Category: 104-10-9

An article Antiplatelet activity and TNF- release inhibition of phthalimide derivatives useful to treat sickle cell anemia WOS:000472968400013 published article about NECROSIS-FACTOR-ALPHA; PHARMACOLOGICAL EVALUATION; HYBRID COMPOUNDS; PLATELETS; DESIGN; ASSAY in [Chelucci, Rafael C.; de Oliveira, Isabela J.; Barbieri, Karina P.; Polesi, Marisa C.; Chiba, Diego E.; Carlos, Iracilda Z.; Dos Santos, Jean L.; Chung, ManChin] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara, SP, Brazil; [Lopes-Pires, Maria E.; Marcondes, Sisi] State Univ Campinas Unicamp, Fac Med Sci, Campinas, SP, Brazil in 2019.0, Cited 24.0. Application In Synthesis of 2-(4-Aminophenyl)ethanol. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

Sickle Cell Anemia (SCA) is one of the most prevalent hereditary hematological diseases worldwide. The disease is characterized by chronic inflammation, hypercoagulable state, and pro-thrombotic profile, which lead the vaso-occlusive process. In this work, we described the antiplatelet activity and the ability to reduce tumor necrosis factor-alpha (TNF-) levels of phthalimide derivatives. All compounds inhibited platelet aggregation induced by collagen and adenosine diphosphate, at levels ranging from 26.0 to 74.2% and 30.7 to 79.6%, respectively. The compounds exhibited reduced bleeding time compared to acetylsalicylic acid (ASA). Moreover, compounds 4c and 10c inhibited TNF- levels at 73.5% and 65.0%, respectively. These findings suggest that phthalimide derivatives 4c and 10c are promising lead compounds useful to prevent vaso-occlusion and inflammation associated with the sickle cell anemia. [GRAPHICS] .

Application In Synthesis of 2-(4-Aminophenyl)ethanol. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Chelucci, RC; de Oliveira, IJ; Barbieri, KP; Lopes-Pires, ME; Polesi, MC; Chiba, DE; Carlos, IZ; Marcondes, S; Dos Santos, JL; Chung, MC or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Enantioselective Hydrative para-Dearomatization of Sulfonanilides by an Indanol-based Chiral Organoiodine Catalyst WOS:000641165200001 published article about HYPERVALENT IODINE REAGENTS; OXIDATIVE SPIROLACTONIZATION; SPIROCYCLIZATION; DIARYLAMINES; FLUORINATION; ANILINES; PHENOLS in [Shimazaki, Yuto; Maruoka, Keiji] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan; [Wata, Chisato; Hashimoto, Takuya] Chiba Univ, Chiba Iodine Resource Innovat Ctr, Inage Ku, 1-33 Yayoi, Chiba 2638522, Japan; [Wata, Chisato; Hashimoto, Takuya] Chiba Univ, Dept Chem, Grad Sch Sci, Inage Ku, 1-33 Yayoi, Chiba 2638522, Japan; [Maruoka, Keiji] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Panyu District, Peoples R China; [Maruoka, Keiji] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan in 2021.0, Cited 89.0. Safety of 2-(4-Aminophenyl)ethanol. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

We report herein the development of an enantioselective oxidative para-dearomatization of sulfonanilides with water by use of an indanol-based chiral organoiodine catalyst, originally developed in our group. This reaction proceeds efficiently by the use of N-mesyl-protected anilines as substrates, giving functionalized p-quinol imines in good yields and moderate to high enantioselectivities.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Shimazaki, Y; Wata, C; Hashimoto, T; Maruoka, K or concate me.. Safety of 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Ibric, A; Battisti, V; Deckardt, S; Haller, AV; Lee, C; Protsch, C; Langer, T; Heffeter, P; Schueffl, HH; Marian, B; Haider, N in PERGAMON-ELSEVIER SCIENCE LTD published article about TOPOISOMERASE-I INHIBITOR; S-PHASE; DNA; ARREST; CAMPTOTHECIN; DOXORUBICIN; INDUCTION; EFFICIENT; APOPTOSIS; DERIVATIVES in [Ibric, Amra; Battisti, Verena; Deckardt, Sophie; Haller, Anna Veronika; Lee, Calvin; Proetsch, Corinna; Langer, Thierry; Haider, Norbert] Univ Vienna, Dept Pharmaceut Chem, Althanstr 14, A-1090 Vienna, Austria; [Heffeter, Petra; Schueffl, Hemma Henrike; Marian, Brigitte] Med Univ Vienna, Inst Canc Res, Borschkegasse 8a, A-1090 Vienna, Austria; [Heffeter, Petra; Schueffl, Hemma Henrike; Marian, Brigitte] Med Univ Vienna, Comprehens Canc Ctr, Borschkegasse 8a, A-1090 Vienna, Austria in 2020.0, Cited 56.0. Formula: C8H11NO. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

A series of new Luotonin A derivatives with substituents at rings A and E was synthesized, together with some E-ring-unsubstituted derivatives. Subsequently, the compound library was examined in silico for their binding into a previously proposed site in the DNA/topoisomerase I binary complex. Whereas no convincing correlation between docking scores and biological data from in vitro assays could be found, one novel 4,9-diamino Luotonin A derivative had strong antiproliferative activity based on massive G2/M phase arrest. As this biological activity clearly differs from the reference compound Camptothecin, this strongly indicates that at least some Luotonin A derivatives may be potent antiproliferative agents, however with a different mode of action.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Ibric, A; Battisti, V; Deckardt, S; Haller, AV; Lee, C; Protsch, C; Langer, T; Heffeter, P; Schueffl, HH; Marian, B; Haider, N or concate me.. Formula: C8H11NO

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Quality Control of 2-(4-Aminophenyl)ethanol. In 2021.0 ASIAN J ORG CHEM published article about HYPERVALENT IODINE REAGENTS; OXIDATIVE SPIROLACTONIZATION; SPIROCYCLIZATION; DIARYLAMINES; FLUORINATION; ANILINES; PHENOLS in [Shimazaki, Yuto; Maruoka, Keiji] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan; [Wata, Chisato; Hashimoto, Takuya] Chiba Univ, Chiba Iodine Resource Innovat Ctr, Inage Ku, 1-33 Yayoi, Chiba 2638522, Japan; [Wata, Chisato; Hashimoto, Takuya] Chiba Univ, Dept Chem, Grad Sch Sci, Inage Ku, 1-33 Yayoi, Chiba 2638522, Japan; [Maruoka, Keiji] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Panyu District, Peoples R China; [Maruoka, Keiji] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan in 2021.0, Cited 89.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

We report herein the development of an enantioselective oxidative para-dearomatization of sulfonanilides with water by use of an indanol-based chiral organoiodine catalyst, originally developed in our group. This reaction proceeds efficiently by the use of N-mesyl-protected anilines as substrates, giving functionalized p-quinol imines in good yields and moderate to high enantioselectivities.

Quality Control of 2-(4-Aminophenyl)ethanol. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Shimazaki, Y; Wata, C; Hashimoto, T; Maruoka, K or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Modular quadruplex-duplex hybrids as biomolecular scaffolds for asymmetric Michael addition reactions WOS:000571281400005 published article about DNA; CATALYSIS; RECOGNITION in [Yum, Ji Hye; Sugiyama, Hiroshi; Park, Soyoung] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kitashirakawa Oiwakecho, Kyoto 6068502, Japan; [Sugiyama, Hiroshi] Kyoto Univ, Inst Integrated Cell Mat Sci iCeMS, Sakyo Ku, Yoshida Ushinomiyacho, Kyoto 6068501, Japan in 2020.0, Cited 45.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Recommanded Product: 2-(4-Aminophenyl)ethanol

Asymmetric synthesis based on DNA scaffolds has been actively exploited because of the advantages of DNA such as diverse tertiary structures, chemical stability, and easy handling. Since duplex DNA-based hybrid catalysts have demonstrated this remarkable capability, efforts have been made to investigate new biomolecular scaffolds. Herein, we report modular quadruplex-duplex (QD) hybrid DNA catalysts containing bipyridine ligands and hydrogen donor moieties. The conformation, thermal stability, and metal-binding ability of modified QD hybrid DNA were characterized using spectroscopy. The QD hybrid-based DNA catalysts were successfully applied to asymmetric Michael addition reactions (86% conversion and 76% ee). This study describes a new type of DNA hybrid catalyst produced by the construction of a cooperative active site with a Lewis acid and a H-bond donor.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Yum, JH; Sugiyama, H; Park, S or concate me.. Recommanded Product: 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020 CHEM SCI published article about ONE-POT SYNTHESIS; FLUORESCENT-PROBES; SULFONYL; REARRANGEMENT; TACHYKININ; ALKYNES; ACCESS; FUNCTIONALIZATION; 1,2,3-TRIAZOLES; ANNULATION in [Li, Guofeng; Zhao, Man; Yao, Ying; Xu, Jiecheng; Xue, Jianzhong; Hu, Tao; Li, Min; Hong, Liang] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China; [Xie, Junqiu; Mou, Lingyun; Zhang, Xiaowei; Guo, Xiaomin; Sun, Wangsheng; Zhang, Ming] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China; [Wang, Zheng] Peking Univ, Sch Chem Biol & Biotechnol, Guangdong Key Lab Nanomicro Mat Res, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China in 2020, Cited 67. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Product Details of 104-10-9

Novel 10 pi-electron cyclic amidines with excellent fluorescence properties were synthesized by a general and efficient 6 pi-electrocyclic ring closure of ketenimine and imine starting from N-sulfonyl triazoles and arylamines. The photophysical properties of cyclic amidine fluorophores have been studied in detail and have shown good properties of a large Stokes shift, pH insensitivity, low cytotoxicity and higher photostability, which have great potential for biological imaging. Furthermore, this novel fluorophore was successfully applied to the localization of the NK-1 receptor in living systems.

Product Details of 104-10-9. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Li, GF; Zhao, M; Xie, JQ; Yao, Y; Mou, LY; Zhang, XW; Guo, XM; Sun, WS; Wang, Z; Xu, JC; Xue, JZ; Hu, T; Zhang, M; Li, M; Hong, L or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Product Details of 104-10-9. Lamaa, D; Lin, HP; Bzeih, T; Retailleau, P; Alami, M; Hamze, A in [Lamaa, Diana; Lin, Hsin-Ping; Bzeih, Tourin; Alami, Mouad; Hamze, Abdallah] Univ Paris Saclay, Univ Paris Sud, CNRS, BioCIS,Equipe Labellisee Ligue Canc, F-92290 Chatenay Malabry, France; [Retailleau, Pascal] CNRS, Inst Chim Subst Nat, UPR 2301, F-91198 Gif Sur Yvette, France published TBAB-Catalyzed Csp(3)-N Bond Formation by Coupling Pyridotriazoles with Anilines: A New Route to (2-Pyridyl)alkylamines in 2019.0, Cited 52.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

A new metal-free procedure allowing Csp(3)-N bond formation through coupling of pyridotriazoles and weakly nucleophilic anilines has been developed. This sustainable reaction shows high tolerance towards functional groups (ketones, free alcohols) leading to 2-picolylamine derivatives. The key to our success is the use of a catalytic amount of TBAB and water as a co-solvent leading to the formation of pyridylalkylamine derivatives. As this coupling tolerates the presence of Csp(2)-Br bond on both partners of the reaction, we performed a sequential one-pot reaction between functionalized triazolopyridines and anilines followed by a second coupling with N-tosylhydrazones leading to the formation of Csp(3)-N and Csp(2)-Csp(2) bonds.

Product Details of 104-10-9. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Lamaa, D; Lin, HP; Bzeih, T; Retailleau, P; Alami, M; Hamze, A or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 BIOORGAN MED CHEM published article about TOPOISOMERASE-I INHIBITOR; S-PHASE; DNA; ARREST; CAMPTOTHECIN; DOXORUBICIN; INDUCTION; EFFICIENT; APOPTOSIS; DERIVATIVES in [Ibric, Amra; Battisti, Verena; Deckardt, Sophie; Haller, Anna Veronika; Lee, Calvin; Proetsch, Corinna; Langer, Thierry; Haider, Norbert] Univ Vienna, Dept Pharmaceut Chem, Althanstr 14, A-1090 Vienna, Austria; [Heffeter, Petra; Schueffl, Hemma Henrike; Marian, Brigitte] Med Univ Vienna, Inst Canc Res, Borschkegasse 8a, A-1090 Vienna, Austria; [Heffeter, Petra; Schueffl, Hemma Henrike; Marian, Brigitte] Med Univ Vienna, Comprehens Canc Ctr, Borschkegasse 8a, A-1090 Vienna, Austria in 2020.0, Cited 56.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Product Details of 104-10-9

A series of new Luotonin A derivatives with substituents at rings A and E was synthesized, together with some E-ring-unsubstituted derivatives. Subsequently, the compound library was examined in silico for their binding into a previously proposed site in the DNA/topoisomerase I binary complex. Whereas no convincing correlation between docking scores and biological data from in vitro assays could be found, one novel 4,9-diamino Luotonin A derivative had strong antiproliferative activity based on massive G2/M phase arrest. As this biological activity clearly differs from the reference compound Camptothecin, this strongly indicates that at least some Luotonin A derivatives may be potent antiproliferative agents, however with a different mode of action.

Product Details of 104-10-9. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Ibric, A; Battisti, V; Deckardt, S; Haller, AV; Lee, C; Protsch, C; Langer, T; Heffeter, P; Schueffl, HH; Marian, B; Haider, N or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Quality Control of 2-(4-Aminophenyl)ethanol. Recently I am researching about PROLIFERATOR-ACTIVATED RECEPTORS; GAMMA MODULATOR; FATTY-ACIDS; BINDING; IDENTIFICATION, Saw an article supported by the Japan Society for the Promotion of Science [KAKENHI]Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [17K13264]. Published in MDPI in BASEL ,Authors: Utsugi, Y; Kobuchi, H; Kawamura, Y; Atito, ASA; Nagao, M; Isoda, H; Miyamae, Y. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol

Covalent agonists of PPAR cause unique receptor conformational changes and behave as selective PPAR modulators, whereas there are few covalent agonists other than endogenous unsaturated fatty acids metabolites. Previously, we established a cell-based strategy to identify new PPAR ligands and synthesized a new-type of covalent agonist that possesses the hybrid structure of a plant-derived cinnamic acid derivative and GW9662, a covalent antagonist. Herein, we report six analogues that differ in how the two fragments are linked together. Compounds with a simplified linker showed potent agonistic activity with improved EC50 values (less than 5 nM), indicating that close proximity between the two fragments improves binding affinity. When the position of cinnamic acid moiety was placed at 4 carbon of aniline ring, PPAR agonist activity was completely abolished. Docking studies suggested that the activation profile likely depends on interaction with the cavity around helix 3, -sheet, and -loop region in the ligand-binding domain. Furthermore, a cell-based assay revealed that agonist-type compounds activate PPAR transcription in a manner dependent on covalent linkage with the Cys285 residue leading to prolonged transactivation. This activation feature reflects pharmacological benefits of covalent drugs, suggesting that these hybrid compounds may serve as potential leads for a new-class of covalent PPAR ligands.

Quality Control of 2-(4-Aminophenyl)ethanol. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Utsugi, Y; Kobuchi, H; Kawamura, Y; Atito, ASA; Nagao, M; Isoda, H; Miyamae, Y or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about STRESS-MEDIATED APOPTOSIS; THIOREDOXIN REDUCTASE; ARSENIC-BINDING; CELLS; DESIGN; QUANTIFICATION; IDENTIFICATION; FLUOROGENS; CONVERSION; THIOLS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21778028]; Ministry of Science and Technology National Key RD Project [2018YFE0205100]; Natural Science Foundation of Gansu Province [18JR4RA003]; 111 projectMinistry of Education, China – 111 Project. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Hu, GD; Jia, HY; Hou, YN; Han, X; Gan, L; Si, J; Cho, DH; Zhang, H; Fang, JG. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol. Computed Properties of C8H11NO

Vicinal dithiol-containing proteins (VDPs) play an important role in maintaining the structures and functions of proteins mainly through the conversion between dithiols and disulfide bonds. The content of VDPs also reflects the redox status of an organism. To specifically and expediently detect VDPs, we developed a turn-on monoarsenical fluorescent probe (NEP) based on the intramolecular charge transfer mechanism. Naphthalimide was chosen as a fluorophore and linked with the receptor moiety (cyclic dithiarsolane) via carbamate segment. In the presence of VDPs, NEP displays a strong green fluorescence signal produced by the cyclic dithiarsolane cleavage and subsequent intramolecular cyclization to liberate the fluorophore. Furthermore, NEP exhibits high selectivity toward VDPs over other protein thiols and low molecular weight thiols. The favorable properties of NEP enable it readily to detect VDPs in live cells and in vivo. In addition, a remarkable decrease of VDPs in parkinsonism was disclosed for the first time, highlighting that regulating VDPs level has a therapeutic potential for parkinsonism.

Computed Properties of C8H11NO. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Hu, GD; Jia, HY; Hou, YN; Han, X; Gan, L; Si, J; Cho, DH; Zhang, H; Fang, JG or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics