Author: Jessica.F

On October 3, 2019, Bi, Yingzhi; Dorsey, Bruce D.; Fan, Yi; Moore, Christopher Brooks; Nguyen, Duyan published a patent.Product Details of 5455-98-1 The title of the patent was Preparation of substituted 1,1′-biphenyl compounds and analogues thereof, and methods for using them for treatment of HBV and HDV infections. And the patent contained the following:

The invention is related to the preparation of compounds I [X1 = CH, N; X2 = R2a = OCH2**, CH2O**, CONH**, NHCO**, wherein the bond marked with ** is to the Ph ring carbon marked with *; R1a, R1b = independently H, alkyl, alkoxy, CN, halo, haloalkyl; R1c = H, alkyl, OH, alkoxy optionally substituted; R2a = alkyl, alkoxy, (CH2)1-3(optionally substituted phenyl), etc.; R3a = CHO, COOH and derivatives, CONH2 and derivatives, etc.; R4a = halo, CN, alkyl], including substituted 3,3′-bis(phenoxymethyl)-1,1′-biphenyl compounds and their analogs, their salts, solvates, geometric isomers, stereoisomers, tautomers or any mixtures thereof, and compositions comprising them, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. Thus, II was prepared from (2-methyl-3-phenylphenyl)methanol using 2,4-dihydroxybenzaldehyde, 3-(bromomethyl)benzonitrile and ethane-1,2-diamine. II displayed an IC50 of 0.28 in a PD-L1 HTRF assay. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Product Details of 5455-98-1

The Article related to biphenyl analog preparation pd1 pdl1 inhibitor antiviral hbv hdv, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Product Details of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Barham, Joshua P.; Tamaoki, Souma; Egami, Hiromichi; Ohneda, Noriyuki; Okamoto, Tadashi; Odajima, Hiromichi; Hamashima, Yoshitaka published an article in 2018, the title of the article was C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor.Product Details of 685-91-6 And the article contains the following content:

C-Alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and pharmaceutically-relevant scaffolds in excellent mass balance. Various amide and styrene derivatives were tolerated, rapidly affording mol. complexity in a single step; thus highlighting the future utility of this transformation in the synthetic chem. toolbox. Reaction scalability (up to 65 g h-1 product) was demonstrated using a microwave flow reactor, as the first example of a C-alkylation reaction using styrenes in continuous flow. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to arylbutanamide preparation microwave flow reactor, alkylamide styrene alkylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2018, Laha, Joydev K.; Patel, Ketul V.; Tummalapalli, K. S. Satyanarayana; Hunjan, Mandeep Kaur published an article.Recommanded Product: 685-91-6 The title of the article was Palladium-Catalyzed Serendipitous Synthesis of Arylglyoxylic Amides from Arylglyoxylates and N,N-Dialkylamides in the Presence of Halopyridines. And the article contained the following:

A palladium-catalyzed synthesis of arylglyoxylic amides by the reaction of arylglyoxylates and N,N-dialkylamides in the presence of a 2,3-dihalopyridine has been realized for the first time. An anticipated 2,3-diaroylpyridine did not form in this reaction. The current study unveils an unprecedented role of 2,3-dihalopyridine toward this amidation. Our mechanistic study reveals that the arylglyoxylate could react with halopyridine to form a traceless activated pyridyl ester of arylglyoxylic acid, which upon subsequent reaction with amino surrogate, N,N-dialkylamides could form the arylglyoxylic amides. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: 685-91-6

The Article related to arylglyoxylate dialkylamide dihalopyridine palladium amidation catalyst, arylglyoxylic amide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 4, 2020, Lv, Ningning; Yu, Shuling; Hong, Chao; Han, De-Man; Zhang, Yuhong published an article.Quality Control of N,N-Diethylacetamide The title of the article was Selectively Oxidative C(sp2)-H/C(sp3)-H Cross-Coupling of Benzamides with Amides by Nickel Catalysis. And the article contained the following:

The oxidative cross-coupling between the α-C(sp3)-H bond of amide in DMAc and the inert ortho-C(sp2)-H bond of benzamides is achieved for the first time by nickel catalysis, with the assistance of 8-aminoquinolyl group in the presence of a silver oxidant. Notably, the selectivity of conversion can be perfectly controlled by modulating the oxidant additives, and the products from the coupling of the C(sp3)-H bond adjacent to nitrogen of amides with benzamides are approached through the use of peroxide. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Quality Control of N,N-Diethylacetamide

The Article related to benzamide amide nickel catalyst regioselective dehydrogenative oxidative cross coupling, functionalized benzamide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Quality Control of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 1, 2021, Gu, Xiaoke; Zhang, Yinpeng; Zou, Yueting; Li, Xin; Guan, Mingyu; Zhou, Qingqing; Qiu, Jingying published an article.Electric Literature of 27115-50-0 The title of the article was Synthesis and evaluation of new phenyl acrylamide derivatives as potent non-nucleoside anti-HBV agents. And the article contained the following:

As a continuation of our previous work, a series of new Ph acrylamide derivatives were designed and synthesized as non-nucleoside anti-HBV agents. Among them, compound I could potently inhibit HBV DNA replication in wild-type and lamivudine (3TC)/entecavir resistant HBV mutant strains with IC50 values of 0.19 and 0.18μM, resp. Notably, the selective index value of I was above 526, indicating the favorable safety profile. Interestingly, unlike nucleoside analog 3TC, I could significantly inhibit 3.5 kb pgRNA expression. Mol. docking study revealed that I could fit well into the dimer-dimer interface of HBV core protein by hydrophobic, π-π and H-bond interactions. Considering the potent anti-HBV activity, low toxicity and diverse anti-HBV mechanism from that of nucleoside anti-HBV agent 3TC, compound I might be a promising lead to develop novel non-nucleoside anti-HBV therapeutic agents, and warranted further investigation. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to ph acrylamide preparation potent non nucleoside antihbv agent safety, anti-hbv agents, non-nucleoside, phenyl acrylamide derivatives, synthesis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2022, Pinheiro, Danielle L. J.; Nielsen, Martin published an article.Safety of 2-(4-Methylbenzamido)acetic acid The title of the article was Chemoselective Transfer Hydrogenation of Enamides Using Ru Pincer Complexes for the Synthesis of α-Amino Acids. And the article contained the following:

The chemoselective reduction of enamides to α-amino acids with iPrOH and EtOH as H-donors and solvents catalyzed by Ru pincer complexes was demonstrated. A range of α-amino acids was synthesized in good to excellent yields. Applications, large scale and a one-pot experiment was also reported. Finally, deuterium-labeling experiments show high regioselectivity between the α- and β-positions of the alkene unit. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to aryl phenyl formamidopropenoate alkanol ruthenium catalyst chemoselective transfer hydrogenation, alkyl benzamido aryl propanoate preparation green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Moglie, Yanina; Buxaderas, Eduardo; Mancini, Agustina; Alonso, Francisco; Radivoy, Gabriel published an article in 2019, the title of the article was Amide Bond Formation Catalyzed by Recyclable Copper Nanoparticles Supported on Zeolite Y under Mild Conditions.Application In Synthesis of N,N-Diethylacetamide And the article contains the following content:

A series of catalysts based on supported copper nanoparticles were prepared and tested in the amide bond formation from tertiary amines and acid anhydrides, in the presence of tert-Bu hydroperoxide as an oxidant. Copper nanoparticles on zeolite Y (CuNPs/ZY) was found to be the most efficient catalyst for the synthesis of amides, working in acetonitrile as solvent, under ligand- and base-free conditions in air. The products were obtained in good to excellent yields and in short reaction times. The CuNPs/ZY system also exhibited higher catalytic activity than some com. available copper and iron sources and it was reused in ten reaction cycles without any further pre-treatment. This methodol. was successfully scaled-up to a gram scale with no detriment to the yield. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to reusable zeolite support copper nanoparticle preparation surface area, tertiary amine caboxylic anhydride copper nanocatalyst amidation, aryl alkyl amide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 10, 2019, Angel, Matthew; Kostas, Franklin; Rohde, Christopher published a patent.COA of Formula: C11H9NO3 The title of the patent was Cationic lipids and transfection methods. And the patent contained the following:

Cationic lipids of formula I [n = 1-15] are prepared which are used in liposomes for delivering nucleic acids to cells. Thus, I (n = 4) (DHDLinS) was prepared, and transfected human epidermal keratinocytes with RNA. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).COA of Formula: C11H9NO3

The Article related to cationic lipid preparation liposome nucleic acid delivery, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.COA of Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 7, 2021, Angel, Matthew; Kostas, Franklin; Rohde, Christopher published a patent.Related Products of 5455-98-1 The title of the patent was Preparation of cationic lipids for delivery of nucleic acids to cells. And the patent contained the following:

Cationic lipids of formula I [n = 1-15] are prepared for use in liposomes for the delivery of nucleic acids to cells. Thus, I (n = 4) was prepared, and used for mRNA delivery to a human subject by intradermal injection. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to lipid cationic preparation liposome nucleic acid delivery, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Related Products of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 12, 2022, Zhong, Pinyong; Wu, Junran; Liu, Jin-Biao; Luo, Nianhua published an article.Recommanded Product: 1,3-Diphenylurea The title of the article was Atmosphere-controlled selective synthesis of ureas and thioureas from isothiocyanates. And the article contained the following:

An atmosphere-controlled selective synthesis of ureas and thioureas from isothiocyanates in the presence of 4-dimethylaminopyridine is described. A series of disubstituted ureas and thioureas were prepared in air and nitrogen atm., resp. This protocol employs benign reagents and exhibits good chemoselectivity and practicality. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea

The Article related to urea thiourea preparation chemoselective atm controlled, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Recommanded Product: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics