Author: Jessica.F

Chen, Jing published the artcileSelectfluor-promoted Synthesis of 2,4- and 2,6-Diarylpyridines Through Annulation of Aromatic Ketones with an Ammonium Source in DMF, Computed Properties of 123-39-7, the main research area is diarylpyridine preparation regioselective; aromatic ketone ammonium acetate DMF condensation cyclization Selectfluor.

An efficient one-pot four-component condensation and cyclization of ketones with DMF and ammonium acetate for the synthesis of 2,4-diarylsubstituted pyridines promoted by Selectfluor has been achieved. Sym. pyridines were obtained selectively when non-Me ketones were used as the starting materials. Two C-C and C-N bonds are formed during the oxidative cyclization process.

ChemistrySelect published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cinelli, Maris A. published the artcileFirst Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is phenyl aminoquinoline preparation neuronal nitric oxide synthase inhibitor human; mol docking SAR phenyl aminoquinoline crystal structure.

Inhibition of neuronal nitric oxide synthase (nNOS), an enzyme implicated in neurodegenerative disorders, is an attractive strategy for treating or preventing these diseases. Several classes of 2-aminoquinoline-based nNOS inhibitors were developed previously, but these compounds had drawbacks including off-target promiscuity, low activity against human nNOS, and only modest selectivity for nNOS over related enzymes. In this study, new nNOS inhibitors based on 7-phenyl-2-aminoquinoline were synthesized and assayed them against rat and human nNOS, human eNOS, and murine and (in some cases) human iNOS. Compounds with a meta-relationship between the aminoquinoline and a pos. charged tail moiety were potent and had up to nearly 900-fold selectivity for human nNOS over human eNOS. X-ray crystallog. indicates that the amino groups of some compounds occupy a water-filled pocket surrounding an nNOS-specific aspartate residue (absent in eNOS). This interaction was confirmed by mutagenesis studies, making 7-phenyl-2-aminoquinolines the first aminoquinolines to interact with this residue.

Journal of Medicinal Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Hayden A. published the artcileEnantioselective catalytic 1,2-boronate rearrangements, Quality Control of 343338-28-3, the main research area is enantioselective boronate rearrangement boronic ester dichloromethane lithium ureaboronate catalyst; lithium urea boronate complex preparation catalyst boronate rearrangement dichloromethane; crystal structure lithium urea boronate complex; mol structure lithium urea boronate complex.

A strategy that facilitates the construction of a wide variety of trisubstituted stereocenters through a catalytically accessed common chiral intermediate could prove highly enabling for the field of synthetic chem. The authors report the discovery of enantioselective, catalytic 1,2-boronate rearrangements for the synthesis of α-chloro pinacol boronic esters from readily available boronic esters and CH2Cl2. The chiral building blocks produced in these reactions can undergo two sequential stereospecific elaborations to generate a wide assortment of trisubstituted stereocenters. The enantioselective reaction is catalyzed by a Li-isothiourea-boronate complex, which is proposed to promote rearrangement through a dual-Li-induced chloride abstraction orchestrated by Lewis basic functionality on the catalyst scaffold.

Science (Washington, DC, United States) published new progress about Addition reaction catalysts (Li-isothiourea-boronate complex). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Quality Control of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Le Falher, Laetitia published the artcilePreparation of Halogen-Containing 4H-Pyrido[e][1,3]oxazin-4-ones and Their Transformation into 2-Hydroxypyridinyl-Substituted 1,2,4-Oxadiazoles and 1,2,4-Triazoles, SDS of cas: 13958-99-1, the main research area is pyridylimide sodium salt intramol arylation; pyridooxazinone halo preparation microwave irradiation hydroxylamine cyclocondensation hydrazine; oxadiazole hydroxypyridyl triazole preparation regioselective.

A complete study on the preparation of original halogen-containing 4H-pyrido[e][1,3]oxazin-4-ones I (R = C6H5, 2-H3CC6H4, 4-ClC6H4, 4-H3COC6H4, etc.; R1 = H, Br) and their transformation into 2-hydroxypyridinyl-substituted 1,2,4-oxadiazoles II (W = O) and 1,2,4-triazoles II (W = NH, NC6H5) is presented. The efficiency of the intramol. O-arylation of pyridyl-imide sodium salts e.g., III was studied on three series of compounds, with different fluoro-, chloro-, and bromophenyl substituents at the C-2 position. The final halogenated compounds I are of interest as new synthons for future functionalization. A rapid, and complementary access to 2-substituted 4H-benzo[e][1,3]oxazinones IV (R2 = 2-bromo-4-pyridyl, phenyl) were discovered. Finally, the one-step transformation of some of these pyrido-oxazinones I into the corresponding II was explored, and the regioselectivity of the reaction was proved by X-ray crystallog.

European Journal of Organic Chemistry published new progress about Acid halides Role: RCT (Reactant), RACT (Reactant or Reagent). 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, SDS of cas: 13958-99-1.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Francisco, Karol R. published the artcileStructure property relationships of N-acylsulfonamides and related bioisosteres, Application of (S)-2-Methylpropane-2-sulfinamide, the main research area is acylsulfonamide structure property relationship bioisostere; Bioisostere; Isosteric replacement; N-Acylsulfonamide isostere; Oxetane; Physicochemical properties; Structure property relationship (SPR); Thietane.

The N-acylsulfonamide functional group is a feature of the pharmacophore of several biol. active mols., including marketed drugs. Although this acidic moiety presents multiple points of attachments that could be exploited to introduce structural diversification, depending on the circumstances, the replacement of the functional group itself with a suitable surrogate, or bioisostere, may be desirable. A number of N-acylsulfonamide bioisosteres have been developed over the years that provide opportunities to modulate both structure and physicochem. properties of this important structural motif. To enable an assessment of the relative impact on physicochem. properties that these replacements may have compared to the N-acylsulfonamide group, we conducted a structure-property relationship study based on matched mol. pairs, in which the N-acylsulfonamide moiety of common template reference structures is replaced with a series of bioisosteres. The data presented, which include an assessment of relative changes in acidity, permeability, lipophilicity and intrinsic solubility, provides a basis for informed decisions when deploying N-acylsulfonamides, or surrogates thereof, in analog design.

European Journal of Medicinal Chemistry published new progress about Biological permeation (artificial membrane permeability assay). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application of (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xu, Hong-Hui published the artcileThioamidation of Arylpropyne Derivatives with Sulfur and Formamides for the Synthesis of Aryl Propanethioamides, Computed Properties of 123-39-7, the main research area is aryl propanethioamide preparation; arylpropyne sulfur formamide three component cascade thioamidation.

An efficient synthesis of aryl propanethioamides ArCH2CH2C(S)NRR1 [R = H, Me; R1 = Me, Et; RR1 = (CH2)4, (CH2)2O(CH2)2] by a three-component reaction of arylpropynes, elemental sulfur and formamides was developed. The cascade thioamidation proceeded smoothly through the hydrolysis of the C-C triple bond and formamides, the formation of C-N bond and C-S double bond in one-pot reaction.

Asian Journal of Organic Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Lixian published the artcileAmino Acid Derived Chiral Aminobenzimidazole Manganese Catalysts for Asymmetric Transfer Hydrogenation of Ketones, Application of (S)-2-Methylpropane-2-sulfinamide, the main research area is ketone manganese chiral aminobenzimidazole asym transfer hydrogenation catalyst; alc stereoselective preparation.

A series of Mn(I) catalysts with chiral bidentate benzimidazoles derived from easily available amino acids has been developed. These types of phosphine-free chiral Mn catalysts demonstrate high activity and enantioselectivity in asym. transfer hydrogenation (ATH) for a broad range of ketone substrates. A bulkier substrate, such as 2,6-dichloro-3-fluoroacetophenone, can be converted into the drug intermediate alc. with up to 90% yield and 92% ee (e.g., crizotinib). On the basis of exptl. and DFT studies, a possible mechanism for this Mn-catalyzed ATH is also proposed. DFT calculations further render a plausible model for enantiocontrol in ketone hydrogenation, in which the π-π stacking interaction between the catalyst and the substrate plays an important role.

ACS Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application of (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sorribes, Ivan published the artcilePalladium doping of In2O3 towards a general and selective catalytic hydrogenation of amides to amines and alcohols, Category: amides-buliding-blocks, the main research area is palladium doping indium oxide catalyst hydrogenation amide amine alc.

Herein, the first general heterogeneous catalytic protocol for the hydrogenation of primary, secondary and tertiary amides to their corresponding amines and alcs. is described. Advantageously, this catalytic protocol works under additive-free conditions and is compatible with the presence of aromatic rings, which are fully retained in the final products. This hydrogenative C-N bond cleavage methodol. is catalyzed by a Pd-doped In2O3 catalyst prepared by a microwave hydrothermal-assisted method followed by calcination. This catalyst displays highly dispersed Pd2+ ionic species in the oxide matrix of In2O3 that have appeared to be essential for its high catalytic performance.

Catalysis Science & Technology published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vazquez-Chavez, Josue published the artcileThe effect of chiral N-substituents with methyl or trifluoromethyl groups on the catalytic performance of mono- and bifunctional thioureas, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is ketoester unsaturated aldehyde thiourea chiral Michael addition catalyst oxidation; dihydropyran stereoselective preparation; enone aldehyde thiourea chiral baylis hillman reaction catalyst; hydroxymethyl enone preparation.

We evaluated thiourea organocatalysts that incorporate a chiral group which includes a trifluoromethyl moiety and contrasted their performance with non-fluorinated analogs. The comparison between such systems allows the direct study of the NH acidity of a thiourea bonded to an aliphatic substituent. In principle, -CF3 systems feature an enhanced hydrogen bond (HB) donor capacity that is undoubtedly beneficial for HB-catalysis applied to the Baylis-Hillman reaction. We found that the thiourea substituted on both nitrogens with this group accelerates this reaction like Schreiner’s thiourea. On the other hand, we observed a different behavior in reactions promoted by bifunctional catalysts (thiourea-primary amine). In the Michael addition of isobutyraldehyde to Me benzylidenepyruvate, the -CF3 containing catalysts were better than the -CH3 systems, whereas the conjugate addition to N-phenylmaleimide showed the opposite behavior. Theor. calculations of the transition states indicated that the phenylethyl group in fluorinated and non-fluorinated compounds have different kinds of interactions with the electrophile. These interactions are responsible for a different arrangement of the electrophile and thereby the selectivity of the catalyst. Therefore, it cannot be generalized that in all cases NH acidity correlates with the performance of the catalyst, particularly, with aliphatic substituents that unlike the aromatic ones possess groups that are outside the plane of the thiourea.

Organic & Biomolecular Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Devi, E. Sankari published the artcileN-Heterocyclic Carbene Catalyzed Synthesis of Trisubstituted Epoxides via Tandem Amidation/Epoxidation Sequence, Name: N-Methylformamide, the main research area is chalcone preparation formamide TBHP NHC catalyst tandem amidation epoxidation; benzoyl aryloxiranyl carboxamide diastereoselective preparation green chem.

A tandem amidation/epoxidation sequence between various substituted chalcones and N,N-dimethylformamide (DMF) for the synthesis of trisubstituted epoxides employing N-heterocyclic carbene catalysis was developed. This reaction was performed under metal-free conditions in the presence of tert-Bu hydroperoxide (TBHP) as the oxidant. Trisubstituted epoxides bearing a ketone and an amide functionality (N,N-di-Me formyl group) were synthesized starting from a wide range of chalcones in moderate to good yields with excellent diastereoselectivity.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics