Author: Jessica.F

Riyanto, Sugeng published an article in 2008, the title of the article was Spectral analysis of aegelin isolated from maja leaves (Aegle marmelos Corr.).Category: amides-buliding-blocks And the article contains the following content:

Aegelin is an alkaloid which isolated from Maja (Aegle marmelos Corr.) leaves. The mol. structure of the compound contains a chiral carbon atom. In our earlier publications the existence and influence of a chiral carbon atom have not been discussed yet. The existing of the chiral carbon atom gave rise two pair of doublets at 未 3.67 J=3.4 Hz and 未 3.43 J=8.5 Hz in the proton NMR spectrum. The doublets are signal of two proton which attached on adjacent atom of the chiral carbon atom which is confirmed by the two dimension NMR spectrum (HMQC). The two protons are magnetic unequivalent which cause their chem. shifts are different. The protons appear as two doublet with different J value because its couple to a proton attached at the chiral carbon atom and the spin-spin splitting is observed The existence of the two pairs of the doublets at 未 3.67 d,J=3.4 Hz and 未 3.42 d,J=8.5 Hz because the isolated aegelin from E. marmelos leaves contains of its enantiomer. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to aegelin stereochem nmr maja leaf aegle marmelos, Plant Biochemistry: Composition and Products and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chang, Qiaoying; Ge, Lijuan; Li, Jian; Qiu, Guoyu; Wu, Fuxiang; Zhang, Hongyan; Xu, Fenghua; Zhu, Renyuan; Qi, Pengfei; Bai, Ruobin; Ren, Fazheng published an article in 2021, the title of the article was Automated QuEChERS for the determination of 482 pesticide residues in Radix codonopsis by GC-Q-TOF/MS and LC-Q-TOF/MS.COA of Formula: C13H12N2O And the article contains the following content:

A rapid procedure for the determination of 482 pesticide residues in Chinese Materia Medica by GC-Q-TOF/MS and LC-Q-TOF/MS (379 pesticides for LC, 327 pesticides for GC, and 226 pesticides for both) was developed. Radix codonopsis was chosen as the matrix for verification, and a comparative study on the QuEChERS sample preparation was carried out, between a fully automated workstation and manual operation, in terms of limits of quantitation, recovery rate and RSD at 3 spiked levels of 10渭g kg-1, 20渭g kg-1 and 100渭g kg-1. In the linear range of each pesticide in a concentration range of 5-100渭g L-1, the linear correlation coefficients R2 of 85% of the pesticides for GC and 88% for LC were equal to or greater than 0.990. Taking recovery 70-120% and RSD 鈮?20% as the satisfactory standard, the automated workstation performed better at 10渭g kg-1 and 20渭g kg-1 than manual operation, and the numbers of satisfactory pesticides of GC & LC were 401 and 418 for the automated approach, and 378 and 400 for manual, while the two approaches were almost even at 100渭g kg-1, 421 vs. 424. Besides, the automated workstation presented lower RSD (more pesticides 鈮?0%) and better recovery quality (more pesticides within 90-110%). Following the method verification, 50 Radix codonopsis samples purchased from local markets were prepared with the automated workstation and analyzed by GC and LC-Q-TOF/MS. 18 pesticides were detected in 38 samples, one of which was a highly toxic pesticide. The automated QuEChERS workstation can handle 40 samples in one cycle within 6 h, and realize whole-process automation covering from samples after “weighing” to “injection into vials”. The batch-to-batch, day-to-day, and lab-to-lab consistency and 24 x 7 workability of the automated solution have demonstrated a promising and ideal replacement for manual operation in sample preparation The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).COA of Formula: C13H12N2O

The Article related to radix codonopsis pesticide residue gcq lcq tofms, Pharmaceutical Analysis: Inorganic Compounds and other aspects.COA of Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kiraly, Peter; Dal Poggetto, Guilherme; Castanar, Laura; Nilsson, Mathias; Deak, Andrea; Morris, Gareth A. published an article in 2021, the title of the article was Broadband measurement of true transverse relaxation rates in systems with coupled protons: application to the study of conformational exchange.Electric Literature of 685-91-6 And the article contains the following content:

Accurate measurement of transverse relaxation rates in coupled spin systems is important in the study of mol. dynamics, but is severely complicated by the signal modulations caused by scalar couplings in spin echo experiments The most widely used experiments for measuring transverse relaxation in coupled systems, CPMG and PROJECT, can suppress such modulations, but they also both suppress some relaxation contributions, and average relaxation rates between coupled spins. Here we introduce a new experiment which for the first time allows accurate broadband measurement of transverse relaxation rates of coupled protons, and hence the determination of exchange rate constants in slow exchange from relaxation measurements. The problems encountered with existing methods are illustrated, and the use of the new method is demonstrated for the classic case of hindered amide rotation and for the more challenging problem of exchange between helical enantiomers of a gold(I) complex. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Electric Literature of 685-91-6

The Article related to transverse relaxation rate conformational exchange, General Physical Chemistry: General Theories and other aspects.Electric Literature of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 16, 2020, Zhao, Yulei; Guo, Xuqiang; Si, Zhiyao; Hu, Yanan; Sun, Ying; Liu, Yunlin; Ji, Zhongyin; You, Jinmao published an article.Electric Literature of 102-07-8 The title of the article was Hydrosilane-Assisted Synthesis of Urea Derivatives from CO2 and Amines. And the article contained the following:

A methodol. employing CO2, amines, and phenylsilane was discussed to access aryl- or alkyl-substituted urea derivatives This procedure was characterized by adopting hydrosilane to promote the formation of ureas directly, without the need to prepare silylamines in advance. Control reactions suggested that FeCl3 was a favorable additive for the generation of ureas, and this 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed reaction might proceed through nucleophilic addition, silicon migration, and the subsequent formal substitution of silylcarbamate. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to hydrosilane carbon dioxide amine, urea preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Borde, Vinod U.; Pangrikar, Prashant P.; Wadikar, Madhukar S.; Tekale, Sunil U. published an article in 2011, the title of the article was Extraction and thin layer chromatography of alkaloids from Bael (Aegle marmelos) leaves.Recommanded Product: 456-12-2 And the article contains the following content:

Bael tree, (Aegle marmelos, Family – Rutaceae), is a sacred tree widely grown in Indian forests, Ceylon, Burma, Thailand and Indo-China. All parts of the tree are used for medicinal purpose. Some of the medicinal properties are astringent, antidiarreal, antidystentric, demulcent, stomachic, fever curing, insulin-promoter, anti-inflammatory, cardio tonic and cures ophthalmic, urinary trouble, palpitation and many more. Most of these properties are believed to be due to presence of bioactive alkaloids in Bael. This study was carried out to develop an easy method of extraction and separation of alkaloids from dried Bael leaves. Alkaloids from the dried leaves of Bael were extracted in 95% ethanol and separated with chloroform in presence of synthetic antioxidants butylated hydoxytoluene (BHT) and butylated hydroxyaniosole (BHA) by thin layer chromatog. BHT and BHA seem to protect alkaloids from their degradation/conversion to other components. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: 456-12-2

The Article related to aegle leaf butylated hydoxytoluene hydroxyanisole alkaloid, Plant Biochemistry: Composition and Products and other aspects.Recommanded Product: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2009, Faizi, Shaheen; Farooqi, Fatima; Zikr-Ur-Rehman, Sadia; Naz, Aneela; Noor, Fatima; Ansari, Farheen; Ahmad, Aqeel; Khan, Shakeel Ahmed published an article.Category: amides-buliding-blocks The title of the article was Shahidine, a novel and highly labile oxazoline from Aegle marmelos: the parent compound of aegeline and related amides. And the article contained the following:

A rare alkaloid, shahidine (1), having an unstable oxazoline core has been isolated as a major constituent from the fresh leaves of Aegle marmelos. It is moisture-sensitive, and found to be the parent compound of aegeline and other amides, however, it is stable in DMSO. Its structure was established by spectroscopic anal. Biogenetically, oxazolines may be considered as the precursor of hydroxy amides and oxazoles found in plants. Shahidine (1) showed activity against a few Gram-pos. bacteria. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to mol structure shahidine aegle alkaloid antibacterial anticancer, Plant Biochemistry: Composition and Products and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 21, 2000, Wagner, Alain; Mioskowski, Charles; Mohar, Barbara; Desmurs, Jean-roger; Le Guyader, Frederic; Schlama, Thierry published a patent.Application of 167316-28-1 The title of the patent was Sulfonamides and carboxamides and their use in asymmetrical catalysis. And the patent contained the following:

Optically active diamines were converted to their monosulfonamides with fluorinated alkane- or arenesulfonyl halides. The resulting sulfona,ides were used as ligands in the stereoselective reduction of ketones or in the stereoselective oxidation of racemic alcs. Thus, (1S,2S)-1,2-cyclohexanediamine was treated with F3CSO2Cl to give (1S,2S)-N-trifluoromethylsulfonyl-1,2-cyclohexanediamine (I). I was used together with [RuCl2(p-cymene)]2 to reduce PhCOMe to (S)-HOCHPhMe and to preferentially oxidize (S)-HOCHPhMe to PhCOMe, leaving enriched (R)-HOCHPhMe. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Application of 167316-28-1

The Article related to diamine monosulfonamide preparation ligand asym reduction oxidation, General Organic Chemistry: Synthetic Methods and other aspects.Application of 167316-28-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 18, 2022, Ondari, Mark E.; Klosin, Jerzy; Kruper, William R.; Lysenko, Ivan; Thomas, Pulikkottil J.; Cheng, Kevin; Abboud, Khalil A.; Kruper, William J. published an article.Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Diol-Ritter Reaction: Regio- and Stereoselective Synthesis of Protected Vicinal Aminoalcohols and Mechanistic Aspects of Diol Monoester Disproportionation. And the article contained the following:

Herein, a mechanism-based study of the less known diol-Ritter reaction had provided a highly regioselective procedure for the synthesis of 1-vic-amido-2-esters from either terminal epoxides or 1,2-diols via Lewis Acid-catalyzed monoesterification. When treated with stoichiometric Lewis Acid catalyst (BF3), these diol monoesters form dioxonium cation intermediates that are ring-opened with nitrile nucleophiles to form nitrilium intermediates, which undergo rapid and irreversible hydration to give the desired amidoesters. Diester byproduct formation was irreversible and appears to occur through a disproportionation of diol monoester. With chiral epoxide starting materials, the formation of amidoester occurs with retention of configuration and no apparent erosion of optical purity as determined by single-crystal X-ray analyzes and chiral chromatog., resp. The direct access to chiral vic-amidoesters was especially practical with regard to the synthesis of Gram-pos., antibacterial, oxazolidinone analogs of the Zyvox antimicrobial family. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to protected vicinal aminoalc regioselective stereoselective preparation, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 16, 2019, Xu, Jian-Xing; Wu, Xiao-Feng published an article.Synthetic Route of 5455-98-1 The title of the article was Cobalt-Catalyzed Alkoxycarbonylation of Epoxides to 尾-Hydroxyesters. And the article contained the following:

Herein, the authors developed a new and practical catalytic system for the carbonylative synthesis of 尾-hydroxyesters. By using simple, cheap, and air-stable cobalt(II) bromide as the catalyst, combined with pyrazole and catalytic amount of manganese, active cobalt complex can be generated in situ and can catalyze various epoxides to give the corresponding 尾-hydroxyesters in moderate to excellent yields. Mechanism studies indicate that pyrazole plays a crucial role in this reaction. Moreover, with the addition of the catalytic amount of manganese, the active cobalt catalyst can be regenerated, which provides a possibility for reusing the cobalt catalyst. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to hydroxyester beta preparation cobalt catalyst epoxide alkoxycarbonylation, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 3, 2017, Gu, Guoxian; Yang, Tilong; Yu, Ouran; Qian, Hua; Wang, Jiang; Wen, Jialin; Dang, Li; Zhang, Xumu published an article.Application of 65645-88-7 The title of the article was Enantioselective Iridium-Catalyzed Hydrogenation of 伪-Keto Amides to 伪-Hydroxy Amides. And the article contained the following:

A highly enantioselective iridium-catalyzed hydrogenation of 伪-keto amides to form 伪-hydroxy amides has been achieved with excellent results (up to >99% conversion and up to >99% ee, TON up to 100 000). As an example, this protocol was applied to the synthesis of (S)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol, the enantiomer of norepinephrine, which is widely used as an injectable drug for the treatment of critically low blood pressure. D. functional theory (DFT) calculations were also carried out to reveal the reaction mechanism. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Application of 65645-88-7

The Article related to enantioselective iridium catalyzed hydrogenation keto amide hydroxy amide, General Organic Chemistry: Synthetic Methods and other aspects.Application of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics