Author: Jessica.F

On September 2, 2015, Cheng, Guolin; Li, Tuan-Jie; Yu, Jin-Quan published an article.Electric Literature of 5455-98-1 The title of the article was Practical Pd(II)-Catalyzed C-H Alkylation with Epoxides: One-Step Syntheses of 3,4-Dihydroisocoumarins. And the article contained the following:

Pd(II)-catalyzed ortho-alkylation of benzoic acids with both terminal and internal epoxides affords 3,4-dihydroisocoumarins I [ R1 = Me, F, Cl, etc; R = H, Me, Bn, etc] in one step. The presence of potassium countercations is crucial for this reaction. Monoprotected amino acid ligands significantly promote this reaction, enabling the development of a practical C-H alkylation reaction using 0.5 mol % Pd catalyst. The inversion of stereochem. in the C-H alkylation step is consistent with a redox-neutral SN2 nucleophilic ring-opening process as opposed to a Pd(II)/Pd(IV) pathway. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Electric Literature of 5455-98-1

The Article related to benzoic acid epoxide alkylation palladium catalyst, dihydroisocoumarin preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Electric Literature of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 15, 2022, Misaela, Francisco-Marquez; Alexander, Perez de la Luz; Catalina, Soriano-Correa; Carolina, Barrientos-Salcedo; Ignacio, Sainz-Diaz C. published an article.Formula: C8H10N2O3S The title of the article was Tautomerism and IR spectroscopy of arylsulfonamides by quantum mechanical calculations. And the article contained the following:

The mol. structures of sulfonamides are interesting for evaluating their mobility in soils and preparing composite complexes for optimizing the use of these drugs. In this work, the mol. structures of several arylsulfonamides along with conformational anal. and tautomerism were investigated theor. The spectroscopical properties of several arylsulfonamides, were also studied at mol. level by using a computational modeling at quantum mechanics level. Besides, the controversial exptl. results found in the IR (IR) spectroscopy bands assignments of solid sulfonamides pushed us up to study computationally the crystal structure of sulfamethazine for clarifying previous assignment discrepancies. The previously proposed polymorphism in the crystal structure of this drug has been also clarified in this work. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Formula: C8H10N2O3S

The Article related to aryl sulfonamide tautomerism crystal polymorphism ir spectra, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 8, 2020, Yang, Wenbo; Sukhanov, Andrei A.; Lim, Jong Hyeon; Li, Xiaoxin; Meng, Yinshan; Zhao, Jianzhang; Sun, Haoling; Lee, Jin Yong; Gurzadyan, Gagik G.; Voronkova, Violeta K. published an article.Recommanded Product: 102-07-8 The title of the article was N^N Pt(II) Bisacetylide Complexes with Oxoverdazyl Radical Ligands: Preparation, Photophysical Properties, and Magnetic Exchange Interaction between the Two Radical Ligands. And the article contained the following:

To study the effect of a stable radical on the photophys. properties of a phosphorescent Pt(II) coordination framework and the intramol. magnetic interaction between radical ligands in the N^N Pt(II) bisacetylide complexes, authors prepared a series of N^N Pt(II) bis(acetylide) complexes with oxoverdazyl radical acetylide ligands. The linker between the Pt(II) center and the spin carrier was systematically varied, to probe the effect on the sign and magnitude of the spin exchange interactions between the radical ligands and photophys. properties. The complexes were studied with steady-state and femtosecond/ns transient absorption spectroscopy, continuous-wave ESR spectroscopy, and d. functional theory (DFT) computations. The transient absorption spectral studies show that the doublet excited state of the radicals are short-lived (τD ≈ 2 ps) and nonfluorescent. Moreover, the intrinsic long-lived triplet excited state (τT = 1.2μs) of the Pt(II) coordination center was efficiently quenched by the radical (τT = 6.9 ps for one representative radical Pt(II) complex). The intramol. magnetic interaction between the radical ligands through the diamagnetic Pt(II) atom was studied with temperature-dependent EPR spectroscopy; antiferromagnetic exchange interaction (-J S1S2, J = -5.4 ± 0.1 cm-1) for the complex with the shortest radical-radical distance through bridge fragments was observed DFT computations give similar results for the sign and magnitude of the J values. For complexes with larger inter-radical distance, however, very weak coupling between the radical ligands was observed (|J| < 0.7 cm-1). The results are useful for the study of the effect of a radical on the photophys. properties of the phosphorescent transition-metal complexes. A series of Pt(II) complexes containing oxoverdazyl radical ligands was prepared The length of the linker between Pt(II) center and spin carrier exerts significant effect on photophys. and magnetic property. The intrinsic long-lived triplet excited state of the Pt(II) coordination center was efficiently quenched by the presence of the radical. Antiferromagnetic interaction between the two radical ligands was observed The sign and the magnitude of the electronic spin-spin exchange was reproduced with DFT computations. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 102-07-8

The Article related to oxoverdazyl radical platinum bisacetylide preparation mol structure calculation electrochem, photophys magnetic exchange oxoverdazyl radical platinum bisacetylide complex and other aspects.Recommanded Product: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Raheem, Islam Ali Abdel; Razek, Amro Abdul; Elgendy, Abeer Abdelaziz; Saleh, Noha Mohamed; Shaaban, Mona Ibrahem; Abd El-Had, Faten K. published an article in 2019, the title of the article was Design, evaluation and antimicrobial activity of egyptian propolis-loaded nanoparticles: intrinsic role as a novel and naturally based root canal nanosealer.Synthetic Route of 685-91-6 And the article contains the following content:

Propolis is a unique natural adhesive product collected by honeybees. It contains a diversity of bioactive compounds with reported functional properties such as antioxidants, antibacterial, antifungal, anti-inflammatory, antiviral and anticancer activity. Dental caries is a worldwide problem that caused by microbial growth usually progress from tooth enamel to the underlying pulpal tissues and root canal. This situation could be controlled by a sequence of steps to remove microorganisms and fill root canal with a suitable long-lasting root canal sealer. Unfortunately, leachable and degradation products of the currently used sealers compromised their antimicrobial activity by inflammatory modulation associated with irritation and toxicity of periapical tissues. Hence, propolis was selected to be designed as a natural root canal sealer due to its amazing functional properties. Moreover, its handling properties were enhanced and potentiated by its incorporation in polymeric nanoparticles (NPs). Frist, propolis was collected, extracted and analyzed for its bioactive compounds After that, propolis-loaded NPs of PLGA (ProE-loaded NPs) were developed and fully characterized regarding physicochem. properties, in vitro release and in vitro cytotoxicity. Then, root canal sealers were fabricated and assayed for their antimicrobial activity. Both cytotoxicity and antimicrobial activity were compared to those of a model sealer; AH Plus. The results revealed that spherical nanoscopic NPs with narrow size distribution were obtained. ProE-loaded NPs exhibited accepted entrapment efficiency (>80) and prolonged release. In vitro cytotoxicity study confirmed the safety of ProE-loaded NPs. Also, the developed sealers showed antimicrobial activity vs. bacterial strains of Enterococcus faecalis and Streptococcus mutans and antifungal activity against Candida albicans. ProE-loaded NPs could be incorporated in and represented as a root canal sealer with prolonged release and enhanced cytocompatibility as well as antimicrobial activities. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to egyptian propolis nanoparticle antimicrobial activity root canal nanosealer, plga, antimicrobial activity, in vitro cytotoxicity, polymeric nanoparticles, propolis, sealer and other aspects.Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Leimbacher, Markus; Zhang, Yixin; Mannocci, Luca; Stravs, Michael; Geppert, Tim; Scheuermann, Joerg; Schneider, Gisbert; Neri, Dario published an article in 2012, the title of the article was Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library.Synthetic Route of 27115-50-0 And the article contains the following content:

Libraries of chem. compounds individually coupled to encoding DNA tags (DNA-encoded chem. libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNA-encoded chem. library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic anal. of selection strategies and statistically robust identification of binding mols. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by mol. docking. Our findings suggest that DNA-encoded chem. libraries allow the facile identification of drug-like ligands principally to any protein of choice, including mols. capable of disrupting high-affinity protein-protein interactions. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Synthetic Route of 27115-50-0

The Article related to dna encoded chem library drug discovery protein ligand, interleukin 2 inhibitor dna encoded chem library, tumor antigen carbonic anhydrase ix inhibitor dna encoded library and other aspects.Synthetic Route of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 8, 2020, Lajin, Bassam; Goessler, Walter published an article.Recommanded Product: 79-07-2 The title of the article was Fluorinated carboxylic acids as “ion repelling agents” in reversed-phase chromatography. And the article contained the following:

Fluorinated carboxylic acids have been in use as ion-pairing reagents for over three decades. It has been observed that ion-pairing reagents not only increase the retention of oppositely charged analytes on reversed-phase HPLC columns but also decrease the retention of similarly charged analytes; these latter effects, however, have not been thoroughly investigated for the fluorinated carboxylic acids, and the application of these reagents has been rather restricted to their ion-pairing capacity to sep. basic analytes. In the present study, we report a systematic investigation about the effects of three fluorinated carboxylic acids (trifluoroacetic acid (TFA), pentafluoropropionic acid (PFPA), and heptafluorobutyric acid (HFBA)) on the retention and selectivity of the separation of halogenated carboxylic acids and sulfonic acids by reversed-phase chromatog. with an inductively coupled plasma mass spectrometry detector (ICPMS). Several eluents were tested and compared at different concentrations (0-100 mM) and pH values, including sulfate, nitrate, phosphate, oxalate, TFA, PFPA, and HFBA. The fluorinated carboxylic acids resulted in a consistent decrease in the retention factors (up to ca. 9-fold with HFBA) in a concentration dependent manner, which plateaued at around 50 mM. Significant improvement of the peak symmetry of the chromatographed acids was also observed We highlight the advantages of incorporating the fluorinated carboxylic acids in modifying the selectivity and retention of organic acids in reversed phase chromatog. in general, and particularly when employing chromatog. detectors with limited compatibility with organic mobile phases such as the ICPMS. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 79-07-2

The Article related to fluorinated carboxylic acid ion repelling agent reversed phase chromatog, alkyl sulfonate, fluorinated acetic acids, heptafluorobutyric acid, icpms, ion-pair chromatography and other aspects.Recommanded Product: 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 14, 2022, Nishioka, Kiho; Tanaka, Mizuki; Fujimoto, Hayato; Amaya, Toru; Ogoshi, Sensuke; Tobisu, Mamoru; Nakanishi, Shuji published an article.Electric Literature of 685-91-6 The title of the article was Overlooked Factors Required for Electrolyte Solvents in Li-O2 Batteries: Capabilities of Quenching 1O2 and Forming Highly-Decomposable Li2O2. And the article contained the following:

Although sufficient tolerance against attack by superoxide radicals (O2-) has been mainly recognized as an important property for Li-O2 battery (LOB) electrolytes, recent evidence has revealed that other critical factors also govern the cyclability, prompting a reconsideration of the basic design guidelines of LOB electrolytes. Here, we found that LOBs equipped with a N,N-dimethylacetamide (DMA)-based electrolyte exhibited better cyclability compared with other standard LOB electrolytes. This superior cyclability is attributable to the capabilities of quenching 1O2 and forming highly decomposable Li2O2. The1O2 quenching capability is equivalent to that of a tetraglyme-based electrolyte containing a several millimolar concentration of a typical chem. quencher. Based on these overlooked factors, the DMA-based electrolyte led to superior cyclability despite its lower O2- tolerance. Thus, the present work provides a novel design guideline for the development of LOB electrolytes. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Electric Literature of 685-91-6

The Article related to lithium oxygen battery electrolyte solvent electrochem stability current density, electrochemistry, electrolyte, lithium-air battery, lithium-oxygen battery, singlet oxygen and other aspects.Electric Literature of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 9, 2020, Yamashita, Yu; Vinogradova, Ekaterina V.; Zhang, Xiaoyu; Suciu, Radu M.; Cravatt, Benjamin F. published an article.Formula: C2H4ClNO The title of the article was A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. And the article contained the following:

Target engagement assays are crucial for establishing the mechanism-of-action of small mols. in living systems. Integral membrane transporters can present a challenging protein class for assessing cellular engagement by small mols. The chem. proteomic discovery of alpha-chloroacetamide (αCA) compounds that covalently modify cysteine-54 (C54) of the MPC2 subunit of the mitochondrial pyruvate carrier (MPC) is presented. This finding is used to create an alkyne-modified αCA, YY4-yne, that serves as a cellular engagement probe for MPC2 in click chem.-enabled western blotting or global mass spectrometry-based proteomic experiments Studies with YY4-yne revealed that UK-5099, an alpha-cyanocinnamate inhibitor of the MPC complex, engages MPC2 with remarkable selectivity in human cells. These findings support a model where UK-5099 inhibits the MPC complex by binding to C54 of MPC2 in a covalent reversible manner that can be quantified in cells using the YY4-yne probe. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to chem proteomic probe mitochondrial pyruvate carrier complex mcp2 uk5099, chemical proteomics, cysteine, mitochondrial pyruvate complex, target engagement, α-chloroacetamide and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 12, 2019, Zamani, Parisa; Phipps, Joshua; Hu, Jiyun; Cheema, Faizan; Amiri Rudbari, Hadi; Bordbar, Abdol-Khalegh; Khosropour, Ahmad R.; Beyzavi, Hudson published an article.Safety of 2-(4-Methylbenzamido)acetic acid The title of the article was Multicomponent Synthesis of Diversified Chromeno[3,2-d]oxazoles. And the article contained the following:

A practical and efficient synthetic procedure to novel chromeno[3,2-d]oxazoles through a one-pot sequential multistep process is presented. This procedure proceeds efficiently in propylene carbonate (PC) as a green solvent and affords a wide range of the chromenooxazole scaffolds. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to chromeno oxazole diversity oriented synthesis multistep cyclization, chromenooxazoles, one-pot multicomponent reaction, propylene carbonate, sequential annulation reactions and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 14, 2017, Loubert, Gael; Volkringer, Christophe; Henry, Natacha; Arab-Chapelet, Benedicte; Delahaye, Thibaud; Loiseau, Thierry published an article.COA of Formula: C6H13NO The title of the article was Structural studies of a series of uranyl alkylacetamides and piracetam complexes obtained in nitric acid aqueous solution. And the article contained the following:

Three uranyl amide complexes have been isolated from slow evaporation technique from an aqueous solution of nitric acid (0.5 M), in the presence of N’,N-diethylacetamide (noted dam; compound 1), N-ethylacetamide (noted eam; compound 2) and 2-(2-oxopyrrolidino)acetamide (or piracetam, noted pam; compound 3). It results in the formation of crystalline mol. assemblies of UO2(L)2(NO3)2 neutral moieties (L = amide ligand), in which the uranyl center is coordinated to two chelating nitrate groups either in cis positions (1) or trans positions (2 and 3) and two organic ligands, through the amide functionality. The corresponding coordination geometry for uranyl is a hexagonal bipyramid, with the two typical trans U:O bondings. Single-crystal x-ray diffraction anal. revealed the bond lengths of U-Oamide are for 2.362(3), 2.363(3) and 2.374(2) Å for 1, 2 and 3, resp. The three complexes have been further characterized by IR spectroscopy and their thermal behavior has been evaluated by thermogravimetry. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).COA of Formula: C6H13NO

The Article related to uranyl alkylacetamide piracetam complex preparation crystal mol structure, diethylacetamide ethylacetamide oxopyrrolidinoacetamide reaction uranium nitrate aqueous solution and other aspects.COA of Formula: C6H13NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics