Author: Jessica.F

Jia, Yibo; Li, Lin; Duan, Lili; Li, Yue-Ming published the artcile< The aza-Prins Cyclization of Unfunctionalized Olefins Promoted by NHC-Cu Complex and ZrCl4>, Related Products of 6961-82-6, the main research area is piperidine preparation diastereoselective zirconium tetrachloride NHC copper catalyst; homoallylic amine aldehyde aza Prins cyclization.

The aza-Prins cyclization reaction catalyzed by ZrCl4 and NHC (N-heterocyclic carbene) metal complexes is firstly reported. NHC-copper complexes as promoter and ZrCl4 as chloride source are utilized under a mild condition, where homoallylic amines and aldehydes are successfully converted to piperidine derivatives in satisfactory yields and diastereoselectivity.

Applied Organometallic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Related Products of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Kui; Li, Yajun published the artcile< Solid-liquid phase equilibrium and solution thermodynamics of 2-chlorobenzenesulfonamide in 16 mono solvents at temperature ranging from 273.15 K to 324.65 K>, Application In Synthesis of 6961-82-6, the main research area is chlorobenzenesulfonamide solid liquid phase equilibrium solution thermodn.

The synthesis and separation processes of chem. intermediate is based on the knowledge of its solid-liquid phase equilibrium with solvents in industry. In this work, the solubility of 2-chlorobenzenesulfonamide in 16 single pure solvents including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, acetone, 2-butanone, 2-pentanone, cyclohexanone, cyclopentanone, Et acetate, Me acetate, Et formate, acetonitrile and THF was determined at temperature range from 273.15 to 324.65 K and atm. pressure. The mole fraction solubility of 2-chlorobenzenesulfonamide in all selected mono solvents was enhanced by an increase in temperature In addition, the exptl. data were further correlated by the modified Apelblat equation, λh equation, NRTL model and Wilson model. The values of RAD with NRTL equation were smaller than those with other three models, and thus the NRTL model offered the best fitting performance. The thermodn. functions of dissolution including enthalpy, entropy, and Gibbs energy were derived, and the results expectedly suggested a spontaneous and entropy-driven mixing process. All the crystallog. and thermodn. data reported in this study provides the fundamental data for designing and optimizing of the reaction and crystallization processes of 2-chlorobenzenesulfonamide.

Journal of Molecular Liquids published new progress about Crystallization. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application In Synthesis of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Amin, Mohammad A.; Camerino, Michelle A.; Mountford, Simon J.; Ma, Xiao; Manallack, David T.; Chalmers, David K.; Wills, Martin; Thompson, Philip E. published the artcile< (S)-(-)-Fluorenylethylchloroformate (FLEC); preparation using asymmetric transfer hydrogenation and application to the analysis and resolution of amines>, COA of Formula: C30H31ClN2O2RuS, the main research area is fluorenylethylchloroformate preparation hydrogenation.

An improved preparation of (S)-(-)-fluorenylethylchloroformate (FLEC) using an efficient asym. catalytic transfer hydrogenation as the key step was described. The application of FLEC as a chiral Fmoc equivalent for chiral resolution, with facile deprotection, of (S,S)/(S,R)-tetrahydroquinaldines I, and its capacity for inducing regioselective outcomes in nitration reactions were also demonstrated.

Tetrahedron published new progress about Chiral resolution. 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, COA of Formula: C30H31ClN2O2RuS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vu, Huu-Manh; Yong, Jia-Yuan; Chen, Fei-Wu; Li, Xu-Qin; Shi, Guo-Qing published the artcile< Rhodium-Catalyzed C(sp2)-H Amidation of Azine with Sulfonamides>, Quality Control of 6961-82-6, the main research area is regioselective rhodium catalyzed amidation azine sulfonamide.

Direct C-H amidation of azine with sulfonamide was developed for the first time. The reactions proceeded smoothly under benign conditions and gave the corresponding products with high selectivity. This approach shows high regioselectivity, wide substrate scope, and functional group tolerance. Addnl., this transformation can also be scaled up to the gram level. This strategy allows for the direct preparation of ortho-sulfonamide-substituted ketone products, thus providing a good complement to previous C-H amidation.

Journal of Organic Chemistry published new progress about Amidation. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Quality Control of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Feng; Lu, Lei; Liu, Pengcheng published the artcile< Acceptorless Dehydrogenative Coupling of o-Aminobenzamides with the Activation of Methanol as a C1 Source for the Construction of Quinazolinones>, HPLC of Formula: 5004-88-6, the main research area is dehydrogenative coupling aminobenzamide methanol iridium catalyst; quinazolinone preparation dehydrogenative coupling aminobenzamide methanol iridium catalyst.

A strategy for the synthesis of quinazolinones I (R = H, 7-Me, 6-MeO, 8-F, etc.) via acceptorless coupling of o-aminobenzamides with methanol has been accomplished in the presence of the metal-ligand bifunctional catalyst [Cp*Ir(2,2′-bpyO)(H2O)]. Notably, this research exhibited the potential of transition-metal-catalyzed activation of methanol as a C1 source for the construction of heterocycles.

Organic Letters published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent) (o-aminobenzamides). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, HPLC of Formula: 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nevidalova, Hana; Michalcova, Lenka; Glatz, Zdenek published the artcile< Applicability of capillary electrophoresis-frontal analysis for displacement studies: Effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin>, Synthetic Route of 94-20-2, the main research area is tryptophan lidocaine human serum albumin binding constant capillary electrophoresis; drug protein binding screening; binding constant; binding sites; capillary electrophoresis-frontal analysis; drug competition; human serum albumin.

The effective concentration of a drug in the blood, i.e. the concentration of a free drug in the blood, is influenced by the strength of drug binding onto plasma proteins. Besides its efficacy, these interactions subsequently influence the liberation, absorption, distribution, metabolism, excretion, and toxicol. properties of the drug. It is important to not only determine the binding strength and stoichiometry, but also the binding site of a drug on the plasma protein mol., because the co-administration of drugs with the same binding site can affect the above-mentioned concentration and as a result the pharmacol. behavior of the drugs and lead to side effects caused by the change in free drug concentration, its toxicity. In this study, the binding characteristics of six drugs with human serum albumin, the most abundant protein in human plasma, were determined by capillary electrophoresis-frontal anal., and the obtained values of binding parameters were compared with the literature data. The effect of several drugs and site markers on the binding of L-tryptophan and lidocaine to human serum albumin was investigated in subsequent displacement studies which thus demonstrated the usability of capillary electrophoresis as an automated high-throughput screening method for drug-protein binding studies.

Journal of Separation Science published new progress about Capillary electrophoresis. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Synthetic Route of 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Amico, Giandomenico; Carollo, Anna; Conaldi, Pier Giulio; Bai, Ruoli; Hamel, Ernest; Daidone, Giuseppe published the artcile< 2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action>, Formula: C9H12N2O3, the main research area is cinnamamido phenylpropiolamido phenylpropanamidobenzamide preparation anticancer; 2-(3-Phenylpropanamido)benzamides; 2-(3-Phenylpropiolamido)benzamides; 2-Cinnamamidobenzamides; Antiproliferative activity; Apoptosis; DYCGFIFOMKVDQP-UHFFFAOYSA-N; GAEWJVNXMYWFOT-FPYGCLRLSA-N; GLOIPBXNPXFMCD-CMDGGOBGSA-N; GTMVKWANDDSBPP-UHFFFAOYSA-N; GUWKFLZAMNTMFA-UHFFFAOYSA-N; IBBGALVVPWZGNP-JXMROGBWSA-N; IRYCZCAWVJZWKT-QPJJXVBHSA-N; JZURWIGFELHAQF-UHFFFAOYSA-N; LIWFXFAWCAUFBU-UHFFFAOYSA-N; LRIOFNWWMBLPSV-RMKNXTFCSA-N; MTEXNJMFEMIDJZ-CSKARUKUSA-N; MVXMFTXNNUIRAF-UHFFFAOYSA-N; MWHVYZNXRYFKFD-UHFFFAOYSA-N; OEHLQIRCXNADOK-JXMROGBWSA-N; PIQFLKOEQNXADK-QPJJXVBHSA-N; QUNOMTLXTSUWOB-CMDGGOBGSA-N; RHBJSXACCJTPRE-UHFFFAOYSA-N; USJUKEPNAZAKSG-UHFFFAOYSA-N; WMHHXKMPUMTPIJ-RMKNXTFCSA-N; WPPDXKZWCFUROB-UHFFFAOYSA-N; XMXNTDIXMAUMEJ-UHFFFAOYSA-N; ZLNSPXKNAWBJIG-ZHACJKMWSA-N; ZXBUZBGNIFHLGX-UHFFFAOYSA-N.

Several new benzamides were synthesized by stirring in pyridine the acid chlorides with the appropriate anthranilamide derivatives Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

European Journal of Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Formula: C9H12N2O3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ogawa, Nobuo; Yoshida, Toshihiko; Aratani, Takayuki; Koshinaka, Eiichi; Kato, Hideo; Ito, Yasuo published the artcile< Synthesis and histamine H2-antagonist activity of 4-quinazolinone derivatives>, Quality Control of 5004-88-6, the main research area is piperidinylmethylphenoxypropylaminoquinazolinone preparation antiulcer histamine antagonist; quinazolinone piperidinylmethylphenoxypropylamino preparation histamine antagonist; structure activity aminomethylphenoxyalkylaminoquinazolinone histamine antagonist.

With the aim of developing new antiulcer agents, a series of 4-quinazolinone derivatives e.g., I (R = piperidino, pyrrolidino, morpholino, R1 = H, OMe, R2 = H, Me; n = 2, 3, 4) was synthesized and tested for histamine H2-antagonist activity and gastric antisecretory activity. Thus, 2-alkylamino-, 2-alkylthio-, and 2-alkyl-4-quinazolinones were prepared by the condensation of alkylamines with 2-chloro- or 2-methylthio-4-quinazolinones, the condensation of alkyl bromides with 2-mercapto-4-quinazolinones, and the condensation of alkylcarboxylic acids with anthranilamides, resp. Several of the 4-quinazolinone derivatives showed potent H2-antagonist activity, and one of them, I (R = piperidino, R1 = R2 = H, n = 3), showed the most potent antisecretory activity. The structure-activity relationships are discussed.

Chemical & Pharmaceutical Bulletin published new progress about Histamine H2 receptor antagonists. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Quality Control of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Qing; Zhou, Yue; Feng, Xingyu; Gao, Yuan; Huang, Chengzhi; Yao, Xueqing published the artcile< Low-dose orlistat promotes the therapeutic effect of oxaliplatin in colorectal cancer>, COA of Formula: C29H53NO5, the main research area is Apoptosis; Colorectal cancer; Low-dose Orlistat; Oxaliplatin; PDX models.

The failure of and resistance to oxaliplatin (OXA)-based chemotherapies may lead to poor prognosis in colorectal cancer (CRC) patients. It has been reported that orlistat (Orli) exhibits potent antitumor effects in several malignant tumors. Here, we identified that OXA in combination with low-dose Orli could sensitize CRC cells to OXA and induce marked synergistic apoptosis in vitro and in vivo. The potential synergistic effects were confirmed and quantified by in silico anal. Furthermore, we validated the synergistic anti-tumor effects in CRC PDX mice model. A qPCR array was performed to evaluate the changes in 85 apoptosis-related genes to elucidate the possible mol. mechanisms in combination-induced cytotoxicity. To conclude, the antitumor synergistic effects of OXA and Orli make them effective and promising candidates for cancer treatment.

Biomedicine & Pharmacotherapy published new progress about 96829-58-2. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, COA of Formula: C29H53NO5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Appel, Rolf; Montenarh, Mathias published the artcile< Addition reaction of N,N-dialkylsulfamides, tertiary amines, and phosphines with fluorosulfonyl isocyanate>, Category: amides-buliding-blocks, the main research area is addition sulfamide fluorosulfonyl isocyanate; amine fluorosulfonyl isocyanate reaction; phosphine fluorosulfonyl isocyanate reaction; urea fluorosulfonyl sulfamoyl.

Addition of RSO2NH2 to FSO2NCO gave 72-98% RSO2NHCONHSO2F (R = Me2N, piperidino, morpholino, MeO), thermal decomposition of which gave 20-48% RSO2F (R = Me2N, piperidino, morpholino). The reaction of FSO2NCO with amines and phosphines gave 91-99% 1:1 adducts RR12E+CON-SO2F (RR12E = Et3N, pyridine, Me3P, PhEt2P, MePh2P, Ph3P).

Chemische Berichte published new progress about Addition reaction. 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics