Author: Jessica.F

On June 22, 2020, Palazzesi, Ferruccio; Hermann, Markus R.; Grundl, Marc A.; Pautsch, Alexander; Seeliger, Daniel; Tautermann, Christofer S.; Weber, Alexander published an article.Application In Synthesis of 2-Chloroacetamide The title of the article was BIreactive: A Machine-Learning Model to Estimate Covalent Warhead Reactivity. And the article contained the following:

In the past decade, the pharmaceutical industry has paid closer attention to covalent drugs. Differently from standard noncovalent drugs, these compounds can exhibit peculiar properties, such as higher potency or longer duration of target inhibition with a potentially lower dosage. These properties are mainly driven by the reactive functional group present in the compound, the so-called warhead that forms a covalent bond with a specific nucleophilic amino-acid on the target. In this work, we report the possibility to combine ab initio activation energies with machine-learning to estimate covalent compound intrinsic reactivity. The idea behind this approach is to have a precise estimation of the transition state barriers, and thus of the compound reactivity, but with the speed of a machine-learning algorithm. We call this method “BIreactive”. Here, we demonstrate this approach on acrylamides and 2-chloroacetamides, two warhead classes that possess different reaction mechanisms. In combination with our recently implemented truncation algorithm, we also demonstrate the possibility to use BIreactive not only for fragments but also for lead-like mols. The generic nature of this approach allows also the extension to several other warheads. The combination of these factors makes BIreactive a valuable tool for the covalent drug discovery process in a pharmaceutical context. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to machine learning covalent warhead reactive functional group acrylamide derivative, Pharmacology: Methods and other aspects.Application In Synthesis of 2-Chloroacetamide

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Amide – an overview | ScienceDirect Topics

On April 15, 2021, Vulichi, Srinivasa R.; Kabra, Atul; Kumar, Rupak; Suman, Kapur; Rao, Chunduri Venkata; Cruz-Martins, Natalia published an article.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Concise perspectives on some synthetic thiazolidine-2,4-dione derivatives and their specific pharmacodynamic aspects. And the article contained the following:

A review. Glitazones are synthetic derivatives of thiazolidinedione, and are designated as oral anti-diabetic agents, primarily acting on peroxisome proliferator-activated receptor-gamma (PPAR-γ) receptors and driving some crucial metabolic pathways linked to glucose and lipid metabolism at transcriptional level. Despite presenting adverse effects, including weight gain, fluid retention, prostate hyperplasia, hyperinsulinemia, and myocardial infarction, they are still preferred in clin. settings due to their utmost efficacy and selectivity. However, these complications kept glitazones restrained for long-term usage. The present review briefly highlights some important synthetic derivatives of thiazolidine2,4-dione and emphasizes the influence of various structural manipulations on their bio-efficacy. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to review oncise thiazolidine dione derivative pharmacodynamic aspect, anti-diabetic, insulin resistance, ppar-γ, side effects, thiazolidinedione, Pharmacology: Reviews and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 15, 2021, Baran, Nicole; Surdyk, Nicolas; Auterives, Chrystelle published an article.Quality Control of 2-Chloroacetamide The title of the article was Pesticides in groundwater at a national scale (France): Impact of regulations, molecular properties, uses, hydrogeology and climatic conditions. And the article contained the following:

Contaminants in groundwater are a major issue worldwide. Temporal trends of such occurrences in French groundwaters were evaluated for several active substances of pesticides belonging to different chem. classes, to identify key factors explaining groundwater contamination. Our study relied on exploitation of a French national database (ADES, created in the mid-1990s and remarkable for the available data, including over 88 million analyses). Temporal changes in the frequency of exceeding a reference value of 0.1μg/L for several substances were determined at yearly and monthly scales. Such trends were examined by distinguishing different periods according to changes in regulations (new approval, withdrawal, or dose reduction), and were combined with data on effective rainfall as a proxy for groundwater recharge, on aquifer lithol., and on sales of active substances as a proxy for actual applications. A review of monthly data shows that a rapid transfer of pesticides with contrasting physico-chem. properties can occur after application in many aquifers, regardless of their lithol. For substances such as metolachlor, showing a sharp increase in sales, a clear relationship exists between quantities sold and frequency of exceeding the reference value. For other active substances, such as isoproturon or chlortoluron, frequencies of exceedance are governed by both sales and effective rainfall. Finally, the occurrence of active substances in groundwater several years after their withdrawal from the market is explained by at least three major mechanisms: the transfer time from soil into groundwater, processes of remobilization from soil and/or unsaturated zone, and no or low degradation in the saturated zone. While these processes are well documented for atrazine and different types of aquifers, they can be virtually unknown for other active substances. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Quality Control of 2-Chloroacetamide

The Article related to atrazine terbuthylazine climate change groundwater pollution france, dose reduction, groundwater, occurence, pesticide, trend, withdrawal, Water: Water Pollution and other aspects.Quality Control of 2-Chloroacetamide

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Amide – an overview | ScienceDirect Topics

On September 15, 2021, Zhang, Biao; Qin, Shang; Guan, Xiangyu; Jiang, Kaidi; Jiang, Minhui; Liu, Fei published an article.COA of Formula: C8H10N2O3S The title of the article was Distribution of Antibiotic Resistance Genes in Karst River and Its Ecological Risk. And the article contained the following:

In recent years, karst water has been polluted by emerging pollutants such as antibiotics. In this study, the bacterial communities and antibiotic resistance genes (ARGs) in antibiotics contaminated karst river was studied in summer and winter. The concentration of antibiotics in winter karst river is higher than that in summer, and there are significant differences in structure of bacterial community and ARGs between karst river water samples. Aminoglycoside, beta-lactamase and multidrug are the main types of ARGs, and transposons play an important role in the spread of ARGs. The horizontal gene transfer (HGT) of ARGs between bacteria mediated by mobile genetic elements (MGEs) would cause the spread of ARGs and bring potential ecol. risks. In addition, we found that the risk of antibiotic resistant pathogenic bacteria (ARPB) in winter was possibly higher than that in summer. It was suggested that the discharge of antibiotics, water amount and seasonal occurrence time of human intestinal diseases affect the risks caused by antibiotics contaminants. This study helps us to understand the transmission mechanism of ARGs and their potential seasonal ecol. risks in complex karst water systems. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).COA of Formula: C8H10N2O3S

The Article related to distribution antibiotic resistance gene karst river ecol risk, antibiotic pollution, antibiotic resistance genes, environmental risk, karst river, microbial community, Water: Water Pollution and other aspects.COA of Formula: C8H10N2O3S

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Amide – an overview | ScienceDirect Topics

Jaydeep, Chauhan; Harshita, Gupta; Komal, Pandey; Viral, Shah; Bhagyashree, Kamble published an article in 2019, the title of the article was Herbosome an approach to deliver Aegle marmelos extract: Formulation, characterization and stability study.Quality Control of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Aegle marmelos fruit has tremendous potential to treat the various ailments for instance; diabetes, microbial diseases and many more. Despite, having abundant therapeutic activity poor lipid solubility and gastric instability limits the efficacy of Aegle marmelos extract (AME). With an idea to overcome these hurdles, AME was formulated as Herbosome in this study. The concept of Herbosome is gaining popularity, as it provides a sheet of lipid on the outer part of drug or extract, which helps in the bioavailability enhancement. In the present work, AME was prepared by cold extraction method and percentage yield was found to be 20% weight/weight Here, Marmelosin one of the major phytoconstituent in Aegle marmelos, was used as a marker for standardization of the prepared extract Further, preliminary phytochem. screening and thin layer chromatog. (TLC) was carried out. Whereas, quant. estimation of Marmelosin in AME by High-performance thin layer chromatog. (HPTLC) was conducted. In further steps, pre-formulation parameters (effect of several processes and formulation parameters) were studied and Herbosome loaded AME was formulated by conventional technique i.e. thin film method and soyalecithin were used as phospholipids. Several parameters including, percent entrant efficiency (%EE), particle size, polydispersity index (PDI) and zeta-potential were taken into consideration for the evaluation of AME Herbosome. Later on, followed by, In vitro release of optimized formulation was studied and the formulation was able to release up to 92% even after 12 h. After developing successful AME Herbosome, stability study was performed as per the International Conference on Harmonisation (ICH) guidelines up to the period of a month. Herbosome was found to be stable at room temperature, even between 2-4°C. Henceforth, to confirm the efficacy of optimized formulation, In vitro studies (antidiabetic) are going on in the laboratory The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Quality Control of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle herbosome marmelosin phytoconstituent stability, Pharmaceuticals: General and other aspects.Quality Control of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2021, Ma, Xinyan; Zhang, Ying; Guan, Mingyang; Zhang, Weidong; Tian, Huifang; Jiang, Caixiao; Tan, Xiaoxin; Kang, Weijun published an article.Electric Literature of 79-07-2 The title of the article was Genotoxicity of chloroacetamide herbicides and their metabolites in vitro and in vivo. And the article contained the following:

The toxicity of chloroacetamide herbicide in embryo development remains unclear. Acetochlor (AC) is a chloroacetamide that metabolizes into 2-ethyl-6-methyl-2-chloroacetanilide (CMEPA) and 6-ethyl-o-toluidine (MEA). The present study determined the potential effect of AC and its metabolites on embryo development. Both HepG2 cells and zebrafish embryos were exposed to AC, CMEPA and MEA in the presence or absence of co treatment with anti reactive oxygen species (ROS) reagent N acetylcysteine. The generation of ROS, levels of superoxide dismutase (SOD) and glutathione (GSH) in HepG2 cells and lactate dehydrogenase (LDH) leakage from HepG2 cells were investigated. The effects of AC, CMEPA and MEA on DNA breakage, MAPK/ERK pathway activity, viability and apoptosis of HepG2 cells were examined by comet assay, western blotting, MTT assay and flow cytometry, resp. Levels of LDH, SOD and GSH in zebrafish embryos exposed to AC, CMEPA and MEA were measured. The hatching and survival rates of zebrafish embryos exposed to AC, CMEPA and MEA, were determined, and apoptosis of hatched fish was investigated using acridine orange staining. The present data showed AC, CMEPA and MEA induced generation of ROS and decreased levels of SOD and GSH in HepG2 cells, which in turn promoted DNA breakage and LDH leakage from cells, ultimately inhibiting cell viability and inducing apoptosis, as well as phosphorylation of JNK and P38. However, co treatment with N-acetylcysteine alleviated the pro apoptosis effect of AC and its metabolites. Moreover, exposure to AC, CMEPA and MEA lead to toxicity of zebrafish embryos with decreased SOD and GSH and increased LDH levels and cell apoptosis, ultimately decreasing the hatching and survival rates of zebrafish, all of which was attenuated by treatment with N-acetylcysteine. Therefore, AC and its metabolites (CMEPA and MEA) showed cytotoxicity and embryo development toxicity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Electric Literature of 79-07-2

The Article related to danio embryos liver cancer chloroacetamide herbicides genotoxicity, acetochlor, apoptosis, chloroacetamide herbicide, embryo toxicity, reactive oxygen species, zebrafish, Toxicology: Agrochemical and other aspects.Electric Literature of 79-07-2

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Amide – an overview | ScienceDirect Topics

On November 30, 2018, Duan, Gaigai; Fang, Hong; Huang, Chaobo; Jiang, Shaohua; Hou, Haoqing published an article.Synthetic Route of 685-91-6 The title of the article was Microstructures and mechanical properties of aligned electrospun carbon nanofibers from binary composites of polyacrylonitrile and polyamic acid. And the article contained the following:

High mech. performance carbon nanofibers are highly required for the carbon nanofiber-reinforced composites, and it is necessary to develop novel precursors for the preparation of carbon nanofibers. Blends of poly(acrylonitrile-Bu acrylate mono-Bu itaconate) (co-PAN) and polyamic acid (PAA) were electrospun into aligned nanofibers and the nanofibers were converted to carbon nanofibers by thermal imidization, pre-oxidation, and high-temperature carbonization. FT-IR spectroscopy was applied to monitor the chem. structures of the nanofibers before and after pre-oxidation Tensile tests were used to characterize the mech. properties of electrospun carbon nanofibers (ECNFs). The microstructures of ECNFs were investigated by high-resolution TEM and Raman spectroscopy. The ECNFs derived from blend of co-PAN/PAA with molar ratio of 6/4 and with carbonization temperature of 1400° possessed the highest tensile strength of 1212 MPa, which could be attributed to the ordered graphitic structures in ECNFs. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to microstructure mech property carbon nanofiber polyacrylonitrile polamate, Ceramics: Carbon Products and other aspects.Synthetic Route of 685-91-6

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Rawat, Taniya; Uniyal, Sushmita published an article in 2021, the title of the article was A review on phytoconstituents and reported pharmacological activities of rutaceae family plant: Aegle marmelos (L.) correa leaf.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

A review. The only plant in the genus Aegle is bael, a slow-growing, resistant subtropical spiky tree. Family: Rutaceae (Citrus family). It’s also known as wood apple, Bengal quince, golden apple, Indian quince, holy fruit, and stone apple in English. In Sanskrit-Bilwa and in Hindi-Bael, bel. The leaf is one of the plant’s most accumulative sections, holding bioactive substances that are generated as secondary metabolites. Traditionally bael is effective in the treatment of dropsy, diarrhoea, dysentery, and intestinal problems. Phenol, flavonoid, tannin, carbohydrate, sterols, Saponin and alkaloid are all found in leaf extract Skimmianine, Aegeline, lupeol, cineol, eugenol, cuminaldehyde, marmesinine, citronella, and essential oils are isolated compounds from bael. The main components were limonene (82.4%) and (Z)-ocimene (5.1%), which together made up 87.5 percent of the leaf oil. Limonene has been shown to be a useful marker for identifying Aegle marmelos oil samples. Reported pharmacol. studies of A.marmelos leaf extract are Learning and memory, Anxiolytic and Antidepressant, Anticonvulsant, Analgesic, Antipyretic, Anti-inflammatory, Immunomodulatory, hepatoprotective, Cardioprotective, Nephrotoxicity, Antiulcer, Antidiarrhoeal, Antimicrobial, Antiobesity, Anti-proliferative, Antidiabetic, Poly cystic ovarian syndrome, Antithroid activity. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to review aegle phytoconstituent drug, Plant Biochemistry: Reviews and other aspects.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

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Nitsche, Johannes M.; Kasting, Gerald B. published an article in 2013, the title of the article was A correlation for 1,9-decadiene/water partition coefficients.Computed Properties of 27115-50-0 And the article contains the following content:

An important series of papers by Xiang, Anderson, and coworkers has established the strong correlation between phospholipid bilayer membrane permeability and the 1,9-decadiene/water partition coefficient over a wide range of compounds, elevating the importance of Kdecadiene/w as a predictor of mol. bioavailability. On the basis of a 58-point dataset developed by these authors, this research note develops an optimal correlation predicting log10Kdecadiene/w in terms of the octanol/water partition coefficient and four of the Abraham solvation parameters, namely A (hydrogen bond acidity), S (polarity/polarizability), E (excess molar refraction), and V (McGowan characteristic volume). The fitted dataset is described to within a root-mean-square error of 0.42, and the probable error in making a prediction for a compound not present therein is 0.49. It is shown that this correlation error for Kdecadiene/w is the dominant source of uncertainty in applying a comprehensive new model of phospholipid bilayer membrane permeability developed in a companion paper (Nitsche and Kasting, submitted for publication), which superposes the effects of mol. size and lipid d. upon the decadiene lipophilicity scale. Thus, more exptl. studies to augment the limited existing database on Kdecadiene/w are called for. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Computed Properties of 27115-50-0

The Article related to decadiene water partition coefficient membrane permeability prediction, General Biochemistry: Other and other aspects.Computed Properties of 27115-50-0

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Amide – an overview | ScienceDirect Topics

Upadhyay, Ravi Kant published an article in 2015, the title of the article was Bel plant: A source of pharmaceuticals and ethno medicines.Category: amides-buliding-blocks And the article contains the following content:

A review. Bel is a holy native tree of India, which has high ethnomedicinal, therapeutic, and pharmaceutical importance. Bel contains many diverse bioactive components in leaves, flowers, fruits, wood, root, and bark which show multiple biol. activity and high therapeutic importance. Plant contains coumarins, marmelosin, marmesin, imperatorin, marmin, alloimperatorin, Me ether, xanthotoxol, scoparone, scopoletin, umbelliferone, psoralen and marmelide and marmenol, aegelin, aegelenine, marmeline, dictamine, fragrine which show anticancer, antioxidant, antimicrobial, anti-plasmodial, and hepatoprotective activities. Plant possesses various polysaccharides such as galactose, arabinose, uronic acid, and L-rhamnose. Its seed oil contains palmitic, stearic, oleic, linoleic, and linolenic acids which possess very high nutritive value. Plant also possesses very high tannin contents (9%) in fruits, pulp leaves. Tannin found in leaves as skimmianine. Marmelosin, skimmianine, and umbelliferone are therapeutically important active principles. Aegle marmelos is also a good source of gum, wound healers, carotenoids, vitamins, sugars, and nutritive oils. The plant is used to cure digestive disorders, ulcers, headache, hypertension, diabetes, constipation, and numerous other ailments. The ripe fruits are used as a laxative, while unripe Bel fruit, promotes digestion, and cures diarrhea. A. marmelos contains plant essential oil which shows chemotypic and seasonal variations. In the present review article, ethnomedicinal, therapeutic, pharmaceuticals, and insecticidal properties of A. marmelos have been described in detail. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to review aegle leaf flower fruit phytochem pharmaceutical ethno medicine, Plant Biochemistry: Reviews and other aspects.Category: amides-buliding-blocks

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Amide – an overview | ScienceDirect Topics