Author: Jessica.F

《Surface-Active Ionic-Liquid-Encapsulated Polyoxometalate Nanospheres: Construction, Self-Assembly, Adsorption Behavior, and Application for Dye Removal》 was written by Qi, Lubin; Gong, Yanjun; Fang, Ming; Jia, Zhiwei; Cheng, Ni; Yu, Li. Quality Control of 2-Bromoacetamide And the article was included in ACS Applied Nano Materials in 2020. The article conveys some information:

Preparation of materials which efficiently adsorb environmental pollutants, e.g., non-biodegradable dyes, is urgently demanded. Preparation, characterization, and use of surface-active, ionic liquid-encapsulated polyoxometalates (SAILEP) are reported. These ordered structured hybrid materials were prepared in the aqueous phase by one-pot self-assembly at room temperature They demonstrated a high capacity for rapid cationic dye adsorption. Rhodamine B (RhB) adsorption equilibrium time was only 1 min. These SAILEP materials can also selectively sep. RhB from an eosin Y/RhB mixture Fast, selective adsorption was attributed to electrostatic interactions and high affinity between SAILEP and RhB. An assessment of adsorption isotherms and kinetics indicated dye adsorption followed Langmuir isotherm models and pseudo-second-order kinetics. Self-assembly was assessed by small-angle x-ray scattering, Fourier transform IR, and dynamic light scattering. Results provide addnl. insight on SAILEP hybrid materials, which have great potential for dye decontamination. In the experiment, the researchers used 2-Bromoacetamide(cas: 683-57-8Quality Control of 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Quality Control of 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《An in-line capillary electrophoresis assay for the high-throughput screening of histone deacetylase inhibitors》 was written by Li, Yue; Fang, Hao; Hou, Zhun; Sang, Lihong; Yang, Xinying. Recommanded Product: H-Lys(Boc)-OH And the article was included in Journal of Chromatography A on April 26 ,2019. The article conveys some information:

Histone deacetylases (HDACs) are important enzymes that cause chromatin structure contraction and transcription repression, which can downregulate some cancer-suppression genes and lead to the occurrence of cancer. HDAC-specific inhibition is an effective approach to cancer therapy. Hence, a method with which to investigate HDAC activity is needed. We developed an in-line capillary electrophoresis method based on electrophoretically mediated microanal. The optimized conditions were thoroughly validated, and the method was applied to determine the enzyme’s kinetic parameters and the inhibition characteristics of three potent probe inhibitors. The obtained values were comparable to the literature data. Hence, the presented method, with its advantages of miniaturization and full automation, could be used for kinetic and inhibition studies of HDACs, which are targets for drug discovery, in the early stages of new drug development. In the experiment, the researchers used many compounds, for example, H-Lys(Boc)-OH(cas: 2418-95-3Recommanded Product: H-Lys(Boc)-OH)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. Amino acids are not generally considered to be electrochemically active because products of the oxidation accumulate on the electrode surface and prevent it from participating in any further electrochemical processes.Recommanded Product: H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Facile synthesis of 2(1H)-pyrazinone derivatives from dipeptides》 was published in Peptide Chemistry in 1995. These research results belong to Taguchi, Hiroaki; Yokoi, Toshio; Okada, Yoshio. Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide The article mentions the following:

A facile and racemization-free synthetic procedure for the preparation of title compounds, e.g. I, from dipeptidyl aldehydes Me3CO2CNHCHR2CONHCHR1CHO is given. The application of this method to the synthesis of naturally occurring products, such as deoxyaspergillic acid [I; R1 = (R)-CHMeEt, R2 = CH2CHMe2], flavacol (I; R1 = R2 = CH2CHMe2), and deoxymutaaspergilic acid (I; R1 = CHMe2, R2 = CH2CHMe2) is demonstrated. In the part of experimental materials, we found many familiar compounds, such as (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamideAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Safety of H-Lys(Boc)-OHOn September 30, 2021 ,《Label-retention expansion microscopy》 was published in Journal of Cell Biology. The article was written by Shi, Xiaoyu; Li, Qi; Dai, Zhipeng; Tran, Arthur A.; Feng, Siyu; Ramirez, Alejandro D.; Lin, Zixi; Wang, Xiaomeng; Chow, Tracy T.; Chen, Jiapei; Kumar, Dhivya; McColloch, Andrew R.; Reiter, Jeremy F.; Huang, Eric J.; Seiple, Ian B.; Huang, Bo. The article contains the following contents:

Expansion microscopy (ExM) increases the effective resolving power of any microscope by expanding the sample with swellable hydrogel. Since its invention, ExM has been successfully applied to a wide range of cell, tissue, and animal samples. Still, fluorescence signal loss during polymerization and digestion limits mol.-scale imaging using ExM. Here, we report the development of label-retention ExM (LR-ExM) with a set of trifunctional anchors that not only prevent signal loss but also enable high-efficiency labeling using SNAP and CLIP tags. We have demonstrated multicolor LR-ExM for a variety of subcellular structures. Combining LR-ExM with superresoln. stochastic optical reconstruction microscopy (STORM), we have achieved mol. resolution in the visualization of polyhedral lattice of clathrin-coated pits in situ. In addition to this study using H-Lys(Boc)-OH, there are many other studies that have used H-Lys(Boc)-OH(cas: 2418-95-3Safety of H-Lys(Boc)-OH) was used in this study.

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. These amino acids may be present in low concentrations and play a vital part as an intermediate in a biosynthetic pathway, e.g., ornithine, homoserine, or cystathionine. In contrast they may act as a major storage form of nitrogen, e.g., canavanine in the seed of Canavalia ensiformis, or may be formed in high amounts in response to an external stress, e.g., γ-aminobutyrate.Safety of H-Lys(Boc)-OH It is possible that some of these nonprotein amino acids may serve as insecticidal or fungicidal agents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of N-(Pyridin-4-yl)isonicotinamideOn September 30, 1999 ,《New coordination networks constructed from N-(4-pyridyl)isonicotinamide》 was published in Crystal Engineering. The article was written by Kondo, Mitsuru; Asami, Akiko; Chang, Ho-Chol; Kitagawa, Susumu. The article contains the following contents:

New coordination polymers of N-(4-pyridyl)isonicotinamide (pia) were prepared and crystallog. characterized. Compound 1, [Cd(pia)(NCS)2]n, provides a rectangular, two-dimensional network, which is constructed by a single bridging of the pia ligand and double bridging of the NCS ligands. Compound 2, [Cu(pzdc)(pia)2]n (pzdc = pyrazine-2,3-dicarboxylate), forms a fishbone-type, 1-dimensional network, which is comprised of -(Cu-pzdc)- chains with pia ligands. The imino-pyridine donor of the pia binds to the chains, in which the other remains free. The π-π and hydrogen bonding interactions between the pia ligands in the adjacent chains provide a three-dimensional structure. In the part of experimental materials, we found many familiar compounds, such as N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Quality Control of N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Quality Control of N-(Pyridin-4-yl)isonicotinamideAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of N-(Pyridin-4-yl)isonicotinamideOn September 2, 2014 ,《Targeted Structure Modulation of “”Pillar-Layered”” Metal-Organic Frameworks for CO2 Capture》 was published in Inorganic Chemistry. The article was written by Xuan, Zhi-Hong; Zhang, Da-Shuai; Chang, Ze; Hu, Tong-Liang; Bu, Xian-He. The article contains the following contents:

Two new zinc MOFs with similar “”pillar-layered”” framework structures based on 1,1′-biphenyl-2,2′,6,6′-tetracarboxylic acid (H4bpta) and two different bipyridine pillar ligands, namely {[Zn4(bpta)2(4-pna)2(H2O)2]·4DMF·3H2O}n (1) and {[Zn2(bpta)(bpy-ea)(H2O)]·2DMF·H2O}n (2) (4-pna = N-(4-pyridyl)isonicotinamide and bpy-ea = 1,2-bis(4-pyridyl)ethane), were synthesized and studied with their CO2 adsorption properties. By anal. of the structure properties and the CO2 adsorption performances of these two MOFs, the introduction of polar acylamide groups via 4-pna resulted in 1 with enhanced CO2 capacity and CO2/CH4 selectivity at low pressure. In contrast, the framework of 2 shows flexible properties originating from the flexibility of the ethanediylidene group in the bpy-ea ligand, which benefits the sieve effect of pores to give higher CO2/CH4 selectivity at a relatively high pressure range. The results came from multiple reactions, including the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Computed Properties of C13H26N2O4On September 30, 2009 ,《Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals》 was published in ACS Chemical Biology. The article was written by Chen, Dianjun; Brahimi, Fouad; Angell, Yu; Li, Yu-Chin; Moscowicz, Jennifer; Saragovi, H. Uri; Burgess, Kevin. The article contains the following contents:

This study was initiated to find small mol. ligands that would induce a functional response when docked with neurotrophin Trk receptors. “”Minimalist”” mimics of β-turns were designed for this purpose. These mimics are (i) rigid, yet easily folded into turn-like conformations, and (ii) readily accessible from amino acids bearing most of the natural side chains. Gram quantities of 16 of these turn mimics were prepared and then assembled into 152 fluorescein-labeled bivalent peptidomimetics via a solution-phase combinatorial method. Fluorescence-based screening of these mols. using cells transfected with the Trk receptors identified 10 potential ligands of TrkC, the receptor for neurotrophin-3. Analogs of these bivalent peptidomimetics with biotin replacing the fluorescein label were then prepared and tested to confirm that binding was not due to the fluorescein. Several assays were conducted to find the mode of action of these biotinylated compounds Thus, direct binding, survival and neuritogenic, and biochem. signal transduction assays showed 8 of the original 10 hits were agonistic ligands binding to the ectodomain of TrkC. Remarkably, some peptidomimetics afford discrete signals leading to either cell survival or neuritogenic differentiation. The significance of this work is three-fold. First, we succeeded in finding small, selective, proteolytically stable ligands for the TrkC receptor; there are very few of these in the literature. Second, we show that it is possible to activate distinct and biased signaling pathways with ligands binding at the ectodomain of wild-type receptors. Third, the discovery that some peptidomimetics initiate different modes of cell signaling increases their potential as pharmacol. probes and therapeutic leads. The experimental process involved the reaction of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Computed Properties of C13H26N2O4)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Computed Properties of C13H26N2O4 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tunoori, Ashok Rao; White, Jonathan M.; Georg, Gunda I. published their research in Organic Letters on December 14 ,2000. The article was titled 《A One-Flask Synthesis of Weinreb Amides from Chiral and Achiral Carboxylic Acids Using the Deoxo-Fluor Fluorinating Reagent》.COA of Formula: C13H26N2O4 The article contains the following contents:

The reagent [bis(2-methoxyethyl)amino]sulfur trifluoride (Deoxo-Fluor reagent) converts carboxylic acids to the corresponding acid fluorides, which then react with N,O-dimethylhydroxylamine to give the corresponding Weinreb amides in high yields. The reaction proceeds without racemization when optically active acids are used as the starting material. This method is operationally simple and provides the products in high purity. Thus, N,N-diisopropylethylamine was added to a suspension of N,O-dimethylhydroxylamine hydrochloride in dichloromethane to give the free base N,O-dimethylhydroxylamine. Treatment of trans-crotonic acid with Deoxo-Fluor reagent resulted in the formation of the intermediate acid fluoride, which upon addition of N,O-dimethylhydroxylamine gave the desired N-methoxy-N-Me-trans-crotonamide [(2E)-N-methoxy-N-methyl-2-butenamide]. Similar treatment of N-BOC-L-alanine gave (-)-(S)-2-[(tert-butoxycarbonyl)amino]-N-methoxy-N-methylpropanamide. The experimental part of the paper was very detailed, including the reaction process of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6COA of Formula: C13H26N2O4)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.COA of Formula: C13H26N2O4Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2010,Vanek, V.; Picha, J.; Budesinsky, M.; Sanda, M.; Jiracek, J.; Holz, R. C.; Hlavacek, J. published 《Synthesis of N-succinyl-L,L-diaminopimelic acid mimetics via selective protection》.Protein & Peptide Letters published the findings.Computed Properties of C11H24N2O The information in the text is summarized as follows:

The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodol. for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing different carboxyl groups or lipophilic moieties on their amino group. In addition to this study using tert-Butyl N,N’-diisopropylcarbamimidate, there are many other studies that have used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Computed Properties of C11H24N2O) was used in this study.

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Computed Properties of C11H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Eshtiyaghi, Mahbobeh; Deldar, Hamid; Pirsaraei, Zarbakht Ansari; Shohreh, Bahram published 《Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro and embryonic development following in vitro fertilization》.Theriogenology published the findings.Synthetic Route of C4H9NO2 The information in the text is summarized as follows:

The aim of this study was to investigate the effect of different concentrations of royal jelly (RJ) on in vitro maturation (IVM), fertilization, cleavage, blastocyst rates, glutathione (GSH) content in ovine oocyte, mRNA abundance of antioxidant enzymes in both oocyte and cumulus, and glucose metabolism-related genes in cumulus cells. In vitro maturation of oocyte was performed in the presence of control (RJ0), 2.5 (RJ2.5), 5 (RJ5), and 10 (RJ10) mg/mL of RJ. Nuclear status, intracellular GSH content in oocytes, and mRNA abundance of selected genes were evaluated following 24 h of IVM. Following the IVM, fertilization and embryo culture were carried out in all the groups and embryonic development was examined The addition of 10-mg/mL RJ to maturation media not only yielded a higher number of oocytes at MII stage but also showed an increased level of intracellular GSH content than did RJ2.5 and control groups. Fertilization, cleavage, and blastocyst rate were higher in the RJ10 treatment group in comparison to the control one. In cumulus cells, the expression of PFKM, PFKL, and G6PDH were increased following the addition of RJ to the maturation media. Supplementation of 10-mg/mL RJ to IVM medium increased the GPx mRNA abundance in both oocyte and cumulus cells and SOD expression in the cumulus cells. The CAT mRNA abundance was not influenced by the addition of RJ to the maturation media in either oocyte or cumulus cells. It seems that the improvement of oocyte maturation and its subsequent development in RJ10 group may be associated with amelioration of redox status in the oocytes and activation of glucose metabolic pathways in their surrounding cumulus cells. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Synthetic Route of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics