Author: Jessica.F

Jacobs, Jeffrey W. published the artcileDiscovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3, SDS of cas: 35203-88-4, the main research area is tenapanor inhibitor intestine sodium hydrogen exchanger isoform 3 NHE3.

We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na+/H+ exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in the kidney and gastrointestinal tract where it acts as the major absorptive sodium transporter. We desired minimally systemic agents that would block sodium absorption in the gastrointestinal tract but avoid exposure in the kidney. Starting with a relatively low-potency highly bioavailable hit compound (1), potent and minimally absorbed NHE3 inhibitors were designed, culminating with the discovery of tenapanor (28). Tenapanor has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of irritable bowel syndrome with constipation in adults.

ACS Medicinal Chemistry Letters published new progress about Digestive tract. 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, SDS of cas: 35203-88-4.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Machida, Shingo published the artcileA novel approach to characterization of a relatively unstable intercalation compound under ambient conditions: revisiting a kaolinite-acetone intercalation compound, Name: N-Methylformamide, the main research area is kaolinite acetone intercalation hydrogen bond.

Characteristics of a kaolinite-acetone intercalation compound prepared using a kaolinite N-methylformamide intercalation compound (Kaol-NMF) as an intermediate were obtained by a set of techniques with attention to suppressing evaporation and deintercalation of acetone. X-ray diffraction (XRD) with spectroscopic analyses, Fourier-transform IR spectroscopy (FTIR) accompanied by solid-state 13C and 29Si NMR (NMR) spectroscopy with cross polarization (CP) and magic angle spinning (MAS) enable us to demonstrate full replacement of a pre-intercalated NMF monolayer with an acetone monolayer between the layers of kaolinite with an increase in the basal spacing from 1.08 nm (Kaol-NMF) to 1.12 nm. In addition, the appearance of an addnl. OH stretching band at 3630 cm-1 and the shift of the C=O stretching band to a lower wavenumber, from 1714 to 1701 cm-1, in the FTIR spectrum, along with a downfield shift of the signal due to C=O groups from 209 ppm, where a singlet was observed in the liquid-state 13C NMR spectrum of acetone in CDCl3, to 219 ppm in the 13C CP/MAS NMR spectrum, indicate hydrogen bond formation between interlayer hydroxyl groups of kaolinite and C=O groups of the intercalated acetone mols. These careful characterization studies provide information on an interaction between kaolinite and acetone under ambient conditions.

Dalton Transactions published new progress about Deintercalation. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Di Girolamo, Diego published the artcileSolvents for Processing Stable Tin Halide Perovskites, Application In Synthesis of 123-39-7, the main research area is solvent processing stable tin halide perovskite.

Tin is one of the most promising alternatives to lead to make lead-free halide perovskites for optoelectronics. However, the stability of tin-based perovskites is hindered by the oxidation of Sn(II) to Sn(IV). Recent works established that DMSO, which is one of the best-performing solvents for processing perovskite, is the primary source of tin oxidation The quest for a stable solvent could be a game-changer in the stability of tin-based perovskites. Starting from a database of over 2000 solvents, we identified a series of 12 new solvents suitable for the processing of formamidinium tin iodide perovskite (FASnI3) by investigating (1) the solubility of the precursor chems. FAI and SnI2, (2) the thermal stability of the precursor solution, and (3) the possibility of forming perovskite. Finally, we demonstrate a new solvent system to produce solar cells outperforming those based on DMSO. Our work provides guidelines for further identification of new solvents or solvent mixtures for preparing stable tin-based perovskites.

ACS Energy Letters published new progress about Crystallization. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fujiwara, Nobuyuki published the artcileEvaluation of influence of fine particle surface modification with Hansen solubility parameters, Category: amides-buliding-blocks, the main research area is fine particle surface modification solubility silane coupling agent.

In this study, we determined the Hansen solubility parameters (HSPs) of metal fine particles by experiments based on the Hansen solubility sphere method. A silane coupling treatment was applied to the metal fine particles to determine the HSPs from their dispersibilities. We examined changes in the HSP values after treatment by a silane coupling. We confirmed that the treatment with silane coupling agents, caused the HSPs of the particles to tend towards the HSPs of the surface treatment agent. We suggest that HSP theory is useful for selection of silane coupling agents.

Materials Chemistry and Physics published new progress about Coupling agents. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mukesh, B. published the artcileThermodynamic, DFT and molecular dynamics studies of intermolecular interactions between 2-methoxyaniline and N- substituted amide mixtures, Quality Control of 123-39-7, the main research area is intermol interaction methoxyaniline substituted amide mixture mol dynamic.

The exptl. data of d.(ρ) and speed of the sound(u) of 2-methoxyaniline and N-alkyl amides binary liquid mixtures have been evaluated at temperatures T = (303.15 to 318.15) K. Values of excess molar volume (VEm), excess isentropic compressibility (kEs), excess partial molar volumes (V̅Em,1,V̅Em,2), and excess partial molar volumes at infinite dilution(V̅E,∞m,1,V̅E,∞m,2) over the whole composition range have been calculated by using the d. and the speed of sound measurements. The calculated excess parameters were used to discuss the intermol. interactions. A quantum mech. approach was performed in gas phase and classical mol. dynamic simulations were done in liquid phase to study the intermol. interactions in self and cross-associated complexes. The details of exptl., quantum mech. and classical mol. dynamic methods are used to investigate the formation of a hydrogen-bonded network between 2-methoxyaniline and N-alkyl amide mixtures

Chemical Data Collections published new progress about Compressibility. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kumar, Mukesh published the artcilePhysicochemical parameters of the binary mixtures of formamide/N-methylformamide with 2-chloroethanol at different temperatures, SDS of cas: 123-39-7, the main research area is formamide methylformamide chloroethanol binary mixture temperature physicochem property.

The pseudo-Gruneisen parameter , effective Debye temperature, acoustic nonlinearity parameter , internal pressure and isobaric thermal expansion coefficient have been evaluated for binary liquid mixtures of formamide (FA) and N-methylformamide (NMF) with 2-chloroethanol (2Cl-OH) at 298.15 K, 308.15 K and 318.15 K, over the entire concentration range. The excess pseudo-Gruneisen parameter ΓE, excess effective Debye temperature θED , excess nonlinearity parameter (B/A)E, excess internal pressure PEIn and excess isobaric thermal expansion coefficient αEwere also calculated The calculated values are reasonably satisfactory with the exptl. results on sound propagation data of liquid mixtures These physicochem. parameters play an important role in understanding of the significance of anharmonic and nonlinear behavior with regard to intermol. interactions in the liquid mixtures

Physics and Chemistry of Liquids published new progress about Compressibility. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, SDS of cas: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mako, Eva published the artcileNanoscale structural and morphological features of kaolinite nanoscrolls, Computed Properties of 123-39-7, the main research area is kaolinite nanoscroll nanoscale structural morphol feature.

One-dimensional kaolinite nanoscrolls have been arousing great interest due to their applicability in advanced materials for adsorption and slow release of reagents, as well as in nanoscale reactors and carriers. Production of high-quality halloysite-like nanoscrolls with controlled morphol., however, remains challenging as there is a lack of understanding of the curling process of kaolinite layers on the at. scale. In the present work, the nanoscrolls were efficiently produced from the readily available natural kaolinite using a two-pot solvothermal exfoliation of the kaolinite-dimethyl sulfoxide, kaolinite-urea, and kaolinite-N-methylformamide precursors. The structures, sizes, shapes and crystallog. properties of the produced halloysite-like nanoscrolls were characterized using X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM) and electron tomog. in scanning transmission mode (STEM). In order to avoid structural disintegration of the highly electron beam-sensitive nanoscrolls, we used a low imaging current (70-240 e/A2); as a result, the acquisition of structure images was possible. In contrast to the triclinic symmetry of kaolinite, electron diffraction patterns suggest a hexagonal symmetry of exfoliated layers. Both HRTEM and STEM tomog. show partially and completely rolled up layers, with the axis of curvature being parallel to either the a or b axes. The methanol-grafted nanoscrolls have a variable but larger basal spacing (from 0.76 to 0.90 nm) than the value in ordered kaolinite (0.72 nm). Their external diameters range from 22 to 75 nm, lengths from 218 to 2287 nm, aspect ratios from 5 to 74, and the scrolls have recognizable chirality. Crystallog. image processing of HRTEM structure images suggest that the tetrahedral sheet can be on either the outer or the inner sides of the nanoscrolls. Mol. simulation results for the curled kaolinite layers are consistent in their details with the exptl. observations, suggesting that the layers may roll up either way.

Applied Clay Science published new progress about Cell morphology. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tinjaca, Dario A. published the artcileSolubility of meloxicam in aqueous binary mixtures of formamide, N-methylformamide and N,N-dimethylformamide: Determination, correlation, thermodynamics and preferential solvation, SDS of cas: 123-39-7, the main research area is meloxicam formamide n methylformamide nndimethylformamide correlation thermodn preferential solvation.

In this research the exptl. solubility of meloxicam (MLX) in {formamide (FM) + water}, {N-methylformamide (NMF) + water} and {N,N-dimethylformamide (DMF) + water} mixtures were determined at five temperatures, 293.15 K, 298.15 K, 303.15 K, 308.15 K and 313.15 K. MLX solubility increases with the cosolvent proportion in the mixtures and with temperature arising. Exptl. solubility of MLX was modelled by using three well-known cosolvency models, namely the combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), Modified-Wilson model and Jouyban-Acree model. The mean relative deviation (MPD%), in the accuracy of each math. model in relation to exptl. solubility, shown CNIBS/R-K model is better in contrast to the other models. The model results were below of 3.21% for (FM + water) mixtures, to each temperature in the study. Furthermore, these were below of 1.72% for (NMF + water) mixtures and below of 1.70% for (DMF + water) mixtures, resp. Apparent thermodn. quantities of dissolution and mixing, as well as the preferential solvation parameters of MLX were calculated Gibbs energies and enthalpies of dissolution were pos. whereas the resp. entropies were neg. MLX is preferentially solvated by water mols. in water-rich mixtures but preferentially solvated by cosolvent mols. in mixtures of cosolvent-rich mixtures

Journal of Chemical Thermodynamics published new progress about Binary mixtures. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, SDS of cas: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gaudin, Theophile published the artcileSubstructure shock-friction theory for molecular transport in liquids, Application of N-Methylformamide, the main research area is liquid mol transport shock friction theory.

Transport properties, such as viscosity and diffusion coefficient, are of fundamental importance in chem. processes and in formulation science. In this paper, a math. simple theory, based on frictions between “”substructures””, which are effective units of motion, and contact probabilities, is proposed for transport properties. Its predictive power is demonstrated on viscosity. Fitted on a set of 82 pure liquids containing mols. of various sizes, rigidities, and functionalities, with many of them multifunctional and/or hydrogen-bonded, the method is then tested on 882 binary mixtures (represented by 13,687 compositions and containing 234 different compounds), yielding a standard error of 0.30 log units. This corresponds to an accuracy of a factor of two, in line with other free energy-based predictions methods like COSMO-RS, supporting a pseudo-thermodn. representation of transport properties.

Journal of Molecular Liquids published new progress about Binary mixtures. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sikorski, Patryk published the artcileSolid-liquid equilibria and excess enthalpies in binary mixtures of propiophenone with some aliphatic amides, Quality Control of 123-39-7, the main research area is propiophenone aliphatic amide binary mixture solid liquid equilibrium enthalpy.

The solid-liquid equilibrium and excess enthalpies of the binary systems of propiophenone and {N-methylformamide, or N,N-dimethylformamide, or N,N-dimethylacetamide, or N-methyl-2-pyrrolidone} were measured. The SLE data were determined by the cloud-point method, partly supplemented by the DSC technique. The excess enthalpies were measured by the titration calorimetry at 298.15 K and 308.15 K for all the systems and addnl. at 293.15 K and 318.15 K for the system with N-methylformamide, and at 293.15 K for the system with N,N-dimethylformamide. The activity coefficients of both components as a function of concentration and temperature were calculated by the correlation which included both types of data. The results of the prediction by the modified UNIFAC model were compared with the exptl. data. The observed trends and differences between the systems were discussed.

Journal of Molecular Liquids published new progress about Binary mixtures. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics