Author: Jessica.F

On January 10, 2022, Xu, Xiaolei; Gujarati, Priyansh D.; Okwor, Neechi; Sivey, John D.; Reber, Keith P.; Xu, Wenqing published an article.Reference of 2-Chloroacetamide The title of the article was Reactivity of chloroacetamides toward sulfide + black carbon: Insights from structural analogues and dynamic NMR spectroscopy. And the article contained the following:

Chloroacetamides are commonly used in herbicide formulations, and their occurrence has been reported in soils and groundwater. However, how their chem. structures affect transformation kinetics and pathways in the presence of environmental reagents such as hydrogen sulfide species and black carbon has not been investigated. In this work, we assessed the impact of increasing Cl substituents on reaction kinetics and pathways of six chloroacetamides. The contribution of individual pathways (reductive dechlorination vs. nucleophilic substitution) to the overall decay of selected chloroacetamides was differentiated using various exptl. setups; both the transformation rates and product distributions were characterized. Our results suggest that the number of Cl substituents affected reaction pathways and kinetics: trichloroacetamides predominantly underwent reductive dechlorination whereas mono- and dichloroacetamides transformed via nucleophilic substitution. Furthermore, we synthesized eight dichloroacetamide analogs (Cl2CHC(=O)NRR′) with differing R groups and characterized their transformation kinetics. Dynamic NMR spectroscopy was employed to quantify the rotational energy barriers of dichloroacetamides. Our results suggest that adsorption of dichloroacetamides on black carbon constrained R groups from approaching the dichloromethyl carbon and subsequently favored nucleophilic attack. This study provides new insights to better predict the fate of chloroacetamides in subsurface environments by linking their structural characteristics to transformation kinetics and pathways. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Reference of 2-Chloroacetamide

The Article related to black carbon chloroacetamide transformation kinetics structural analog dynamic nmr, dechlorination, dynamic nmr spectroscopy, halogenated agrochemical fate, polysulfides, subsurface environments and other aspects.Reference of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2022, Han, Lingxi; Liu, Tong; Fang, Kuan; Li, Xianxu; You, Xiangwei; Li, Yiqiang; Wang, Xiuguo; Wang, Jun published an article.Electric Literature of 79-07-2 The title of the article was Indigenous functional microbial communities for the preferential degradation of chloroacetamide herbicide S-enantiomers in soil. And the article contained the following:

This study investigated indigenous functional microbial communities associated with the degradation of chloroacetamide herbicides acetochlor (ACE), S-metolachlor (S-MET) and their enantiomers in repeatedly treated soils. The results showed that biodegradation was the main process for the degradation of ACE, S-MET and their enantiomers. Eight dominant bacterial genera associated with the degradation were found: Amycolatopsis, Saccharomonospora, Mycoplasma, Myroides, Mycobacterium, Burkholderia, Afipia, and Kribbella. The S-enantiomers of ACE and S-MET were preferentially degraded, which mainly relied on Amycolatopsis, Saccharomonospora and Kribbella for the ACE S-enantiomer and Amycolatopsis and Saccharomonospora for the S-MET S-enantiomer. Importantly, the relative abundances of Amycolatopsis and Saccharomonospora increased by 146.3%-4467.2% in the S-enantiomer treatments of ACE and S-MET compared with the control, which were significantly higher than that in the corresponding R-enantiomer treatments (25.3%-4168.2%). Both metagenomic and qPCR analyses demonstrated that four genes, ppah, alkb, benA, and P 450, were the dominant biodegradation genes (BDGs) potentially involved in the preferential degradation of the S-enantiomers of ACE and S-MET. Furthermore, network anal. suggested that Amycolatopsis, Saccharomonospora, Mycoplasma, Myroides, and Mycobacterium were the potential hosts of these four BDGs. Our findings indicated that Amycolatopsis and Saccharomonospora might play pivotal roles in the preferential degradation of the S-enantiomers of ACE and S-MET. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Electric Literature of 79-07-2

The Article related to chloroacetamide enantiomer microbial community biodegradation wastewater treatment china, chloroacetamide herbicides, degradation, enantiomers, functional microbial communities, network analysis and other aspects.Electric Literature of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 1, 2022, Sai Kumar, Gobbilla; Bhattacharjee, Jayeeta; Kumari, Kusum; Moorthy, Shruti; Bandyopadhyay, Ayan; Kumar Singh, Saurabh; Panda, Tarun K. published an article.Category: amides-buliding-blocks The title of the article was Hydroboration of nitriles, esters, and amides catalyzed by simple neosilyllithium. And the article contained the following:

We present here an efficient method for the hydroboration of organic nitriles, carboxylic esters, and carboxamides with pinacolborane (HBpin) using an alkali metal catalyst, neosilyllithium (LiCH2SiMe3), in neat reaction conditions. The reactions were accomplished with efficient catalytic reactivity and demonstrated by neosilyllithium at room temperature, in solvent-free condition, to afford a high yield of the corresponding N-boryl amines, boryl ethers, and amine hydrochlorides. The protocol for the catalytic reaction presented in this paper is simple and efficient, with diverse substrate scope for nitriles, carboxylic esters, and carboxamides showing excellent functional group tolerance. DLPNO-CCSD(T) calculations were also performed, showing that the hydroboration of nitriles catalyzed by neosilyllithium occurs through the pre-coordination of the nitrile at Lewis acid lithium followed by hydride migration from the B-H entity. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Category: amides-buliding-blocks

The Article related to hydroboration nitrile ester amide preparation aralkyl amine alc, lithium organometallic catalyst hydroboration reduction nitrile ester amide, crystal mol optimized structure picolyl diborylamine and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2021, Zhao, Wentao; Jiang, Rui; Guo, Wenping; Guo, Chao; Li, Shilei; Wang, Juanqiang; Wang, Shouwei; Li, Yingying published an article.Product Details of 144-80-9 The title of the article was Screening and Analysis of Multiclass Veterinary Drug Residues in Animal Source Foods using UPLC-Q-Exactive Orbitrap/MS. And the article contained the following:

A rapid, simple, and sensitive method of detecting veterinary drug residues in animal food sources, including poultry and pork, was developed and validated. The method was optimized for over 155 veterinary drugs of 21 different classes. Sample pretreatment included a simple solid-liquid extraction step with 0.2% formic acid-acetonitrile-water and a purification step with a PRiME HLB (hydrophile-lipophile balance) solid-phase extraction cartridge. Data were collected using ultra-high-performance liquid chromatog. coupled to Quadrupole-Exactive Orbitrap mass spectrometry. The limits of detection of 155 veterinary drugs ranged from 0.1μg/kg to 10μg/kg. The recovery rates were between 79.2 and 118.5% in all matrixes studied, with relative standard deviation values less than 15% (n = 6). The evaluated method allows the reliable screening, quantification, and identification of 155 veterinary drug residues in animal source food and has been successfully applied in authentic samples. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to veterinary drug residue animal source food uplcqexactive orbitrap ms, animal source foods, qualitative screening, quantitative determination, uplc-q-exactive orbitrap/ms, veterinary drug residues and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 1, 2021, Chiu, Chun-Hui; Chen, Chi-Tsung; Cheng, Ming-Huei; Pao, Li-Heng; Wang, Chi; Wan, Gwo-Hwa published an article.Electric Literature of 27115-50-0 The title of the article was Use of urinary hippuric acid and o-/p-/m-methyl hippuric acid to evaluate surgical smoke exposure in operating room healthcare personnel. And the article contained the following:

Toluene and xylene are common components of surgical smoke, whereas hippuric acid (HA) and methylhippuric acid (MHA) are the products of toluene and xylene metabolism in humans, resp. HA and MHA can be used as indicators to evaluate the exposure hazards of toluene and xylene. In this study, we used liquid chromatog. tandem mass spectrometry (LC-MS/MS) to simultaneously analyze the HA, o-/m-/p-MHA, and creatinine contents in the urine of healthcare personnel. Concentrations of HA and o-/m-/p-MHAs were normalized to those of creatinine and used to analyze urine samples of 160 operating room (OR) healthcare personnel, including administrative staff, surgical nurses, nurse anesthetists, and surgeons. The results showed that the five analytes could be accurately separated and exhibited good linearity (r > 0.9992). The rate of recovery was between 86% and 106%, and the relative standard deviation was less than 5%. Urine from administrative staff presented the highest median concentration of hippuric acid (0.25 g/g creatinine); this was significantly higher than that found in the urine of surgeons (0.15 g/g). The concentrations of urinary o-/m-/p-MHAs in surgical nurses were higher than those in administrative staff, nurse anesthetists, and surgeons. Furthermore, the type, sex, and age of healthcare personnel were associated with changes in urine HA and o-/m-/p-MHA concentrations Healthcare personnel should be aware of the risk of exposure to surgical smoke. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to methyl hippuric acid surgical smoke occupational health hazard, high-performance liquid chromatography tandem mass spectrometry, hippuric acid, methylhippuric acid, operating room, surgical smoke and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 28, 2017, Liu, He; Qu, Menghua; Xu, Lina; Han, Xu; Wang, Changyuan; Shu, Xiaohong; Yao, Jihong; Liu, Kexin; Peng, Jinyong; Li, Yanxia; Ma, Xiaodong published an article.Product Details of 16230-24-3 The title of the article was Design and synthesis of sulfonamide-substituted diphenylpyrimidines (SFA-DPPYs) as potent Bruton’s tyrosine kinase (BTK) inhibitors with improved activity toward B-cell lymphoblastic leukemia. And the article contained the following:

A new series of diphenylpyrimidine derivatives (SFA-DPPYs) were synthesized by introducing a functional sulfonamide into the C-2 aniline moiety of pyrimidine template, and then were biol. evaluated as potent Bruton’s tyrosine kinase (BTK) inhibitors. Among these mols., inhibitors 10c, 10i, 10j and 10k (I – IV, resp.) displayed high potency against the BTK enzyme, with IC50 values of 1.18 nM, 0.92 nM, 0.42 nM and 1.05 nM, resp. In particular, compound 10c could remarkably inhibit the proliferation of the B lymphoma cell lines at concentrations of 6.49 μM (Ramos cells) and 13.2 μM (Raji cells), and was stronger than the novel agent spebrutinib. In addition, the inhibitory potency toward the normal PBMC cells showed that inhibitor 10c possesses low cell cytotoxicity. All these explorations indicated that mol. 10c could serve as a valuable inhibitor for B-cell lymphoblastic leukemia treatment. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Product Details of 16230-24-3

The Article related to sulfonamide phenylpyrimidine bruton tyrosine kinase inhibitor lymphoblastic leukemia, b cell lymphoblastic leukemia sulfonamide phenylpyrimidine, btk, inhibitor, leukemia, pyrimidine, sulfonamide and other aspects.Product Details of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 1, 2021, Lu, Xiaogang; Zhang, Zixuan; Liu, Haibo; Tang, Hui; Gao, Runli; Pei, Chengxin; Wang, Hongmei; Xiao, Junhua published an article.Product Details of 685-91-6 The title of the article was Forensic signatures of a chemical weapon precursor DMPADC for determination of a synthetic route. And the article contained the following:

Chem. forensics has been widely recognized as an important tool to investigate alleged use of chem. weapons and/or to identify the illicit production of chem. warfare agents. This paper describes the use of gas chromatog. and mass spectrometry (GC-MS) to determine chem. attribution signatures (CAS) N,N-dimethylphosphoramidic dichloride (DMPADC), a key precursor of tabun, for tracking the production of tabun. Synthetic samples were identified and classified by using GC-MS and chemometrics. Anal. samples (n = 27) were collected from three synthetic DMPADC routes; 20 potential CAS were identified, and the structures of five CAS were assigned. Principal component anal. (PCA) was performed to summarize the distribution trend of the samples and to check for the presence of outliers. A Partial least squares discriminant anal. (PLSDA) model was established to discriminate and classify the synthetic samples. The proposed model in this paper has high predictive ability, and the test set samples can be correctly categorized. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to dimethylphosphoramidic dichloride forensic analysis gas chromatog mass spectrometry, chemical attribution signatures, chemical forensics, chemometrics, n,n-dimethylphosphoramidic dichloride, tabun and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

De Jesus, Victor R.; Bhandari, Deepak; Zhang, Luyu; Reese, Christopher; Capella, Kimberly; Tevis, Denise; Zhu, Wanzhe; Del Valle-Pinero, Arseima Y.; Lagaud, Guy; Chang, Joanne T.; van Bemmel, Dana; Kimmel, Heather L.; Sharma, Eva; Goniewicz, Maciej L.; Hyland, Andrew; Blount, Benjamin C. published an article in 2020, the title of the article was Urinary biomarkers of exposure to volatile organic compounds from the population assessment of tobacco and health study wave 1 (2013-2014).Related Products of 27115-50-0 And the article contains the following content:

Volatile organic compounds (VOCs) are ubiquitous in the environment. In the United States (U.S.), tobacco smoke is the major non-occupational source of exposure to many harmful VOCs. Exposure to VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment of Tobacco and Health (PATH) Study is a U.S. national longitudinal study of tobacco use in the adult and youth civilian non-institutionalized population. We measured 20 VOCMs in urine specimens from a subsample of adults in Wave 1 (W1) (2013-2014) to characterize VOC exposures among tobacco product users and non-users. We calculated weighted geometric means (GMs) and percentiles of each VOCM for exclusive combustible product users (smokers), exclusive electronic cigarette (e-cigarette) users, exclusive smokeless product users, and tobacco product never users. We produced linear regression models for six VOCMs with sex, age, race, and tobacco user group as predictor variables. Creatinine-ratioed levels of VOCMs from exposure to acrolein, crotonaldehyde, isoprene, acrylonitrile, and 1,3-butadiene were significantly higher in smokers than in never users. Small differences of VOCM levels among exclusive e-cigarette users and smokeless users were observed when compared to never users. Smokers showed higher VOCM concentrations than e-cigarette, smokeless, and never users. Urinary VOC metabolites are useful biomarkers of exposure to harmful VOCs. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Related Products of 27115-50-0

The Article related to volatile oragnic compound metabolite biomarker tobacco smoke adult population, path study, e-cigarette users, smokeless tobacco users, tobacco smoke exposure, volatile organic compound metabolites and other aspects.Related Products of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2021, Tevis, Denise S.; Flores, Sharon R.; Kenwood, Brandon M.; Bhandari, Deepak; Jacob, Peyton 3rd; Liu, Jia; Lorkiewicz, Pawel K.; Conklin, Daniel J.; Hecht, Stephen S.; Goniewicz, Maciej L.; Blount, Benjamin C.; De Jesus, Victor R. published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Harmonization of acronyms for volatile organic compound metabolites using a standardized naming system. And the article contained the following:

Increased interest in volatile organic compound (VOC) exposure has led to an increased need for consistent, systematic, and informative naming of VOC metabolites. As anal. methods have expanded to include many metabolites in a single assay, the number of acronyms in use for a single metabolite has expanded in an unplanned and inconsistent manner due to a lack of guidance or group consensus. Even though the measurement of VOC metabolites is a well-established means to investigate exposure to VOCs, a formal attempt to harmonize acronyms amongst investigators has not been published. The aim of this work is to establish a system of acronym naming that provides consistency in current acronym usage and a foundation for creating acronyms for future VOC metabolites. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to volatile organic compound metabolite acronym standardized naming system, acronyms, biomonitoring, mercapturic acids, naming systems, volatile organic compound metabolites, volatile organic compounds and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 14, 2010, De Vries, Maria Andreas Hendrikus; Domin, Doris; Helms, Matthias; Imboden, Chistoph; Koberstein, Ralph; Nazir, Zarghun; Skranc, Wolfgang; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Maria Gerardus Karel; Stichler, Juergen published a patent.Formula: C9H11NO2 The title of the patent was Process and intermediates for preparation of almorexant hydrochloride.. And the patent contained the following:

(S)-6,7-Dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydro-1H-isoquinoline acetate was prepared via asym. hydrogenation of 6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydroisoquinoline in the presence of bis(chloro-1,5-cyclooctadieneiridium), taniaphos, and I2 in a solvent at 1-200 bar H2. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Formula: C9H11NO2

The Article related to almorexant hydrochloride preparation, methoxytrifluoromethylphenylethyldihydroisoquinoline acetate chiral preparation, hydroisoquinoline asym hydrogenation taniaphos cyclopentadiene iridium chloride and other aspects.Formula: C9H11NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics