Author: Jessica.F

Zhao, Xue-Mei; Huang, En-Ling; Zhu, Yu-Shen; Li, Jing; Song, Bing; Zhu, Xinju; Hao, Xin-Qi published the artcile< Oxidative sulfonamidomethylation of imidazopyridines utilizing methanol as the main C1 source>, Formula: C6H6FNO2S, the main research area is phenyl imidazopyridine methanol sulfamide oxidative sulfonamidomethylation; imidazopyridine methanol amine oxidative aminomethylation.

An efficient one-pot, three-component synthesis of C3 sulfonamidomethylated imidazopyridines was disclosed under metal-free conditions, which utilized the com. available and renewable reagent methanol as the main methylene source. A wide range of substituted imidazopyridines and sulfamides/amines were well tolerated to afford the corresponding products in up to 92% yield. In the isotopic labeling experiment, it was found that a minor part of the methylene also originated from DTBP. Moreover, the radical scavenger reactions were conducted, which suggested that a free-radical mechanism was probably not involved. The current methodol. featured several advantages, including broad substrate scope, good functional group tolerance and high reaction efficiency.

Organic & Biomolecular Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Formula: C6H6FNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Gaolei; Chen, Xiulei; Deng, Yayun; Li, Zhong; Xu, Xiaoyong published the artcile< Synthesis and Nematicidal Activities of 1,2,3-Benzotriazin-4-one Derivatives against Meloidogyne incognita>, Recommanded Product: 2-Amino-4-bromobenzamide, the main research area is nematicide benzotriazinone derivative preparation Meloidogyne pest control; 1,2,3-benzotriazin-4-one; 2-cyanoiminothiazolidin-4-one; Meloidogyne incognita; in vivo; nematicide.

A series of novel 1,2,3-benzotriazin-4-one derivatives (I) where R is H, Cl, Br, etc.; and n = 1,2,3,or 4; were synthesized by the reaction of 3-bromoalkyl-1,2,3-benzotriazin-4-ones with potassium salt of 2-cyanoimino-4-oxothiazolidine in the presence of potassium iodide. Nematicidal assays in vivo showed that some of them exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita, up to 100% at the concentration of 10.0 mg L-1, which indicated that 1,2,3-benzotriazin-4-one derivatives might be potential for novel promising nematicides. The nematicidal activity was influenced by the combination of substituent type, substituted position, and linker length in the mol. The inhibition rate data at the concentrations of 5.0 and 1.0 mg L-1 for the compounds with high inhibitory activities were also provided. When tested in vitro, none of them showed direct inhibition against M. incognita. The investigation of a significant difference between in vivo and in vitro data is in progress.

Journal of Agricultural and Food Chemistry published new progress about Cucumis sativus, disease (root knot nematode, control of). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Recommanded Product: 2-Amino-4-bromobenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adel Fathy, Shrouk; Ibrahim, Amany K.; Eltamany, Enas E.; Badr, Jihan M. published the artcile< A developed high-performance thin-layer chromatographic method for the determination of orlistat in pharmaceutical preparations>, Recommanded Product: (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate, the main research area is high performance thin layer chromatog orlistat pharmaceutical preparation.

A sensitive and simple high-performance thin-layer chromatog. method is developed and validated according to the International Conference on Harmonisation (ICH) guidelines. The procedure was applied for the estimation of orlistat in different pharmaceutical preparations In the proposed method, thin-layer chromatog. aluminum sheets pre-coated with silica gel were employed as the stationary phase. A number of solvent mixtures were used as the mobile phase for trials to obtain compact bands of orlistat. The solvent mixture consisting of chloroform and methanol (98:2) was found to be the best. The data obtained from the calibration curves of standard orlistat showed a good linear relationship over the concentration range of 1000-3800 ng per band with respect to the area. Scanning was performed at λ = 200 nm, where the correlation coefficient (R2) was 0.970, and the linear regression equation was found to be: y = 4.1419x – 4181.1. After revealing of the spots by anisaldehyde-concentrate sulfuric acid, compact violet bands were obtained and, accordingly, scanning was performed at λ = 600 nm, where a good linear relationship over the concentration range of 600-4000 ng per band with respect to the area was obtained. The correlation coefficient (R2) was 0.991 with a linear regression equation: y = 4.025x – 1159.3. The method was evaluated regarding accuracy, precision, limits of detection and quantification, and robustness. Revealing of the spots by anisaldehyde-concentrate sulfuric acid improved the sensitivity of the method and increased the range within which a linear relationship between concentration and response occurs.

Journal of Planar Chromatography–Modern TLC published new progress about Antiobesity agents. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Recommanded Product: (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tigori, Mougo Andre; Kouyate, Amadou; Kouakou, Victorien; Niamien, Paulin Marius; Trokourey, Albert published the artcile< Inhibition performance of some sulfonylurea on copper corrosion in nitric acid solution evaluated theoretically by DFT calculations>, Category: amides-buliding-blocks, the main research area is sulfonylurea copper corrosion nitric acid density functional theory calculation.

The theor. study of chlorpropamide, tolazamide and glipizide was carried out by the D. Functional Theory (DFT) at B3LYP/6-31G(d) level. This study made it possible to determine the global reactivity parameters in order to better understand the interactions between the mols. studied and the copper surface. Then, the determination of local reactivity indexes (Fukui functions and dual descriptor) on these mols. resulted in the precision on the most probable centers of nucleophilic and electrophilic attacks within each mol. The results obtained, show that chloropropamide, tolazamide and glipizide can be good inhibitors against copper corrosion. Thus, the mechanism of copper corrosion inhibition of these compounds in nitric acid solution has been explained by means of theor. calculations

Open Journal of Physical Chemistry published new progress about Band gap. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Shikha; Ghosh, Sunil K.; Anitha, M.; Sharma, Joti N. published the artcile< α-Dialkylamino N,N-diisobutylacetamides: a new class of anion exchanger with intramolecular buffering properties>, Reference of 5326-82-9, the main research area is molybdenum dialkylamino diisobutylacetamide anion exchanger intramol buffering.

A new class of ammonium based anion exchangers embedded with a terminal amide group, viz. α-dialkylamino N,N-diisobutylacetamides was designed, synthesized and tested for their ability to extract oxometalate anions from HNO3 medium. As a representative example, the molybdate anion was chosen for the present studies and its extraction behavior was compared with routinely used anion exchangers like Alamine 336, Aliquat 336 and Primene JMT having no amide functionality. A higher %E value for molybdate was observed with α-dialkylamino N,N-diisobutylacetamides compared to Alamine 336, Aliquat 336 and Primene JMT, from the same HNO3 acidity. The presence of amide group in the ligand is the key to the success of extraction from a relatively higher concentration of HNO3 medium. The amide group in the extractant leads to extra acidity through the intramol. buffering effect thus enabling the ligand to extract the molybdate anion at higher acidities. Stoichiometry of the ion pair formed during extraction was ascertained by the slope anal. method. The composition of the complex is (LH)2MoO4·HNO3. FTIR and NMR of the loaded extractant indicated that MoO42- is associated with the ammonium site while binding of HNO3 occurred at the amide group.

RSC Advances published new progress about Amines, C16-22-tert-alkyl Role: RGT (Reagent), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (Primene JMT). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Reference of 5326-82-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Joyce, Paul; Meola, Tahlia R.; Schultz, Hayley B.; Prestidge, Clive A. published the artcile< Biomaterials that regulate fat digestion for the treatment of obesity>, Application of C29H53NO5, the main research area is review biomaterial fat digestion obesity.

Obesity is a rapidly growing concern worldwide, with over one-third of the global population classified as overweight or obese. While significant research has focused on developing new and improved nutritional and dietary approaches for regulating energy intake, there has been little success in overcoming the rising obesity statistics. Consequently, increasing attention is being afforded to designing safe, inexpensive and highly efficacious food-based materials that control fat and carbohydrate bioavailability in order to successfully manage the nutritional value of our food and combat chronic diseases associated with obesity, such as heart disease and diabetes. This review focuses on bioactive and nanostructured materials that have been shown to regulate energy intake by (i) manipulating the fat digestion process, and/or (ii) restricting the absorption of fat digestion products into the systemic bloodstream. The mechanistic approach of such technologies will be discussed in detail, with corresponding preclin. and clin. findings highlighted, to provide insights for the design and development of future anti-obesity therapeutics. Bioactive materials that regulate the fat digestion and absorption process have revealed promising preclin. and clin. findings with respects to modulating calorie intake and thus, weight gain. Insights derived from this review suggest materials that adsorb fat/fat digestion products, rather than interfering with enzyme action, are the most promising therapies, due to their ability to overcome the adverse effects associated with orlistat (the only FDA approved anti-obesity therapy with a localized mechanism of action within the gastrointestinal tract).

Trends in Food Science & Technology published new progress about Homo sapiens. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Application of C29H53NO5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tang, Guozhi; Kertesz, Denis J.; Yang, Minmin; Lin, Xianfeng; Wang, Zhanguo; Li, Wentao; Qiu, Zongxing; Chen, Junli; Mei, Jianghua; Chen, Li; Mirzadegan, Taraneh; Harris, Seth F.; Villasenor, Armando G.; Fretland, Jennifer; Fitch, William L.; Hang, Julie Qi; Heilek, Gabrielle; Klumpp, Klaus published the artcile< Exploration of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses>, Category: amides-buliding-blocks, the main research area is piperidinylpyrimidinamine preparation HIV 1 reverse transcriptase inhibitor; pyrimidinamine piperidinyl preparation structure activity relationship antiviral.

Further investigation on the recently reported N-(piperidin-4-yl)pyrimidin-2-amines I (R = H, 4-Cl, 5-Cl, 6-Cl; R1 = H, 4-SO2NH2, 3-SO2NH2, 2-CONH2, 3-CONH2, 4-CONH2, 3-SO2Me, 3-CN, 3-CO2H; R2 = H, Br, Cl, F, Me, CF3, NH2, NO2; R3 = Me, Cl, OMe, F) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) was carried out. Thus, preparation of a series of N-phenylpiperidine analogs resulted in the identification of 3-carboxamides as a particularly active series. Two of the compounds were very potent vs. wild-type HIV-1 and a broad range of NNRTI-resistant mutant viruses. Synthesis (no data), structure-activity relationship (SAR), clearance data, and crystallog. evidence for the binding motif were discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about AIDS (disease). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Feng; Lu, Lei; Ma, Juan published the artcile< Acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes to quinazolinones in water catalyzed by a water-soluble iridium complex [Cp*Ir(H2O)3][OTf]2>, Computed Properties of 5004-88-6, the main research area is quinazolinone preparation green chem; aminobenzamide aldehyde acceptorless dehydrogenative condensation iridium complex catalyst.

A general and efficient method for the synthesis of quinazolinones, e.g., I via acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes in water has been accomplished. In the presence of [Cp*Ir(H2O)3][OTf]2, a variety of desirable products were obtained in high yields with high atom economy under environmentally benign conditions. Notably, this research will facilitate the progress of acceptorless dehydrogenative reactions in water catalyzed by water-soluble organometallic complexes.

Organic Chemistry Frontiers published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Computed Properties of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Gao-Lei; Chen, Xi; Chang, Ya-Ning; Du, Dan; Li, Zhong; Xu, Xiao-Yong published the artcile< Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation>, Safety of 2-Amino-4-bromobenzamide, the main research area is spirocycle indolinone benzotriazinone derivative preparation nematicidal.

To discover new chemotypes of nematicides with proper toxicol. profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy against Meloidogyne incognita at 10.0 mg/L in vivo. Among them, compounds 1-(4-(4-oxo-7-methoxylbenzo[d][1,2,3]triazin-3(4H)-yl)butyl)spiro[indoline-3,2′-[1,3]dioxolan]-2-one and 1-(4-(4-oxo-7-nitrobenzo[d][1,2,3]triazin-3(4H)-yl)butyl)spiro[indoline-3,2′-[1,3]dioxolan]-2-one displayed 100% inhibitory activities at this concentration, which implied that they could be used as lead compounds for promising nematicides.

Chinese Chemical Letters published new progress about Nematocides. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Safety of 2-Amino-4-bromobenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yen, Fu-Shun; Lai, Jung-Nien; Wei, James Cheng-Chung; Chiu, Lu-Ting; Hwu, Chii-Min; Hou, Ming-Chih; Hsu, Chih-Cheng published the artcile< Sulfonylureas may be useful for glycemic management in patients with diabetes and liver cirrhosis>, Electric Literature of 94-20-2, the main research area is sulfonylurea antidiabetic agent hyperglycemia diabetes liver cirrhosis.

This study aimed to investigate the long-term outcomes of sulfonylurea (SU) use in patients with T2DM and compensated liver cirrhosis. From Jan. 1, 2000, to Dec. 31, 2012, we selected the data of 3781 propensity-score-matched SU users and nonusers from Taiwan’s National Health Insurance Research Database. The mean follow-up time for this study was 5.74 years. Cox proportional hazards models with robust sandwich standard error estimates were used to compare the risks of main outcomes between SU users and nonusers. The incidence of mortality during follow-up was 3.24 and 4.09 per 100 person-years for SU users and nonusers, resp. The adjusted hazard ratios and 95% confidence intervals for all-cause mortality, major cardiovascular events, and decompensated cirrhosis in SU users relative to SU nonusers were 0.79 (0.71-0.88), 0.69 (0.61-0.80), and 0.82 (0.66-1.03), resp. The SU-associated lower risks of death and cardiovascular events seemed to have a dose-response trend. This population-based cohort study demonstrated that SU use was associated with lower risks of death and major cardiovascular events compared with SU non-use in patients with T2DM and compensated liver cirrhosis. SUs may be useful for glycemic management for patients with liver cirrhosis.

PLoS One published new progress about Angiotensin-converting enzyme inhibitors. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Electric Literature of 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics