Author: Jessica.F

Toda, Yasunori; Tanaka, Katsumi; Matsuda, Riki; Suga, Hiroyuki published an article in 2019, the title of the article was Visible-light-triggered Catalytic Halohydrin Synthesis from Epoxides and Trichloroacetonitrile by Copper and Iron Salts.Related Products of 5455-98-1 And the article contains the following content:

Preparation of vicinal halohydrins by the ring-opening reaction of epoxides under visible-light conditions using copper or iron chlorides catalyst was described. The use of trichloroacetonitrile as a chloride source enabled catalytic HCl generation under the mild conditions. This method can also be applied to the aziridine ring-opening reaction. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to epoxide trichloroacetonitrile metal chloride catalyst regioselective photochem ring opening, chlorohydrin preparation, Aliphatic Compounds: Alcohols and Thiols and other aspects.Related Products of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 15, 2017, Gonzalez, Johannes L.; Pell, Albert; Lopez-Mesas, Montserrat; Valiente, Manuel published an article.HPLC of Formula: 27115-50-0 The title of the article was Simultaneous determination of BTEX and their metabolites using solid-phase microextraction followed by HPLC or GC/MS: An application in teeth as environmental biomarkers. And the article contained the following:

Applications of benzene, toluene, ethylbenzene, and o-, m-, and p-xylenes (BTEX) release them into the environment exposing living organism. These endocrine disruptors are toxic, highly volatile and easily absorbed by the lungs and can cause adverse consequences for the human health as neurol. diseases and cancer. A method for the anal. of BTEX and its metabolites (phenols and aromatic acids) in teeth is presented. The method consists in a one-step simple extraction procedure from spiked tooth using NaOH solution followed by SPME-HPLC or HS-SPME-GC/MS determination Optimization of both, spiking procedure and extraction step of these analytes from tooth, was carried out. Two fibers CAR/PDMS for BTEX and PA for BTEX metabolites were used for the SPME and variables were optimized for analytes at 30° using spiked solutions The optimized adsorption times were 30, 75 and 30 min and desorption times were 10, 40 and 30 min for BTEX, phenols and aromatic acids, resp. Linearity for SPME-HPLC method was established using spiked solutions with both, BTEX and metabolites, at 2.5, 5.0, 10.0, 25.0 μg/mL. The obtained results indicated a good linearity (R2 above 0.994) for all analytes. Triplicate analyses were performed with RSD lower than 15%. LODs were in the range 0.2-33.3 ng/mL for SPME-HPLC and 0.06-0.09 pg/mL for HS-SPME-GC/MS methods in spiking solutions Once the method was optimized, bovine teeth were used as biol. matrix model for the tuning of spiking and extraction steps. Optimal adsorption and desorption times were 4 h for both procedures. Micrograms per tooth gram of BTEX and phenols were quantified in ten human teeth and aromatic acids were not identified. The developed method for BTEX and metabolites analyses using SPME-HPLC or HS-SPME-GC/MS shows good precision, linearity and sensitivity. The method was successfully applied in human teeth as environmental biomarker of BTEX and metabolites. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).HPLC of Formula: 27115-50-0

The Article related to btex metabolite biomarker determination tooth hplc gc ms, btex, btex metabolites, hplc, gc–ms, human teeth samples, spme, Toxicology: Methods (Including Analysis) and other aspects.HPLC of Formula: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 1, 2010, Caporossi, Lidia; De Rosa, Mariangela; Papaleo, Bruno published an article.Formula: C10H11NO3 The title of the article was Complete separation of urinary metabolites of xylene in HPLC/DAD using β-cyclodextrin: Application for biological monitoring. And the article contained the following:

To determine the biomarkers of exposure to xylene, urinary 2-, 3- and 4-methyl-hippuric acids, a new HPLC/DAD anal. method has been developed, which uses β-cyclodextrin as an additive for elution; its complexing abilities are exploited to achieve complete chromatog. separation of the three isomers. The mobile phase was a 3% aqueous solution of β-cyclodextrin, pH 3, and methanol, 80:20, in isocratic conditions, with a flow rate of 1 mL/min. To optimize quant. anal. three wavelengths were employed for detection: λ = 198 nm, λ = 200 nm, and λ = 202 nm. SPE was applied for the extraction from urine samples of analytes. Validation parameters show recoveries always above 82%; LOD was set at 1 μg/mL with an LOQ of 3 μg/mL. The linear dynamic range (from 4 to 100 μg/mL) showed excellent correspondence. This method is rapid and inexpensive and can be applied to several samples simultaneously using a manifold for SPE extraction The analytes were separated completely and could be fully quantified. The method was used for the anal. of urine samples from 54 workers exposed to xylene in hospital laboratories and showed a good applicability while allowing quantification even at low doses. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3

The Article related to xylene occupational exposure methylhippuric acid biomarker urine analysis, methylhippuric acid urine analysis hplc cyclodextrin, Toxicology: Methods (Including Analysis) and other aspects.Formula: C10H11NO3

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Amide – an overview | ScienceDirect Topics

Kim, Hye Jin; Seo, Young Ju; Htwe, Khin Myo; Yoon, Kee Dong published an article in 2021, the title of the article was Chemical constituents from Aegle marmelos fruits.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Aegle marmelos (Rutaceae) is a deciduous shrub or tree and typically known as bael throughout Southeast Asia and has been used as a medicinal plant and a food ingredient. In this study eight compounds were determined to be O-(3,3-dimethylallyl) halfordinol (1), (R)-aegeline (2), (R)-marmeline (3), imperatorin (4), xanthotoxol (5), valencic acid (6), vanillic acid (7) and rutin (8). The chem. structures of the isolates were elucidated through spectroscopic evidence including 1D, 2D NMR, ESI-Q-TOF-MS and optical rotation. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle marmelos fruit chem constituent, Pharmaceuticals: Pharmacognostic Products and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
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Amide – an overview | ScienceDirect Topics

On October 20, 2002, Li, Maojin; Hu, Junfeng; Li, Guozhen; Xie, Lin published an article.HPLC of Formula: 97-09-6 The title of the article was Antagonism of rhizoma gastrodiae to lead-induced damage of hippocampus in rats. And the article contained the following:

The antagonism of rhizoma gastrodiae (RGT) to the impairment of learning and memory ability induced by Lead was studied in rats. 36 Wistar rats were randomly divided into 3 groups, 12 rats in every group, (1) control group: treated with distilled water; lead group: treated with lead acetate(0.1 g/kg d); (3)lead-RGT group:lead acetate(0.1 g/kg d)+RGT(4.0 g/kg d). The ability of learning and memory of the rats was measured monthly by swimming test; 3 mo later, the rats were decapitated and nitric oxide(NO) and total antioxidative capacity(TAOC) in hippocampus were measured immediately and the examination for pathol. was also made. In swimming test, the number of seeking for anchorage in lead group(1, 2, 3 mo: 10.10±1.10, 7.80±1.32, 5.40±0.97 resp.) were significantly decreased, compared with the control(P < 0.01). The number of seeking for anchorage in RGT-lead group(1, 2, 3 mo: 11.90±0.95, 10.90±0.95, 9.7±0.96 resp.) were significantly increased, compared with lead group(P < 0.01). NO(0.733±0.015) μmol/g pro and TAOC(0.945±0.017) U/mg pro in hippocampus of lead group were significantly decreased compared with the control(P < 0.01) whereas NO(0.769±0.021) μmol/g pro and TAOC(0.986±0.010) U/mg pro in hippocampus of RGT-lead group were significantly increased compared with lead group(P < 0.01). Pathol. examination showed that in lead group, marked atrophy in hippocampus, cellular denaturation and necrosis, dissolution and disappearance in axon were found. In lead-RGT group, the atrophy of hippocampus was not obvious, the cell morphol. was nearly normal, no obvious abnormal changes were seen. RGT is antagnostic to the impairment of hippocampus and of learning and memory ability induced by lead. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).HPLC of Formula: 97-09-6

The Article related to lead gastrodia tianma hippocampus damage, Pharmaceuticals: Pharmacognostic Products and other aspects.HPLC of Formula: 97-09-6

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pan, Jie; Li, Haocong; Sun, Kai; Tang, Shi; Yu, Bing published an article in 2022, the title of the article was Visible-Light-Induced Decarboxylation of Dioxazolones to Phosphinimidic Amides and Ureas.Application of 102-07-8 And the article contains the following content:

A visible-light-induced external catalyst-free decarboxylation of dioxazolones was realized for the bond formation of N = P and N-C bonds to access phosphinimidic amides and ureas. Various phosphinimidic amides and ureas (47 examples) were synthesized with high yields (up to 98%) by this practical strategy in the presence of the system′s ppm Fe. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to dioxazolone phosphinimidic amide urea visible light decarboxylation, decarboxylation, dioxazolones, phosphinimidic amides, ureas, visible light, Placeholder for records without volume info and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 27, 2022, Duss, Michael; Soto, Miguel A.; Patrick, Brian O.; MacLachlan, Mark J. published an article.Safety of 1,3-Diphenylurea The title of the article was A Supramolecular Strategy for the Synthesis of Cyclic Oligomers and Polymers by Ring Expansion. And the article contained the following:

Ring-opening metathesis polymerization (ROMP) of strained macrocycles is a key method to prepare diverse polymers. However, lack of ring strain in most macrocycles is an impediment to polymerization In this paper, the polymerization/oligomerization of unstrained macrocycles was achieved using a supramol. approach, leading selectively to cyclic products. Di-Ph thiourea and other guest mols. were used as additives to the ROMP reaction of unstrained macrocycles. An intermediate host-guest complex leads to the stabilization of the open form of the macrocycle after treatment with Grubbs catalysts, thereby favoring polymerization by inhibiting the ring-closing reaction back to the monomer. This proof-of-concept enables ring-expansion polymerization of unstrained macrocycles leading to cyclic polymers with mol. weights up to 6700 Da. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Safety of 1,3-Diphenylurea

The Article related to supramol cyclic oligomer polymer ring expansion, cyclic polymers, host-guest chemistry, macrocycle, olefin metathesis, supramolecular chemistry, Chemistry of Synthetic High Polymers: Other and other aspects.Safety of 1,3-Diphenylurea

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Priyanka; Joshi, Tushar; Mathpal, Shalini; Chandra, Subhash; Tamta, Sushma published an article in , the title of the article was In silico identification of antidiabetic target for phytochemicals of A. marmelos and mechanistic insights by molecular dynamics simulations.HPLC of Formula: 456-12-2 And the article contains the following content:

The leaves and fruits of Aegle marmelos (L.) have antidiabetic activity. However, the mode of action and mols. having antidiabetic activity are not known. Hence, we conducted mol. docking of phytochems. with various mol. antidiabetic targets to find the same. Docking prioritized Dipeptidyl peptidase-4 (DPP-4) as the main target for phytochems. of Aegle marmelos. DPP-4 inactivates intestinal peptides, glucagon-like peptide-1 (GLP-1), and Gastric inhibitory polypeptide (GIP). GLP-1 and GIP stimulate a decline in blood glucose levels, but DPP-4 inhibits their functions resulting high level of glucose. Hence inhibiting the activity of DPP-4 is a well-known strategy to treat Type 2 diabetes. Therefore, to find a mechanism that may be involved to act as a natural inhibitor of DPP-4, we screened five phytochems. out of seventy-three based on Virtual Screening, ADMET Drug-likeness anal., and PAINS filtering. Further, all five phytochems., i.e. Aegeline, Citral, Marmesinin, Auraptene, β-Bisabolene, and reference compound subjected MDS for analyzing the stability of docked complexes to assess the fluctuation and conformational changes during protein-ligand interaction. The values of RMSD, RG, RMSF, SASA, and Gibbs energy revealed the good stability of these phytochems. in the active site pocket of DPP-4 in comparison to reference Addnl., we have done the pharmacophore anal., which revealed many common pharmacophore features between screened phytochems. of A. marmelos and reference mol. Our results show that these phytochems. are potential antidiabetic candidates and can be further modified and evaluated to develop more effective antidiabetic drugs against DPP-4 to treat Type 2 Diabetes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2

The Article related to aegle marmelos phytochem antidiabetic mol dynamics simulation, aegle marmelos, dpp-4, type 2 diabetes, igemdock, molecular dynamics simulations, Placeholder for records without volume info and other aspects.HPLC of Formula: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2022, Sobh, Eman A.; Khalil, Nadia A.; Faggal, Samar I.; Hassan, Marwa S. A. published an article.Application of 79-07-2 The title of the article was New benzothienopyrimidine derivatives as dual EGFR/ARO inhibitors: Design, synthesis, and their cytotoxic effect on MCF-7 breast cancer cell line. And the article contained the following:

New cytotoxic agents based on benzothienopyrimidine scaffold were designed, synthesized, and evaluated against the MCF-7 breast cancer line in comparison to erlotinib and letrozole as reference drugs. Eight compounds demonstrated up to 20-fold higher anticancer activity than erlotinib, and five of these compounds were up to 11-fold more potent than letrozole in MTT assay. The most promising compounds were evaluated for their inhibitory activity against EGFR and ARO enzymes. Compound 12, which demonstrated potent dual EGFR and ARO inhibitory activity with IC50 of 0.045 and 0.146 μM, resp., was further evaluated for caspase-9 activation, cell cycle anal., and apoptosis. The results revealed that the tested compound 12 remarkably induced caspase-9 activation (IC50 = 16.29 ng/mL) caused cell cycle arrest at the pre-G1/G1 phase and significantly increased the concentration of cells at both early and late stage of apoptosis. In addition, it showed a higher safety profile on normal MCF-10A cells, and higher antiproliferative activity on cancer cells (IC50 = 8.15 μM) in comparison to normal cells (IC50 = 41.20 μM). It also revealed a fivefold higher selectivity index than erlotinib towards MCF-7 cancer cells. Docking studies were performed to rationalize the dual inhibitory activity of compound 12. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to benzothienopyrimidine derivative preparation aromatase egfr inhibitor antitumor activity, aro and egfr inhibitors, benzothienopyrimidine, cytotoxic, Placeholder for records without volume info and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics