Author: Jessica.F

Ahmed, Riyaz; Gupta, Ria; Akhter, Zaheen; Kumar, Mukesh; Singh, Parvinder Pal published an article in 2022, the title of the article was TCT-mediated click chemistry for the synthesis of nitrogen-containing functionalities: conversion of carboxylic acids to carbamides, carbamates, carbamothioates, amides and amines.Category: amides-buliding-blocks And the article contains the following content:

Reported a s-trichlorotriazine (TCT, also known as cyanuric chloride) mediated one-pot general method for the conversion of carboxylic acids into ubiquitous functionalities such as carbamides, carbamates, carbamothioates, amides and amines. The TCT-mediated activation of acids followed by azidation and heating led to the isocyanate formation via Curtius rearrangement which involved click chem. in the presence of nucleophiles and provided the coupled product. The TCT were employed at ≤40 mol% with respect to the starting materials; however, its bulk availability and low cost provide a unique opportunity towards its applicability in the synthesis of functional mols. The optimized conditions was successfully demonstrated for gram scale synthesis and late-stage functionalization of natural products and drugs such as podophyllotoxin, eugenol, diosgenin, geraniol and fluvoxamine. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Category: amides-buliding-blocks

The Article related to benzoic acid amine cyanuric chloride azidation click chem, phenylurea preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Jian; He, Wang; Lei, Pan; Song, Jiacheng; Huo, Jiyou; Wei, Hongbo; Bai, Hongjin; Xie, Weiqing published an article in 2021, the title of the article was 2,2,2-Trifluroenthanol promoted synthesis of unsymmetrical ureas from dioxazolones and amines via tandem Lossen rearrangement/condensation process.Computed Properties of 102-07-8 And the article contains the following content:

A 2,2,2-trifluroenthanol (TFE) promoted synthesis of unsym. ureas was described. This approach enabled the construction of a variety of ureas from the readily prepared and easy-to-handle dioxazolones and amines via tandem Lossen rearrangement/condensation process. The reaction featured mild conditions for the urea synthesis under metal-free conditions, which was successively applied in the scale-up synthesis of herbicides monuro and isoproturon. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Computed Properties of 102-07-8

The Article related to unsym urea preparation, dioxazolone amine tandem lossen rearrangement condensation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Computed Properties of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2021, Zeng, Honglan; Du, Hongyan; Gong, Xu; Zhang, Jie; Han, Wei published an article.Related Products of 102-07-8 The title of the article was Palladium-Catalyzed Aerobic Oxidative Carbonylation of Amines Enables the Synthesis of Unsymmetrical N,N’-Disubstituted Ureas. And the article contained the following:

A ligand-free palladium-catalyzed aerobic oxidative carbonylation of amines for the synthesis of ureas, particular unsym. N,N’-disubstituted ureas, which cannot be accessed by any other palladium-catalyzed oxidative carbonylation of amines to date, is presented. An array of sym. and unsym. ureas were straightforwardly synthesized by using inexpensive, readily available, stable, and safe amines with good to excellent yields under a pressure of 1 atm. This novel method employs oxygen as the sole oxidant and offers an attractive alternative to transition-metal-based oxidant systems. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to unsym disubstituted urea preparation, amine aerobic oxidative carbonylation palladium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Jinchen; Chen, Ling; Dong, Yibo; Zhang, Jinli; Wu, Yangjie published an article in 2022, the title of the article was Di-tert-butyl peroxide (DTBP)-mediated synthesis of symmetrical N,N’-disubstituted urea/thiourea motifs from isothiocyanates in water.Application In Synthesis of 1,3-Diphenylurea And the article contains the following content:

A direct approach to N,N’-disubstituted urea/thiourea from the self-condensation reactions of isothiocyanates in water has been developed. This access tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to N,N’-disubstituted urea/thiourea in moderate to excellent yields from safe and easily available starting materials. A plausible mechanism of the desulfurization self-condensation reaction for urea was also proposed and the role of di-tert-Bu peroxide (DTBP) and copper catalyst in the present strategy was demonstrated with the help of ESI mass spectrometry of intermediate studies. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application In Synthesis of 1,3-Diphenylurea

The Article related to urea thiourea preparation green chem, isothiocyanate desulfurization self condensation ditert butyl peroxide, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Application In Synthesis of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2021, Harish, N.; Kathyayini, N.; Baby, Bindhu; Nagaraju, N. published an article.Application of 102-07-8 The title of the article was Investigation of active sites using solid state 27Al and 31P MAS NMR in ceramic amorphous aluminophosphate materials prepared from different potassium salts of phosphate for the synthesis of diphenyl urea derivatives. And the article contained the following:

Ceramic amorphous aluminophosphate (CAmAlP) catalysts were prepared by precipitation method using different phosphate salts of potassium such as KH2PO4, K4P2O7 and K2HPO4 as well as H3PO4. The prepared materials were characterized by PXRD, FT-IR, XPS, SEM, BET Surface area, NH3-TPD, 27Al NMR and 31P NMR anal. methods. The catalytic activity of the materials was checked in the synthesis of di-Ph urea (DPU) from aniline and di-Et carbonate, under refluxing conditions. Further, the general application of the catalysts was tested using various substituted anilines. The recyclability of the catalysts was also studied. Uncertainties in percentage yields were calculated to check the reproducible surface properties. The P-XRD, BET Surface area and NH3-TPD results indicated that the materials were amorphous with mesoporous texture, surface areas and acidities in the range 200-260 m2/g and 0.4-0.7 mmol/g resp. 27Al NMR studies revealed that Al was present in three different coordination states such as tetrahedral, pentagonal and octahedral. The relative percentages of these Al sites depended on the type of the potassium precursor phosphate salt used. Both tetrahedral and pentagonal Al sites in conjunction with each other represented catalytically active sites. An increase in the pentagonal sites contributed to addnl. increments to the catalytic activity of CAmAlP. The catalyst prepared from KH2PO4 was found to be the best and demonstrated 96% DPU yield. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to diphenyl urea preparation, aniline diethyl carbonate condensation ceramic amorphous aluminophosphate catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 26, 2022, Joseph, Devaneyan; Lee, Sunwoo published an article.Application In Synthesis of 1,3-Diphenylurea The title of the article was Reaction of Amide and Sodium Azide for the Synthesis of Acyl Azide, Urea, and Iminophosphorane. And the article contained the following:

Amides reacted with NaN3 to give the acyl azides in DMF at 25°C and produce the sym. ureas in THF/H2O at 80°C via the sequential reaction of acyl substitution and Curtius rearrangement. All acyl azides were also obtained from the secondary amides via sequential reaction of p-toluenesulfonyl chloride and NaN3. In addition, keto-stabilized iminophosphoranes were prepared from a one-pot reaction of amides, NaN3, and phosphines. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application In Synthesis of 1,3-Diphenylurea

The Article related to acyl azide sym aromatic urea iminophosphorane preparation, amide sodium azide phosphine substitution curtius rearrangement, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Application In Synthesis of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Song, Xizhong; Liu, Xiaoyu; Yu, Wei; Jin, Yi published an article in 2021, the title of the article was Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea.HPLC of Formula: 102-07-8 And the article contains the following content:

A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride was established for the efficient synthesis of 1,3-diphenylurea derivatives A variety of electronically and sterically different 1,3-diphenylurea derivatives could be obtained in good to excellent yields, and a proposed reaction mechanism was also presented. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).HPLC of Formula: 102-07-8

The Article related to hydroxyarylformimidoyl chloride rearrangement, diphenylurea preparation, diarylurea, benzamide, hydroxyarylformimidoyl chloride, rearrangement, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.HPLC of Formula: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 29, 2020, Zhang, Guofu; Cui, Yin; Zhao, Yiyong; Cui, Yunqiang; Bao, Shenxiao; Ding, Chengrong published an article.Category: amides-buliding-blocks The title of the article was A Practical Approach to Ureas and Thiocarbamates: SO2F2-Promoted Lossen Rearrangement of Hydroxamic Acid. And the article contained the following:

A simple, mild and practical method for the synthesis of sym. urea ArNHC(O)NHAr (Ar = C6H5, 1-naphthyl, 2-pyridyl, etc.) via Lossen rearrangement promoted by SO2F2, which achieves the conversion from hydroxamic acid ArC(O)NHOH to sym. urea in high selectivity and provides a new method for facile initiation of Lossen rearrangement has been described. Meanwhile, the reaction within amines R1NHR2 (R1 = 4-CH3OC6H4, 4-ClC6H4, C6H5CH2; R2 = H, Me) or thiols like 4-methylbenzene-1-thiol and phenylmethanethiol also provide the efficient synthetic strategy towards unsym. ureas C6H5NHC(O)NR1R2 or thiocarbamates like S-(p-tolyl) phenylcarbamothioate and S-benzyl phenylcarbamothioate. Significant for gram-scale application, the desired product on gram-scale by filtration without further purifn was afforded. A plausible mechanism which is supported by control exptl. and spectral data is proposed. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Category: amides-buliding-blocks

The Article related to urea preparation, hydroxamic acid lossen rearrangement, amine hydroxamic acid lossen rearrangement, thiocarbamate preparation, thiol hydroxamic acid lossen rearrangement, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 14, 2017, Ombrato, Rosella; Magaro, Gabriele; Garofalo, Barbara; Furlotti, Guido; Mangano, Giorgina; Capezzone de Joannon, Alessandra published a patent.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of fused heterocyclic compounds as antibacterial agents. And the patent contained the following:

The invention relates to novel antibacterial compounds of formula A-L1-Y-L2-R-B (wherein A is cyclic group; L1 is σ bond, (un)substituted C1-3 alkylenyl; Y is piperidinyl, piperazinyl, pyrrolidinyl, etc.; L2 is σ bond, (un)substituted C1-3 alkylenyl, NH and derivatives, etc.; R is α bond and heterocyclyl; B is substituted benzopyranopyrrolyl), and addition salts with pharmaceutically acceptable organic or inorganic acids or basis, enantiomers, N-oxides and quaternary ammonium salts thereof, pharmaceutical compositions containing them and their use as antimicrobials. Example compound I was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their antibacterial activities (data given). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to fused heterocyclic compound antibacterial agent preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 14, 2017, Ombrato, Rosella; Magaro’, Gabriele; Garofalo, Barbara; Furlotti, Guido; Mangano, Giorgina; Capezzone de Joannon, Alessandra published a patent.Category: amides-buliding-blocks The title of the patent was Preparation of fused hetereocyclic compounds as antibacterial agents. And the patent contained the following:

The invention relates to novel antibacterial compounds of formula A-L1-Y-L2-R-B (wherein A is cyclic group; L1 is σ bond, (un)substituted C1-3 alkylenyl; Y is piperidinyl, piperazinyl, pyrrolidinyl, etc.; L2 is σ bond, (un)substituted C1-3 alkylenyl, NH and derivatives, etc.; R is α bond and heterocyclyl; B is substituted benzopyranopyrrolyl), and addition salts with pharmaceutically acceptable organic or inorganic acids or basis, enantiomers, N-oxides and quaternary ammonium salts thereof, pharmaceutical compositions containing them and their use as antimicrobials. Example compound I was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their antibacterial activities (data given). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Category: amides-buliding-blocks

The Article related to fused hetereocyclic compound antibacterial agent preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics