Author: Jessica.F

Zheng, Guihua; Yang, Yiyi; Deng, Linghui; Zhang, Ting; Zhu, Feiyun; Sun, Jing; Li, Shuangjiang; Feng, Xiaonan published an article in 2022, the title of the article was Pollution status and health impact assessment of antibiotics in environmental – and drinking water.Electric Literature of 144-80-9 And the article contains the following content:

The problem of antibiotics pollution in environmental water and drinking water has attracted the attention of environmental protection departments and all walks of life. At present, antibiotics have been widely detected in many water systems, and the concentration range is from ng/L to pg/L. In this paper, a method for the anal. of antibiotics in water by high performance liquid chromatog. tandem mass spectrometry (HPLC-MS/MS) was established. Then, the risk quotient (HQ) of antibiotics in wastewater treatment plant effluent and river water was calculated and studied. The results showed that some antibiotics did not cause direct ecol. risk. Finally, the health risk assessment of environmental water and drinking water was carried out. The results showed that the non carcinogenic risk caused by antibiotic pollution in the reservoir was far lower than the acceptable risk level, even far lower than the negligible risk level, indicating that the residues of these antibiotics in the drinking water would not pose significant non carcinogenic harm to human body. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

The Article related to antibiotic wastewater treatment plant drinking water health risk assessment, Placeholder for records without volume info and other aspects.Electric Literature of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2019, Gupta, Ena; Shakyawar, Snehlata; Sundaram, Shanthy published an article.Related Products of 456-12-2 The title of the article was Therapeutic and Nutraceutical Potential of Bioactive Compounds in Aegle marmelos (L.): An Overview. And the article contained the following:

A review. Aegle Marmelos (L.) Correa (A. marmelos), is a medicinal plant of Rutaceae family having a long history of curative property in traditional medicine. This plant is a rich source of bioactive compounds and natural antioxidants which can be isolated from its various parts such as fruit (carotenoids, tannins, flavonoids, ascorbic acid, marmelosin, marmelide, psoralen, aurapten, luvangetin); leaf (phenols, lupeol, skimmianine, citral, aegeline, eugenol, citronella, marmesinine) and bark (marmin, skimmianine, fagarine), etc. Many clin. and pre-clin. researches suggest the therapeutic applications of A. marmelos, such as anti-bacterial, anti-fungal, anti-viral, anti-ulcer, anti-diabetic, anticancer, anti-inflammatory and antioxidant properties which play a potential role in the prevention and treatment of various diseases. This review article focuses on exploring novel bioactive compounds of the above plant possessing potential therapeutic and health promoting applications. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to review aegle marmelos therapeutic nutraceutical potential bioactive compound, Placeholder for records without volume info and other aspects.Related Products of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2021, Zhou, Luli; Wang, Dingfa; Zhou, Hanlin published an article.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Metabolic profiling of two medicinal Piper species. And the article contained the following:

Piper sarmentosum Roxb. (PS) and Piper cathayanum M. G. Gilbert & N. H. Xia (PC) are both listed as Traditional Chinese Medicine herbs. In this study, ultra-performance liquid chromatog. mass spectrometry (UPLC-MS/MS) was used to analyze secondary metabolites and metabolically profile the leaves, stems and roots in PS and PC. A total of 110 and 92 differential metabolites were shared from various organs of PS and PC, resp. Compared to the stems and roots of PS or PC, alkaloids and phenols in leaves of PS or PC accounted for 70% and 57% of the total alkaloids and phenols, resp. An anal. of enriched metabolic pathways demonstrated that L-tyrosine and 4-hydroxycinnamic acid in PS were directly involved in five and three metabolic pathways, which are related to the biosynthesis of isoquinoline alkaloids and phenol backbones, resp. The L-glutamic acid and oxoglutaric acid in PC were involved in seven and two metabolic pathways, resp. L-glutamic acid synthesizes heme, tropane, piperidine and pyridine alkaloids, and the type II polyketide backbone. Moreover, oxoglutaric acid generated via L-glutamic acid was mainly involved in the citrate cycle and played a fundamental role in determining these important metabolic processes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to piper tyrosine 4 hydroxycinnamic acid isoquinoline alkaloid tropane piperidine, Placeholder for records without volume info and other aspects.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Konda, Satyanand; Asati, Ankita; Williams, Mike; Mudiam, Mohana Krishna Reddy published an article.Electric Literature of 144-80-9 The title of the article was Development and evaluation of a multi-class analytical method based on solid-phase extraction combined with liquid chromatography-tandem mass spectrometry for the analysis of pharmaceuticals and personal care products in urban wastewater samples. And the article contained the following:

An anal. method has been developed for the quant. evaluation of 64 pharmaceuticals and personal care products in urban wastewater using solid-phase extraction coupled with liquid chromatog.-tandem mass spectrometry. Design of experiments approach was used in the multiparametric optimization of solid-phase extraction method for the anal. of pharmaceuticals and personal care products. The method was found to be linear within the range of 0.01-1 渭g/L with coefficient of determination (R2) ranging from 0.990 to 0.999. The limit of detection and limit of quantification were found to be in the range of 0.002-0.028 and 0.007-0.091 渭g/L, resp. The accuracy was calculated with respect to percent recovery, and it was found to be in the range of 70.0-129% for all the analytes. The intra- and interday precisions were found to be less than 15% relative standard deviation for all the analytes. The developed anal. method was applied to real samples collected from four different sampling sites of Musi River in Hyderabad to evaluate its performance. The method found a wide application for the anal. of urban wastewater samples. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

The Article related to wastewater analysis pharmaceutical personal care product solid phase extraction, Placeholder for records without volume info and other aspects.Electric Literature of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yan, Ni; Long, Shengxing; Xiong, Kangning; Zhang, Ting published an article in 2022, the title of the article was Antibiotic bioaccumulation in zooplankton from the Yelang Lake Reservoir of Anshun City, Southwest China.Application of 144-80-9 And the article contains the following content:

Antibiotic (蟽sulfonamide, 蟽fluoroquinolone, 蟽tetracycline and 蟽macrolide) contamination in aquatic systems has remained a global concern in recent years. In this study, fourteen antibiotics, sulfadiazine (SDZ), sulphapyridine (SPD), sulfacetamide (SCT), sulfamethoxazole (SMX), sulfamethazine (SMZ), trimethoprim (TMP), ofloxacin (OFX), lomefloxacin (LFX), ciprofloxacin (CFX), norfloxacin (NFX), oxytetracycline (OTC), tetracycline (TC), dehydroerythromycin (ETM-H2O) and roxithromycin (RTM), were analyzed in zooplankton collected from the Yelang Lake Reservoir between May 2016 and Mar. 2017. Our results demonstrated that the antibiotic TC (mean 95.80 ng g-1), OTC (mean 167.0 ng g-1) and RTM (mean 151.80 ng g-1) concentrations were significantly higher in zooplankton than the other antibiotics. TC, OTC and RTM accumulated intensively in zooplankton, and the BAFs of OTC, RTM and TC were significantly higher, with mean BAF values of 78.43, 108.4 and 110.1, resp. Antibiotic concentrations were strongly correlated with zooplankton phytoplankton biomass, OTC, RTM and SMX concentrations in zooplankton were significantly pos. correlated with bacillariophyte biomass, and SDZ and SMZ concentrations in zooplankton were significantly pos. correlated with T. brevifurcatus, T. mongolicus, and D. pulex biomass. SPD with P. tunguidus, C. cornuta, TMP, ETM and OFX with P. tunguidus, C. cornuta, M. leuckarti, C. vicinus vicinus, CFX with D. pulex, LFX with T. brevifurcatus, T. mongolicus, Bosmina longirostris, and D. dubium were significantly pos. correlated. These results show that bioaccumulation or scavenging of antibiotics across trophic levels is a fundamental and complex component of antibiotic cycling in aquatic environments. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application of 144-80-9

The Article related to antibiotic bioaccumulation zooplankton, yelang lake reservoir anshun city southwest china, Placeholder for records without volume info and other aspects.Application of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 5, 2022, Li, Qinlan; Guo, Qian; Wang, Shuyi; Wan, Shanhe; Li, Zhonghuang; Zhang, Jiajie; Wu, Xiaoyun published an article.Application of 16230-24-3 The title of the article was Design and synthesis of proteolysis targeting chimeras (PROTACs) as an EGFR degrader based on CO-1686. And the article contained the following:

Epidermal growth factor receptor (EGFR) inhibitors represent the first-line treatment of non-small-cell lung cancer (NSCLC). However, the emergence of acquired drug resistance and side effects largely encumbered their application in clinic. The emerging technol. proteolysis targeting chimera (PROTAC) could be an alternative strategy to overcome these problems. Herein, we reported the discovery of EGFRL858R/T790M degraders based on CO-1686. Promising PROTAC 1q could effectively and selectively inhibit the growth of PC-9 (EGFRDel 19) and H1975 (EGFRL858R/T790M) cells, but not that of A549 (EGFRWT) cells. In addition, 1q could time- and dose-dependently induce degradation of EGFRL858R/T790M in H1975 cells with a DC50 value of 355.9 nM, while did not show obvious effect on the EGFRDel 19 and EGFRWT protein. Preliminary mechanism study demonstrated that the protein degradation was mediated through ubiquitin-proteasome system (UPS). Furthermore, 1q could significantly induce the apoptosis of H1975 cells and arrest the cells in G0/G1 phase. These findings demonstrated that compound 1q could be used as initial lead compound for the development of new EGFRL858R/T790M degraders based therapy. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Application of 16230-24-3

The Article related to human lung adenocarcinoma nsclc apoptosis protac egfr degrader co1686, co-1686, degrader, egfr, protac, Placeholder for records without volume info and other aspects.Application of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics