Author: Jessica.F

Zhou, Wenjing; Zhang, Jing; Yan, Mingkun; Wu, Jin; Lian, Shuo; Sun, Kang; Li, Baiqing; Ma, Jia; Xia, Jun; Lian, Chaoqun published the artcile< Orlistat induces ferroptosis-like cell death of lung cancer cells.>, Recommanded Product: (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate, the main research area is FAF2; ferroptosis; lung cancer; orlistat.

Aberrant de novo lipid synthesis is involved in the progression and treatment resistance of many types of cancers, including lung cancer; however, targeting the lipogenetic pathways for cancer therapy remains an unmet clinical need. In this study, we tested the anticancer activity of orlistat, an FDA-approved anti-obesity drug, in human and mouse cancer cells in vitro and in vivo, and we found that orlistat, as a single agent, inhibited the proliferation and viabilities of lung cancer cells and induced ferroptosis-like cell death in vitro. Mechanistically, we found that orlistat reduced the expression of GPX4, a central ferroptosis regulator, and induced lipid peroxidation. In addition, we systemically analyzed the genome-wide gene expression changes affected by orlistat treatment using RNA-seq and identified FAF2, a molecule regulating the lipid droplet homeostasis, as a novel target of orlistat. Moreover, in a mouse xenograft model, orlistat significantly inhibited tumor growth and reduced the tumor volumes compared with vehicle control (P < 0.05). Our study showed a novel mechanism of the anticancer activity of orlistat and provided the rationale for repurposing this drug for the treatment of lung cancer and other types of cancer. Frontiers of medicine published new progress about 96829-58-2. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Recommanded Product: (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Khedr, Naglaa F.; Ebeid, Abla M.; Khalil, Rania M. published the artcile< New insights into weight management by orlistat in comparison with cinnamon as a natural lipase inhibitor>, Reference of 96829-58-2, the main research area is obesity orlistat cinnamon weight management; Cinnamon; Dopamine; Dyslipidemia; Glutamate; Obesity; Orlistat.

Background and objectives: Orlistat which is taken by obese patients may present some therapeutic assistance through its inhibition of lipase activity. Otherwise, a natural lipase inhibitor as cinnamon is widely used traditional medicine to decrease cholesterol and body weight The current study aimed to investigate the weight management of orlistat in comparison with cinnamon through different obesity related targets. Methods: Subjects were divided into: Group 1: subjects received cinnamon capsules for 60 days. Results: Both orlistat and cinnamon groups showed a significant reduction in BMI, lipid profile, and lipase activity compared with baseline. Orlistat group showed significant elevation (p < 0.001) in glucagon, insulin-degrading enzyme (IDE) and dopamine level concomitant with the decrease of serum glutamate compared with baseline level of the same group and cinnamon group. However, cinnamon reduced serum insulin level and insulin resistance (IR) compared with baseline level of the same group and orlistat group. Conclusions: Orlistat can be used in weight management not only for its pancreatic lipase inhibition but also, due to its indirect appetite reduction effect through elevated glucagon, IDE and dopamine levels and its inhibitory effect on glutamate neurotransmitter, whereas, cinnamon improves BMI and glycemic targets. Endocrine published new progress about Blood serum. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Reference of 96829-58-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bisset, Alexander A.; Dishington, Allan; Jones, Teyrnon; Clarkson, Guy J.; Wills, Martin published the artcile< Synthesis and reduction reactions of pyridones and 5-acyl-2-methoxypyridines>, Electric Literature of 1192620-83-9, the main research area is pyridine pyridinone preparation.

The synthesis of a series of pyridones, from their 2-hydroxypyridine or 2-methoxypyridine precursors, is described, along with studies into their reductions to saturated heterocycles. A number of 5-acyl-pyridones were prepared and were evaluated as substrates for asym. transfer hydrogenation prior to conversion to saturated heterocycles. The enantioselective reduction of 5-acetyl-1-benzyl-2,4(1H,3H)-pyrimidinedione is also described. The synthesis of the target compounds was achieved using [(R)-BINAP]ruthenium diacetate, [N-[(1R,2R)-1,2-diphenyl-2-[[3-(η6-phenyl)propyl](3-phenylpropyl)amino-κN]ethyl]-4-methylbenzenesulfonamidato-κN](chloro)ruthenium [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium and [N-[(1S,2S)-1,2-diphenyl-2-[[3-(η6-phenyl)propyl](3-phenylpropyl)amino-κN]ethyl]-4-methylbenzenesulfonamidato-κN](chloro)ruthenium as catalysts. The title compounds thus formed included chiral 5-(1-hydroxyethyl)-2-piperidinone derivatives

Tetrahedron published new progress about Enantioselective synthesis. 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Electric Literature of 1192620-83-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dong, Wei; Ge, Zemei; Wang, Xin; Li, Ridong; Li, Runtao published the artcile< Cu-mediated one-pot three-component synthesis of 3-N-substituted 1,4,2-benzodithiazine 1,1-dioxide derivatives>, Quality Control of 6961-82-6, the main research area is halobenzenesulfonamide amine carbon disulfide copper catalyst three component reaction; amino benzodithiazine dioxide preparation.

A novel and efficient copper-catalyzed one-pot procedure for the synthesis of 3-N-substituted 1,4,2-benzodithiazine 1,1-dioxide derivatives from 2-halobenzenesulfonamides, amines and CS2 was described. The reaction proceeded through Ullmann-type S-arylation, intramol. addition of NH2 with C=S and dehydrosulfide, which provided a new and useful strategy for construction of cyclic aromatic sulfonamides.

Tetrahedron published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Quality Control of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fu, Shaomin; Yang, Honghao; Li, Guoqiang; Deng, Yuanfu; Jiang, Huanfeng; Zeng, Wei published the artcile< Copper(II)-Catalyzed Enantioselective Intramolecular Cyclization of N-Alkenylureas>, Quality Control of 1524-40-9, the main research area is copper catalyzed enantioselective intramol cyclization alkenylurea bicyclic heterocycle synthesis; vicinal diamine cyclic enantioselective synthesis.

The first Cu(II)-catalyzed highly enantioselective intramol. cyclization of N-alkenylureas was developed for the concise assembly of chiral vicinal diamino bicyclic heterocycles [e.g., I → II (73%, 90% ee)]. Facile removal of carbonyl group of the carbamido moiety allowed for ready access to enantioenriched cyclic vicinal diamines.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkenylureas). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Quality Control of 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Abou-El-Naga, I. F.; Sa, D. E.; Gaafar, M. R.; Ahmed, S. M.; El-Deeb, S. A. published the artcile< A new scope for orlistat: Effect of approved anti-obesity drug against experimental microsporidiosis>, Product Details of C29H53NO5, the main research area is antiobesity drug orlistat microsporidiosis intestine.

As the current therapies for intestinal microsporidiosis are either inconsistent in their efficacies or hampered by several adverse effects, alternative antimicrosporidial agents are being sought. The present study is the first that was designed to evaluate the potency of orlistat, an approved anti-obesity drug, against intestinal microsporidiosis caused by both Enterocytozoon bieneusi and Encephalitozoon intestinalis. Results were assessed through studying fecal and intestinal spore load, intestinal histopathol. changes, viability, and infectivity of spores from treated animals. Results showed that orlistat has promising antimicrosporidia potential, with better results in E. intestinalis than E. bieneusi. The animals that received orlistat showed statistically significant decrease in the fecal and intestinal spore load, when compared to the corresponding control infected nontreated mice. The results were insignificant compared to fumagillin and albendazole. Light microscopic examination of stained intestinal sections revealed amelioration of the pathol. changes and decreased inflammatory cells detected in the control infected nontreated mice. Spores encountered from stool of orlistat-treated E. bieneusi and E. intestinalis mice showed low viability and significant reduction of infectivity vs. their control. Thus, considering the results of the present work, orlistat proved its effectiveness against the intestinal microsporidial infection.

Medical Mycology published new progress about Antiobesity agents. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Product Details of C29H53NO5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Feng, Jian-Bo; Wu, Xiao-Feng published the artcile< A general iodine-mediated synthesis of primary sulfonamides from thiols and aqueous ammonia>, Computed Properties of 1524-40-9, the main research area is sulfonamide primary aryl preparation green chem; thiol aryl ammonia oxidation iodine catalyst.

A general and efficient methodol. for preparing a wide range of primary sulfonamides, RSO2NH2 (R = 3,4-dichlorophenyl, naphthalen-2-yl, 1H-1,3-benzodiazol-2-yl, etc.) from the corresponding thiols RSH and aqueous ammonia, by using iodine as the catalyst and TBHP (70% in water) as the oxidant, in moderate to good yields has been developed.

Organic & Biomolecular Chemistry published new progress about Arenesulfonamides Role: SPN (Synthetic Preparation), PREP (Preparation). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Computed Properties of 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Xiulei; Zhou, Zhen; Li, Zhong; Xu, Xiaoyong published the artcile< Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita>, Name: 2-Amino-4-bromobenzamide, the main research area is benzotriazinone dihydrothiazole thiol preparation nematocidal activity.

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol I (R = H, 5-OMe, 7-F, 8-NO2, etc.) was synthesized. The bioassay results showed that compounds I (R = 7-OMe, 6-NO2, 7-Cl (A)) exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L-1 in vivo. Compound (A) showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Benzotriazines Role: AGR (Agricultural Use), BSU (Biological Study, Unclassified), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Name: 2-Amino-4-bromobenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sakthi, G. published the artcile< Contradictory opinion of the Terminalia chebula linn. -literature review>, SDS of cas: 94-20-2, the main research area is review Terminalia chebula drug interaction toxicity.

A review. Terminalia chebula is used as common and effective herb in traditional, Siddha & Ayurvedic medicine as Indian Medicine. In siddha medical system know as “”Mother of Herb”” is mentioned in manuscripts texts. In this research paper objected as enumerate the side effect or toxicity effect from Gall Nut or safe drug for all by searching the literatures in books and articles. Finally concluded by collected data results as; continuous drug period of intake for up to 3 mo. And drug interactions reported as; Taking Terminalia along with diabetes medications might cause your blood sugar to go too low. In toxicity studies shows as; In the acute phase of the study, the safe dose was ≤5000 mg/kg for both extracts In sub- acute phase, LD50 (95% CI) of Terminalia chebula extract 2754.436 (2438-3114) mg/kg. The highest dose of T. chebula extract induced few histopathol. changes.

European Journal of Biomedical and Pharmaceutical Sciences published new progress about Diabetes mellitus. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, SDS of cas: 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Irigoyen, Sonia; Ramasamy, Manikandan; Pant, Shankar; Niraula, Prakash; Bedre, Renesh; Gurung, Meena; Rossi, Denise; Laughlin, Corinne; Gorman, Zachary; Achor, Diann; Levy, Amit; Kolomiets, Michael V.; Setamou, Mamoudou; Badillo-Vargas, Ismael E.; Avila, Carlos A.; Irey, Michael S.; Mandadi, Kranthi K. published the artcile< Plant hairy roots enable high throughput identification of antimicrobials against Candidatus Liberibacter spp.>, Electric Literature of 94-20-2, the main research area is antimicrobial hairy root disease Candidatus.

A major bottleneck in identifying therapies to control citrus greening and other devastating plant diseases caused by fastidious pathogens is our inability to culture the pathogens in defined media or axenic cultures. As such, conventional approaches for antimicrobial evaluation (genetic or chem.) rely on time-consuming, low-throughput and inherently variable whole-plant assays. Here, we report that plant hairy roots support the growth of fastidious pathogens like Candidatus Liberibacter spp., the presumptive causal agents of citrus greening, potato zebra chip and tomato vein greening diseases. Importantly, we leverage the microbial hairy roots for rapid, reproducible efficacy screening of multiple therapies. We identify six antimicrobial peptides, two plant immune regulators and eight chems. which inhibit Candidatus Liberibacter spp. in plant tissues. The antimicrobials, either singly or in combination, can be used as near- and long-term therapies to control citrus greening, potato zebra chip and tomato vein greening diseases.

Nature Communications published new progress about Antimicrobial agents. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Electric Literature of 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics