Author: Jessica.F

Soni, Yogesh published the artcileEffects of different concentration and combinations of cryoprotectants on sperm quality, functional integrity in three Indian horse breeds, Quality Control of 123-39-7, the main research area is glycerol dimethyl formamide toxicity cryoprotectant horse sperm breed; Acrosome integrity; Cryopreservation; Cryoprotectant; DMF; Glycerol.

Traditionally Glycerol (Gly) is being used as major cryoprotectant and its toxicity could be a reason for the variation on stallion sperm freezability and fertility. In an effort to minimize Gly toxicity alternative cryoprotective agents like DMF (DMF) have been investigated. The effect of the cryoprotectant and dose of cryoprotective agent varies from breed to breed and also from stallion to stallion within the same breed. Considering these factors a study was designed to study the effects of Gly and DMF at different concentrations and combinations on the plasma membrane, acrosome and DNA integrity as well as other post thaw seminal characteristics of semen of three Indigenous stallion breeds. In the current study, semen was collected from apparently healthy 4-6 years old 3 Marwari, 3 Manipuri and 3 Zanskari breed stallions. After semen collection and evaluation of fresh semen, each semen sample was extended with semen extender containing different concentrations and combinations of Gly and DMF cryoprotectants (i.e. 5% Gly, 5% DMF, 2% Gly, 2% DMF, 2.5% Gly +2.5% DMF and 1% Gly +1% DMF) and frozen. Post thaw semen evaluation was done on the basis of post thaw motility, live sperm count, hypo osmotic swelling test, acrosomal integrity and DNA integrity. Frozen thawed semen showed that the values of plasma membrane integrity, acrosome integrity and DNA integrity parameters were significantly higher (P < 0.05) with 5% DMF than the other cryoprotectants levels and combinations of Gly and DMF. From the present study, it was inferred that the combination of cryoprotectants at different concentrations (Gly and DMF @ 2.5 and 1%) also could not show better enhancement compared to the single cryoprotectant i.e DMF @5% in various post thaw seminal characteristics of Indigenous stallion semen. DMF at 5% concentration gave better protection to the plasma membrane and retained the acrosome and DNA integrity of the spermatozoa. Hence it can be concluded that DMF at 5% can be used for the cryopreservation of the Indigenous stallion with better preservation of the seminal quality. Cryobiology published new progress about Acrosome. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hermes, Robert published the artcileFirst cryopreservation of phyllostomid bat sperm, HPLC of Formula: 123-39-7, the main research area is Carollia cryopreservation media sperm motility artificial insemination; Assisted reproduction technology; Methylformamide; Species conservation; Yangochiroptera.

Bats, the second-largest mammalian order, are widely distributed and provide crucial ecosystem services. Their reproductive biol. comprises noteworthy characteristics, such as long-term sperm storage, delayed implantation or even delayed fetal development. The understanding of these mechanisms remains limited. Research in reproductive biol. may become crucial for the conservation of endangered bat species. Indeed, the IUCN Red List of Threatened Species currently lists 76 bat species as endangered or critically endangered, for which conservation measures should be taken. The development of assisted reproductive technologies (ART) in bats would thus open new perspectives. In this context we here describe the first successful cryopreservation of bat sperm in the Seba′s short-tailed bat (Carollia perspicillata). Epididymal sperm of 30 males was pooled in 6 sample sets and diluted using four different cryo-diluents: Canifreeze, modified Canifreeze, BotuCrio and Test egg yolk extender. Glycerol and a mixture of glycerol and methylformamide were used as cryoprotectants. Best post-thaw results were achieved when sperm was diluted in Test egg yolk extender containing a mixture of glycerol and methylformamide as cryoprotectant. Post-thaw sperm motility, progressive motility and acrosome integrity of 42.0 ± 3.4%, 28.3 ± 6.3% and 87.7 ± 1.7%, resp. were superior to all other variants tested. It remains to be determined if the post-thaw quality of cryopreserved bat spermatozoa achieved in this study is sufficient for the use in artificial inseminations and produces acceptable pregnancy rates. Successful cryopreservation of spermatozoa in C. perspicillata may serve as the first model to establish gamete rescue programs and develop ART in other, critically endangered bat species.

Theriogenology published new progress about Acrosome. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, HPLC of Formula: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Iwasaki, Machio published the artcileE.S.R. spectra of γ-irradiated polycrystalline powders of some fluorine-containing compounds, Product Details of C2H3F2NO, the main research area is .

The powder spectra of γ-irradiated salts and amides of some fluorinated acids were interpreted, based on the spectral shapes of the α-F hyperfine-coupling line. Because of the large anisotropy of the α-F coupling tensor, it was possible to observe the shoulders corresponding to the maximum principal value of the coupling tensor. The separation between the wing patterns and the wing hyperfine structures made it possible to identify the radical species produced. The probable radicals were the ones formed by the removal of the atoms attached to the α C atom.

Journal of Chemical Physics published new progress about Gamma ray. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Product Details of C2H3F2NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nimje, Roshan Y. published the artcileDevelopment of a Stereoselective and Scalable Synthesis for the Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor, BMT-297376; N-((R)-1-((cis)-4-(3-(Difluoromethyl)-2-methoxypyridin-4-yl)cyclohexyl)propyl)-6-methoxynicotinamide, Quality Control of 343338-28-3, the main research area is difluoromethyl methoxypyridinyl cyclohexyl methoxynicotinamide preparation enantioselective indoleamine dioxygenase inhibitor.

The current work describes a stereoselective and scalable route to N-((R)-1-((cis)-4-(3-(difluoromethyl)-2-methoxypyridin-4-yl)cyclohexyl)propyl)-6-methoxynicotinamide I from readily available 1,4-dioxaspiro[4.5]decan-8-one. The developed process encompasses an efficient 1,4-trans-selective synthesis of (trans)-4-(3-(difluoromethyl)-2-methoxypyridin-4-yl)cyclohexyl methanesulfonate as the key intermediate and the use of Ellman sulfinamine methodol. to install an alkyl amine in a stereoselective manner. Various synthetic routes were screened to accomplish a stereoselective and scalable protocol to access the title compound I. This advancement enabled a competent route to the title compound in an enantioselective, safe, cost-effective, and scalable manner.

Organic Process Research & Development published new progress about Cyanation. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Quality Control of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Yaqi published the artcileEnantioselective Syntheses of Axially Chiral Phosphonates or Phosphine Oxides via Asymmetric Suzuki Reactions with Chiral Sulfinamide Monophosphine Ligands, Synthetic Route of 343338-28-3, the main research area is stereoselective Suzuki chiral sulfinamide phosphine oxide phosphonate chiral preparation.

A class of chiral sulfinamide monophosphine ligands Ming-Phos were firstly employed in the asym. Suzuki coupling reactions. Using the in-situ formed catalyst from PdCl2 and (R, SS)-M07, 22 axially chiral phosphonates or phosphine oxides were successfully synthesized in 29-99% yields with up to 98% ee. This method provides a simple and efficient protocol for the synthesis of axially chiral biaryl monophosphine oxides.

ChemistrySelect published new progress about Chirality. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Synthetic Route of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kamimura, Akio published the artcileA study on the stereochemistry of direct conversion of polyamides to hydroxyesters using monomeric secondary chiral amines as a model compound, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is stereochem mechanism polyamide hydroxyester secondary chiral amine model compound.

Stereochem. of direct conversion of polyamides to hydroxyesters was investigated using model compounds Optically active secondary-alkyl amines underwent the conversion to corresponding secondary alcs. in moderate yields by treatment with supercritical methanol in the presence of glycolic acid. The reaction progressed through almost completely stereochem. inversion to give secondary alcs. in high yields. The substitution reaction of amino group to hydroxyl group progressed through SN2 transition state accompanying with stereoinversion.

Polymer Degradation and Stability published new progress about Chirality. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tang, Jing-Jing published the artcileVisible-Light-Promoted Iron-Catalyzed N-Arylation of Dioxazolones with Arylboronic Acids, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is benzamide preparation; arylboronic acid dioxazolone arylation visible light iron catalyst.

Synthesis of benzamides ArC(O)NAr1 [Ar = Ph, 4-FC6H4, furan-2-yl, etc.; Ar1 = Ph, 4-MeC6H4, 4-BrC6H4, etc.] via visible-light-promoted iron salt-catalyzed N-arylation of arylboronic acids and bench-stable dioxazolones was achieved efficiently under external photosensitizer-free conditions. This reaction featured high reactivity, wide substrate scope, good functional group tolerance, simple operation procedure, and mild reaction conditions. Preliminary mechanistic investigations were conducted to support a radical pathway. This method may contribute to shift the paradigm of iron-catalyzed C-N bond construction and nitrene transfer chem.

ACS Catalysis published new progress about Arylation. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Ming-Jun published the artcileThe deleterious effects of N,N-dimethylformamide on liver: A mini-review, COA of Formula: C2H5NO, the main research area is review liver cell proliferation differentiation apoptosis DMF; Cytochrome P4502E1; Hepatotoxicity; N,N-dimethylformamide; N-methylformamide; Occupational exposure limit; Oxidative stress.

N,N-dimethylformamide (DMF) is a versatile solvent with wide industrial applications. Evidences from animal studies and occupational poisoning cases have clearly demonstrated that DMF exposure can lead to different degrees of liver damage. It is noteworthy that DMF below the threshold limit value (TLV) may also cause liver injury in some sensitive populations. Unfortunately, the underlying mechanisms by which DMF induces hepatotoxicity remain largely unknown, despite considerable attention has been drawn to the hepatotoxic effects of DMF. Although some pilot studies have provided some evidences supporting the involvement of oxidative stress, the disturbance of gut microbiota and calcium homeostasis, etc, the causal roles of these factors on the onset of DMF-induced hepatotoxicity need to be confirmed. This article reviews the current knowledge about the deleterious effects of DMF on the liver.

Chemico-Biological Interactions published new progress about Apoptosis. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, COA of Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fan, Xuelin published the artcileHigh-performance ultra-short channel field-effect transistor using solution-processable colloidal nanocrystals, Recommanded Product: N-Methylformamide, the main research area is ultrashort channel field effect transistor solution processable colloidal nanocrystal.

The authors demonstrate high-mobility solution-processed inorganic field-effect transistors (FETs) with ultra-short channel (USC) length using semiconductor CdSe nanocrystals (NCs). Capping of the NCs with hybrid inorganic-organic CdCl3–butylamine ligands enables coarsening of the NCs during annealing at a moderate temperature, resulting in the devices having good transport characteristics with electron mobilities in the saturation regime reaching 8 cm2 V-1 s-1. Solution-based processing of the NCs and fabrication of thin films involve neither harsh conditions nor the use of hydrazine. Employing photolithog. methods, the authors fabricated FETs with a vertical overlap of source and drain electrodes to achieve a submicrometer channel length. Because of a short channel length, the FETs show a normalized transconductance of 4.2 m V-1 s-1 with a high on/off ratio of 105.

Journal of Physical Chemistry Letters published new progress about Annealing. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ellis, Ryan G. published the artcileHybrid Ligand Exchange of Cu(In,Ga)S2 Nanoparticles for Carbon Impurity Removal in Solution-Processed Photovoltaics, Recommanded Product: N-Methylformamide, the main research area is ligand exchange copper indium gallium sulfide nanoparticle solar cell.

The solution processing of Cu(In,Ga)(S,Se)2 photovoltaics from colloidal nanoparticles has long suffered from deleterious carbonaceous residues originating from long chain native ligands. This impurity carbon has been observed to hinder grain formation during selenization and leave a discrete residue layer between the absorber layer and the back contact. In this work, organic and inorganic ligand exchanges were investigated to remove tightly bound native oleylamine ligands from Cu(In,Ga)S2 nanoparticles, thereby removing the source of carbon contamination. However, incomplete ligand removal, poor colloidal stability, and/or selective metal etching were observed for these methods. As such, an exhaustive hybrid organic/inorganic ligand exchange was developed to bypass the limitations of individual methods. A combination of microwave-assisted solvothermal pyridine ligand stripping followed by inorganic capping with diammonium sulfide was developed and yielded greater than 98% removal of native ligands via a rapid process. Despite the aggressive ligand removal, the nanoparticle stoichiometry remained largely unaffected when making use of the hybrid ligand exchange. Furthermore, highly stable colloidal ink formulations using nontoxic DMSO were developed, supporting stable nanoparticle mass concentrations exceeding 200 mg/mL. Scalable blade coating of the ligand-exchanged nanoparticle inks yielded remarkably smooth and microcrack free films with an RMS roughness less than 7 nm. Selenization of ligand-exchanged nanoparticle films afforded substantially improved grain growth as compared to conventional nonligand-exchanged methods, yielding an absolute improvement in device efficiency of 2.8%. Hybrid ligand exchange nanoparticle-based devices reached total area power conversion efficiencies of 12.0%, demonstrating the feasibility and promise of ligand-exchanged colloidal nanoparticles for the solution processing of Cu(In,Ga)(S,Se)2 photovoltaics.

Chemistry of Materials published new progress about Annealing. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics