Author: Jessica.F

On October 25, 2007, Kansal, Kinod Kumar; Ahmad, Suhail; Mariappan, Shanmugavel; Tyagi, Bhupendra; Perlman, Nurit; Le Paih, Jacques; Zanotti-Gerosa, Antonio published a patent.Recommanded Product: N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide The title of the patent was Processes for the synthesis of azetidinone. And the patent contained the following:

Provided were intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided were processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe (I). The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Recommanded Product: N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

The Article related to azetidinone ezetimibe analog preparation drug delivery system, cholesterol absorption inhibitor azetidinone ezetimibe analog preparation, stereoselective reduction ruthenium catalyst ezetimibe preparation and other aspects.Recommanded Product: N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2021, Nanda, Tanmayee; Biswal, Pragati; Pati, Bedadyuti Vedvyas; Banjare, Shyam Kumar; Ravikumar, Ponneri Chandrababu published an article.Formula: C13H12N2O The title of the article was Palladium-Catalyzed C-C Bond Activation of Cyclopropenone: Modular Access to Trisubstituted α,β-Unsaturated Esters and Amides. And the article contained the following:

Strain-driven palladium/N-heterocyclic carbene-catalyzed C-C bond activation of diphenylcyclopropenone (DPC) was explored for one-step access to trisubstituted α,β-unsaturated esters and amides. The designed transformation worked under mild conditions providing exclusively a single stereoisomer. Mechanistic studies support the oxidative addition of the C-C bond of cyclopropenone to in-situ-generated Pd(0) intermediate. Vinylic hydrogen in the product was proved that it is coming from phenol/aniline through deuterium-labeling studies. Late-stage functionalization of bioactive mols. such as procaine, estrone, and hymecromone demonstrated the robustness of this protocol. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Formula: C13H12N2O

The Article related to trisubstituted unsaturated ester preparation, phenol cyclopropenone bond activation palladium catalyst, amide trisubstituted unsaturated preparation, amine cyclopropenone bond activation palladium catalyst and other aspects.Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2022, Liu, Junwei; Bao, Yixuan; Zhang, Xuan; Zhao, Shiyu; Qiu, Jiguo; Li, Na; He, Jian published an article.Reference of 2-Chloroacetamide The title of the article was Anaerobic biodegradation and detoxification of chloroacetamide herbicides by a novel Proteiniclasticum sediminis BAD-10T. And the article contained the following:

Chloroacetamide herbicides (CAAHs) are important herbicides that were widely used to control agricultural weeds. However, their mass applications have seriously contaminated environment, and they are toxic to living beings. CAAHs are easy to enter anoxic environments such as subsoil, wetland sediment, and groundwater, where CAAHs are mainly degraded by anaerobic organisms. To date, there are no research on the anaerobic degradation of CAAHs by pure isolate and toxicity of anaerobic metabolites of CAAHs. In this study, the anaerobic degradation kinetics and metabolites of CAAHs by an anaerobic isolate BAD-10T and the toxicity of anaerobic metabolites were studied. Isolate BAD-10T could degrade alachlor, acetochlor, propisochlor, butachlor, pretilachlor and metolachlor with the degradation kinetics fitting the pseudo-first-order kinetics equation. The degradation rates of CAAHs were significantly affected by the length of N-alkoxyalkyl groups, the shorter the N-alkoxyalkyl groups, the higher the degradation rates. Four metabolites 2-ethyl-6-methyl-N-(ethoxymethyl)-acetanilide (EMEMA), N-(2-methyl-6-ethylphenyl)-acetamide (MEPA), N-2-ethylphenyl acetamide and 2-ethyl-N-carboxyl aniline were identified during acetochlor degradation, and an anaerobic catabolic pathway of acetochlor was proposed. The toxicity of EMEMA and EMPA for zebrafish, Arabidopsis and Chlorella ellipsoidea were obviously lower than that of acetochlor, indicating that the anaerobic degradation of acetochlor by isolate BAD-10T is a detoxification process. The work reveals the anaerobic degradation kinetics and catabolic pathway of CAAHs and highlights a potential application of Proteiniclasticum sediminis BAD-10T for bioremediation of CAAHs residue-contaminated environment. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Reference of 2-Chloroacetamide

The Article related to chloroacetamide herbicide anaerobic biodegradation detoxification, acetochlor, anaerobic biodegradation, catabolic pathway, chloroacetamide herbicides, detoxification, proteiniclasticum sediminis bad-10(t) and other aspects.Reference of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 9, 2009, De Vries, Andreas Hendrikus Maria; Domin, Doris; Helms, Matthias; Imboden, Christoph; Koberstein, Ralf; Nazir, Zarghun; Skranc, Wolfgang; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Gerardus Karel Maria published a patent.Synthetic Route of 65645-88-7 The title of the patent was Process for preparation of (S)-6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-1,2,3,4-tetrahydro-1H-isoquinoline acetate via asymmetric hydrogenation. And the patent contained the following:

(S)-6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-1,2,3,4-tetrahydro-1H-isoquinoline acetate was prepared via asym. hydrogenation of 6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydro-1H-isoquinoline in the presence of bis(chloro-1,5-cyclooctadieneiridium), (S)-1-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]ferrocene, iodine, and a solvent under 1-200 bar H2. The above reaction was carried out at 5 bar H2 and 30° in CH2Cl2 with a I2/Ir ratio of 2:1 to give the title product in 95% enantiomeric excess with 100% conversion. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Synthetic Route of 65645-88-7

The Article related to phenethyldihydroisoquinoline asym hydrogenation iridium phosphinoferrocene catalyst, methoxytrifluoromethylphenylethyltetrahydroisoquinoline acetate chiral preparation, almorexant hydrochloride preparation and other aspects.Synthetic Route of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 29, 2019, Horner, Anthony R.; Wilson, Rachael E.; Groskreutz, Stephen R.; Murray, Bridget E.; Weber, Stephen G. published an article.COA of Formula: C10H11NO3 The title of the article was Evaluation of three temperature- and mobile phase-dependent retention models for reversed-phase liquid chromatographic retention and apparent retention enthalpy. And the article contained the following:

Predicting retention and enthalpy allows for the simulation and optimization of advanced chromatog. techniques including gradient separations, temperature-assisted solute focusing, multidimensional liquid chromatog., and solvent focusing. In this paper we explore the fits of three expressions for retention as a function of mobile phase composition and temperature to retention data of 101 small mols. in reversed phase liquid chromatog. The three retention equations investigated are those by Neue and Kuss (NK) and two different equations by Pappa-Louisi et al., one based on a partition model (PL-P) and one based on an adsorption model (PL-A). More than 25,000 retention factors were determined for 101 small mols. under various mobile phase and temperature conditions. The pure exptl. uncertainty is very small, approx. 0.22% uncertainty in retention factors measured on the same day (2.1% when performed on different days). Each of the three equations for ln(k) was fit to the exptl. data based on a least-squares approach and the results were analyzed using lack-of-fit residuals. The PL-A model, while complex, gives the best overall fits. In addition to examining the equations’ adequacy for retention, we also examined their use for apparent retention enthalpy. This enthalpy can be predicted by taking the derivative of these expressions with respect to the inverse of absolute temperature The numerical values of the fitted parameters based on retention data can then be used to predict retention enthalpy. These enthalpy predictions were compared to those obtained from a modified van ‘t Hoff equation that included a quadratic term in inverse temperature Based on anal. of 1 211 van ‘t Hoff plots (solute-mobile phase-day combinations), ninety-eight percent showed a significantly better fit when using the modified van ‘t Hoff expression, justifying its use to provide apparent enthalpies as a function of mobile phase composition and temperature The foregoing apparent enthalpies were compared to the apparent enthalpies predicted by the three models. The PL-A model, which contains a temperature dependent enthalpy, provided the best enthalpy prediction. However, there is virtually no correlation between the overall lack of fit to exptl. ln(k) for each model and the corresponding lack of fit of the linear (in 1/T) van ‘t Hoff expression. Thus, the temperature-dependent enthalpy is apparently not the cause of a model’s ability to fit ln(k) as a function of mobile phase composition and temperature The value in these expressions is their ability to predict chromatograms, allowing for optimization of an advanced chromatog. technique. The two simpler models NK and PL-P, which do not contain a temperature dependent enthalpy, have their merits in modeling retention (NK being the better of the two) and enthalpy (PL-P being the better of the two) if a simpler expression is required for a given application. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).COA of Formula: C10H11NO3

The Article related to reversed phase liquid chromatog retention model enthalpy, chromatographic simulation, liquid chromatography, mobile phase composition dependence, retention enthalpy, retention models, temperature dependence and other aspects.COA of Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2016, Huang, Zhenhua; Zhang, Qian; Yan, Lianzhong; Zhong, Guizhen; Zhang, Linqi; Tan, Xiaojuan; Wang, Yanli published an article.Electric Literature of 16230-24-3 The title of the article was Approaching the active conformation of 1,3-diaminopyrimidine based covalent inhibitors of Bruton’s tyrosine kinase for treatment of Rheumatoid arthritis. And the article contained the following:

By applying conformational restrictions, the authors were able to discover highly potent 1,3-diaminopyrimidine based covalent inhibitors of BTK, such as (I) (IC50 = 3.76 nM), and providing useful information of its active conformation. The authors are developing these novel small mol. covalent inhibitors of BTK toward oral agents for Rheumatoid arthritis. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Electric Literature of 16230-24-3

The Article related to diaminopyrimidine preparation conformation bruton tyrosine kinase inhibitor antirheumatic, 1,3-diamino-pyrimidine, bruton’s tyrosine kinase (btk), collagen-induced arthritis (cia), rheumatoid arthritis (ra) and other aspects.Electric Literature of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 25, 2021, Rimnacova, Lucie; Moos, Martin; Opekar, Stanislav; Vodrazka, Petr; Pejchal, Vladimir; Mraz, Jaroslav; Simek, Petr published an article.Computed Properties of 27115-50-0 The title of the article was Ethyl chloroformate mediated gas chromatographic-mass spectrometric biomonitoring of acidic biomarkers of occupational exposure and endogenous metabolites in human urine. And the article contained the following:

Numerous industrial organic pollutants such as aromates, alkoxyalcs., other organic solvents and monomers are absorbed, metabolized, and finally excreted in urine mostly as carboxylic acids that are determined as biomarkers of exposure. For a number of these xenometabolites, biol. limits (levels of biomarkers in biol. material) have been established to prevent damage to human health. Till now, most of the anal. procedures used have been optimized for one or a few analytes. Here, we report a more comprehensive approach enabling rapid GC-MS screening of sixteen acidic biomarkers in urine that are metabolized in the human body from several important industrial chems.; benzene, toluene, styrene, xylenes, alkoxyalcs., carbon disulfide, furfural and N,N-dimethylformamide. The new method involves immediate in situ derivatization – liquid liquid microextraction of urine by an Et chloroformate-ethanol-chloroform-pyridine medium and GC-MS anal. of the derivatized analytes in the lower organic phase. The xenometabolite set represents diverse chem. structures and some of hippuric and mercapturic acids also provided unusual derivatives that were unambiguously elucidated by means of new Et chloroformates labeled with stable isotopes and by synthesis of the missing reference standards In the next step, an automated routine was developed for GC-MS/MS anal. using a MetaboAuto sample preparation workstation and the new method was validated for fourteen metabolites over the relevant concentration range of each analyte in the spiked pooled human urine. It shows good linearity (R2 ≥ 0.982), accuracy (from 85% to 120%), precision (from 0.7% to 20%) and recovery (from 89% to 120%). The method performance was further successfully proved by GC-MS/MS anal. of the certified IP45 and RM6009 reference urines. Moreover, we show that the new method opens up the possibility for biomonitoring of combined and cumulative occupational exposures as well as for urinary metabolite profiling of persons exposed to harmful industrial chems. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Computed Properties of 27115-50-0

The Article related to ethyl chloroformate gcms occupational exposure acidic biomarker metabolite urine, biomarker of occupational exposure, endogenous metabolites, ethyl chloroformate mediated derivatization, urine, xenometabolite and other aspects.Computed Properties of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dobashi, Yasuo; Dobashi, Akira; Hara, Shoji published an article in 1984, the title of the article was Chiral recognition conducted by tartaric acid derivatives in nonaqueous media.SDS of cas: 65645-88-7 And the article contains the following content:

Chiral recognition of hydroxycarboxylic acids, amino acids and 1,2-diols using diastereomeric complexation based on H bonding with L-(+)-N,N’-diisopropyltartramide is described (liquid-solid chromatog.). The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).SDS of cas: 65645-88-7

The Article related to chiral recognition tartramide, tartaric acid chiral recognition, chromatog tartaric chirality, hydrogen bond tartramide, hydroxycarboxylase enantiomerism chromatog, amino acid enantiomerism, diol enantiomerism and other aspects.SDS of cas: 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 3, 2018, Lamie, Phoebe F.; Philoppes, John N.; Rarova, Lucie published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Design, synthesis, and biological evaluation of novel 1,2-diaryl-4-substituted-benzylidene-5(4H)-imidazolone derivatives as cytotoxic agents and COX-2/LOX inhibitors. And the article contained the following:

A new series of 1,2-diaryl-4-substituted-benzylidene-5(4H)-imidazolone derivatives I (R = H, Me; R1 = H, OMe, Cl; X = O, S) was synthesized. Their cytotoxic activities in vitro were evaluated against breast, ovarian, and liver cancer cell lines and also against normal human skin fibroblasts. Cyclooxygenase (COX)-1, COX-2 and lipoxygenase (LOX) inhibitory activities were measured. The synthesized compounds showed selectivity toward COX-2 rather than COX-1, and the IC50 values (0.25-1.7 μM) were lower than that of indomethacin (IC50 = 9.47 μM) and somewhat higher than that of celecoxib (IC50 = 0.071 μM). The selectivity index for COX-2 of the oxazole derivative I (R = Me; R1 = OMe; X = O) (SI = 3.67) was nearly equal to that of celecoxib (SI = 3.66). For the LOX inhibitory activity, the new compounds showed IC50 values of 0.02-74.03 μM, while the IC50 of the reference zileuton was 0.83 μM. The most active compound I (R = H; R1 = Cl; X = O) was found to have dual COX-2/LOX activity. All the synthesized compounds were docked inside the active site of the COX-2 and LOX enzymes. They linked to COX-2 through the N atom of the azole scaffold, while C=O of the oxazolone moiety was responsible for the binding to amino acids inside the LOX active site. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to benzylidene imidazolone preparation antiinflammatory antitumor mol docking human, cyclooxygenase lipoxygenase inhibitor, anti-inflammatory, cytotoxicity, diaryl imidazolone derivatives, molecular docking study and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 1, 2020, Qian, Yunkun; Hu, Yue; Chen, Yanan; An, Dong; Westerhoff, Paul; Hanigan, David; Chu, Wenhai published an article.SDS of cas: 79-07-2 The title of the article was Haloacetonitriles and haloacetamides precursors in filter backwash and sedimentation sludge water during drinking water treatment. And the article contained the following:

Haloacetonitriles (HANs) and haloacetamides (HAMs) are nitrogenous disinfection byproducts that are present in filter backwash water (FBW) and sedimentation sludge water (SSW). In many cases FBW and SSW are recycled to the head of drinking water treatment plants. HAN and HAM concentrations in FBW and SSW, without addnl. oxidants, ranged from 6.8 to 11.6 nM and 2.9 to 3.6 nM of three HANs and four HAMs, resp. Upon oxidant addition to FBW and SSW under formation potential conditions, concentrations for six HANs and six HAMs ranged from 92.2 to 190.4 nM and 42.2 to 95.5 nM, resp. Therefore, at common FBW and SSW recycle rates (2 to 10% of treated water flows), the precursor levels in these recycle waters should not be ignored because they are comparable to levels present in finished water. Brominated HAN and chlorinated HAM were the dominant species in FBW and SSW, resp. The lowest mol. weight ultrafiltration fraction (< 3 kDa) contributed the most to HAN and HAM formations. The hydrophilic (HPI) organic fraction contributed the greatest to HAN precursors in sand-FBW and SSW and were the most reactive HAM precursors in both sand- or carbon-FBWs. Fluorescence revealed that aromatic protein-like compounds were dominant HAN and HAM precursors. Therefore, strategies that remove low mol. weight hydrophilic organic matter and aromatic protein-like compounds will minimize HAN and HAM formations in recycled FBW and SSW. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).SDS of cas: 79-07-2

The Article related to haloacetonitrile haloacetamide filter backwash sedimentation sludge water, drinking water treatment, filter backwash water, haloacetamides, disinfection byproducts, haloacetonitriles, sedimentation sludge water and other aspects.SDS of cas: 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics