Author: Jessica.F

On November 30, 2016, Guillon, Jean; Moreau, Stephane; Ronga, Luisa; Basmacyian, Louise; Cohen, Anita; Rubio, Sandra; Bentzinger, Guillaume; Savrimoutou, Solene; Azas, Nadine; Mullie, Catherine; Sonnet, Pascal published an article.HPLC of Formula: 5455-98-1 The title of the article was Design, Synthesis and Antimalarial Activity of Some New Aminoalcoholpyrrolo[1,2-a]quinoxaline Derivatives. And the article contained the following:

Following our search for antimalarial compounds, novel series of piperazinylalc. pyrrolo[ 1,2-a]quinoxaline derivatives 1-2 were synthesized from 2-nitroaniline or 2-amino-3- nitrophenol and tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium falciparum strains. Biol. results showed good antimalarial activity with IC50 ranging from 0.3 to 21.1 μM. In attempting to investigate the large broad-spectrum antiprotozoal activities of these pyrrolo[1,2-a]quinoxaline derivatives, their properties toward the promastigote form of Leishmania donovani were also investigated and revealed their selective antiplasmodial profile. In parallel, the in vitro cytotoxicity of these mols. was assessed on the human HepG2 cell line. Structure-activity relationships of these new synthetic compounds are here discussed. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).HPLC of Formula: 5455-98-1

The Article related to antimalarial msbar, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2016, Beloglazkina, Anastasia A.; Wobith, Birgit; Barskaia, Elena S.; Zefirov, Nikolay A.; Majouga, Alexander G.; Beloglazkina, Elena K.; Zyk, Nikolay V.; Kuznetsov, Sergei A.; Zefirova, Olga N. published an article.Application of 27115-50-0 The title of the article was Synthesis and biological testing of (5Z)-2-aryl-5-arylmethylidene-3,5-dihydro-4H-imidazol-4-ones as antimitotic agents. And the article contained the following:

Compounds interacting with cell protein tubulin and microtubules represent an important type of antimitotic agents. A series of tubulin-targeted 2-aryl-4-benzoyl-imidazoles were reported to possess high cytotoxicity, and so, the authors prepared a series of structural isomers of these to be evaluated as antimitotic agents. The synthesis of the novel (Z)-2-aryl-5-arylmethylidene-3,5-dihydro-4H-imidazol-4-ones involved coupling of substituted hippuric acids with aromatic aldehydes. Subsequent conversion of the resulting oxazolones to the corresponding imidazolones was carried out under microwave irradiation in the presence of urea and ammonium acetate. The cytotoxicity of the majority of the compounds to human epithelial carcinoma cancer cell line A549 was in the sub-micromolar range and was found to be more sensitive to the substituents on the 5-arylmethylidene fragment than on the 2-aryl ring in general. The cytotoxicities of the synthesized compounds were lower than those of the previously reported isomeric 2-aryl-4-benzoyl-imidazoles, and the basic structure-activity relationships in the isomeric pairs were different. Synthesized (5Z)-5-[(4-bromophenyl)methylidene]-2-(4-methylphenyl)-3,5-dihydro-4H-imidazol-4-one, which had the highest cytotoxicity (IC50 ∼ 440 nM) in the series of novel compounds, had a definite cytostatic effect on the A549 cells, but its antiproliferative properties were not linked to action on the microtubules. This would be an interesting lead compound for addnl. investigation into the mechanism of cytostatic action, and further structural optimization. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application of 27115-50-0

The Article related to antimitotic antitumor neoplasm, Pharmacology: Structure-Activity and other aspects.Application of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cornwell, E. published an article in 2007, the title of the article was Application of the Vc3 topographic QSPR parameter to benzene sulfonamide derivatives.Application of 97-09-6 And the article contains the following content:

A novel QSPR topog. parameter (Vc3) is used for reduction of the number of independent variables to one variable Vc3, consistent with Euclidian distances relations. This procedure was applied to a model of 19 benzene sulfonamide derivatives, using benzenesulfonamide as a reference The derivatives were characterized by physicochems. properties used as independent variables. The variables are: refraction index, surface tension and an extra dummy variable that indicated the presence or absence chlorine atoms in the mol., while pKa was used like dependent variable. The linear regression proposed is of the form. pKa = m* Vc3 + n, that is more coherent than its counterpart multivariable regression. The use of this variable reduction eliminated problems of orthogonal procedure or the use of Principal Component Anal. (PCA) to obtain consistent models. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to qspr benzene sulfonamide derivative, General Organic Chemistry: Other and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2011, Munigunti, Ranjith; Mulabagal, Vanisree; Calderon, Angela I. published an article.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Screening of natural compounds for ligands to PfTrxR by ultrafiltration and LC-MS based binding assay. And the article contained the following:

In our study, we have screened 133 structurally diverse natural compounds from the MEGx collection of AnalytiCon Discovery and three synthetic hispolone analogs for binding affinity to Plasmodium falciparum thioredoxin reductase (PfTrxR) using an ultrafiltration (UF) and liquid chromatog. (LC/MS) based ligand-binding assay newly developed in our laboratory PfTrxR catalyzes the reduction of thioredoxin (PfTrx) protein. In reduced form, PfTrx is essentially involved in the antioxidative defense and redox regulation of P. falciparum. Nine compounds (yohimbine (1), catharanthine (2), vobasine (3), gnetifolin E (4), quinidine N-oxide (5), 11-hydroxycoronaridine (6), hispolone (7), hispolone Me ether (8), and hernagine (9)) displayed binding affinity for PfTrxR at 1 μM. The ranking order of compound’s binding affinities for PfTrxR is 7 > 6 > 2 > 4 > 5 > 8 > 1 > 9 > 3. On the other hand, compounds 6, 7, 2 and 8 demonstrated specific binding to the active site of PfTrxR, when ligands were tested in an equimolar mixture of 1 μM. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to screening ligand lc ms thioredoxin reductase, Pharmacology: Structure-Activity and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 15, 2004, Jaiswal, Mona; Khadikar, Padmakar V.; Supuran, Claudiu T. published an article.COA of Formula: C6H5ClN2O4S The title of the article was Topological modeling of lipophilicity, diuretic activity, and carbonic inhibition activity of benzene sulfonamides: a molecular connectivity approach. And the article contained the following:

A large series of distance-based topol. indexes has been used for modeling lipophilicity, diuretic activity, and carbonic anhydrase inhibition activity of a library of simple substituted benzene sulfonamides. The results have shown that the topol. approach used is quite useful for modeling carbonic anhydrase inhibition and the use of mol. connectivity is the best for this purpose. Excellent results are obtained in multiparametric regressions. The results are critically discussed on the basis of statistical parameters. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).COA of Formula: C6H5ClN2O4S

The Article related to qsar benzene sulfonamide diuretic carbonic anhydrase, Pharmacology: Structure-Activity and other aspects.COA of Formula: C6H5ClN2O4S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Khadikar, Padmakar V.; Jatiwala, Yusuf Ali; Lakhwani, Meenakshi; Thakur, Poornima; Joshi, Shobha; Joshi, Ashok published an article in 2006, the title of the article was QSAR studies on inhibitory properties of benzenesulfonamides towards CAI. Dominating role of Vander Waals repulsion energy.SDS of cas: 97-09-6 And the article contains the following content:

The structure-activity correlations as well as quant. structure activity relation (QSAR) study for benzene-sulfonamides possessing carbonic anhydrase (CA) inhibitory property towards CAI have been discussed using a series of distance-based topol. indexes together with binding energy of the sulfonamide to CA, Van der Waals repulsion energy and indicator parameters. Excellent results were obtained though multiple regression anal. The results are discussed with a variety of statistics. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to qsar carbonic anhydrase inhibitor benzenesulfonamide, Pharmacology: Structure-Activity and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 1989, Menziani, Maria Cristina; De Benedetti, Pier G.; Gago, Federico; Richards, W. Graham published an article.Related Products of 97-09-6 The title of the article was The binding of benzenesulfonamides to carbonic anhydrase enzyme. A molecular mechanics study and quantitative structure-activity relationships. And the article contained the following:

Mol. mechanics methods were used to study the interaction between a series of 20 deprotonated benzenesulfonamides and the enzyme carbonic anhydrase. The different contributions to the binding energy were evaluated and correlated with exptl. inhibition data and MO indexes of the sulfonamides in their bound conformation. The results suggest that the discrimination shown by the enzyme towards these inhibitors is dominated by the short-range van der Waals forces. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Related Products of 97-09-6

The Article related to benzenesulfonamide binding carbonic anhydrase structure, Pharmacology: Structure-Activity and other aspects.Related Products of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2011, Kong, Hyesik; Kim, Hyunjeong; Do, Heejeong; Lee, Yonghyun; Hong, Sungchae; Yoon, Jeong-Hyun; Jung, Yunjin; Kim, Young Mi published an article.Synthetic Route of 27115-50-0 The title of the article was Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon-specific prodrug with controlled conversion rate at the target site. And the article contained the following:

N-aromatic acyl-amino acid conjugates possess a colon-targeted property, implying that such conjugates are stable and are not absorbable until reaching the large intestine in which they are microbially converted (hydrolyzed) to the parent drugs that are therapeutically active. To investigate the structural effect of N-aromatic acyl-amino acid conjugates on the large intestinal deconjugation, the hydrolysis of various N-aromatic acyl-amino acid conjugates was examined in the cecal contents. On incubation of conjugates with glycine, D or/andL forms of alanine or phenylalanine in the cecal contents, the conjugates with D amino acids were not hydrolyzed. The other conjugates are susceptible to the hydrolysis, the rates of which decreased as the size of the substituent on the 2-position of the amino acids increased. The conjugates with alkyl analogs (2-4 carbons) of glycine and taurine were resistant to the hydrolysis, while taurine- and glycine-conjugates were hydrolyzed effectively. The hydrolysis of N-aromatic acyl-glycine conjugates was enhanced by para-substitution of electron withdrawing groups on the aromatic acyl moiety and vice versa for electron-donating groups. While a Me, methoxy or chloro group on the ortho-position retarded the hydrolysis, a hydroxyl group on the position accelerated it. Our data may provide useful information for the design of a colon-specific prodrug with controlled conversion rate in the large intestine. Copyright © 2011 John Wiley & Sons, Ltd. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Synthetic Route of 27115-50-0

The Article related to n aromatic acylamino acid conjugate hydrolysis cecum sar, Pharmacology: Structure-Activity and other aspects.Synthetic Route of 27115-50-0

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 15, 2005, Khadikar, Padmakar V.; Sharma, Vimukta; Karmarkar, Sneha; Supuran, Claudiu T. published an article.SDS of cas: 97-09-6 The title of the article was Novel use of chemical shift in NMR as molecular descriptor: a first report on modeling carbonic anhydrase inhibitory activity and related parameters. And the article contained the following:

A novel use of NMR chem. shift of the SO2NH2 protons (in dioxane as solvent) as a mol. descriptor is described for modeling the inhibition constant for benzene sulfonamides against the zinc enzyme carbonic anhydrase (CA, E.C. 4.2.1.1). The methodol. is extended to model diuretic activity and lipophilicity of benzene sulfonamide derivatives The regression anal. of the data has shown that the NMR chem. shift is incapable of modeling lipophilicity. However, it is quite useful for modeling the diuretic activity of these derivatives The results are compared with those obtained using distance-based topol. indexes: Wiener (W)-, Szeged (Sz)-, and PI (Padmakar-Ivan) indexes. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to nmr chem shift carbonic anhydrase inhibitor diuretic qsar, Pharmacology: Structure-Activity and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pandey, Asutosh Kumar published an article in 2013, the title of the article was On diuretic activity of benzene sulfonamide using 113 C NMR chemical shift as a molecular descriptor: regular vs ridge regression.Application In Synthesis of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

Diuretic activity p1/C of benzene sulfonamides was modeled using 13 C NMR chem. shift as a mol. descriptor. The regression analyses were carried out using regular as well as Ridge multiple regression analyses. Application of variety of statistics namely statistics, Ridge regression and parameter derived there were used for modeling the diuretic activity. Results have shown that 13 C NMR chem. shift yields an excellent model. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application In Synthesis of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to benzene sulfonamide diuretic nmr chem shift mol descriptor qsar, Pharmacology: Structure-Activity and other aspects.Application In Synthesis of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics