Author: Jessica.F

In 2018,Yu, Chang-Bin; Wang, Jie; Zhou, Yong-Gui published 《Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles》.Organic Chemistry Frontiers published the findings.Name: N-Methoxy-N-methylacetamide The information in the text is summarized as follows:

A concise and enantioselective procedure for the synthesis of optically active indolines I [R = Me, n-Bu, Bn, etc.; R1 = H, 2-Me, 2-OMe, 4-OMe, 2,4-di-Me] was developed through intramol. condensation, deprotection and palladium-catalyzed asym. hydrogenation in a one-pot process with up to 96% ee. A strong Bronsted acid played an important role in both the formation of indoles and asym. hydrogenation process. This strategy could be scaled-up with excellent reactivity and enantioselectivity. The results came from multiple reactions, including the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Name: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Name: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Engaging Sulfonamides: Intramolecular Cross-Electrophile Coupling Reaction of Sulfonamides with Alkyl Chlorides》 was published in Journal of Organic Chemistry in 2020. These research results belong to Lucas, Erika L.; Hewitt, Kirsten A.; Chen, Pan-Pan; Castro, Anthony J.; Hong, Xin; Jarvo, Elizabeth R.. Recommanded Product: 4-Methylbenzenesulfonamide The article mentions the following:

The application of amine derivatives as coupling partners is rare due to the inherent strength of the C-N bond. Herein, the first cross-electrophile coupling reaction of unstrained benzylic sulfonamides is repoted. Nickel-catalyzed intramol. cross-electrophile coupling reactions of acyclic and cyclic benzylic sulfonamides with pendant alkyl chlorides generate cyclopropane products. Mechanistic experiments and DFT calculations are consistent with initiation of the reaction by magnesium iodide accelerated oxidative addition of the benzylic sulfonamide. This work establishes neutral and unstrained amine derivatives as XEC partners, furnishes structural rearrangement of benzylic sulfonamides, and provides valuable information regarding catalyst design for the development of new cross-electrophile coupling reactions of carbon-heteroatom bonds. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sun, Bin; Tang, Xiaoli; Shi, Rongcheng; Yan, Zhiyang; Li, Bingqian; Tang, Chen; Jin, Can; Wu, Chunlei L.; Shen, Runpu P. published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Self-photocatalyzed Homolytic Dehalogenative Alkylation/Cyclization of Unactivated Alkenes Based on the Quinazolinone Skeleton via Energy Transfer》.Recommanded Product: 2-Bromoacetamide The article contains the following contents:

A mild, external photocatalyst- and additive-free protocol for photo-induced alkylation/cyclization of unactivated alkenes with halides has been developed. This strategy showed excellent regioselectivity and simple operation to synthesize alkyl-substituted quinazolinones with a broad substrate scope. More importantly, chlorinated alkanes were also compatible with this transformation. In the experiment, the researchers used 2-Bromoacetamide(cas: 683-57-8Recommanded Product: 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Recommanded Product: 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chakraborty, Moubani; Haag, Stephanie L.; Bernards, Matthew T.; Waynant, Kristopher V. published an article in 2021. The article was titled 《Synthesis of a zwitterionic N-Ser-Ser-C dimethacrylate cross-linker and evaluation in polyampholyte hydrogels》, and you may find the article in Biomaterials Science.Name: tert-Butyl N,N’-diisopropylcarbamimidate The information in the text is summarized as follows:

Polyampholyte hydrogels are attractive materials for tissue engineering scaffolds as they offer a wide variety of features including nonfouling, selective protein delivery, and tunable phys. characteristics. However, to improve the potential performance of these materials for in vivo applications, there is a need for a higher diversity of zwitterionic cross-linker species to replace commonly used ethylene glycol (EG) based chemistries. Toward this end, the synthesis of a dipeptide based zwitterionic cross-linker, N-Ser-Ser-C dimethacrylate (S-S) from N-Boc-L-serine is presented. The strategy utilized a convergent coupling of methacrylated serine partners followed by careful global deprotection to yield the zwitterionic cross-linker with good overall yields. This novel cross-linker was incorporated into a polyampholyte hydrogel and its phys. properties and biocompatibility were compared against a polyampholyte hydrogel synthesized with an EG-based cross-linker. The S-S cross-linked hydrogel demonstrated excellent nonfouling performance, while promoting enhanced cellular adhesion to fibrinogen delivered from the hydrogel. Therefore, the results suggest that the S-S cross-linker will demonstrate superior future performance for in vivo applications. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Name: tert-Butyl N,N’-diisopropylcarbamimidate)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Name: tert-Butyl N,N’-diisopropylcarbamimidate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Liu, Guodong; Hou, Ruilin; Xu, Lijuan; Zhang, Xinqi; Yan, Jianyu; Xing, Chengguo; Xu, Ke; Zhuang, Chunlin published an article in Journal of Medicinal Chemistry. The title of the article was 《Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides》.Safety of 2-Bromoacetamide The author mentioned the following in the article:

Directly inhibiting the Keap1-Nrf2 protein-protein interaction has been investigated as a promising strategy to activate Nrf2 for anti-inflammation. We previously reported a naphthalensulfonamide Keap1-Nrf2 inhibitor NXPZ-2, but have not determined the exact binding mode with Keap1. This sym. naphthalenesulfonamide compound has relatively low solubility Herein, we first determined a crystal complex (resolution: 2.3 Å) of human Keap1 Kelch domain with NXPZ-2. Further optimizations on the solvent exposed region obtained asym. naphthalenesulfonamides and three crystal structures of Keap1 in complex with designed compounds Among them, the asym. piperazinyl-naphthalenesulfonamide 6k with better aqueous solubility showed the best KD2 value of 0.21μM to block the interaction. The productions of ROS and NO and the expression of TNF-α were inhibited by 6k in the in vitro model. This compound could relieve inflammations by significantly increasing the Nrf2 nuclear translocation in the LPS-induced ALI model with promising pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, 2-Bromoacetamide(cas: 683-57-8Safety of 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Safety of 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 70-55-3In 2019 ,《Multicomponent Aromatic and Benzylic Mannich Reactions through C-H Bond Activation》 was published in Chemistry – A European Journal. The article was written by Xavier, Tania; Rayapin, Corinne; Le Gall, Erwan; Presset, Marc. The article contains the following contents:

The straightforward generation of densely substituted-amines I [R = H, Me; R1 = Me, 4-MeC6H4, 2-thienyl; R2 = Ph, 4-MeC6H4, 2-thienyl, etc.; R3 = H, 3-Me, 4-OMe, etc.] was described via multicomponent Mannich reaction of sulfonamides, acetals and arylpyridines through C-H bond activation in good yields. The reaction involved a reaction between two transient species: an organometallic species, generated by transition-metal-catalyzed sp2 or sp3 C-H bond activation and an in situ generated imine. The use of an acetal as an aldehyde surrogate was found essential for the reaction to proceed. The process could be successfully applied to RhIII-catalyzed sp2 C-H bond functionalization and extended to CuII-catalyzed sp3 C-H bond functionalization. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Application of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Fe-BPsalan Complex-Catalyzed Asymmetric [4 + 2] Cycloaddition of Cyclopentadiene with α,β-Unsaturated Heterocycles》 was written by Chen, Kai-Ge; Lu, Hao; Zhou, Yi-Ming; Wan, Xiao-Long; Wang, Hao-Yang; Xu, Zhen-Jiang; Guo, Hai-Ming; Che, Chi-Ming. Category: amides-buliding-blocksThis research focused onunsaturated acyl imidazole cyclopentadiene iron catalyst enantioselective cycloaddition reaction; imidazolyl bicycloheptenyl methanone preparation; cinnamoylisoindolinedione cyclopentadiene iron catalyst enantioselective cycloaddition reaction; bicycloheptene carbonyl isoindolinedione preparation. The article conveys some information:

An efficient iron-catalyzed asym. [4 + 2] cycloaddition of cyclopentadiene with α,β-unsaturated acyl imidazoles or 2-cinnamoylisoindoline-1,3-dione derivatives was developed to afford the addition products in high yield and selectivity. Interestingly, the absolute structures of the addition products were controlled by the auxiliaries via different coordination modes with the same type of catalyst. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Category: amides-buliding-blocks)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《How Robust Is the N-H···Cl2-Cu Synthon? Crystal Structures of Some Perchlorocuprates》 was written by Kumar, D. Krishna; Ballabh, Amar; Jose, D. Amilan; Dastidar, Parthasarathi; Das, Amitava. Computed Properties of C11H9N3O And the article was included in Crystal Growth & Design on April 30 ,2005. The article conveys some information:

Perchlorocuprate salts, namely, [4,4′-H2diazastilbene][CuCl4] 1, [H2-N-(4-pyridyl)isonicotinamide][CuCl4] 2, [H2-N-(3-pyridyl)isonicotinamide][CuCl4] 3, [H2-N-(4-pyridyl)nicotinamide][CuCl4] 4, [H2-N,N’-bis(4-pyridyl)urea][CuCl4] 5, [H-isonicotinic acid]2[CuCl4].2H2O 6, [2-aminopyridinium]2[CuCl4] 7, and [3-aminopyridinium]2[CuCl4] 8 were synthesized and analyzed by single-crystal x-ray diffraction. N-H···Cl-Cu H-bonding interaction is important in supramol. syntheses of these solids. However, occurrence of bifurcated H bonding N-H···Cl2Cu (synthon A) appears to be dependent on the topol. of the cations, geometry of the anions, and other weak interactions such as C-H···Cl-Cu. Salts of isomeric cations such as 2, 3 and 4, and 7 and 8 are crystallog. isostructural in their resp. groups despite having different H-bonding site topologies. The H-bonding-capable backbones (amide and urea moieties) in 2, 3, 4, and 5 do not display the typical H-bonding network involving these moieties. In the experiment, the researchers used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Computed Properties of C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Computed Properties of C11H9N3O In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Safety of H-Lys(Boc)-OHOn June 1, 2020, Vangala, Venugopal; Nimmu, Narendra Varma; Khalid, Sara; Kuncha, Madhusudana; Sistla, Ramakrishna; Banerjee, Rajkumar; Chaudhuri, Arabinda published an article in Molecular Pharmaceutics. The article was 《Combating Glioblastoma by Codelivering the Small-Molecule Inhibitor of STAT3 and STAT3siRNA with α5β1 Integrin Receptor-Selective Liposomes》. The article mentions the following:

Glioblastoma multiforme (GBM) is one of the most aggressive tumors with a median survival of only 15 mo. Effective therapeutics need to overcome the formidable challenge of crossing the blood-brain barrier (BBB). Receptors and transporters overexpressed on BCECs are being used for designing liposomes, polymers, polymeric micelles, peptides, and dendrimer-based drug carriers for combating brain tumors. Herein, using the orthotopic mouse glioblastoma model, we show that codelivering a small-mol. inhibitor of the JAK/STAT pathway (WP1066) and STAT3siRNA with nanometric (100-150 nm) α5β1 integrin receptor-selective liposomes of RGDK-lipopeptide holds therapeutic promise in combating glioblastoma. Rh-PE (red)-labeled liposomes of RGDK-lipopeptide were found to be internalized in GL261 cells via integrin α5β1 receptors. I.v. administered near-IR (NIR)-dye-labeled α5β1 integrin receptor-selective liposomes of RGDK-lipopeptide were found to be accumulated preferentially in the mouse brain tumor tissue. Importantly, we show that iv injection of WP1066 (a com. sold small-mol. inhibitor of the JAK/STAT pathway) and STAT3siRNA cosolubilized within the liposomes of RGDK-lipopeptide leads to significant inhibition (>350% compared to the untreated mice group) of orthotopically growing mouse glioblastoma. The present strategy may find future use in combating GBM. After reading the article, we found that the author used H-Lys(Boc)-OH(cas: 2418-95-3Safety of H-Lys(Boc)-OH)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. Amino acids are not generally considered to be electrochemically active because products of the oxidation accumulate on the electrode surface and prevent it from participating in any further electrochemical processes.Safety of H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 64479-78-3On May 1, 2016 ,《Unsubstituted and substituted copper malonate coordination polymers with isomeric dipyridylamide ligands: Chain, layer, diamondoid, and self-penetrated topologies》 appeared in Inorganica Chimica Acta. The author of the article were Stone, Brandon S.; Staples, Richard J.; LaDuca, Robert L.. The article conveys some information:

Six dual-ligand divalent Cu malonate coordination polymers were prepared via solvent diffusion methods, and structurally characterized by single-crystal x-ray diffraction. The resulting dimensionality and topol. depend crucially on the steric bulk of the malonate ligand and the N donor disposition within the dipyridylamide coligand. {[Cu(mal)(3-pina)(H2O)]·2H2O}n (1, mal = malonate, 3-pina = 3-pyridylisonicotinamide) possesses a simple 1-dimensional chain structure, while the isomeric 4-pyridylnicotinamide (4-pna) ligand afforded a 2-fold interpenetrated (6,3) grid layer structure in {[Cu(mal)(4-pna)(H2O)]·3H2O}n (2). Employing Cu dimethylmalonate (dmmal) in the synthetic regime permitted synthesis of the (4,4) grid layered phase {[Cu2(dmmal)2(4-pna)2(H2O)3]·7H2O}n (3) and {[Cu2(dmmal)2(3-pina)2]·9.5H2O}n (4), which exhibited a 3-fold interpenetrated diamondoid net with large H2O-filled incipient channels, built from [Cu4(dmmal)4] tetranuclear clusters. {[Cu2(Hdmmal)2(dmmal)(4-pina)2]·0.5H2O}n (5, 4-pina = 4-pyridylisonicotinamide) manifested a unique 5-connected self-penetrated 3-dimensional network with 42678 topol. {[Cu(emal)(4-pna)(H2O)]·3H2O}n (6, emal = ethylmalonate) is another simple 1-dimensional chain phase. Ferromagnetic coupling (J = 11(3) cm-1) was observed within the tetranuclear clusters in 4. Thermal properties of these materials are also presented. In the experiment, the researchers used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Recommanded Product: 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Recommanded Product: 64479-78-3Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics