Category: 104-10-9

Category: amides-buliding-blocks. In 2019.0 J MED CHEM published article about CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; CAMP-SPECIFIC PHOSPHODIESTERASE; LONG-TERM-MEMORY; PROTEIN-KINASE; MOLECULAR-MECHANISMS; ADENYLYL-CYCLASE; STRUCTURAL BASIS; AMP PRODUCTION; KNOCKOUT MICE; DROSOPHILA in [Gurney, Mark E.; Nugent, Richard A.; Mo, Xuesheng; Sindac, Janice A.] Tetra Discovery Partners Inc, 38 Fulton St West, Grand Rapids, MI 49503 USA; [Hagen, Timothy J.] Northern Illinois Univ, Dept Chem & Biochem, 1425 West Lincoln Highway, De Kalb, IL 60115 USA; [Fox, David, III] Beryllium Discovery Corp, 7869 NE Day Rd West, Bainbridge Isl, WA 98110 USA; [O’Donnell, James M.; Zhang, Chong; Xu, Ying] SUNY Buffalo, Dept Pharmaceut Sci, Sch Pharm & Pharmaceut Sci, Buffalo, NY 14214 USA; [Zhang, Han-Ting] West Virginia Univ, Hlth Sci Ctr, Rockefeller Neurosci Inst, Dept Behav Med & Psychiat, 1 Med Ctr Dr, Morgantown, WV 26506 USA; [Zhang, Han-Ting] West Virginia Univ, Hlth Sci Ctr, Rockefeller Neurosci Inst, Dept Physiol Pharmacol & Neurosci, 1 Med Ctr Dr, Morgantown, WV 26506 USA; [Groppi, Vincent E.] Univ Michigan, Michigan Drug Discovery, Life Sci Inst, 210 Washtenaw Ave, Ann Arbor, MI 48103 USA; [Bailie, Marc] INDS Inc, 6111 Jackson Rd,Suite 100, Ann Arbor, MI 48103 USA; [White, Ronald E.] White Global Pharma Consultants, 31 Kinglet Dr, South Cranbury, NJ 08512 USA; [Romero, Donna L.] Pharma Vat Consulting LLC, 1201 Turnberry Ridge Court, Chesterfield, MO 63005 USA; [Vellekoop, A. Samuel; Walker, Joel R.; Surman, Matthew D.; Zhu, Lei; Campbell, Robert F.] Albany Mol Res Inc, 21 Corp Circle, Albany, NY 12203 USA; [Fox, David, III] UCB Pharma, 7869 NE Day Rd West, Bainbridge Isl, WA 98110 USA; [Zhang, Chong] Janssen China R&D, 65 Guiqing Rd,Bldg A,Floor 6, Shanghai 200233, Peoples R China; [Campbell, Robert F.] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA in 2019.0, Cited 81.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis. The design and optimization of lead compounds was based on iterative analysis of X-ray crystal structures combined with metabolite identification. Selectivity for the activated, dimeric form of PDE4D provided potent memory enhancing effects in a mouse model of novel object recognition with improved tolerability and reduced vascular toxicity over earlier PDE4 inhibitors that lack subtype selectivity. The lead compound, 28 (BPN14770), has entered midstage, human phase 2 clinical trials for the treatment of Fragile X Syndrome.

Welcome to talk about 104-10-9, If you have any questions, you can contact Gurney, ME; Nugent, RA; Mo, XS; Sindac, JA; Hagen, TJ; Fox, D; O’Donnell, JM; Zhang, C; Xu, Y; Zhang, HT; Groppi, VE; Bailie, M; White, RE; Romero, DL; Vellekoop, AS; Walker, JR; Surman, MD; Zhu, L; Campbell, RF or send Email.. Category: amides-buliding-blocks

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Matsumoto, K; Takeda, S; Hirokane, T; Yoshida, M in AMER CHEMICAL SOC published article about BOND FORMATION; DERIVATIVES; ARYLATION; BINAM; BIPHENOLS; PHENOLS in [Matsumoto, Kenji; Takeda, Satoshi; Hirokane, Tsukasa; Yoshida, Masahiro] Tokushima Bunri Univ, Fac Pharmaceut Sci, 180 Nishihama Boji, Yamashiro, Tokushima 7708514, Japan in 2019.0, Cited 58.0. Application In Synthesis of 2-(4-Aminophenyl)ethanol. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

The first catalytic oxidative aniline-aniline cross-coupling reaction using oxygen as the terminal oxidant is reported. Anilines possessing a pyrrolidino group can be preferentially oxidized under mild aerobic conditions and reacted with other anilines to afford a variety of nonsymmetrical 2-aminobiphenyls with high selectivities. A heterogeneous palladium catalyst is used for the dehydrogenative cross-coupling of anilines with structurally diverse arenes. This reaction does not require stoichiometric oxidants and is an economical and environmentally friendly method.

Application In Synthesis of 2-(4-Aminophenyl)ethanol. Welcome to talk about 104-10-9, If you have any questions, you can contact Matsumoto, K; Takeda, S; Hirokane, T; Yoshida, M or send Email.

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Amide – Wikipedia,
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Authors Li, GF; Zhao, M; Xie, JQ; Yao, Y; Mou, LY; Zhang, XW; Guo, XM; Sun, WS; Wang, Z; Xu, JC; Xue, JZ; Hu, T; Zhang, M; Li, M; Hong, L in ROYAL SOC CHEMISTRY published article about ONE-POT SYNTHESIS; FLUORESCENT-PROBES; SULFONYL; REARRANGEMENT; TACHYKININ; ALKYNES; ACCESS; FUNCTIONALIZATION; 1,2,3-TRIAZOLES; ANNULATION in [Li, Guofeng; Zhao, Man; Yao, Ying; Xu, Jiecheng; Xue, Jianzhong; Hu, Tao; Li, Min; Hong, Liang] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China; [Xie, Junqiu; Mou, Lingyun; Zhang, Xiaowei; Guo, Xiaomin; Sun, Wangsheng; Zhang, Ming] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China; [Wang, Zheng] Peking Univ, Sch Chem Biol & Biotechnol, Guangdong Key Lab Nanomicro Mat Res, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China in 2020, Cited 67. Recommanded Product: 104-10-9. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

Novel 10 pi-electron cyclic amidines with excellent fluorescence properties were synthesized by a general and efficient 6 pi-electrocyclic ring closure of ketenimine and imine starting from N-sulfonyl triazoles and arylamines. The photophysical properties of cyclic amidine fluorophores have been studied in detail and have shown good properties of a large Stokes shift, pH insensitivity, low cytotoxicity and higher photostability, which have great potential for biological imaging. Furthermore, this novel fluorophore was successfully applied to the localization of the NK-1 receptor in living systems.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 ORG BIOMOL CHEM published article about DNA; CATALYSIS; RECOGNITION in [Yum, Ji Hye; Sugiyama, Hiroshi; Park, Soyoung] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kitashirakawa Oiwakecho, Kyoto 6068502, Japan; [Sugiyama, Hiroshi] Kyoto Univ, Inst Integrated Cell Mat Sci iCeMS, Sakyo Ku, Yoshida Ushinomiyacho, Kyoto 6068501, Japan in 2020.0, Cited 45.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Quality Control of 2-(4-Aminophenyl)ethanol

Asymmetric synthesis based on DNA scaffolds has been actively exploited because of the advantages of DNA such as diverse tertiary structures, chemical stability, and easy handling. Since duplex DNA-based hybrid catalysts have demonstrated this remarkable capability, efforts have been made to investigate new biomolecular scaffolds. Herein, we report modular quadruplex-duplex (QD) hybrid DNA catalysts containing bipyridine ligands and hydrogen donor moieties. The conformation, thermal stability, and metal-binding ability of modified QD hybrid DNA were characterized using spectroscopy. The QD hybrid-based DNA catalysts were successfully applied to asymmetric Michael addition reactions (86% conversion and 76% ee). This study describes a new type of DNA hybrid catalyst produced by the construction of a cooperative active site with a Lewis acid and a H-bond donor.

Welcome to talk about 104-10-9, If you have any questions, you can contact Yum, JH; Sugiyama, H; Park, S or send Email.. Quality Control of 2-(4-Aminophenyl)ethanol

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An article Improved synthesis of the bifunctional chelator p-SCN-Bn-HOPO WOS:000476549400018 published article about RATIONAL DESIGN; COMPLEXATION; ZR-89; DESFERRIOXAMINE; ZIRCONIUM-89 in [Bhupathiraju, N. V. S. Dinesh K.; Younes, Ali; Cao, Minhua; Ali, Jafar; Cicek, Huseyin T.; Francesconi, Lynn C.; Drain, Charles Michael] CUNY Hunter Coll, Dept Chem, New York, NY 10065 USA; [Tully, Kathryn M.; Lewis, Jason S.] Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA; [Tully, Kathryn M.; Lewis, Jason S.] Mem Sloan Kettering Canc Ctr, Dept Radiol, Program Pharmacol, New York, NY 10065 USA; [Tully, Kathryn M.; Lewis, Jason S.] Mem Sloan Kettering Canc Ctr, Radiochem & Mol Imaging Probes Core, New York, NY 10065 USA; [Ponnala, Shashikanth; Babich, John W.] Weill Cornell Med, Radiophamaceut Sci, New York, NY USA; [Ponnala, Shashikanth; Babich, John W.] Weill Cornell Med, Dept Radiol, New York, NY USA; [Deri, Melissa A.] CUNY, Lehman Coll, Bronx, NY 10468 USA; [Deri, Melissa A.; Francesconi, Lynn C.; Drain, Charles Michael] CUNY, Grad Ctr, Chem Program, New York, NY 10016 USA in 2019.0, Cited 14.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Recommanded Product: 104-10-9

The bifunctional ligand p-SCN-Bn-HOPO, which has four 1,2-hydroxypyridinone groups on a spermine backbone with an isothiocyanate linker, has been shown to be an efficient and stable chelator for Zr(iv) and, more importantly, the radioisotope Zr-89 for use in radiolabeling antibodies for positron emission tomography (PET) imaging. Previous studies of Zr-89-HOPO-trastuzumab in mice showed low background, good tumor to organ contrast, and very low bone uptake which show p-SCN-Bn-HOPO to be an important next-generation bifunctional chelator for radioimmunoPET imaging with Zr-89. However, the reported synthesis of p-SCN-Bn-HOPO involves nine steps and multiple HPLC purifications with an overall yield of about 1.4%. Herein we report an improved and efficient synthesis of p-SCN-Bn-HOPO in four steps with 14.3% overall yield which will improve its availability for further biological studies and wider application in PET imaging. The new synthetic route also allows variation in linker length and chemistries which may be helpful in modifying in vivo clearance behaviors of future agents.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Bhupathiraju, NVSDK; Younes, A; Cao, MH; Ali, J; Cicek, HT; Tully, KM; Ponnala, S; Babich, JW; Deri, MA; Lewis, JS; Francesconi, LC; Drain, CM or concate me.. Recommanded Product: 104-10-9

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Amide – Wikipedia,
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Biagini, C; Fielden, SDP; Leigh, DA; Schaufelberger, F; Di Stefano, S; Thomas, D in [Biagini, Chiara; Fielden, Stephen D. P.; Leigh, David A.; Schaufelberger, Fredrik; Thomas, Dean] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England; [Biagini, Chiara; Di Stefano, Stefano] Univ Roma La Sapienza, Dipartimento Chim, Edificio Cannizzaro VEC,Piazzale Aldo Moro 5, I-00185 Rome, Italy published Dissipative Catalysis with a Molecular Machine in 2019.0, Cited 70.0. Quality Control of 2-(4-Aminophenyl)ethanol. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

We report on catalysis by a fuel-induced transient state of a synthetic molecular machine. A [ 2] rotaxane molecular shuttle containing secondary ammonium/amine and thiourea stations is converted between catalytically inactive and active states by pulses of a chemical fuel (trichloroacetic acid), which is itself decomposed by the machine and/or the presence of additional base. The ON-state of the rotaxane catalyzes the reduction of a nitrostyrene by transfer hydrogenation. By varying the amount of fuel added, the lifetime of the rotaxane ON-state can be regulated and temporal control of catalysis achieved. The system can be pulsed with chemical fuel several times in succession, with each pulse activating catalysis for a time period determined by the amount of fuel added. Dissipative catalysis by synthetic molecular machines has implications for the future design of networks that feature communication and signaling between the components.

Welcome to talk about 104-10-9, If you have any questions, you can contact Biagini, C; Fielden, SDP; Leigh, DA; Schaufelberger, F; Di Stefano, S; Thomas, D or send Email.. Quality Control of 2-(4-Aminophenyl)ethanol

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An article Antiplatelet activity and TNF- release inhibition of phthalimide derivatives useful to treat sickle cell anemia WOS:000472968400013 published article about NECROSIS-FACTOR-ALPHA; PHARMACOLOGICAL EVALUATION; HYBRID COMPOUNDS; PLATELETS; DESIGN; ASSAY in [Chelucci, Rafael C.; de Oliveira, Isabela J.; Barbieri, Karina P.; Polesi, Marisa C.; Chiba, Diego E.; Carlos, Iracilda Z.; Dos Santos, Jean L.; Chung, ManChin] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara, SP, Brazil; [Lopes-Pires, Maria E.; Marcondes, Sisi] State Univ Campinas Unicamp, Fac Med Sci, Campinas, SP, Brazil in 2019.0, Cited 24.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Computed Properties of C8H11NO

Sickle Cell Anemia (SCA) is one of the most prevalent hereditary hematological diseases worldwide. The disease is characterized by chronic inflammation, hypercoagulable state, and pro-thrombotic profile, which lead the vaso-occlusive process. In this work, we described the antiplatelet activity and the ability to reduce tumor necrosis factor-alpha (TNF-) levels of phthalimide derivatives. All compounds inhibited platelet aggregation induced by collagen and adenosine diphosphate, at levels ranging from 26.0 to 74.2% and 30.7 to 79.6%, respectively. The compounds exhibited reduced bleeding time compared to acetylsalicylic acid (ASA). Moreover, compounds 4c and 10c inhibited TNF- levels at 73.5% and 65.0%, respectively. These findings suggest that phthalimide derivatives 4c and 10c are promising lead compounds useful to prevent vaso-occlusion and inflammation associated with the sickle cell anemia. [GRAPHICS] .

Computed Properties of C8H11NO. Welcome to talk about 104-10-9, If you have any questions, you can contact Chelucci, RC; de Oliveira, IJ; Barbieri, KP; Lopes-Pires, ME; Polesi, MC; Chiba, DE; Carlos, IZ; Marcondes, S; Dos Santos, JL; Chung, MC or send Email.

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Recently I am researching about IMAGING AGENTS, Saw an article supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [CIFMS 2016-I2M-3-022, 2017-I2M-3-019]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [3332018117]; Science and Technology Project of Tianjin, China [18ZXXYSY00110]; Natural Science Foundation of Tianjin, ChinaNatural Science Foundation of Tianjin [18JCQNJC09500]. Formula: C8H11NO. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Jia, JH; Wei, HQ; Duan, YQ; Ning, HX; Yu, J; Zhu, Y; Hou, WB; Li, YL. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol

An improved five-step synthesis of triethylene glycol-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine (6) is described. Using cost-effective starting materials, the developed synthesis route was synthetic, efficient, and chromatographic purification-free. The key point of the work is the one-pot synthesis of tert-butyl methyl(4-vinylphenyl)carbamate through methylation and elimination in the NaH/THF system. The new synthesis route shows the potential to achieve scaled-up preparation of 6 in the future.

Formula: C8H11NO. Welcome to talk about 104-10-9, If you have any questions, you can contact Jia, JH; Wei, HQ; Duan, YQ; Ning, HX; Yu, J; Zhu, Y; Hou, WB; Li, YL or send Email.

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Name: 2-(4-Aminophenyl)ethanol. Authors Fronczak, M; Kasprzak, A; Bystrzejewski, M in ELSEVIER SCI LTD published article about in [Fronczak, Maciej; Bystrzejewski, Michal] Univ Warsaw, Fac Chem, Pasteura 1 Str, PL-02093 Warsaw, Poland; [Fronczak, Maciej] Lodz Univ Technol, Fac Proc & Environm Engn, Wolczanska 213 Str, PL-90924 Lodz, Poland; [Kasprzak, Artur] Warsaw Univ Technol, Fac Chem, Noakowskiego 3 Str, PL-00664 Warsaw, Poland in 2021.0, Cited 39.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

A novel easy-to-prepare magnetic catalyst, composed of palladium nanoparticles supported on surface-oxidized carbon-encapsulated iron nanoparticles, has been synthesized. The synthesis involved the reduction of palladium precursor in the presence of magnetic core-shell nanomaterial. The size of the palladium nanoparticles distributed over the support does not exceed 15 nm. The catalytic performance of this composite material was tested in hydrogenation of seven various nitro compounds to the respective amino derivatives. The composite exhibits excellent catalytic activity and can be easily separated from the reaction mixture after the reaction. The determined reaction yields were above 90 % and this value was not worsened even after ten cycles, for the case of hydrogenation of nitrobenzene. Importantly, the method is chromatography-free and employs the ammonium formate as a hydrogen source, which makes the herein presented protocol safer in comparison with the previously reported reductions in which highly dangerous gaseous hydrogen was used.

Welcome to talk about 104-10-9, If you have any questions, you can contact Fronczak, M; Kasprzak, A; Bystrzejewski, M or send Email.. Name: 2-(4-Aminophenyl)ethanol

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Amide – Wikipedia,
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Application In Synthesis of 2-(4-Aminophenyl)ethanol. Ito, T; Shiota, R; Taniguchi, N; Spontak, RJ; Nagai, K in [Ito, Tsubasa; Shiota, Ryunosuke; Taniguchi, Naomi; Nagai, Kazukiyo] Meiji Univ, Dept Appl Chem, Tama Ku, 1-1-1 Higashi Mita, Kawasaki, Kanagawa 2148571, Japan; [Spontak, Richard J.] North Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA; [Spontak, Richard J.] North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA published Gas-separation and physical properties of ABA triblock copolymers synthesized from polyimide and hydrophilic adamantane derivatives in 2020.0, Cited 44.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

In this study, ABA triblock copolymers derived from 4,4′-(hexafluoroisopropylidene)-diphthalic anhydride-2,3,5,6-tetramethyl-1,4-phenylenediamine (6FDA-TeMPD; PI) and 3-hydroxy-1-adamantyl methacrylate (HAdMA) or 3,5-dihydroxy-1-adamantyl methacrylate (DHAdMA) have been synthesized via atom transfer radical polymerization to generate mechanically tough and thermally stable gas-separation membranes with composition-tunable transport properties. Due to the inherent thermodynamic incompatibility between the chemically dissimilar blocks, these two series of triblock copolymers appear microphase-separated. While the gas permeability coefficients of these triblock copolymer membranes are consistently lower than that of PI due to the reduced fractional free volume of HAdMA and DHAdMA, the solubility coefficients of the copolymers are higher than that of PI due presumably to specific interactions between the polar hydroxyl group(s) and penetrant gas molecules. These triblock copolymers synthesized from PI and hydrophilic adamantane derivatives constitute a new class of nanostructured polymeric materials possessing excellent thermomechanical properties in conjunction with designer gas-separation properties.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics