Wang, Bin et al. published their research in Bioorganic & Medicinal Chemistry in 2021 |CAS: 97-09-6

The Article related to acute lymphoblastic leukemia synthesis acyl sulfonamide bcl2 inhibitor design, acyl sulfonamide, apoptosis, bcl-2 inhibitors, metabolic stability, selectivity, Placeholder for records without volume info and other aspects.Electric Literature of 97-09-6

On October 1, 2021, Wang, Bin; Feng, Weiwei; Wang, Jinan; Dong, Yuanzhen; Liu, Yanlong; Yao, Yiyan; Zhang, Jianqing; Shi, Wei; Liu, Limin; Zhang, Hongying; He, Xiangyi; Chang, Xiayun; Wang, Xiaojin; Xu, Hongjiang; Liu, Fei; Feng, Jun published an article.Electric Literature of 97-09-6 The title of the article was Discovery of potent and selective Bcl-2 inhibitors with acyl sulfonamide skeleton. And the article contained the following:

The antiapoptotic protein B-cell lymphoma 2 (Bcl-2), overexpressed in many tumor cells, is an attractive target for potential small mol. anticancer drug discovery. Herein, a series of novel derivatives with acyl sulfonamide skeleton was designed, synthesized, and evaluated as Bcl-2 inhibitors by means of bioisosteric replacement. Among them, compound 24g demonstrated equal efficient inhibition activity against RS4;11 cell line compared to pos. control ABT-199. Moreover, it showed improved selectivity for Bcl-2/Bcl-xL inhibitory effects, the result of which was consistent with platelet toxicity studies. In vitro and in vivo pharmacokinetic properties of compound 24g had a significantly improved profiles. Taken together, those results suggested it as a promising candidate for development of novel therapeutics targeting Bcl-2 in cancer. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Electric Literature of 97-09-6

The Article related to acute lymphoblastic leukemia synthesis acyl sulfonamide bcl2 inhibitor design, acyl sulfonamide, apoptosis, bcl-2 inhibitors, metabolic stability, selectivity, Placeholder for records without volume info and other aspects.Electric Literature of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dehghan Haghighi, Javid et al. published their research in Toxicology and Industrial Health in 2022 |CAS: 27115-50-0

The Article related to toluene xylene blood serum printing worker biomarker oxidative stress, occupational exposure, antioxidants, oxidative stress, printing workers, toluene, xylene, Placeholder for records without volume info and other aspects.Electric Literature of 27115-50-0

On May 31, 2022, Dehghan Haghighi, Javid; Hormozi, Maryam; Payandeh, Abolfazl published an article.Electric Literature of 27115-50-0 The title of the article was Blood serum levels of selected biomarkers of oxidative stress among printing workers occupationally exposed to low-levels of toluene and xylene. And the article contained the following:

Printing workers (PWs) are exposed to a mixture of solvents, yet the health risks associated with such exposuer are unknown. This study aimed to compare the serum levels of selected biomarkers of oxidative stress among occupationally exposed PWs to low-level of toluene and xylenes and unexposed controls. Associations between levels of such biomarkers and occupational exposures to toluene and xylene were also investigated. Urinary levels of hippuric acid (HA) and Me hippuric acids (MHAs) as exposure biomarkers of toluene and xylenes, resp., and serum levels of oxidative stress biomarkers, including total antioxidant capacity (TAC), malondialdehyde (MDA), and the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were measured among the 84 subjects, comprising 44 PWs and 40 unexposed subjects. Mean concentrations of urinary HA and MHAs of PWs showed a significant increase compared with the unexposed controls. Although levels of urinary biomarkers of exposure to toluene (HA) and xylenes (MHAs) were well below the biol. exposure indexes (BEIs; ACGHI), PWs presented significantly increased serum levels of MDA, and significantly decreased serum activities of SOD and GPx compared to the unexposed controls. However, for serum TAC and CAT activity, no significant difference was observed between the two groups. Correlation analyses indicated that urinary levels of HA and MHAs were pos. correlated with MDA levels and neg. correlated with GPx and SOD. Our study suggested that the alterations evidenced in serum levels of MDA, SOD, and GPx could be involved in the oxidative stress caused by co-exposure to low levels of toluene and xylene. Further investigation is needed to clarify the effect of low-level occupational exposure to solvents among PWs. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to toluene xylene blood serum printing worker biomarker oxidative stress, occupational exposure, antioxidants, oxidative stress, printing workers, toluene, xylene, Placeholder for records without volume info and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pal, Vineet Kumar et al. published their research in Science of the Total Environment in 2022 |CAS: 27115-50-0

The Article related to volatile organic compound metabolite oxidative stress biomarker, benzene, biomonitoring, intra-class correlation coefficients, oxidative stress, voc, variability, Placeholder for records without volume info and other aspects.HPLC of Formula: 27115-50-0

On April 20, 2022, Pal, Vineet Kumar; Li, Adela Jing; Zhu, Hongkai; Kannan, Kurunthachalam published an article.HPLC of Formula: 27115-50-0 The title of the article was Diurnal variability in urinary volatile organic compound metabolites and its association with oxidative stress biomarkers. And the article contained the following:

Volatile organic compounds (VOCs) are ubiquitous environmental pollutants that are associated with birth defects, leukemia, neurocognitive deficits, reproductive impairment and cancer in humans exposed to these compounds Exposure to VOCs can be assessed by measuring their metabolites in urine. Little is known, however, about the temporal variability in urinary VOC metabolite (VOCM) concentrations within- and between-individuals. In this study, we determined the variability in the concentrations of 38 VOCMs in urine samples collected from 19 healthy individuals across a period of 44 days. We also measured seven biomarkers of oxidative stress (lipid, protein and DNA damage) in urine to assess the relationship of VOC exposure to oxidative stress. Seventeen VOCMs had detection frequencies (DFs) of >60% in urine, and we limited further data anal. to those compounds The creatinine-adjusted geometric mean concentrations of VOCMs ranged from 2.70 渭g/g to 327 渭g/g in spot and 2.60 渭g/g to 551 渭g/g in first morning void (FMV) urine samples. Calculation of the intra-class correlation coefficients (ICCs) for 17 VOCM concentrations to assess their predictability and repeatability in urinary measurements showed ranges of 0.080-0.425 in spot and 0.050-0.749 in FMV urine samples, revealing notable within-individual variability. Our results suggest that taking only single measurements of VOCM concentrations in urine in epidemiol. investigations may lead to exposure misclassification. In addition, VOCM concentrations were significantly and pos. correlated with oxidative stress biomarkers. This study thus provides important information for formulating sampling strategies in the biomonitoring of VOC exposure in human populations. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).HPLC of Formula: 27115-50-0

The Article related to volatile organic compound metabolite oxidative stress biomarker, benzene, biomonitoring, intra-class correlation coefficients, oxidative stress, voc, variability, Placeholder for records without volume info and other aspects.HPLC of Formula: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wiktelius, Daniel et al. published their research in Angewandte Chemie, International Edition in 2021 |CAS: 79-07-2

The Article related to arylvinylpyridinium choline acetyltransferase inhibitor hydrothiolation, choline acetyltransferase, coenzyme a, drug discovery, hydrothiolation, in situ assembly, Placeholder for records without volume info and other aspects.Product Details of 79-07-2

On January 11, 2021, Wiktelius, Daniel; Allgardsson, Anders; Bergstroem, Tomas; Hoster, Norman; Akfur, Christine; Forsgren, Nina; Lejon, Christian; Hedenstroem, Mattias; Linusson, Anna; Ekstroem, Fredrik published an article.Product Details of 79-07-2 The title of the article was In Situ Assembly of Choline Acetyltransferase Ligands by a Hydrothiolation Reaction Reveals Key Determinants for Inhibitor Design. And the article contained the following:

The potential drug target choline acetyltransferase (ChAT) catalyzes the production of the neurotransmitter acetylcholine in cholinergic neurons, T-cells, and B-cells. Herein, we show that arylvinylpyridiniums (AVPs), the most widely studied class of ChAT inhibitors, act as substrate in an unusual CoA-dependent hydrothiolation reaction. This in situ synthesis yields an adduct that is the actual enzyme inhibitor. The adduct is deeply buried in the active site tunnel of ChAT and interactions with a hydrophobic pocket near the choline binding site have major implications for the mol. recognition of inhibitors. Our findings clarify the inhibition mechanism of AVPs, establish a drug modality that exploits a target-catalyzed reaction between exogenous and endogenous precursors, and provide new directions for the development of ChAT inhibitors with improved potency and bioactivity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to arylvinylpyridinium choline acetyltransferase inhibitor hydrothiolation, choline acetyltransferase, coenzyme a, drug discovery, hydrothiolation, in situ assembly, Placeholder for records without volume info and other aspects.Product Details of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Szulc, Justyna et al. published their research in International Journal of Environmental Research and Public Health in 2022 |CAS: 102-07-8

The Article related to physicochem microbiol toxicol hazard, uhplc-q-tof-uhrms analysis, bioaerosol, harmful biological agents, illegal landfill, metagenome analysis, toxicological analysis, Placeholder for records without volume info and other aspects.Name: 1,3-Diphenylurea

Szulc, Justyna; Okrasa, Malgorzata; Nowak, Adriana; Niziol, Joanna; Ruman, Tomasz; Kuberski, Slawomir published an article in 2022, the title of the article was Assessment of Physicochemical, Microbiological and Toxicological Hazards at an Illegal Landfill in Central Poland.Name: 1,3-Diphenylurea And the article contains the following content:

This study aimed to assess the physicochem., microbiol. and toxicol. hazards at an illegal landfill in central Poland. The research included the anal. of airborne dust (laser photometer), the number of microorganisms in the air, soil and leachate (culture method) and the microbial diversity in the landfill environment (high-throughput sequencing on the Illumina Miseq); the cytotoxicity (PrestoBlue) and genotoxicity (alk. comet assay) of soil and leachate were tested. Moreover, an anal. of UHPLC-Q-ToF-UHRMS (ultra-high-performance liquid chromatog.-quadrupole-time-of-flight ultrahigh-resolution mass spectrometry) was performed to determine the toxic compounds and microbial metabolites. The PM1 dust fraction constituted 99.89% and 99.99% of total dust and exceeded the threshold of 0.025 mg m-3 at the tested locations. In the air, the total number of bacteria was 9.33 x 101-1.11 x 103 CFU m-3, while fungi ranged from 1.17 x 102 to 4.73 x 102 CFU m-3. Psychrophilic bacteria were detected in the largest number in leachates (3.3 x 104 to 2.69 x 106 CFU mL-1) and in soil samples (8.53 x 105 to 1.28 x 106 CFU g-1). Bacteria belonging to Proteobacteria (42-64.7%), Bacteroidetes (4.2-23.7%), Actinobacteria (3.4-19.8%) and Firmicutes (0.7-6.3%) dominated. In the case of fungi, Basidiomycota (23.3-27.7%), Ascomycota (5.6-46.3%) and Mortierellomycota (3.1%) have the highest abundance. Bacteria (Bacillus, Clostridium, Cellulosimicrobium, Escherichia, Pseudomonas) and fungi (Microascus, Chrysosporium, Candida, Malassezia, Aspergillus, Alternaria, Fusarium, Stachybotrys, Cladosporium, Didymella) that are potentially hazardous to human health were detected in samples collected from the landfill. Tested leachates and soils were characterised by varied cyto/genotoxins. Common pesticides (carbamazepine, prometryn, terbutryn, permethrin, carbanilide, pyrethrin, carbaryl and prallethrin), quaternary ammonium compounds (benzalkonium chlorides), chems. and/or polymer degradation products (melamine, triphenylphosphate, diphenylphtalate, insect repellent diethyltoluamide, and drugs (ketoprofen)) were found in soil and leachate samples. It has been proven that the tested landfill is the source of the emission of particulate matter; microorganisms (including potential pathogens) and cyto/genotoxic compounds The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to physicochem microbiol toxicol hazard, uhplc-q-tof-uhrms analysis, bioaerosol, harmful biological agents, illegal landfill, metagenome analysis, toxicological analysis, Placeholder for records without volume info and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Belarbi, Saida et al. published their research in Molecules in 2021 |CAS: 79-07-2

The Article related to rapeseed solid phase extraction sorbent pesticide hplc ms, hplc-ms/ms, quechers extraction, dispersive solid-phase extraction, multiresidue pesticide analyses, rapeseeds, Placeholder for records without volume info and other aspects.Formula: C2H4ClNO

Belarbi, Saida; Vivier, Martin; Zaghouani, Wafa; De Sloovere, Aude; Agasse, Valerie; Cardinael, Pascal published an article in 2021, the title of the article was Comparison of Different d-SPE Sorbent Performances Based on Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) Methodology for Multiresidue Pesticide Analyses in Rapeseeds.Formula: C2H4ClNO And the article contains the following content:

Pesticide extraction in rapeseed samples remains a great anal. challenge due to the complexity of the matrix, which contains proteins, fatty acids, high amounts of triglycerides and cellulosic fibers. An HPLC-MS/MS method was developed for the quantification of 179 pesticides in rapeseeds. The performances of the quick, easy, cheap, effective, rugged, and safe (QuEChERS) method were evaluated using different dispersive solid-phase extraction (d-SPE) sorbents containing common octadecylsilane silica/primary-secondary amine adsorbent (PSA/C18) and new commercialized d-SPE materials dedicated to fatty matrixes (Z-Sep, Z-Sep+, and EMR-Lipid). The anal. performances of these different sorbents were compared according to the SANTE/12682/2019 document. The best results were obtained using EMR-Lipid in terms of pesticide average recoveries (103 and 70 of the 179 targeted pesticides exhibited recoveries within 70-120% and 30-70%, resp., with low RSD values). Moreover, the limits of quantification (LOQ) range from 1.72 渭g/kg to 6.39 渭g/kg for 173 of the pesticides. Only the recovery for tralkoxydim at 10 渭g/kg level was not satisfactory (29%). The matrix effect was evaluated and proved to be limited between -50% and 50% for 169 pesticides with this EMR-Lipid and freezing. GC-Orbitrap analyses confirmed the best efficiency of the EMR-Lipid sorbent for the purification of rapeseeds. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to rapeseed solid phase extraction sorbent pesticide hplc ms, hplc-ms/ms, quechers extraction, dispersive solid-phase extraction, multiresidue pesticide analyses, rapeseeds, Placeholder for records without volume info and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Huang, Chunhong et al. published their research in Hunan Wenli Xueyuan Xuebao, Ziran Kexueban in 2009 |CAS: 97-09-6

The Article related to portulaca oleracea feed, Plant Biochemistry: Composition and Products and other aspects.Computed Properties of 97-09-6

On December 31, 2009, Huang, Chunhong; Hu, Zhiyong; Wu, Xiaoqing published an article.Computed Properties of 97-09-6 The title of the article was Study on value of the wide Portulaca oleracea meal as feed in Changde city. And the article contained the following:

To study the feeding value of the flowering wide Portulaca oleracea meal, nutrition compositions such as water, crude protein, ether extract, ash, crude fiber, nitrogen-free extract, minerals, and amino acids were quant. analyzed. Results showed that the water content in the fresh Portulaca oleracea sample was 90.15%, and the crude protein, ether extract, ash, crude fiber content in the dry matter of the Portulaca oleracea meal were 22.94%, 5.89%, 25.18%, 15.77%, 30.22%, resp. Calcium, phosphorus, magnesium, zinc, iron, copper and manganese in the dry matter were 970.96, 570.36, 3131.98, 5.69, 29.14, 2.03, 4.16(mg/100g), resp. The total seventeen amino acids and seven essential amino acids content in the dry matter were 12.96% and 5.47%, resp. Results from nutrition composition comparison with the lucerne meal and sweet potato leaf meal suggested that the flowering wide Portulaca oleracea meal was a good feed origin. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Computed Properties of 97-09-6

The Article related to portulaca oleracea feed, Plant Biochemistry: Composition and Products and other aspects.Computed Properties of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Govindachari, Tuticorin R. et al. published their research in Phytochemistry (Elsevier) in 1983 |CAS: 456-12-2

The Article related to aegle alkaloid structure, Plant Biochemistry: Composition and Products and other aspects.Computed Properties of 456-12-2

On February 24, 1983, Govindachari, Tuticorin R.; Premila, Manakkal S. published an article.Computed Properties of 456-12-2 The title of the article was Some alkaloids from Aegle marmelos. And the article contained the following:

Four new alkaloids, 4-ROC6H4ZNHCOCH:CHPh [I ; R = CH2CH:CMe2, Z = (CH2)2, CH(OH)CH2; R = H, Z = CH(OH)CH2; R = Me, Z = CH:CH], were isolated from dry leaves of A. marmelos. Also isolated were aegeline [I ; R = H, Z = CH(OH)CH2] and a purple alkaloid of unknown structure. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

The Article related to aegle alkaloid structure, Plant Biochemistry: Composition and Products and other aspects.Computed Properties of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, B. R. et al. published their research in Phytochemistry (Elsevier) in 1981 |CAS: 456-12-2

The Article related to aegle alkaloid marmeline structure, Plant Biochemistry: Composition and Products and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

On November 2, 1981, Sharma, B. R.; Rattan, R. K.; Sharma, Perveen published an article.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Constituents of Aegle marmelos. Part III. Marmeline, an alkaloid, and other components of unripe fruits of Aegle marmelos. And the article contained the following:

A new alkaloid, marmeline, was isolated from unripe fruits of A. marmelos and identified as N-2-hydroxy-2-[4-(3′,3′-dimethylallyloxy)phenyl]ethyl cinnamide. Aegeline, imperatorin, alloimperatorin, and xanthotoxol were also present. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle alkaloid marmeline structure, Plant Biochemistry: Composition and Products and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jose, Sindhu et al. published their research in World Journal of Pharmaceutical Research in 2016 |CAS: 456-12-2

The Article related to aegle leaf aegeline enantiomer anticancer, Plant Biochemistry: Composition and Products and other aspects.Related Products of 456-12-2

Jose, Sindhu; Ragunathan, V.; Arunachalam, Thangakumar; Joseph, Milesh; Madipatti, Satish published an article in 2016, the title of the article was Extraction, isolation and analytical characterisation of aegeline enantiomers from Aegle marmelos.Related Products of 456-12-2 And the article contains the following content:

Aegeline or N-[2-hydroxy-2(4-methoxyphenyl)-ethyl]-3-phenyl-2-propenamide is a main alkaloid isolated from the leaves of Aegle marmelos (bael). The plant is extensively used in the Indian traditional system of medicine viz. Ayurveda . It soothes impaired kapha, vata, body pain, poison, diarrhea, dysentery, vomiting and intermittent fever. Its leaves are known as a cure for asthma, inflammation, cough and diabetes. The leaves are trifoliate and aromatic They have a shape, intermediate between ovate and lanceolate with reticulate pinnate venation. The present work was undertaken to provide an easy and reliable method for the extraction and isolation of Aegeline (N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide) using high performance liquid chromatog. (HPLC). The study also included the separation of the two enantiomers of Aegeline using chiral HPLC, its crystallog. structure, activity of the two enantiomers on cervical cancer and a NMR (NMR) method for the enantiomeric purity determination of collected fractions. Linear calibration curves were obtained over the range of 0.7 – 5mM for enantiomer-2 (R2 = 0.998). This study was undertaken with the intention to develop a fast and reliable method for the enantiomeric purity determination of Aegeline and related compounds The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to aegle leaf aegeline enantiomer anticancer, Plant Biochemistry: Composition and Products and other aspects.Related Products of 456-12-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics