Literature of C11H15N2O8P The following contents are mentioned in the article:

β-NMN (NMN) has recently gained attention for a nutritional supplement because it is an intermediate in the biosynthesis of NAD (NAD⁺). In this study, we developed NMN synthesis by coupling two modules. The first module is to culture E. coli MG1655 tktA tktB ptsG to metabolize xylose to generate D-ribose in the medium. The supernatant containing D-ribose was applied in the second module which is composed of EcRbsK-EcPRPS-CpNAMPT reaction to synthesize NMN, that requires addnl. enzymes of CHU0107 and EcPPase to remove feedback inhibitors ADP and pyrophosphate. The second module can be rapidly optimized by comparing NMN production determined by the cyanide assay. Finally, 10 mL optimal biocascade reaction generated NMN with a good yield of 84 % from 1 mM D-ribose supplied from the supernatant of E. coli MG1655 tktA tktB ptsG. Our results can further guide researchers to metabolically engineer E. coli for NMN synthesis. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Electric Literature of C11H15N2O8P).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Electric Literature of C11H15N2O8P

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of Nicotinamide Mononucleotide from Xylose via Coupling Engineered Escherichia coli and a Biocatalytic Cascade was written by Ngivprom, Utumporn;Lasin, Praphapan;Khunnonkwao, Panwana;Worakaensai, Suphanida;Jantama, Kaemwich;Kamkaew, Anyanee;Lai, Rung-Yi. And the article was included in ChemBioChem in 2022.Recommanded Product: 1094-61-7 The following contents are mentioned in the article:

β-NMN (NMN) has recently gained attention for a nutritional supplement because it is an intermediate in the biosynthesis of NAD (NAD⁺). In this study, we developed NMN synthesis by coupling two modules. The first module is to culture E. coli MG1655 tktA tktB ptsG to metabolize xylose to generate D-ribose in the medium. The supernatant containing D-ribose was applied in the second module which is composed of EcRbsK-EcPRPS-CpNAMPT reaction to synthesize NMN, that requires addnl. enzymes of CHU0107 and EcPPase to remove feedback inhibitors ADP and pyrophosphate. The second module can be rapidly optimized by comparing NMN production determined by the cyanide assay. Finally, 10 mL optimal biocascade reaction generated NMN with a good yield of 84 % from 1 mM D-ribose supplied from the supernatant of E. coli MG1655 tktA tktB ptsG. Our results can further guide researchers to metabolically engineer E. coli for NMN synthesis. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Recommanded Product: 1094-61-7).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 1094-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rapid structural determination of amides in Piper longum by high-performance liquid chromatography combined with ion trap mass spectrometry was written by Sun, Cuirong;Pei, Saifeng;Pan, Yuanjiang;Shen, Zhiquan. And the article was included in Rapid Communications in Mass Spectrometry in 2007.Electric Literature of C14H25NO The following contents are mentioned in the article:

A reversed-phase liquid chromatog./tandem multistage mass spectrometry (MS/MS) method was developed for the characterization of amides from the extracts of Piper longum. The characteristic fragmentations of the amides found in P. longum showed diagnostic structural information. Extracted ion chromatog. (EIC) and constant neutral losses were used to guide the search for the amides of interest. Amides of known structures that contain four subtypes of amides were rapidly determined, and novel amides were also identified for this plant. Forty-two amides were rapidly identified, of which 22 were found in this plant for the first time and 9 were new compounds The method is convenient and sensitive, especially for minor components in the unpurified, complex mixture; the structures of unknown constituents could be determined, in the absence of authentic sample, by comparison of the fragmentation patterns with those of homologous compounds This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Electric Literature of C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Electric Literature of C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment was written by Whitson, Jeremy A.;Johnson, Richard;Wang, Lu;Bammler, Theo K.;Imai, Shin-Ichiro;Zhang, Huiliang;Fredrickson, Jeanne;Latorre-Esteves, Elena;Bitto, Alessandro;MacCoss, Michael J.;Rabinovitch, Peter S.. And the article was included in GeroScience in 2022.Recommanded Product: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate The following contents are mentioned in the article:

Abstract: We analyzed the effects of aging on protein abundance and acetylation, as well as the ability of the mitochondrial-targeted drugs elamipretide (SS-31) and NMN (NMN) to reverse aging-associated changes in mouse hearts. Both drugs had a modest effect on restoring the abundance and acetylation of proteins that are altered with age, while also inducing addnl. changes. Age-related increases in protein acetylation were predominantly in mitochondrial pathways such as mitochondrial dysfunction, oxidative phosphorylation, and TCA cycle signaling. We further assessed how these age-related changes associated with diastolic function (Ea/Aa) and systolic function (fractional shortening under higher workload) measurements from echocardiog. These results identify a subset of protein abundance and acetylation changes in muscle, mitochondrial, and structural proteins that appear to be essential in regulating diastolic function in old hearts. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Recommanded Product: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment was written by Whitson, Jeremy A.;Johnson, Richard;Wang, Lu;Bammler, Theo K.;Imai, Shin-Ichiro;Zhang, Huiliang;Fredrickson, Jeanne;Latorre-Esteves, Elena;Bitto, Alessandro;MacCoss, Michael J.;Rabinovitch, Peter S.. And the article was included in GeroScience in 2022.Name: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate The following contents are mentioned in the article:

Abstract: We analyzed the effects of aging on protein abundance and acetylation, as well as the ability of the mitochondrial-targeted drugs elamipretide (SS-31) and NMN (NMN) to reverse aging-associated changes in mouse hearts. Both drugs had a modest effect on restoring the abundance and acetylation of proteins that are altered with age, while also inducing addnl. changes. Age-related increases in protein acetylation were predominantly in mitochondrial pathways such as mitochondrial dysfunction, oxidative phosphorylation, and TCA cycle signaling. We further assessed how these age-related changes associated with diastolic function (Ea/Aa) and systolic function (fractional shortening under higher workload) measurements from echocardiog. These results identify a subset of protein abundance and acetylation changes in muscle, mitochondrial, and structural proteins that appear to be essential in regulating diastolic function in old hearts. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7Name: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate).

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate (cas: 1094-61-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Name: ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Removal rate of Pb Ions through functionalized decoration of MOF cavity was written by Afshariazar, Farzaneh;Morsali, Ali;Wang, Jun;Junk, Peter C.. And the article was included in Chemistry – A European Journal in 2020.Electric Literature of C12H10N4O2 The following contents are mentioned in the article:

To overcome the challenge of developing a multipurpose adsorbent for effective removal of toxic and carcinogenic Pb^II ions from aqueous solutions, a made-for-purpose functional group (N¹,N²-di(pyridine-4-yl)oxalamide) was rationally designed and incorporated into the cavities of a Zn metal-organic framework (MOF), namely, TMU-56. Large enough pore size along with high densities of strong metal chelating sites lead not only to the highest uptake capacity for Pb^II ions, but also the fastest removal rate that has ever been reported for functionalized MOFs, occurring in just 20 s. Moreover, high concentrations of lead ions favor the ion exchange reaction, resulting in a high degree of metal exchange. In addition, TMU-56 can be a practical adsorbent because of its notable performance in the simultaneous removal of several toxic and carcinogenic heavy metals from wastewater, which has rare precedence. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7Electric Literature of C12H10N4O2).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Electric Literature of C12H10N4O2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Antibacterial compounds from Rutaceae with activities against Flavobacterium columnare and Streptococcus iniae was written by Meepagala, Kumudini M.;Schrader, Kevin K.;Burandt, Charles L.. And the article was included in Journal of Agricultural Chemistry and Environment in 2013.Electric Literature of C14H25NO The following contents are mentioned in the article:

From the Et acetate extract of Murraya koenegii (Rutaceae) leaves, isomahanine (1) and mahanine (2) were isolated that showed anti-bacterial activity towards Flavobacterium columnare and Streptococcus iniae which caused columnaris disease and streptococcosis resp. Isomahanine was found to have the strongest activity against F. columnare (isolate ALM-00-173) and S. iniae (isolate LA94-426) based on 24-h 50% inhibition concentration (IC50) and min. inhibition concentration (MIC). Although compound (7), a nicotinamide isolated from Amyris texana had the lowest MIC (2.8 ± 0 mg/L) of any of the test compounds against F. columnare, the 24-h IC50 of 14.8 ± 0.6 mg/L was higher than that of isomahanine and subsequently the 24-h IC50 RDC values for (7) were almost a magnitude of order higher than those obtained for isomahanine. Isomahanine also had the strongest activity against S. iniae, with a 24-h IC50 of 1.3 ± 0.1 mg/L and MIC of 3.5 ± 0 mg/L, resp. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Electric Literature of C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Electric Literature of C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Four-step spin-crossover in an oxamide-decorated metal-organic framework was written by Wu, Siguo;Bala, Sukhen;Ruan, Zeyu;Huang, Guozhang;Ni, Zhaoping;Tong, Mingliang. And the article was included in Chinese Chemical Letters in 2022.COA of Formula: C12H10N4O2 The following contents are mentioned in the article:

Spin-crossover (SCO) complexes with multiple spin states are promising candidates for high-order magnetic storage and multiple switches. Here, by employing the N,N’-4-dipyridyloxalamide (dpo) ligand, the authors synthesize two Hofmann-type metal-organic frameworks (MOFs) [Fe(dpo){Ag(CN)₂}₂]·3DMF (1) and [Fe(dpo){Ag(CN)₂}₂]·0.5MeCN·2DEF (2), which exhibit guest dependent four-step SCO behaviors with the sequences of LS → approx. LS_2/3HS_1/3 → LS_1/2HS_1/2 → approx. LS_3/10HS_7/10 → HS and LS → approx. LS_2/3HS_1/3 → LS_1/2HS_1/2 → approx. LS_1/4HS_3/4 → HS, resp. Therefore, the incorporation of hydrogen-donating/hydrogen-accepting groups into the Hofmann-type MOFs may effectively explore the multi-step SCO materials by tuning hydrogen-bonding interactions. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7COA of Formula: C12H10N4O2).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.COA of Formula: C12H10N4O2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Larvicidal activities of Piper kadsura (Choisy) Ohwi extract and its constituents against Aedes albopictus, toxicity to non-target organisms and development of cellulose nanocrystal-stabilized Pickering emulsion was written by Seo, Seon-Mi;Shin, Jonghyun;Lee, Jae-Woo;Hyun, Jinho;Park, Il-Kwon. And the article was included in Industrial Crops and Products in 2021.SDS of cas: 18836-52-7 The following contents are mentioned in the article:

Among 15 plant methanol extracts, Piper kadsura stem extract (PkSE) showed the strongest larvicidal activity against Aedes albotictus. Larvicidal activities of P. kadsura stem extract were 100% and 80% at 0.01 and 0.005 mg/mL concentrations, resp. Two iso-Bu amides, pellitorine and chingchengenamide A, and one neolignan, piperenone, were isolated as active compounds from PkSE. Larvicidal activities of chingchengenamide A, piperenone, and pellitorine were 100%, 100%, and 87.5% at 0.005 mg/mL concentration, resp., and 100%, 67.5%, and 15.0% at 0.0025 mg/mL. Cellulose nanocrystal (CNC)-stabilized Pickering emulsion of PkSE was developed, and its larvicidal activity was slightly higher than that of pure PkSE. Acute oral and dermal toxicity of PkSE toward rat, Rattus norvegicus, was >2000 mg/kg body weight Acute contact toxicity of PkSE to honeybee was >100μg/bee. The no observed effect concentration (NOEC) of PkSE to Oryzias latipes was 0.031 mg/mL. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7SDS of cas: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics