Author: Jessica.F

On August 1, 2021, Guo, Ruonan; Li, Yunhe; Chen, Ying; Liu, Yu; Niu, Bihui; Gou, Jianfeng; Cheng, Xiuwen published an article.Recommanded Product: 144-80-9 The title of the article was Efficient degradation of sulfamethoxazole by CoCu LDH composite membrane activating peroxymonosulfate with decreased metal ion leaching. And the article contained the following:

In this study, we prepared two types of composite membranes decorated with CoCu layered double hydroxide (LDH) nanoparticles, i.e. LDH@Calotropis gigantean fiber (LDH@CGF) and LDH@polyvinylidene fluoride (LDH@PVDF) for the first time. Besides, the application potential of different types of composite functional membranes based on LDH in PMS activation system was compared. Both of the LDH-based composite membranes exhibited excellent activity in peroxymonosulfate (PMS) activation process. More importantly, the composite membrane could be separated from the treated water to meet the need of practical application. The superior composite membrane was identified as LDH@PVDF, which was with excellent PMS activation capability and pretty lower metal ions leaching concentration (cobalt 0.044 mg L-1, copper 0.026 mg L-1). And then, LDH@PVDF was employed to investigate the PMS activation performance in various pharmaceutical pollutants removal processes. Besides, the activity of LDH@PVDF for SMX degradation in real aquatic environment (tap water and wastewater) was detected, proving the wide practical applicability of LDH@PVDF membrane. Finally, the possible SMX degradation pathway and PMS activation mechanism occurring in LDH-based composite membrane/PMS system were proposed. Hence, this study for LDH-based membranes construction may provide new insights into the environmentally-friendly catalytic membranes preparation and practical application in wastewater treatment. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Recommanded Product: 144-80-9

The Article related to sulfamethoxazole degradation cobalt copper layered double hydroxide composite membrane, composite membrane peroxymonosulfate metal ion leaching pharmaceutical wastewater treatment and other aspects.Recommanded Product: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Konkle, Stacey L.; Zierold, Kristina M.; Taylor, Kira C.; Riggs, Daniel W.; Bhatnagar, Aruni published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. And the article contained the following:

Exposure to air pollution is a leading cause of global mortality. Volatile organic compounds (VOCs) are constituents of ambient air that could exert adverse health effects. To examine the relationship between VOC levels in ambient air and individual-level exposure to VOCs, as assessed by urinary VOC metabolites. Secular trends in 11 ambient air VOCs (2005-2013) and individual-level metabolites of 14 VOCs (2005-2014) were assessed using National Monitoring Programs (NMP) and National Health and Nutrition Examination Survey (NHANES) data, resp. To isolate environmental exposure, individuals reporting exposure to tobacco smoke were excluded. Quantile regression models were used to assess secular trends in VOC exposure, and survey-weighted regression models were built to identify factors associated with VOC exposure. All annual levels of ambient VOCs decreased from 2005 to 2013 (Range: 12.5%-77.2%). However, 11 of the corresponding VOC metabolites increased during the same time (Range: 0.3%-53.6%). There was a proportional change in patterns of VOC exposure across NHANES waves, with the middle quantiles of exposure showing the largest increase. VOC exposures were significantly associated with age, sex, race, education, and phys. inactivity, but not with secular VOC trends. In the United States, individual-level exposure to several VOCs increased between 2005 and 2014 despite a decline in ambient air VOC levels. This inverse relationship suggests that ambient VOCs are not the primary source of VOC exposure, therefore, decreasing ambient VOCs alone may not be sufficient to protect against the adverse health effects associated with VOC exposure. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to ambient air volatile organic compound biomarker united states, air pollution, biomarkers of exposure, environmental health, nhanes, secular trends, vocs, volatile organic compounds and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2021, Jokioja, Johanna; Percival, Jasmine; Philo, Mark; Yang, Baoru; Kroon, Paul A.; Linderborg, Kaisa M. published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was Phenolic Metabolites in the Urine and Plasma of Healthy Men After Acute Intake of Purple Potato Extract Rich in Methoxysubstituted Monoacylated Anthocyanins. And the article contained the following:

Structurally stable acylated anthocyanins have potential in various food applications but the effects of acylation and methoxysubstitution on anthocyanin metabolism are poorly understood. This is the first study thoroughly investigating phenolic metabolites, their time-wise changes, and pharmacokinetics following an acute intake of methoxysubstituted monoacylated anthocyanins. Healthy male volunteers (n = 17) consumed a yellow potato meal with and without purple potato extract rich in acylated anthocyanins (152 mg) and hydroxycinnamic acid conjugates (140 mg). Ultra-high performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) is used for identification and quantification of metabolites from serially collected urine and plasma. While the parent anthocyanins are not detected, 28 phenolic metabolites from urine and 14 from plasma are quantified, including hydroxybenzoic and hydroxycinnamic acids and protocatechuic acid sulfates and glucuronides; three (catechol, gallic acid-4-O-glucuronide, and 2-methoxybenzoic acid) are detected for the first time after anthocyanin-rich food. Urinary hippuric acid is the most abundant with an increase of 139 μM mM-1 creatinine after the treatment. A large addnl. set of tentatively identified phenolic metabolites are detected. Late urinary peak time values suggest colonic degradation Acylated anthocyanins are more bioavailable than earlier reported after extensive degradation in human and/or colonial metabolism to phenolic metabolites, which may be further conjugated and demethylated. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to phenolic metabolite urine plasma purple potato extract anthocyanin, solanum tuberosum l., acylated anthocyanins, mass spectrometry, postprandial metabolites, purple-fleshed potatoes and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 8, 2021, Karimi, Farzaneh; Shariatipour, Monire; Heydari, Akbar published an article.Safety of 1,3-Diphenylurea The title of the article was Deep Eutectic Solvent Mediated Carbonylation of Amines and Alcohols by Using Dimethyl Carbonate: Selective Symmetrical Urea and Organic Carbonate Synthesis. And the article contained the following:

This work presented one-pot synthesis of sym. organic carbonates and ureas by employing cheap and biodegradable deep eutectic solvent as the catalyst and reaction media. The effect of different reaction parameters such as temperature, DMC/amines and alcs. ratio and reaction time were investigated on the reaction efficiency. This new protocol provided a simple, fast, and sustainable approach and proceeded with high efficiency with aliphatic and aromatic amines and alcs. as well. Finally, applicability of this methodol. was also examined for reaction of nucleophiles such as Ph hydrazine and Ph glycine with di-Me carbonate. Interestingly, it was found that this reaction system obtained good yields of product for both of them. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Safety of 1,3-Diphenylurea

The Article related to sym urea preparation, amine dimethyl carbonate carbonylation deep eutectic solvent mediated, carbonate preparation, alc dimethyl carbonate carbonylation deep eutectic solvent mediated and other aspects.Safety of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 7, 2015, Lill, Andreas P.; Roedl, Carmen B.; Steinhilber, Dieter; Stark, Holger; Hofmann, Bettina published an article.Computed Properties of 27115-50-0 The title of the article was Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy. And the article contained the following:

Different inflammatory diseases and allergic reactions are mediated by leukotrienes, which arise from the oxygenation of arachidonic acid catalyzed by 5-lipoxygenase (5-LO). One promising approach for an effective anti-leukotriene therapy (leukotriene antagonists) is the inhibition of this key enzyme. This study presents the synthesis and development of a potent and direct 5-LO inhibitor based on the well characterized 5-benzylidene-2-phenylthiazolone C06, whose further pharmacol. investigation was precluded due to its low solubility Through optimization of C06, evaluation of a structure-activity relationship including profound assessment of the thiazolone core and consideration of the solubility, the 5-benzyl-2-phenyl-4-hydroxythiazoles represented by ST-1829 [i.e., 5-(4-chlorobenzyl)-2-p-tolyl-4-thiazolol] were developed. ST-1829 showed an improved 5-LO inhibitory activity in cell-based (IC50 values 0.14 μM) and cell-free assays (IC50 values 0.03 μM) as well as a prominent enhanced solubility Furthermore, ST-1829 kept its promising inhibitory potency in the presence of blood serum, excluding excessive binding to serum proteins. These facts combined with the non-cytotoxic profile mark a major step towards an effective anti-inflammatory therapy. The synthesis of the target compounds was achieved using 2-thioxo-4-thiazolidinone, 4-methylbenzoic acid, aldehydes, nitriles as simple starting materials. The title compounds thus formed included 2-(4-chlorophenyl)-5-[(4-methoxyphenyl)methyl]-4-thiazolol, 5-[(4-methoxyphenyl)methylene]-2-(4-methylphenyl)-4-thiazolone and related substances. Analogs included (3E)-3-[(4-methoxyphenyl)methylene]-5-(4-methylphenyl)-2(3H)-furanone, (4Z)-4-[(4-methoxyphenyl)methylene]-2-(4-methylphenyl)-5(4H)-oxazolone. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Computed Properties of 27115-50-0

The Article related to thiazole thiazolone thiazolol preparation leukotriene antagonist, 5-lipoxygenase, anti-leukotriene therapy, hydroxythiazoles, inflammation, solubility, structure–activity relationship and other aspects.Computed Properties of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Boscari, Carolina Nasser; Mazzuia, Giovanna Rodrigues; Wisniewski, Celio; Borges, Keyller Bastos; Figueiredo, Eduardo Costa published an article in 2017, the title of the article was Molecularly imprinted probe for solid-phase extraction of hippuric and 4-methylhippuric acids directly from human urine samples followed by MEKC analysis.SDS of cas: 27115-50-0 And the article contains the following content:

Hippuric acid (HA) and 4-methylhippuric acid (4-MHA) are metabolites as well as biol. indicators for toluene and xylenes, resp., and their determination in urine samples is very important, in order to monitor the occupational exposition to these solvents, ensuring a safe working environment. Thus, this paper describes the synthesis and characterization of a probe impregnated with molecularly imprinted polymers (MIPs) for the solid-phase extraction of HA and 4-MHA directly from untreated urine samples followed by micellar electrokinetic chromatog. (MEKC) analyses. The MIP probe selectivity was compared to the non-imprinted polymer probe. The MEKC separations were carried out in 50 mmol/L sodium tetraborate pH 10.0/0.5 mmol/L cetyltrimethylammonium bromide aqueous solution, with a constant voltage of -15 kV. The system variables were optimized to provide ideal conditions for the extraction and desorption of the analytes, as well as for the MEKC analyses. The method was linear from 0.5 to 5.0 g/L for both analytes, with correlation coefficients > 0.994. Precisions and accuracies, expressed as relative standard deviation and relative error, were < 20.0 and within -15.4 to 16.6%, resp., in accordance with the United States Food and Drug Administration recommendation. The MIP probe has proven to be simple, cheap, resistant, and synthetically reproducible, being successfully used to analyze both HA and 4-MHA from real samples. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to hippurate methylhippurate molecularly imprinted polymer solid phase extraction mekc, capillary electrophoresis, hippuric acid, methylhippuric acid, molecularly imprinted polymer, urine and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Paronikyan, Ervand G.; Dashyan, Shushanik Sh.; Mamyan, Suren S. published an article.HPLC of Formula: 79-07-2 The title of the article was Synthesis of pyrano[3,4-c]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridines, representatives of a new fused heterocyclic system. And the article contained the following:

New effective synthesis of functionalized pyrano[3,4-c]thieno-[3,2-e][1,2,4]triazolo[4,3-a]pyridines I (Y = COOEt, C(O)NH2, CN) is described. The synthesis comprises nucleophilic substitution of 8-morpholino-6-thioxopyrano[3,4-c]pyridine-5-carbonitrile with hydrazine hydrate followed by sequential heterocyclization with formic acid and chloroacetic acid derivatives The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).HPLC of Formula: 79-07-2

The Article related to pyranothienotriazolopyridine preparation, morpholino thioxopyranopyridine carbonitrile hydrazine hydrate nucleophilic substitution, formic chloroacetic acid derivative heterocyclization and other aspects.HPLC of Formula: 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2021, Yang, Jing; Chen, Xiaoqian; Yin, Daqiang; Yin, Haowen; Zhang, Ying; Liu, Min; Zhao, Weigang; Zhang, Lu; Liu, Yanan; Yang, Xichen; Zhong, Zhijie published an article.Quality Control of 2-Chloroacetamide The title of the article was Applicability of Enchytraeus bulbosus as a model species in ecotoxicology and risk assessment. And the article contained the following:

Enchytraeus bulbosus is listed in the ISO and OECD standard guidelines as a possible test species of enchytraeid. However, in contrast to other listed species, its applicability in ecotoxicol. studies as well as its sensitivity is widely unknown. Therefore, copper, pentachlorophenol(PCP), carbendazim, and chloroacetamide have been investigated by performing two-generation studies with multiple endpoints. Comparable toxicity trends to the existing studies were shown for copper and PCP in the two-generation studies of E. bulbosus. Dose-related abnormal swelling of clitella were found for the first time with PCP and chloroacetamide treatments. Sensitivity comparisons of E. bulbosus to other terrestrial test species were also conducted. E. bulbosus showed high sensitivity, it has comparable sensitivity as other sensitive species of genus Enchytraeus ( E. albidus or E. luxuriosus)to different chems., and was more sensitive than E. crypticus and earthworm species ( Eisenia fetida or Eisenia andrei). Combined with the phylogenetic and biol. characterization, the results lead to the conclusion that E.bulbosus is a suitable model species in ecotoxicol. and the chem. risk assessment (especially in multi-generation) because it has a short generation time, comparatively moderate fecundity, ideal and reasonable sensitivity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Quality Control of 2-Chloroacetamide

The Article related to copper pentachlorophenol carbendazim chloroacetamide enchytraeus ecotoxicol risk assessment, carbendazim, chloroacetamide, copper, enchytraeus bulbosus, pentachlorophenol, two generations and other aspects.Quality Control of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2022, Liman, Recep; Ali, Muhammad Muddassir; Istifli, Erman Salih; Cigerci, Ibrahim Hakki; Bonciu, Elena published an article.Formula: C2H4ClNO The title of the article was Genotoxic and cytotoxic effects of pethoxamid herbicide on Allium cepa cells and its molecular docking studies to unravel genotoxicity mechanism. And the article contained the following:

Pethoxamid is chloroacetamide herbicide. Pethoxamid is commonly used to kill different weeds in various crops. Pethoxamid can leach in the water and soil and can cause toxic effects to other non-target species. Current study is therefore aimed to perform the investigation of the cytotoxic and genotoxic effects of pethoxamid on Allium cepa cells. The root growth, mitotic index (MI), chromosomal aberrations (CAs), and DNA damage were assessed through root growth inhibition, A. cepa ana-telophase, and alk. comet assays, resp. Furthermore, mol. docking was performed to evaluate binding affinity of pethoxamid on DNA and very-long-chain fatty acid (VLCFA) synthases. In root growth inhibition test, onion root length was statistically significantly decreased in a concentration dependent manner. Concentration- and time-dependent decreases in MI were observed, whereas increase in CAs such as disturbed ana-telophase, chromosome laggards, stickiness, anaphase bridges, and DNA damage was caused by the pethoxamid on A. cepa root cells. Mol. docking revealed that pethoxamid binds selectively to GC-rich regions in the minor groove of the DNA structure and showed remarkable binding affinity against all synthases taking part in the sequential biosynthesis of VLCFAs. It was concluded that the pethoxamid-induced genotoxicity and cytotoxicity may be through multiple binding ability of this herbicide with DNA and VLCFA synthases. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to pethoxamid herbicide allium cepa cell mol docking genotoxicity, binding affinity, chromosomal aberrations, dna damage, long-chain fatty acids, mitotic index, molecular docking, pethoxamid and other aspects.Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 4, 2022, Kumar, Vishal; Dhawan, Sanjeev; Bala, Renu; Girase, Pankaj Sanjay; Singh, Parvesh; Karpoormath, Rajshekhar published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Metal-free direct annulation of 2-aminophenols and 2-aminothiophenols with unactivated amides through transamidation: Access to polysubstituted benzoxazole and benzothiazole derivatives. And the article contained the following:

Simple yet novel oxidant, metal and solvent-free green protocol for synthesizing differently 2-substituted 1,3-benzoxazoles I [R1 = Me, Ph, Bn, etc.; R2 = H, 6-Me, 5-Cl, etc.; X = O] and benzothiazoles I [R1 = Me; R2 = H, 5-Cl; X = S] from 2-aminophenol hydrochloride salt, unactivated amide as in situ carbon source was reported. Further, the hydrogen ion of hydrochloride played a crucial role in amide activation followed nucleophilic attack that through eliminations of amine as a side product, and de-hydrolysis step leads to final annulation. This versatile strategy was applicable to a wide variety of differently substituted o-aminophenols, unactivated aliphatic and aromatic amides, yielding the corresponding product in good to excellent yields in a single step. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to benzoxazole green preparation, aminophenol hydrochloride salt unactivated amide annulation, benzothiazole green preparation, aminothiophenol hydrochloride salt unactivated amide annulation and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics