Author: Jessica.F

Colzi, L. published the artcileThe GUAPOS project. II. A comprehensive study of peptide-like bond molecules, Category: amides-buliding-blocks, the main research area is galaxy mol cloud continuum energy level simulation modeling.

Peptide-like bond mols., which can take part in the formation of proteins in a primitive Earth environment, have been detected only towards a few hot cores and hot corinos up to now. We present a study of HNCO, HC(O)NH2, CH3NCO, CH3C(O)NH2, CH3NHCHO, CH3CH2NCO, NH2C(O)NH2, NH2C(O)CN, and HOCH2C(O)NH2 towards the hot core G31.41+0.31. The aim of this work is to study these species together to allow a consistent study among them. We have used the spectrum obtained from the ALMA 3mm spectral survey GUAPOS, with a spectral resolution of ∼0.488MHz (∼1.3-1.7 km s-1) and an angular resolution of 1.′′2 x 1.′′2 (∼4500 au), to derive column densities of all the mol. species presented in this work, together with 0.′′2 x 0.′′2 (∼750 au) ALMA observations from another project to study the morphol. of HNCO, HC(O)NH2, and CH3C(O)NH2. We have detected HNCO, HC(O)NH2, CH3NCO, CH3C(O)NH2, and CH3NHCHO, but no CH3CH2NCO, NH2C(O)NH2, NH2C(O)CN, or HOCH2C(O)NH2. This is the first time that these mols. have been detected all together outside the Galactic center. We have obtained mol. fractional abundances with respect to H2 from 10-7 down to a few 10-9 and abundances with respect to CH3OH from 10-3 to ∼4 x 10-2, and their emission is found to be compact (∼2′′, i.e. ∼7500 au). From the comparison with other sources, we find that regions in an earlier stage of evolution, such as pre-stellar cores, show abundances at least two orders of magnitude lower than those in hot cores, hot corinos, or shocked regions. Moreover, mol. abundance ratios towards different sources are found to be consistent between them within ∼1 order of magnitude, regardless of the phys. properties (e.g. different masses and luminosities), or the source position throughout the Galaxy. Correlations have also been found between HNCO and HC(O)NH2 as well as CH3NCO and HNCO abundances, and for the first time between CH3NCO and HC(O)NH2, CH3C(O)NH2 and HNCO, and CH3C(O)NH2 and HC(O)NH2 abundances. These results suggest that all these species are formed on grain surfaces in early evolutionary stages of mol. clouds, and that they are subsequently released back to the gas phase through thermal desorption or shock-triggered desorption.

Astronomy & Astrophysics published new progress about Continuum energy level. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jacob, Stephane published the artcileHigh-performance flexible thermoelectric modules based on high crystal quality printed TiS2/hexylamine, Product Details of C2H5NO, the main research area is titanium sulfide hexylamine thermoelec module thermal conductivity; 105 Low-Dimension (1D/2D) materials; 206 Energy conversion / transport / storage / recovery; 210 Thermoelectronics / Thermal transport / insulators; 50 Energy Materials; TiS2/hexylamine; exfoliation; layered structure; printed thermoelectrics; thin films.

Printed electronics implies the use of low-cost, scalable, printing technologies to fabricate electronic devices and circuits on flexible substrates, such as paper or plastics. The development of this new electronic is currently expanding because of the emergence of the internet-of-everything. Although lot of attention has been paid to functional inks based on organic semiconductors, another class of inks is based on nanoparticles obtained from exfoliated 2D materials, such as graphene and metal sulfides. The ultimate scientific and technol. challenge is to find a strategy where the exfoliated nanoparticle flakes in the inks can, after solvent evaporation, form a solid which displays performances equal to the single crystal of the 2D material. In this context, a printed layer, formed from an ink composed of nano-flakes of TiS2 intercalated with hexylamine, which displays thermoelec. properties superior to organic intercalated TiS2 single crystals, is demonstrated for the first time. The choice of the fraction of exfoliated nano-flakes appears to be a key to the forming of a new self-organized layered material by solvent evaporation The printed layer is an efficient n-type thermoelec. material which complements the p-type printable organic semiconductors The thermoelec. power factor of the printed TiS2/hexylamine thin films reach record values of 1460μW m-1 K-2 at 430 K, this is considerably higher than the high value of 900μW m-1 K-2 at 300 K reported for a single crystal. A printed thermoelec. generator based on eight legs of TiS2 confirms the high-power factor values by generating a power d. of 16.0 W m-2 at ΔT = 40 K.

Science and Technology of Advanced Materials published new progress about Additive manufacturing. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Teuscher, Kevin B. published the artcileDiscovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization, Name: (S)-2-Methylpropane-2-sulfinamide, the main research area is cancers WDR5 WIN site inhibitor selectivity pharmacokinetic antiproliferative bioavailability.

WD repeat domain 5 (WDR5) is a nuclear scaffolding protein that forms many biol. important multiprotein complexes. The WIN site of WDR5 represents a promising pharmacol. target in a variety of human cancers. Here, we describe the optimization of our initial WDR5 WIN-site inhibitor using a structure-guided pharmacophore-based convergent strategy to improve its druglike properties and pharmacokinetic profile. The core of the previous lead remained constant while a focused SAR effort on the three pharmacophore units was combined to generate a new in vivo lead series. Importantly, this new series of compounds has picomolar binding affinity, improved cellular antiproliferative activity and selectivity, and increased kinetic aqueous solubility They also exhibit a desirable oral pharmacokinetic profile with manageable i.v. clearance and high oral bioavailability. Thus, these new leads including compound 41 (I), are useful probes toward studying the effects of WDR5 inhibition.

Journal of Medicinal Chemistry published new progress about Acute myeloid leukemia. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Name: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gao, Jianhong published the artcileTotal Synthesis of (+)-Jatrophalactam, Quality Control of 343338-28-3, the main research area is asym total synthesis of jatrophalactam absolute configuration determination; conformationally controlled cyclopropanation asym total synthesis of jatrophalactam; Meldrums acid macrolactam formation asym total synthesis of jatrophalactam; palladium oxidative cyclization asym total synthesis of jatrophalactam.

The first asym. total synthesis of (+)-jatrophalactam was reported, which unambiguously determined the absolute configuration of the titled natural product. The key features entail a conformationally controlled cyclopropanation, a Meldrum’s acid adduct-engaged macrolactam formation, and a Pd(II)-mediated oxidative cyclization.

Organic Letters published new progress about Absolute configuration. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Quality Control of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kutateladze, Dennis A. published the artcileEnantioselective Tail-to-Head Cyclizations Catalyzed by Dual-Hydrogen-Bond Donors, HPLC of Formula: 343338-28-3, the main research area is enantioselective cyclization dual hydrogen bond donor catalyst urea; neryl chloride analog.

Chiral urea derivatives are shown to catalyze enantioselective tail-to-head cyclization reactions of neryl chloride analogs. Exptl. data are consistent with a mechanism in which π-participation by the nucleophilic olefin facilitates chloride ionization and thereby circumvents simple elimination pathways. Kinetic and computational studies support a cooperative mode of catalysis wherein two mols. of the urea catalyst engage the substrate and induce enantioselectivity through selective transition state stabilization.

Journal of the American Chemical Society published new progress about Absolute configuration. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, HPLC of Formula: 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bala, D. published the artcileStudy on Thermodynamic and Transport Properties of Binary Liquid Mixtures (N-Methylformamide with Aniline, N-Methylaniline, and N,N-Dimethylaniline) at Various Temperatures, Formula: C2H5NO, the main research area is thermodn transport property binary liquid mixture Nmethylformamide aniline; Nmethylaniline NNdimethylaniline temperature.

Densities (ρ), speeds of sound (u), and viscosities (η) of binary mixtures of N-methylformamide (N-MF) with aniline (A), N-methylaniline (N-MA), and N, N-dimethylaniline (N, N-DMA) including those of pure liquids, over the entire composition range were measured at temperatures (303.15, 308.15, and 313.15 K) and 0.1 MPa. Using the exptl. data, the excess volume (VE), excess isentropic compressibility (κEs), deviation in viscosity (δη), excess partial molar volumes, [V-Em, 1] and [V-Em, 2], and excess partial molar isentropic compressibilities, [K-Es, m, 1] and [K-Es, m, 2] of the components at infinite dilution were calculated The VE results have been analyzed in the terms of Prigogine-Flory-Patterson theory. An anal. of each of the three contributions viz. interactional, free volume and P* to VE shows that free volume effects are neg. for all the binary mixtures FT-IR (Fourier transform IR spectroscopy) properties have been carried out to study the specific interaction such as formation of hydrogen bond between unlike mols. in the binary liquid mixtures; a good agreement is observed among the excess parameters and FT-IR spectroscopic properties.

Russian Journal of Physical Chemistry A published new progress about Binary mixtures, liquid. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Warminska, Dorota published the artcileThermophysical study of the binary mixtures of triethyl phosphate with N-methylformamide, N,N-dimethylformamide and N,N-dimethylacetamide – Experimental and theoretical approach, Computed Properties of 123-39-7, the main research area is triethyl phosphate methylformamide dimethylacetamide binary mixture thermophys excess property.

Densities at (293.15, 298.15, 303.15 and 308.15) K, and viscosities and ultrasonic velocities at 298.15 K of binary liquid mixtures of tri-Et phosphate with N-methylformamide, N,N-dimethylformamide and N,N-dimethylacetamide have been measured over the entire range of composition at p = 0.1 MPa. From the exptl. data, values of excess molar volume, excess isentropic compressibility, viscosity deviation and excess Gibbs energy of activation for viscous flow have been calculated These results were fitted to the Redlich-Kister-type polynomial equation. The viscosity deviations and the excess Gibbs energy were found to be pos. for the all systems investigated, while the excess volumes and the excess isentropic compressibilities were neg. for TEP + DMA and for TEP + DMF systems, and pos. for mixtures TEP + NMF. These results were interpreted based on the strength of the specific interaction, size and shape of mols. Mol. dynamics simulations were used to provide a detailed explanation of the differences between the TEP + NMF and other systems, which were ultimately traced to strong hydrogen bonding between NMF and TEP.

Journal of Molecular Liquids published new progress about Binary mixtures, liquid. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kalimulla, T. published the artcileUltrasonic investigations in binary liquid mixtures of 2-methylcyclohexanone with formamide, n-methylformamide and N,N-dimethylformamide at different temperatures., Synthetic Route of 123-39-7, the main research area is methylcyclohexanone formamide methylformamide DMF ultrasonic investigation binary liquid mixture.

Ultrasonic velocity(U), viscosity (η) and d. (ρ) of binary liquid mixtures 2-methylcyclohexanone with formamide, N-Methylformamide and N,N-Dimethylformamide have been measured at three temperatures 303.15,308.15 and 313.15 K, over the entire composition range. These exptl. data have been used to calculated the excess isentropic compressibility (KsE), excess enthalpy (HE), excess free length (LfE), excess Gibb’s free energy (ΔG*E) and excess molar volume (VmE). The excess values have been fitted to the Redlich-Kister type polynomial equation. The deviations of excess values provide valuable information that allows us to have a better understanding of the structure of liquids and intermol. interactions in liquid mixtures The results of these observations have been interpreted in terms of structural effects of the solvents. Further the exptl. and derived results are analyzed in terms of structural mol. interactions between component mols. with FT-IR spectral studies.

Journal of Pharmaceutical Sciences and Research published new progress about Binary mixtures, liquid. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

ShaikBabu, K. Govinda Raoand published the artcileAcoustic properties of binary liquid mixtures containing N-methyl formamide with anilines at different temperatures, Recommanded Product: N-Methylformamide, the main research area is methylformamide aniline binary liquid mixture acoustic parameter.

Densities (ρ), viscosity (η) and speed of sound (U) values for the liquid mixture systems of N-Methylformamide with Aniline, N-methylaniline and N,N-Dimethylanilinealong with those of pure liquids were measured over the entire mole fraction range at T = 303.15 K, 308.15 K and 313.15 K. From these exptl. determined values, various acoustic parameters such as excess isentropic compressibility (KsE), excess molar volume (VE) and excess free length (LfE), excess Gibb’s free energy (ΔG*E) and excess enthalpy (HE) have been calculated The excess functions have been fitted to the Redlich-Kister type polynomial equation. The presenceofintermol. interactions in these liquid mixtures was confirmed by studying the deviations observed in the excess parameters.

Rasayan Journal of Chemistry published new progress about Binary mixtures, liquid. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nagarjuna, A. published the artcileMolecular interactions in binary liquid mixtures containing benzyl benzoate, Recommanded Product: N-Methylformamide, the main research area is benzyl benzoate amide binary liquid mixture mol interaction.

Speeds of sound, densities and viscosities of the binary mixture of Benzyl benzoate with mole fractions of amides – Formamide (FA), N-Me formamide (NMF) and Di Me formamide (DMF) have been estimated utilizing the standard strategies at 303.15, 308.15 and 313.15K. From these deliberate values, different thermo-dynamic parameters such as isentropic compressibility (Ks), intermol. free length (Lf), molar volume (Vm), Gibbs free energy (ΔG), enthalpy (H) and their excess properties were determined The figured qualities have been fitted to the Redlich-Kister type polynomial condition utilizing least squares technique to assess the twofold coefficients and standard deviations.

Rasayan Journal of Chemistry published new progress about Binary mixtures, liquid. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics