Author: Jessica.F

Yisimayili, Nuermaimaiti published the artcileStereodivergent Construction of Vicinal Acyclic Quaternary-Tertiary Carbon Stereocenters by Michael-Type Alkylation of α,α-Disubstituted N-tert-Butanesulfinyl Ketimines, Product Details of C4H11NOS, the main research area is tert butanesulfinyl ketimine nitroalkene diastereoselective aza enolization conjugate addition; nitroalkyl tert butanesulfinyl ketimine preparation.

Vicinal quaternary-tertiary carbon stereocenters were constructed with excellent stereoselectivity via aza-enolization of enantioenriched acyclic N-tert-butanesulfinyl ketimines bearing two sterically similar α-linear alkyl substituents followed by conjugate addition to nitroalkenes. Further changes of the absolute configuration of the sulfinyl group and/or the α-stereocenter in the ketimine allowed the facile stereodivergent synthesis of all four diastereomers of the Michael-type alkylation adducts. This reaction is a successful example of acyclic stereocontrol based on stereoselective α-deprotonation for the formation of fully substituted aza-enolates from ketone derivatives

Organic Letters published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ning, Yunyun published the artcileSite-specific Umpolung amidation of carboxylic acids via triplet synergistic catalysis, Quality Control of 7465-88-5, the main research area is nitroalkane carboxylic acid iridium phosphine iron catalyst Umpolung amidation; carboxylic acid nitroarene iridium phosphine iron catalyst Umpolung amidation; aralkyl amide preparation photochem.

In this paper, an Umpolung amidation reaction of carboxylic acids with nitroarenes and nitroalkanes enabled by the triplet synergistic catalysis of FeI2, P(V)/P(III) and photoredox catalysis, which avoids the production of byproducts from stoichiometric coupling reagents were disclosed. A wide range of carboxylic acids, including aliphatic, aromatic and alkenyl acids participated smoothly in such reactions, generating structurally diverse amides in good yields (86 examples, up to 97% yield). This Umpolung amidation strategy opened a method to address challenging regioselectivity issues between nucleophilic functional groups and complemented the functional group compatibility of the classical amidation protocols. The synthetic robustness of the reaction was demonstrated by late-stage modification of complex mols. and gram-scale applications.

Nature Communications published new progress about Alkanes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Quality Control of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dawood, Rafid S. published the artcileStereodivergent Total Syntheses of (+)-Monomorine I and (+)-Indolizidine 195B, Formula: C4H11NOS, the main research area is indolizidine alkaloid preparation diastereoselective enantioselective; monomorine alkaloid preparation diastereoselective enantioselective.

A simple and efficient stereoselective total synthesis of two natural products (+)-monomorine I and (+)-indolizidine 195B in high yields starting from a readily available alc. is described. The key step in this synthetic route exploits the judicious use of solvent to enable a closed or open transition state in a nucleophilic addition of Grignard reagent to sulfinimine, giving selective access to two distinct diastereomers required for the formation of the two target natural products.

European Journal of Organic Chemistry published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Formula: C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Wen published the artcileStructure units oriented approach towards collective synthesis of sarpagine-ajmaline-koumine type alkaloids, Product Details of C4H11NOS, the main research area is sarpagine ajmaline koumine alkaloid preparation.

A unified approach towards the asym. synthesis of three types of alkaloids, leading to a collective synthesis of 14 natural alkaloids is reported. Among them, akuammidine, 19-Z-akuammidine, vincamedine, vincarine, quebrachidine, vincamajine, alstiphyllanine J, and dihydrokoumine were accomplished for the first time. Features of this synthesis are a new Mannich-type cyclization to construct the key indole-fused azabicyclo[3.3.1]nonane common intermediate, an SmI2-mediated coupling to fuse the aza-bridged E-ring, stereoselective olefinations to install either the 19-E or 19-Z terminal alkenes presented in the natural alkaloids, and an efficient iodo-induced cyclization to establish the two vicinal all-carbon quaternary centers in the koumine-type alkaloids.

Nature Communications published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Shen, Xianfu published the artcileCopper(I)-Catalyzed Cascade Cyclization to the Total Synthesis of Hexahydropyrroloindole Alkaloids: Flustramine B and Debromoflustramine B, Safety of (S)-2-Methylpropane-2-sulfinamide, the main research area is oxindole copper catalyst cascade cyclization one pot; hexahydropyrroleindole alkaloid preparation.

The total synthesis of two bioactive hexahydropyrroloindole (HPI) alkaloids beared a C3a tetrasubstituted stereocenters substituted by isopentenyl. This route was based on Cu-catalyzed cascade arylation-alkylation sequence in one-pot as a key step, provided Flustramine B and Debromoflustramine B with 9 steps in 37.6% and 31.1% overall yields, resp.

ChemistrySelect published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Safety of (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Karthik, Shanmugam published the artcileA Straightforward Metal-Free and Mild Base Promoted Amidation and Transesterification via Acyl C-O bond Cleavage-An Expedite Synthesis of Aromatic Amides and Esters, Related Products of amides-buliding-blocks, the main research area is aryl ester amine potassium carbonate promotor amidation; arylamide preparation; aromatic alc aryl ester potassium carbonate promotor transesterification; ester aromatic preparation.

A straight-forward and practical metal-free amidation and transesterification of esters were exemplified in this protocol. This strategic reaction features mild bases and devoid of additives at a reasonable temperature (55°). The wide range of amines including aromatic amines, was successfully subjected to amidation that supplements the scope exploration. Likewise, various transesterification products from alcs. were realized under this optimized condition.

ChemistrySelect published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ma, Peng-Ju published the artcileAddition-Rearrangement of Ketenes with Lithium N-tert-Butanesulfinamides: Enantioselective Synthesis of α,α-Disubstituted α-Hydroxycarboxylic Acid Derivatives, Synthetic Route of 343338-28-3, the main research area is hydroxycarboxamide enantioselective preparation; nonracemic sulfonamide lithiation stereoselective addition ketene rearrangement; tandem stereoselective addition sulfinamide ketene rearrangement.

Addition of the lithium salts of nonracemic sulfinamides such as I (generated in situ) to ketenes such as PhEtC:C:O (either prepared or generated in situ from the corresponding acyl chlorides) followed by Mislow-Evans [2,3]-sigmatropic rearrangement yielded sulfenates of α-hydroxycarboxamides such as II; the absolute stereochem. of the sulfinamide was transferred to the new stereocenter with high fidelity.

Organic Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Synthetic Route of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kwiatkowska, Magdalena published the artcileThe self-disproportionation of enantiomers (SDE) via column chromatography of β-amino-α,α-difluorophosphonic acid derivatives, COA of Formula: C4H11NOS, the main research area is aminophosphonic acid ester synthesis self disproportionation enantiomer column chromatog; acetylated benzyloxycarbonyl dipeptide amine SDEvC aminophosphonic acid; hydrogen bond dimer chirality; Achiral chromatography; Amino acids and derivatives; Enantioenrichment/-depletion; Molecular chirality; Self-disproportionation of enantiomers (SDE).

This work presents the first study of the self-disproportionation of enantiomers via chromatog. (SDEvC) of β-aminophosphonic acid esters, several of which have been synthesized for the first time. Three types of structures were examined, N-acetylated, dipeptide construction with N-Cbz (Cbz = benzyloxycarbonyl) glycine, and a free amine. In the latter case, this is the first time that SDEvC has been reported for free amine amino acids. In all the three types of structures, significant SDE magnitudes (Δee’s up to 55%) were exhibited underscoring the ubiquitous nature of the SDE phenomenon. Chem. models of homo- vs. heterochiral intermol. interactions are proposed to rationalize the SDE magnitude differences amongst these new β-aminophosphonic acid derivatives In addition, the incorporation of addnl., competing binding modes to a mol., was found to lead to a reduction of the SDE magnitude by shifting the intermol. binding away from the stereogenic center and/or by leading to a convoluted binding system that disrupts the structured and relatively stable assemblies that give rise to the SDE.

Amino Acids published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, COA of Formula: C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vala, Manoj Kumar published the artcileThe synthesis of phenyl carbamates catalyzed by iron(II) bromide: An oxidative approach for cross-coupling of phenols with formamides, Application In Synthesis of 123-39-7, the main research area is phenyl carbamate preparation green chem; phenol formamide cross coupling iron bromide catalyst.

The carbamate group is a key structural motif in many approved drugs and pro-drugs. There is increasing use of carbamates in the medicinal chem. and agrochem. industry. The authors present reagents and chem. methodologies for the synthesis of carbamates and recent applications. The direct coupling of simple phenols with mono- and di-alkyl formamides provided the phenylcarbamate products.

Synthetic Communications published new progress about Carbamates Role: SPN (Synthetic Preparation), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhi, Peng published the artcileVilsmeier-Haack reagent mediated synthetic transformations with an immobilized iridium complex photoredox catalyst, Name: 4-Methoxy-N-phenylbenzamide, the main research area is immobilized iridium complex photocatalyst Vilsmeier Haack reagent in situ; amide synthesis Vilsmeier Haack reagent in situ photoredox catalyst; nitrile synthesis Vilsmeier Haack reagent in situ photoredox catalyst; anhydride synthesis Vilsmeier Haack reagent in situ photoredox catalyst.

An immobilized iridium complex photocatalyst Ir(ppy)2(PDVB-py) was synthesized by immobilization of the iridium complex onto the nanoporous vinylpyridine-divinylbenzene copolymer (PDVB-py). Its application for the synthesis of amides, nitriles, and anhydrides was reported via reactions under the action of the visible-light-driven in situ generated Vilsmeier-Haack reagent from CBr4 in DMF. The results showed that this heterogeneous photocatalyst has extremely high activity and excellent stability to be recycled five times.

New Journal of Chemistry published new progress about Acetamides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Name: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics