Author: Jessica.F

On January 1, 2021, Legacy, Christopher J.; Hope, Taylor O.; Gagne, Yohann; Greenaway, Frederick T.; Frenette, Mathieu; Emmert, Marion H. published an article.SDS of cas: 685-91-6 The title of the article was Mechanistic Insights into Fe Catalyzed α-C-H Oxidations of Tertiary Amines. And the article contained the following:

We report detailed mechanistic investigations of an iron-based catalyst system, which allows the α-C-H oxidation of a wide variety of amines. In contrast to other catalysts that effect α-C-H oxidations of tertiary amines, the system under investigation exclusively employs peroxy esters as oxidants. More common oxidants (e. g. tBuOOH) previously reported to affect amine oxidations via free radical pathways do not provide amine α-C-H oxidation products in combination with the described catalyst system. The investigations described herein employ initial rate kinetics, kinetic profiling, DFT calculations as well as Eyring, kinetic isotope effect, Hammett, ligand coordination, and EPR studies to shed light on the Fe catalyst system. The obtained data suggest that the catalytic mechanism proceeds through C-H abstraction at a coordinated substrate mol. This rate-determining step occurs either through an Fe(IV) oxo pathway or a 2-electron pathway at an Fe(II) intermediate with bound oxidant. DFT calculations indicate that the Fe(IV) oxo mechanism will be the preferred route of these two possibilities. We further show via kinetic profiling and EPR studies that catalyst activation follows a radical pathway, which is initiated by hydrolysis of PhCO3tBu to tBuOOH. Overall, the obtained mechanistic data support a non-classical, Fe catalyzed pathway that requires substrate binding, inducing selectivity for α-C-H functionalization. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).SDS of cas: 685-91-6

The Article related to tripropylamine iron oxidation mechanism kinetics hammett constant, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.SDS of cas: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cardenal, Ashley D.; Jeong Park, Hye; Chalker, Cody J.; Ortiz, Kacey G.; Powers, David C. published an article in 2017, the title of the article was cis-Decalin oxidation as a stereochemical probe of in-MOF versus on-MOF catalysis.Recommanded Product: N,N-Diethylacetamide And the article contains the following content:

Development of catalyst-controlled C-H hydroxylation could provide direct access to valuable synthetic targets, such as primary metabolites. Here, we report a new family of porous materials, comprised of 2-dimensional metalloporphyrin layers and flexible aliphatic linkers, and demonstrate C-H hydroxylation activity. We demonstrate that the stereochem. of cis-decalin oxidation provides a useful tool for differentiating catalysis in from catalysis on porous materials, which is critical to leveraging the potential of porous materials for catalyst-controlled oxidation chem. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: N,N-Diethylacetamide

The Article related to metal organic framework porous catalyst hydroxylation stereoselectivity, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Recommanded Product: N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2013, Barati, Behjat; Moghadam, Majid; Rahmati, Abbas; Tangestaninejad, Shahram; Mirkhani, Valiollah; Mohammadpoor-Baltork, Iraj published an article.Electric Literature of 27115-50-0 The title of the article was Ruthenium Hydride Catalyzed Direct Oxidation of Alcohols to Carboxylic Acids via Transfer Hydrogenation: Styrene Oxide as Oxygen Source. And the article contained the following:

Direct oxidation of alcs. to carboxylic acids using styrene epoxide as oxidant in the presence of [RuHCl(CO)(PPh3)3] complex as catalyst is reported. By this catalytic system, a variety of primary alcs. including substituted benzyl alcs. as well as linear ones were directly converted into carboxylic acids in good to excellent yields. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to ruthenium hydride direct oxidation alc carboxylic acid transfer hydrogenation, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 19, 1995, Hashiguchi, Shohei; Fujii, Akio; Takehara, Jun; Ikariya, Takao; Noyori, Ryoji published an article.Safety of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide The title of the article was Asymmetric Transfer Hydrogenation of Aromatic Ketones Catalyzed by Chiral Ruthenium(II) Complexes. And the article contained the following:

A chiral Ru(II) complex, prepared from [RuCl2(η6-mesitylene)]2 and (1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine, effects a highly enantioselective transfer hydrogenation of various aromatic alkyl ketones by iso-PrOH. The reduction of acetophenone in a 0.1M solution of iso-PrOH containing the Ru catalyst (substrate/catalyst (S/C) mole ratio = 200) and KOH (5 equiv to Ru atom) proceeds at room temperature to give (S)-1-phenylethanol in 97% ee and 95% yield. The enantioselectivity is slightly lowered as the reaction proceeds owing to the reversibility of the transfer hydrogenation. In a similar manner, a range of simple aromatic ketones (S/C = 200-500) are convertible to secondary alcs. with high enantiomeric purity. A relevant catalyst precursor was obtained by reacting [RuCl2(η6-benzene)]2 and (1S,2S)-N-trifluoromethanesulfonyl-1,2-diphenylethylenediamine in a 1:4 mol ratio in iso-PrOH. The mol. structure was determined by single-crystal x-ray anal. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Safety of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

The Article related to crystal structure ruthenium benzene sulfonylethylenediamine complex, ruthenium sulfonylethylenediamine transfer hydrogenation catalyst ketone, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Safety of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Klimochkin, Yu. N.; Ivleva, E. A. published an article.COA of Formula: C2H4ClNO The title of the article was Synthesis and Chemical Transformations of N-Adamantylated Amides. And the article contained the following:

N-Adamantylated amides, e.g., I were synthesized from 1-adamantyl nitrate. The reactions were carried out in the sulfuric acid media. The proposed method was usefulness for the preparation of antiviral drug tromantadine. A number of new cage aminoamides were synthesized by reactions of N-(1-adamantyl)-2-chloroacetamide with nitrogen-containing nucleophiles with potential biol. activity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).COA of Formula: C2H4ClNO

The Article related to adamantylated amide preparation, Alicyclic Compounds: Tricyclic Compounds and Higher Analogs, Including Adamantanes, Fullerenes and other aspects.COA of Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 26, 2021, Singh, Amrit Pal; Singh, Lovedeep; Singh, Palwinder; Bhatti, Rajbir published an article.Product Details of 456-12-2 The title of the article was Biological Evaluation of Aegle marmelos Fruit Extract and Isolated Aegeline in Alleviating Pain-Depression Dyad: In Silico Analysis of Aegeline on MAO-A and iNOS. And the article contained the following:

Pain and depression have been assessed to co-occur in up to 80% of patients, and this comorbidity is more debilitating and pricier for the patients as compared to either of these disorders alone. Aegle marmelos is a well-known medicinal plant with a broad spectrum of pharmacol. activities. Aegeline is a relatively unexplored mol. present in Aegle marmelos. Therefore, the current investigation aims to explore the potential of Aegle marmelos fruit extract (AMFE) and isolated aegeline against the reserpine-induced pain-depression dyad. In the current investigation, aegeline was isolated from AMFE, followed by spectroscopic characterization, i.e., using NMR and mass analyses. AMFE (200 mg kg-1 p.o) and aegeline (10 mg kg-1 p.o.) were administered to reserpinized (0.5 mg kg-1 s.c.) mice, and clorgyline (3 mg kg-1 i.p.) was taken as the standard drug. AMFE and aegeline significantly alleviated the reserpine-induced reduction in a pain threshold and an increase in immobility as observed in behavioral tests of pain and depression, resp. In silico mol. docking studies of aegeline showed a good binding interaction at the active sites of MAO-A and iNOS. The in vivo anal. showed that AMFE and aegeline treatment significantly decreased the monoamine oxidase-A (MAO-A) activity, serum interleukin-6 (IL-6) level, and lipid peroxidation, along with an increase in the reduced glutathione level in comparison to the reserpine-treated group. Immunofluorescence studies also showed that AMFE and aegeline abrogated the reserpine-induced increase in iNOS expression. Conclusively, the results delineate that AMFE and aegeline might exert a protective effect via downregulating the MAO-A hyperactivity, IL-6 level, oxidative and nitrosative stress. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Product Details of 456-12-2

The Article related to pain depression aegle marmelos aegeline amfe docking inos maoa, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Product Details of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 20, 2012, Bhupatbhai, Bagatharia Snehal; Kamleshkumar, Joshi Chinmayi; Mahavirsaran, Saxena Akshaykumar published a patent.Recommanded Product: 456-12-2 The title of the patent was A compound Aegeline inhibiting acetylcholinesterase and a method of screening/identifying the same. And the patent contained the following:

The present invention discloses a compound Aegeline inhibiting acetylcholinesterase using a method of screening/identifying the same for treatment of CNS disorders. The structure of Aegeline is developed with the help of a computer application MDL ISIS Draw. The crystal structure of the acetylcholinesterase is retrieved from the Research Collaborator for Structural Bioinformatics (RSCB) Protein Data Bank (PDB) and prepared by energy minimization, assigning bond orders and optimization of the structure. The screening method utilizes the 3D structure of the target protein acetylcholinesterase binding site to prioritize compounds (ligands) by their likelihood to bind to the said protein. The actual free energy is referred as a score and the highest score denotes more preferable compound for acetylcholinesterase. In comparison with the conventional drugs, at the binding site of acetylcholinesterase, Aegeline proves be more effective and can help in the treatment of memory-related disorders. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: 456-12-2

The Article related to aegeline acetylcholinesterase inhibitor screening cns disorder treatment, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2017, Mokhov, V. M.; Butov, G. M.; Saad, K. R. published an article.Formula: C6H13NO The title of the article was Chemical transformations of tetracyclo[3.3.1.13,7.01,3]decane (1,3-dehydroadamantane): II. Reaction of 1,3-dehydroadamantane with N,N-dialkylcarboxamides. And the article contained the following:

Alkylation of N,N-dialkylcarboxamides with 1,3-dehydroadamantane has been accomplished for the first time [e.g., I + N,N-dimethylacetamide → II (59%)]. The reaction involves the C-H bond in the α-position with respect to the carbonyl group and provides a convenient one-step preparation of substituted carboxylic acid amides containing an 1-adamantyl substituent and a pharmacophoric group in the amide moiety. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Formula: C6H13NO

The Article related to alkylation tertiary amide dehydroadamantane, carboxamide adamantyl derivative preparation, Alicyclic Compounds: Tricyclic Compounds and Higher Analogs, Including Adamantanes, Fullerenes and other aspects.Formula: C6H13NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2019, Raheja, Shikha; Girdhar, Amit; Kamboj, Anjoo; Lather, Viney; Pandita, Deepti published an article.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Aegle marmelos leaf extract ameliorates the cognitive impairment and oxidative stress induced by intracerebroventricular streptozotocin in male rats. And the article contained the following:

Therefore, the present study was attempted to investigate the neuroprotective potential of ethanolic extract of A. marmelos leaves (AME) on STZ induced memory impairment in male rats. Albino Wistar rats were pre-treated orally with AME at the doses 200 and 400 mg/kg for two weeks, followed by intracerebroventricular (i.c.v.) injection of STZ (3 mg/kg) on day 1 and 3. Two weeks after STZ administration, behavioral parameters were monitored using Morris water maze task. Biochem. and histopathol. studies were carried out after three weeks of STZ administration. The levels of oxidative stress markers (malondialdehyde (MDA), glutathione, nitrite, catalase) neuroinflammatory mediators; tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) and acetylcholinesterase (AChE) activity were estimated in hippocampus of rat brain. Donepezil (5 mg/kg) was taken as a standard drug. The levels of MDA, nitrite, TNF-a and IL-6 were significantly increased while glutathione levels were significantly decreased in hippocampus of STZ-treated rats. Further, a significant decrease in the activity of catalase and increase in AChE activity was observed indicating cholinergic hypofunction and neuronal damage in STZ-treated animals. All these alterations were significantly ameliorated by AME in a dose dependent manner. The neuroprotective potential of A. marmelos against STZ induced oxidative stress and cognitive deficit in rats indicates its therapeutic value in Alzheimer’s disease (AD). The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle leaf aegeline neuroprotectant oxidative stress, a. marmelos, alzheimer’s disease, memory impairment, oxidative stress, streptozotocin, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 1, 2019, Derf, Asma; Sharma, Ankita; Bharate, Sandip B.; Chaudhuri, Bhabatosh published an article.Computed Properties of 456-12-2 The title of the article was Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. And the article contained the following:

Herein, we have identified yeast Sec22p (ySec22p), a SNARE protein essential for endoplasmic reticulum to Golgi trafficking, as a suppressor of Bax-induced yeast apoptosis and corroborated published observations that ySec22p suppresses α-synuclein’s toxicity in yeast. It has been suggested that compounds which enhance expression, in neurons, of human homologues of ySec22p (Sec22Bp/Sec22p/Sec22A) would prevent synucleinopathies, such as Parkinson’s disease. With the aim of finding a small mol. that would mimic ySec22p, a library of natural products consisting of 394-compounds was screened using yeast cells that express either human α-synuclein or human Bax. The antioxidant aegeline, an alkaloid-amide occurring in the leaves of the plant Aegle marmelos Correa, was the only mol. that overcame apoptosis induced by both α-synuclein and Bax in yeast. Besides, aegeline also prevented growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells. These results highlight the importance of yeast systems to identify rapidly mols. that may prevent the onset of apoptosis that occurs in Parkinson’s disease. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

The Article related to aegeline apoptosis ros sec22p mitochondrial membrane potential, aegeline, apoptosis, dna-fragmentation, mitochondrial-membrane-potential, ros, sec22p, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Computed Properties of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics