Author: Jessica.F

Gediya, Shweta K.; Vyas, Vijyesh K.; Clarkson, Guy J.; Wills, Martin published the artcile< Asymmetric Transfer Hydrogenation of α-Keto Amides; Highly Enantioselective Formation of Malic Acid Diamides and α-Hydroxyamides>, COA of Formula: C30H31ClN2O2RuS, the main research area is hydroxydiamide regioselective enantioselective preparation; oxodiamide ruthenium chiral diamine catalyst asym transfer hydrogenation; hydroxyamide regioselective enantioselective preparation; oxoamide ruthenium chiral diamine catalyst asym transfer hydrogenation.

The asym. transfer hydrogenation (ATH) of α-keto-1,4-diamides using a tethered Ru/TsDPEN catalyst was achieved in high ee. Studies on derivatives identified the structural elements which led to the highest enantioselectivities in the products. The α-keto-amide reduction products were converted to a range of synthetically valuable derivatives

Organic Letters published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, COA of Formula: C30H31ClN2O2RuS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vats, B. G.; Kannan, S.; Pius, I. C.; Noronha, D. M.; Maity, D. K.; Drew, M. G. B. published the artcile< Synthetic, structural, extraction and theoretical studies of uranyl nitrate dithio-diglycolamide compounds>, Safety of 2-Chloro-N,N-diisobutylacetamide, the main research area is crystal structure thioglycolamide thiotolylamide uranyl complex preparation actinide extraction; optimized mol structure glycolamide thioglycolamide uranyl monodentate bidentate extraction.

Dithio-diglycolamide ligands [(CH2SCH2CONR2)2] (R = iPr, Bu, iBu, C8H17) and [C7H6(SCH2CONR2)2] (R = iBu) were prepared and characterized. The complex chem. of these ligands with uranyl nitrate was studied using IR, NMR and ESI-MS techniques and elemental anal. The structures for two of the compounds, [UO2(NO3)2(CH2SCH2CONBu2)2] (2) and [UO2(NO3)2C7H6(SCH2CON{iBu}2)2] (4), were determined by the x-ray diffraction method and revealed a bidentate chelating mode of bonding for the ligands in the solid state. The structures further show that the uranyl group is surrounded by six O atoms in a hexagonal bi-pyramidal geometry. Theor. studies were carried out to explain the relative stability of this chelating mode of ligand bonding. Extraction studies of U(VI), Pu(IV) and Am(III) ions from HNO3 by one of the ligands, [(CH2SCH2CON{C8H17}2)2] (L4), in dodecane show appreciable extractions The extracted metal ions could be back extracted quant. using 0.5M HNO3 or a mixture of 0.5 M HNO3 and 0.5M H2C2O4.

Polyhedron published new progress about Actinide ions Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Safety of 2-Chloro-N,N-diisobutylacetamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Jing; Zhang, Zhanwen; Nie, Dahong; Ma, Hui; Yuan, Gongjun; Su, Shu; Liu, Shaoyu; Liu, Sheng; Tang, Ganghua published the artcile< PET imaging of hepatocellular carcinomas: 18F-fluoropropionic acid as a complementary radiotracer for 18F-fluorodeoxyglucose>, Formula: C29H53NO5, the main research area is F-fluorodeoxyglucose (F-FDG); F-fluoropropionic acid (F-FPA); hepatocellular carcinoma (HCC); positron emission tomography (PET).

Objective: To evaluate the preclin. value of 18F-fluoropropionic acid (18F-FPA) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomog. (PET) for imaging HCCs. Methods: The 18F-FPAand 18F-FDGuptake patterns in 3HCCcell lines (Hep3B,HepG2, and SK-Hep1) were assessed in vitro and in vivo. The 18F-FPAuptakemechanismwas investigated using inhibition experimentswith orlistat and 5-tetradecyloxy-2-furoic acid.The 18F-FPAPET imagingwas performed in different tumor animalmodels and compared with 18F-FDG.We also evaluated the expressions of glucose transporter-1 (GLUT1), fatty acid synthase (FASN), and matrix metalloproteinase-2 (MMP2) in these cell lines. Results: In vitro experiments showed that the radiotracer uptake patterns were complementary in the HCC cell lines. Orlistat and 5-tetradecyloxy-2-furoic acid decreased the uptake of 18F-FPA. The tumor-to-liver ratio of 18F-FPA was superior to that of 18F-FDG in the SK-Hep1 and HepG2 tumors (P < .05). However, in the Hep3B tumors, the tumor-to-liver normalized uptake of 18F-FDG was higher than 18F-FPA (P < .01). FASN was highly expressed in cell lines with high 18F-FPA uptake, whereas GLUT1 was highly expressed in cell lines with high 18F-FDG uptake. The 18F-FPA uptake correlated with FASN (r = 0.89, P = .014) and MMP2 (r = 0.77, P = .002) expressions. Conclusions: PET imaging with 18F-FPA combined with 18F-FDG can be an alternative for detecting HCC. Molecular Imaging published new progress about 96829-58-2. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Formula: C29H53NO5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Huimin; Wang, Shui; Qu, Chao; Li, Manman; Qu, Yixin published the artcile< Solid-Liquid Equilibrium of Chlorpropamide in 14 Pure Solvents at Temperature of 283.15 to 323.15 K>, Formula: C10H13ClN2O3S, the main research area is solid liquid equilibrium chlorpropamide alkanol acetate ester solubility thermodn.

The solubility of chlorpropamide (CPA) in 14 solvents including 8 alcs. (ethanol, n-propanol, isopropanol, n-butanol, 2-butanol, iso-butanol, n-pentanol, and isopentanol) and 6 acetate esters (Et acetate, Pr acetate, iso-Pr acetate, Bu acetate, amyl acetate, and Me propionate) at temperatures of 283.15 to 323.15 K and atm. pressure was determined using a laser method. The solubility as a function of temperature was regressed using modified Apelblat, Van’t Hoff, λh, Wilson, and nonrandom two-liquid (NRTL) models. On the basis of the exptl. and the simulation results, the mixing properties of the solutions, i.e., mixing Gibbs energy, enthalpy, and entropy, were estimated

Journal of Chemical & Engineering Data published new progress about Free energy of transfer (mixing free energy). 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Formula: C10H13ClN2O3S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yuan, Zhong; DeFalco, Frank; Wang, Lu; Hester, Laura; Weaver, James; Swerdel, Joel N.; Freedman, Amy; Ryan, Patrick; Schuemie, Martijn; Qiu, Rose; Yee, Jacqueline; Meininger, Gary; Berlin, Jesse A.; Rosenthal, Norman published the artcile< Acute pancreatitis risk in type 2 diabetes patients treated with canagliflozin versus other antihyperglycemic agents: an observational claims database study>, Related Products of 94-20-2, the main research area is canagliflozin antihyperglycemic SGLT2 inhibitor acute pancreatitis type 2 diabetes; Acute pancreatitis; canagliflozin; observational study; type 2 diabetes.

Observational evidence suggests that patients with type 2 diabetes mellitus (T2DM) are at increased risk for acute pancreatitis (AP) vs. those without T2DM. A small number of AP events were reported in clin. trials of the sodium glucose co-transporter 2 inhibitor canagliflozin, though no imbalances were observed between treatment groups. This observational study evaluated risk of AP among new users of canagliflozin compared with new users of six classes of other antihyperglycemic agents (AHAs). Three US claims databases were analyzed based on a prespecified protocol approved by the European Medicines Agency. Propensity score adjustment controlled for imbalances in baseline covariates. Cox regression models estimated the hazard ratio of AP with canagliflozin compared with other AHAs using on-treatment (primary) and intent-to-treat approaches. Sensitivity analyses assessed robustness of findings. Across the three databases, there were between 12,023-80,986 new users of canagliflozin; the unadjusted incidence rates of AP (per 1000 person-years) were between 1.5-2.2 for canagliflozin and 1.1-6.6 for other AHAs. The risk of AP was generally similar for new users of canagliflozin compared with new users of glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, sulfonylureas, thiazolidinediones, insulin, and other AHAs, with no consistent between-treatment differences observed across databases. Intent-to-treat and sensitivity anal. findings were qual. consistent with on-treatment findings. In this large observational study, incidence rates of AP in patients with T2DM treated with canagliflozin or other AHAs were generally similar, with no evidence suggesting that canagliflozin is associated with increased risk of AP compared with other AHAs.

Current Medical Research and Opinion published new progress about Acute pancreatitis. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Related Products of 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Scott, Andrew D.; Phillips, Chris; Alex, Alexander; Flocco, Maria; Bent, Andrew; Randall, Amy; O’Brien, Ronan; Damian, Luminita; Jones, Lyn H. published the artcile< Thermodynamic Optimisation in Drug Discovery: A Case Study using Carbonic Anhydrase Inhibitors>, Name: 3-Fluorobenzenesulfonamide, the main research area is benzene sulfonamide preparation carbonic anhydrase crystal structure thermodn binding.

The only method that directly measures the thermodn. of a binding event in solution is isothermal titration calorimetry (ITC). We chose human carbonic anhydrase (hCA II) as a favorable system for this investigation as there is already a wealth of both 3D structures and calorimetric data available, which has established this protein as the leading model system. The binding of BSA to hCA II is driven mainly through four H bonds from the sulfonamide, two H bonds to the Zn co-factor (which is itself coordinated by three histidine residues: His94, His96 and His119) and two H bonds to Thr199. ITC anal. was performed on seventeen benzenesulfonamide derivatives (1-17) and three benzylamide para-substituted benzene sulfonamides (18-20) by titration into hCA II. In the case described, ITC measurements, along with X-ray structural studies, indicated that one compound (2-F, 2) was binding to its target by specific (polar) interactions, as opposed to hydrophobicity (e.g. 3-F), and this ultimately led to a higher affinity lead-like compound that retained the enthalpic advantage of the smaller core compound It should be noted that in this case, the compounds chosen were small, fragment-like (< 250 Da) compounds with relatively high affinity for the target, limited flexibility, and a low number of possible interactions (i.e., typical compounds found in fragment libraries), and are therefore related to the concept of ""ligand efficient"" compounds These compounds are ideal for this type of anal. and the utilization of this approach for larger, lower affinity compounds, where the degree of complexity in the thermodn. is substantially greater, requires further investigation. ChemMedChem published new progress about Carbonic anhydrase inhibitors. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Name: 3-Fluorobenzenesulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Daniel, Alyssa; Kim, Kelly; Shanmugam, Neel; Sinha, Sneha; Varadharajan, Advika; Acree, William E. published the artcile< Abraham model correlations for solute transfer into cyclopentanone>, SDS of cas: 6961-82-6, the main research area is cyclopentanone anthracene pyrene Abraham model correlation.

Mole fraction solubilities have been measured for anthracene, benzoic acid, 4-tert-butylbenzoic acid, 3-chlorobenzoic acid, 2-hydroxybenzoic acid, 2-methylbenzoic acid, 3-methylbenzoic acid, 3-nitrobenzoic acid and pyrene dissolved in cyclopentanone at 298.15 K using either spectrophotometric or acid-base titrimetric methods. Results of our exptl. measurements, combined with published solubility data for several inorganic and organic gases, solubility data for several important crystalline pharmaceutical intermediates and activity coefficient data taken from the published literature, were used to derive Abraham model correlations for solute transfer into anhydrous cyclopentanone solvent from both water and from the gas phase. The derived Abraham model correlations back-calculate the observed exptl. data to within 0.10 log units (or less). Reported for the first time are solute descriptor values for several important pharmaceutical intermediates.

Physics and Chemistry of Liquids published new progress about Regression analysis. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, SDS of cas: 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chuang, Hui-Yen; Lee, Yen-Po; Lin, Wei-Chan; Lin, Yi-Hsien; Hwang, Jeng-Jong published the artcile< Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-κB Pathway>, HPLC of Formula: 96829-58-2, the main research area is ionizing radiation androgen receptor FASN NFkappaB signaling radiotherapy.

Elevated fatty acid synthase (FASN) has been reported in both androgen-dependent and -independent prostate cancers. Conventional treatment for prostate cancer is radiotherapy (RT); however, the following radiation-induced radioresistance often causes treatment failure. Upstream proteins of FASN such as Akt and NF-κB are found increased in the radioresistant prostate cancer cells. Nevertheless, whether inhibition of FASN could improve RT outcomes and reverse radiosensitivity of prostate cancer cells is still unknown. Here, we hypothesized that orlistat, a FASN inhibitor, could improve RT outcomes in prostate cancer. Orlistat treatment significantly reduced the S phase population in both androgen-dependent and -independent prostate cancer cells. Combination of orlistat and RT significantly decreased NF-κB activity and related downstream proteins in both prostate cancer cells. Combination effect of orlistat and RT was further investigated in both LNCaP and PC3 tumor-bearing mice. Combination treatment showed the best tumor inhibition compared to that of orlistat alone or RT alone. These results suggest that prostate cancer treated by conventional RT could be improved by orlistat via inhibition of FASN.

Scientific Reports published new progress about Androgen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, HPLC of Formula: 96829-58-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yamaguchi, Hachiro; Nakano, Keiji published the artcile< Hydrolysis of N-substituted derivatives of sulfamide>, Application of C4H10N2O3S, the main research area is sulfamic acid sulfamide hydrolysis; sulfamide alkyl benzyl hydrolysis; alkylsulfamide hydrolysis kinetics; benzylsulfamide hydrolysis kinetics; hydrolysis sulfamide derivative kinetics.

N-Alkyl- or -benzylsulfamides were hydrolyzed to the corresponding N-substituted sulfamates (RNHSO3NH4) in ∼ 44-87% yield with H2O and to H2NSO3Na in ∼ 64-95% yield with aqueous NaOH. N,N-Disubstituted sulfamides containing a heterocyclic ring were hydrolyzed mainly to sulfamates with H2O or NaOH. sym-N,N’-Dialkyl- or -benzylsulfamides were converted into N-substituted sulfamates in 50-97% yield with NaOH and into N,N’-disubstituted sulfamates in 63-93% yield with H2O, but (Et2N)2SO2 was hydrolyzed only with difficulty by H2O or NaOH. The reaction mechanisms were explained through electron density and steric complexity.

Hiroshima Daigaku Kogakubu Kenkyu Hokoku published new progress about Hydrolysis kinetics. 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Application of C4H10N2O3S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Joshi, Vidya; Chaudhari, Rajendra P. published the artcile< Synthesis of some new 4-quinazolinone-2-carboxylic acid esters, -2-carboxamides, -2-carbohydrazides and their tosyl derivatives having potential biological activity>, Formula: C7H7BrN2O, the main research area is quinazolinecarbohydrazide preparation antitubercular.

Quinazolinecarbohydrazides I [R1 = H, Me, OMe, halo, and R2 = H; R1R2 = (CH2O2)] were prepared from the resp. anthranilamides by cyclocondensation with EtO2CCO2Et and subsequent amidation with N2H4; I showed antitubercular activity. Also prepared were tosyl derivatives II.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Tuberculostatics. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Formula: C7H7BrN2O.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics