Author: Jessica.F

《A highly selective chemical probe for activin receptor-like kinases ALK4 and ALK5》 was written by Hanke, Thomas; Wong, Jong Fu; Berger, Benedict-Tilman; Abdi, Ismahan; Berger, Lena Marie; Tesch, Roberta; Tredup, Claudia; Bullock, Alex N.; Mueller, Susanne; Knapp, Stefan. COA of Formula: C2H4BrNO And the article was included in ACS Chemical Biology in 2020. The article conveys some information:

The transforming growth factor beta-receptor I/activin receptor-like kinase 5 (TGFBR1/ALK5) and its close homolog ALK4 are receptor protein kinases associated with the development of diverse diseases, including cancer, fibrosis, heart diseases, and dysfunctional immune response. Therefore, ALK4/5 are among the most studied kinases, and several inhibitors have been developed. However, current com. available inhibitors either lack selectivity or have not been comprehensively characterized, limiting their value for studying ALK4/5 function in cellular systems. To this end, we report the characterization of the 2-oxo-imidazopyridine, TP-008, a potent chem. probe with dual activity for ALK4 and ALK5 as well as the development of a matching neg. control compound TP-008 has excellent cellular potency and strongly abrogates phosphorylation of the substrate SMAD2 (mothers against decapentaplegic homolog 2). Thus, this chem. probe offers an excellent tool for mechanistic studies on the ALK4/5 signaling pathway and the contribution of these targets to disease. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8COA of Formula: C2H4BrNO)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.COA of Formula: C2H4BrNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Maloney, T. Parker; Dohoda, Alexander F.; Zhu, Alec C.; Michael, Forrest E. published an article in 2022. The article was titled 《Stereoretentive and regioselective selenium-catalyzed intermolecular propargylic C-H amination of alkynes》, and you may find the article in Chemical Science.Formula: C7H9NO2S The information in the text is summarized as follows:

Herein, an intermol. propargylic C-H amination of alkynes was reported. This reaction was operationally convenient and required no transition metal catalysts or additives. Terminal, silyl, and internal alkynes bearing a wide range of functional groups can be aminated in high yields. The regioselectivity of amination for unsym. internal alkynes was strongly influenced by substitution pattern (tertiary > secondary > primary) and by relatively remote heteroat. substituents. The amination of alkynes bearing α-stereocenters occurring with retention of configuration at the newly-formed C-N bond was demonstrated. Competition experiments between alkynes, kinetic isotope effects, and DFT calculations were performed to confirm the mechanistic hypothesis that initial ene reaction of a selenium bis(imide) species is the rate- and product-determining step. This ene reaction has a transition state that results in substantial partial pos. charge development at the carbon atom closer to the amination position. Inductive and/or hyperconjugative stabilization or destabilization of this pos. charge explains the observed regioselectivities. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 78191-00-1In 2016 ,《Conformationally Driven Two- and Three-Photon Cascade Processes in the Stereoselective Photorearrangement of Pyrroles》 appeared in Organic Letters. The author of the article were Koovits, Paul J.; Knowles, Jonathan P.; Booker-Milburn, Kevin I.. The article conveys some information:

A TBSO group has been shown to exert a high degree of stereocontrol during the two-photon photocycloaddition/rearrangement of N-butenylpyrroles to complex tricyclic aziridines. Moreover, this and other bulky groups have been shown to change the outcome of the reaction, promoting a new two-photon sequence to tricyclic imines and an unprecedented stereoselective three-photon sequence to azabicyclo[3.3.1]nonanes. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Related Products of 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Computed Properties of C2H4BrNOIn 2022 ,《Reactivity characterization of SiO2-coated nano zero-valent iron for iodoacetamide degradation: The effects of SiO2 thickness, and the roles of dehalogenation, hydrolysis and adsorption》 was published in Chemosphere. The article was written by Ratanaphain, Chatkrita; Viboonratanasri, Duangkamon; Prompinit, Panida; Krajangpan, Sita; Khan, Eakalak; Punyapalakul, Patiparn. The article contains the following contents:

The effect of SiO2-layer thickness in SiO2-coated nano zero-valent iron (nZVI) particles on the reactivity characteristics of iodoacetamide (IAcAm) degradation was evaluated. SiO2-layer thicknesses ranging from 3.6 to 27.3 nm were obtained through varying tetra-Et orthosilicate dosages of 0.001-1 M. The crystallinity, surface chem. composition, and physicochem. properties were evaluated for their effects on synergetic degradation mechanisms, dehalogenation, hydrolysis, and adsorption. At a thickness of 3.6 nm, the SiO2 layer offered the highest observed pseudo-first-order rate (kobs) and higher rates of IAcAm degradation were maintained under pH fluctuations (pH 5-7) and aerobic conditions compared to pristine nZVI. At this SiO2-layer thickness (3.6 nm), the rate of iron oxide-layer formation was reduced and the migration of reactive iron species (Fe0 and Fe2+) for the dehalogenation and hydrolysis reactions was enabled. In a single-solute solution, IAcAm elimination was greater than bromoacetamide and chloroacetamide elimination due to the weak ionic I-C bond. In mixed solute conditions, the hydrophobicity of chloroacetamide played a more significant role in competitive degradation through greater adsorption. The proportion of dehalogenation relative to hydrolysis during IAcAm degradation by pristine nZVI and SiO2-coated nZVI was approx. 0.6:0.4. Iodoacetic acid and acetic acid were detected as intermediates in the degradation pathway of IAcAm by pristine nZVI. In contrast, the SiO2 layer on nZVI can accelerate the transformation of IAcAm to acetamide and iodoacetic acid. The electrolyte background of tap water exhibited a slight inhibitory effect on the degradation of IAcAm for both nZVI and SiO2-coated nZVI. The results came from multiple reactions, including the reaction of 2-Bromoacetamide(cas: 683-57-8Computed Properties of C2H4BrNO)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Computed Properties of C2H4BrNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Expanding Zirconocene Hydride Catalysis: In Situ Generation and Turnover of ZrH Catalysts Enabling Catalytic Carbonyl Reductions》 was written by Kehner, Rebecca A.; Hewitt, Matthew Christian; Bayeh-Romero, Liela. Electric Literature of C4H9NO2This research focused onzirconium hydride in situ preparation zirconocene dichloride hydrosilane; ketone aldehyde enone ynone lactone reduction zirconium hydride catalyst. The article conveys some information:

Despite the wide use and popularity of metal hydride catalysis, methods utilizing zirconium hydride catalysts remain underexplored. Here, authors report the development of a mild method for the in situ prepatation. and use of zirconium hydride catalysts. This robust method requires only 2.5-5 mol % of zirconocene dichloride in combination with a hydrosilane as the stoichiometric reductant and does not necessitate careful air- or moisture-free technique. A key finding of this study concerns an amine-mediated ligand exchange en route to the active zirconocene hydride catalyst. Mechanistic investigation supports the intermediacy of an oxo-bridged dimer precatalyst. The application of this method to the reduction of a wide variety of carbonyl-containing substrates, including ketones, aldehydes, enones, ynones, and lactones is demonstrated with up to 92% yield and exhibiting broad functional group tolerability. These findings open up alternative avenues for the catalytic application of chlorozirconocenes, potentially serving as the foundation for broader applications of zirconium hydride catalysis. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Electric Literature of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Electric Literature of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Synthesis of 3-hydroxy-1,3-dihydro-2H-pyrrolo[2,3-b]-, -[2,3-c]-, or -[3,2-c]pyridin-2-ones from the respective N-pyridinylpivalamides and α-keto esters》 was published in Heterocycles in 2016. These research results belong to Kobayashi, Kazuhiro; Kosuna, Risa; Chikazawa, Yuuki. HPLC of Formula: 70298-88-3 The article mentions the following:

A convenient synthesis of the dihydro pyrrolopyridinones, e.g., I by reaction of N-(pyridinyl)pivalamides with α-keto esters via in situ generated dilithium compounds is described. Thus, N-(3-lithiopyridin-2-yl)pivalamide reacts smoothly leading to the formation of the corresponding α-hydroxy esters. These α-hydroxy esters underwent deprotective cyclization in refluxing hydrochloric acid to afford 3-substituted 3-hydroxy-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-ones. Similarly, starting from N-(pyridin-3- or -4-yl)pivalamides, the corresponding 3-dihydro-2H-pyrrolo[2,3- c]- or -[3,2-c]pyridin-2-one derivatives can be prepd resp. After reading the article, we found that the author used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3HPLC of Formula: 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).HPLC of Formula: 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of H-Lys(Boc)-OHOn May 17, 2019 ,《Construction of bacterial cells with an active transport system for unnatural amino acids》 appeared in ACS Synthetic Biology. The author of the article were Ko, Wooseok; Kumar, Rahul; Kim, Sanggil; Lee, Hyun Soo. The article conveys some information:

Engineered organisms with an expanded genetic code have attracted much attention in chem. and synthetic biol. research. In this work, engineered bacterial organisms with enhanced unnatural amino acid (UAA) uptake abilities were developed by screening periplasmic binding protein (PBP) mutants for recognition of UAAs. A FRET-based assay was used to identify a mutant PBP (LBP-AEL) with excellent binding affinity (Kd ≈ 500 nM) to multiple UAAs from 37 mutants. Bacterial cells expressing LBP-AEL showed up to 5-fold enhanced uptake of UAAs, which was determined by genetic incorporation of UAAs into a green fluorescent protein and measuring UAA concentration in cell lysates. To the best of our knowledge, this work is the first report of engineering cellular uptake of UAAs and could provide an impetus for designing advanced unnatural organisms with an expanded genetic code, which function with the efficiency comparable to that of natural organisms. The system would be useful to increase mutant protein yield from lower concentrations of UAAs for industrial and large-scale applications. In addition, the techniques used in this report such as the sensor design and the measurement of UAA concentration in cell lysates could be useful for other biochem. applications. In the experimental materials used by the author, we found H-Lys(Boc)-OH(cas: 2418-95-3Reference of H-Lys(Boc)-OH)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. Amino acids are not generally considered to be electrochemically active because products of the oxidation accumulate on the electrode surface and prevent it from participating in any further electrochemical processes.Reference of H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 1986,Tetrahedron Letters included an article by Shin, Jai Moo; Kim, Yong Hae. Computed Properties of C8H9NO2. The article was titled 《New facile synthesis of α-hydroxy amides: intermolecular and intramolecular catalysis in the reaction of α-hydroxy carboxylic acids with N-sulfinylamines》. The information in the text is summarized as follows:

α-Hydroxy carboxylic acids reacted with N-sulfinylanilines to give the corresponding α-hydroxy anilides in quant. yields under mild condition. The reaction appeared to involve intermol. catalysts by the carboxylic acid moiety and intramol. catalysis by the HO group. Thus, DL-mandelic acid in MeCN treated with PhN:S:O gave 100% DL-mandelanilide.2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Computed Properties of C8H9NO2) was used in this study.

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.Computed Properties of C8H9NO2 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ogawa, Hidetoshi; Iwasaki, Arihiro; Sumimoto, Shimpei; Iwatsuki, Masato; Ishiyama, Aki; Hokari, Rei; Otoguro, Kazuhiko; Omura, Satoshi; Suenaga, Kiyotake published an article on February 17 ,2017. The article was titled 《Isolation and Total Synthesis of Hoshinolactam, an Antitrypanosomal Lactam from a Marine Cyanobacterium》, and you may find the article in Organic Letters.Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide The information in the text is summarized as follows:

In the search for new antiprotozoal substances, hoshinolactam, an antitrypanosomal lactam, was isolated from a marine cyanobacterium. The gross structure was elucidated by spectroscopic analyses, and the absolute configuration was determined by the first total synthesis. Hoshinolactam showed potent antitrypanosomal activity with an IC50 value of 3.9 nM without cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50 >25 μM). The results came from multiple reactions, including the reaction of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Castro, Goretti; Wang, Gaoji; Gambino, Tanja; Esteban-Gomez, David; Valencia, Laura; Angelovski, Goran; Platas-Iglesias, Carlos; Perez-Lourido, Paulo published an article in 2021. The article was titled 《Lanthanide(III) Complexes Based on an 18-Membered Macrocycle Containing Acetamide Pendants. Structural Characterization and paraCEST Properties》, and you may find the article in Inorganic Chemistry.HPLC of Formula: 683-57-8 The information in the text is summarized as follows:

We report a detailed investigation of the coordination properties of macrocyclic lanthanide complexes containing a 3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane scaffold functionalized with four acetamide pendant arms. The X-ray structures of the complexes with the large Ln3+ ions (La and Sm) display 12- and 10-coordinated metal ions, where the coordination sphere is fulfilled by the six N atoms of the macrocycle, the four O atoms of the acetamide pendants, and a bidentate nitrate anion in the La3+ complex. The analogous Yb3+ complex presents, however, a 9-coordinated metal ion because one of the acetamide pendant arms remains uncoordinated. 1H NMR studies indicate that the 10-coordinated form is present in solution throughout the lanthanide series from La to Tb, while the smaller lanthanides form 9-coordinated species. 1H and 89Y NMR studies confirm the presence of this structural change because the two species are present in solution Anal. of the 1H chem. shifts observed for the Tb3+ complex confirms its D2 symmetry in aqueous solution and evidences a highly rhombic magnetic susceptibility tensor. The acetamide resonances of the Pr3+ and Tb3+ complexes provided sizable paraCEST effects, as demonstrated by the corresponding Z-spectra recorded at different temperatures and studies on tube phantoms recorded at 22°C. A 10-coordinated Tb3+ complex shows remarkably a chem. exchange saturation transfer response with a temperature-sensitive chem. shift. In the experimental materials used by the author, we found 2-Bromoacetamide(cas: 683-57-8HPLC of Formula: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.HPLC of Formula: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics