Author: Jessica.F

Zhu, Bo-Han published the artcileHighly Site-Selective Oxidative Cyclization of Ene-ynamides via Non-Noble-Metal Catalysis: Access to Functionalized Lactams, Category: amides-buliding-blocks, the main research area is lactam preparation diastereoselective regioselective mechanism; chiral lactam preparation diastereoselective regioselective enantioselective mechanism; ene ynamide tandem oxidative cyclization non noble metal catalyst.

Herein, an unprecedented non-noble-metal-catalyzed oxidation/cyclization of ene-ynamides, e.g., R1CCN(R)CH(R2)C(R3):C(Me)R4 (R = Ms, Ts, Bs, benzenesulfonyl; R1 = Ph, 4-chlorophenyl, thiophen-2- yl, etc.; R2 = H, Et, allyl, prop-2-yn-1-yl; R3 = H, Me; R4 = Me, Ph), is developed, allowing the synthesis of diversely functionalized lactams, e.g., I and II, in moderate to good yields with excellent diastereoselectivities without the observation of typical cyclopropanation products. In combination with Ellman′s tert-butylsulfinimine chem., chiral γ-lactams containing three contiguous stereocenters are obtained with high diastereo- and enantioselectivity. Moreover, d. functional theory (DFT) calculations indicate that this protocol probably undergoes a carbon cation or proton transfer process.

Organic Letters published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Jianjian published the artcileChalcogen bond-guided conformational isomerization enables catalytic dynamic kinetic resolution of sulfoxides, Related Products of amides-buliding-blocks, the main research area is chiral sulfoxide preparation enantioselective regioselective; sulfinyl dibenzaldehyde alc esterification.

Conformational isomerization can be guided by weak interactions such as chalcogen bonding (ChB) interactions. Here authors report a catalytic strategy for asym. access to chiral sulfoxides by employing conformational isomerization and chalcogen bonding interactions. The reaction involves a sulfoxide bearing two aldehyde moieties as the substrate that, according to structural anal. and DFT calculations, exists as a racemic mixture due to the presence of an intramol. chalcogen bond. This chalcogen bond formed between aldehyde (oxygen atom) and sulfoxide (sulfur atom), induces a conformational locking effect, thus making the sym. sulfoxide as a racemate. In the presence of N-heterocyclic carbene (NHC) as catalyst, the aldehyde moiety activated by the chalcogen bond selectively reacts with an alc. to afford the corresponding chiral sulfoxide products with excellent optical purities. This reaction involves a dynamic kinetic resolution (DKR) process enabled by conformational locking and facile isomerization by chalcogen bonding interactions.

Nature Communications published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lei, Gaiying published the artcileIn situ preparation of amphibious ZnO quantum dots with blue fluorescence based on hyperbranched polymers and their application in bio-imaging, COA of Formula: C2H5NO, the main research area is zinc oxide quantum dot blue fluorescence hyperbranched polymer; amphibious ZnO quantum dots; bio-imaging; blue fluorescence; hyperbranched polymers.

A new strategy for preparing amphibious ZnO quantum dots (QDs) with blue fluorescence within hyper-branched poly(ethylenimine)s (HPEI) was proposed in this paper. By changing [Zn2+]/[OH-] molar ratio and heating time, ZnO QDs with a quantum yields (QY) of 30% in ethanol were obtained. Benefiting from the amphibious property of HPEI, the ZnO/HPEI nanocomposites in ethanol could be dissolved in chloroform and water, acquiring a QY of 53%, chloroform and 11% in water. By this strategy, the ZnO/HPEI nano-composites could be applied in not only in optoelectronics, but also biomedical fields (such as bio-imaging and gene transfection). The bio-imaging application of water-soluble ZnO/HPEI nanocomposites was investigated and it was found that they could easily be endocytosed by the COS-7 cells, without transfection reagent, and they exhibited excellent biol. imaging behavior.

Polymers (Basel, Switzerland) published new progress about Dialysis Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, COA of Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tian, Chao published the artcileVisible-Light Mediated ortho-Trifluoromethylation of Aniline Derivatives, Computed Properties of 7465-88-5, the main research area is visible light regioselective ortho trifluoromethylation aniline Langlois reagent photocatalyst.

A general visible-light mediated ortho-C-H trifluoromethylation of aniline derivatives by using a low-cost and stable Langlois reagent (CF3SO2Na) as the “”CF3″” source has been developed. In contrast to previous reports, this strategy allowed access to elusive trifluoromethyl lactams. Furthermore, mechanism experiments revealed that a copper/photoredox dual catalytic mechanism enabled general trifluoromethylation of aniline derivatives

Journal of Organic Chemistry published new progress about Photocatalysts. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Computed Properties of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tang, Yanling published the artcileEfficient Pd-Catalyzed Hydrodehalogenation of o-Haloanilides in Water, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is anilide green preparation; haloanilide regioselective hydrodehalogenation palladium catalyst.

A practical methodol. for the synthesis of anilides RC(O)NHPh [R = Me, Bn, 4-FC6H4, etc.] via hydrodehalogenation of o-haloanilides using PdCl2 at 100°C under mild conditions in water was developed. The catalytic system could selectively dehalogenate both aryl chloride and aryl bromide and exhibit a broad functional group tolerance.

Synlett published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Metternich, Jan B. published the artcileAsymmetric Nazarov Cyclizations of Unactivated Dienones by Hydrogen-Bond-Donor/Lewis Acid Co-Catalyzed, Enantioselective Proton-Transfer, Application In Synthesis of 343338-28-3, the main research area is pentadienone Lewis acid catalyst enantioselective Nazarov cyclization; cyclopentenone preparation; Lewis acid; Nazarov; catalysis; electrocyclization; enantioselective; physical organic.

Enantioselective Nazarov cyclization catalyzed by chiral hydrogen-bond-donors in concert with silyl Lewis acids was reported. The developed transformation provides access to tri-substituted cyclopentenones in high levels of enantioselectivity (up to 95% e.e.) from a variety of simple unactivated dienones. Kinetic and mechanistic studies are consistent with a reversible 4π-electrocyclization C-C bond-forming step followed by rate- and enantio-determining proton-transfer as the mode of catalysis.

Advanced Synthesis & Catalysis published new progress about Alkadienones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application In Synthesis of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rayala, Nagamani published the artcileAcid catalyzed multicomponent one-pot synthesis of new quinazolinone based unsymmetrical C-N linked bis heterocycles, Recommanded Product: N-Methylformamide, the main research area is dihydroquinazolinyl hexahydroacridine dione preparation; aminoquinazolinone cyclohexanedione aldehyde multicomponent condensation cyclization hydrochloric acid catalyst.

A novel series of unsym. C-N linked bis heterocycles bearing quinazolinone and acridinedione skeletons I (R = Ph, thiophen-2-yl, 2-chloroquinolin-3-yl, etc.) have been synthesized in an acid promoted one pot multicomponent reaction. A blend of 6-aminoquinazolin-4-(3H)-one, aromatic aldehydes RCHO and cyclohexane-1,3-dione in a simple and efficient condensation-cyclization reaction using hydrochloric acid in catalytic amount as catalyst afforded unsym. bis hybrids in good to excellent yields. Multiheterocyclic hybrid compounds I were also synthesized using heterocyclic ring containing aldehyde in three component reaction. The synthesized quinazolinone-acridindione hybrids I were characterized using spectroscopic techniques.

Asian Journal of Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kharaneko, A. O. published the artcileHeterocyclizations of Di- and Tricarbonyl Indole Derivatives. Synthesis of β-Carbolines, 3H-[1,2,5]Triazepino[5,4-a]indol-4(5H)-one, and 5,10-Dihydro[1,2]diazepino[4,5-b]indol-4(3H)-one, Name: N-Methylformamide, the main research area is carboline triazepinoindolone dihydrodiazepinoindolone preparation.

A synthetic approach to β-carbolines has been proposed on the basis of heterocyclization of Et 2-(2-benzoyl-1H-indol-3-yl)acetate with N-methylformamide or ammonium acetate. Hydrazine hydrate proved to be inefficient in this reaction. The heterocyclization of di-Me 2,2′-(2-benzoyl-1H-indole-1,3-diyl)diacetate with ammonium acetate selectively afforded 2-(3-hydroxy-1-phenyl-9H-pyrido[3,4-b]indol-9-yl)acetamide. Treatment of di-Me 2,2-(2-benzoyl-1H-indole-1,3-diyl)diacetate with hydrazine hydrate, followed by acid-catalyzed heterocyclization, gave Me 2-(4-oxo-1-phenyl-4,5-dihydro-3H-[1,2,5]triazepino[5,4-a]indol-11-yl)acetate or 2-{4-oxo-1-phenyl-4,5-dihydro[1,2]diazepino[4,5-b]indol-10(3H)-yl}acetohydrazide, depending on the conditions.

Russian Journal of Organic Chemistry published new progress about Fused heterocyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nakagawa, Yoshiaki published the artcileAnalysis and prediction of hydrophobicity parameters of substituted acetanilides, benzamides and related aromatic compounds, SDS of cas: 125328-80-5, the main research area is partition prediction acetanilide benzamide aromatic compound; review partition acetanilide benzamide aromatic compound.

The partition coefficient P in the 1-octanol/water system was analyzed for a great number of multisubstituted benzenes of ecotoxicol. importance consisting of acetanilides, benzamides, nitrobenzenes, and anisoles having various substitution patterns in terms of the ΔlogP(log P – log P[unsubstituted benzene]) quant. with free energy-related physicochem. substituent parameters. The analyses showed that the stereoelectronic effects of ortho, meta, and para substituents on the relative solvation of individual polar groups capable of hydrogen bonding with the partitioning solvents are very important in determining the variations in the logP value. The effects were additive in the set of complicated multisubstituted benzenes, leading to a correlation equation represented by a linear combination of terms of hydrophobic, electron, and steric parameters summed up over substituents. It was suggested that the procedure be extended to analyze and predict the logP value of any multiple substituted benzenes.

Environmental Toxicology and Chemistry published new progress about Ecotoxicity. 125328-80-5 belongs to class amides-buliding-blocks, name is N-(4-Bromo-3-chloro-2-methylphenyl)acetamide, and the molecular formula is C9H9BrClNO, SDS of cas: 125328-80-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

He, Shoushou published the artcileSite-Selective Surface Modification of 2D Superatomic Re6Se8, Computed Properties of 123-39-7, the main research area is superatomic rhenium selenide cluster nanosheet preparation surface functionalization.

Coating two-dimensional (2D) materials with mols. bearing tunable properties imparts their surfaces with functionalities for applications in sensing, nanoelectronics, nanofabrication, and electrochem. Here, the authors report a method for site-selective surface functionalization of 2-dimensional superat. Re6Se8Cl2 monolayers. First, the authors activate bulk layered Re6Se8Cl2 by intercalating Li and then exfoliate the intercalation compound Li2Re6Se8Cl2 in N-methylformamide (NMF). Heating the resulting solution eliminates LiCl to produce monolayer Re6Se8(NMF)2-x (x �0.4) as high-quality nanosheets. The unpaired electrons on each cluster in Re6Se8(NMF)2-x enable covalent surface functionalization through radical-based chem. The authors demonstrate this with four previously unknown surface-functionalized 2-dimensional superat. materials: Re6Se8I2, Re6Se8(SPh)2, Re6Se8(SPhNH2)2, and Re6Se8(SC16H33)2. TEM, chem. anal., and vibrational spectroscopy reveal that the in-plane structure of the 2-dimensional Re6Se8 material is preserved through surface functionalization. The incoming groups control the d. of vacancy defects and the solubility of the 2-dimensional material. This approach will find utility in installing a broad array of chem. functionality on the surface of 2-dimensional superat. materials as a means to systematically tune their phys. properties, chem. reactivity, and solution processability.

Journal of the American Chemical Society published new progress about Monolayers. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics