Category: 104-10-9

I found the field of Pharmacology & Pharmacy very interesting. Saw the article 6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis published in 2020.0. Quality Control of 2-(4-Aminophenyl)ethanol, Reprint Addresses Hoehn, KL (corresponding author), Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA.; Hoehn, KL (corresponding author), Univ Virginia, Dept Med, Charlottesville, VA 22908 USA.; Hoehn, KL (corresponding author), Univ New South Wales, Sch Biotechnol & Biomol Sci, Kensington, NSW 2033, Australia.; Santos, WL (corresponding author), Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA.; Santos, WL (corresponding author), Virginia Tech, Virginia Tech Ctr Drug Discovery, Blacksburg, VA 24061 USA.. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol

Small molecule mitochondrial uncouplers have recently garnered great interest for their potential in treating nonalcoholic steatohepatitis (NASH). In this study, we report the structure-activity relationship profiling of a 6-amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol core, which utilizes the hydroxy moiety as the proton transporter across the mitochondrial inner membrane. We demonstrate that a wide array of substituents is tolerated with this novel scaffold that increased cellular metabolic rates in vitro using changes in oxygen consumption rate as a readout. In particular, compound SHS4121705 (12i) displayed an EC50 of 4.3 mu M in L6 myoblast cells and excellent oral bioavailability and liver exposure in mice. In the STAM mouse model of NASH, administration of 12i at 25 mg kg(-1) day(-1) lowered liver triglyceride levels and improved liver markers such as alanine aminotransferase, NAFLD activity score, and fibrosis. Importantly, no changes in body temperature or food intake were observed. As potential treatment of NASH, mitochondrial uncouplers show promise for future development.

Quality Control of 2-(4-Aminophenyl)ethanol. Welcome to talk about 104-10-9, If you have any questions, you can contact Salamoun, JM; Garcia, CJ; Hargett, SR; Murray, JH; Chen, SY; Beretta, M; Alexopoulos, SJ; Shah, DP; Olzomer, EM; Tucker, SP; Hoehn, KL; Santos, WL or send Email.

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Amide – Wikipedia,
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An article Rh(III)-catalyzed N-nitroso-directed C-H olefination polymerization WOS:000466806100018 published article about INDOLE SYNTHESIS; ORTHO-ACYLATION; NITROSOANILINES; BOND; POLYMERS; ACTIVATION; ARYLATION; METAL; ACIDS in [Liu, Zhongsu; Zeng, Hua; Zhang, Wenjing; Song, Chao; Yang, Fan; Liu, Yun; Zhu, Jin] Nanjing Univ, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China in 2019.0, Cited 42.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Product Details of 104-10-9

Transition metal-catalyzed directed C-H functionalization promises a straightforward route to polymerization but remains highly underexplored. We report herein the development of a polymer synthesis protocol based on Rh(III)-catalyzed N-nitroso-directed C-H olefination reaction. The single bifunctional monomer approach allows the high-yield generation of polymers with relatively narrow PDI under mild conditions. Further convenient denitrosation transformation furnishes responsive fluorescent polymers with metal ion-selective quenching behaviors. The high Hg2+ selectivity observed in one system provides a handy enabling tool for detecting this hazardous species.

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Authors Liu, ZS; Zeng, H; Zhang, WJ; Song, C; Yang, F; Liu, Y; Zhu, J in ELSEVIER SCI LTD published article about INDOLE SYNTHESIS; ORTHO-ACYLATION; NITROSOANILINES; BOND; POLYMERS; ACTIVATION; ARYLATION; METAL; ACIDS in [Liu, Zhongsu; Zeng, Hua; Zhang, Wenjing; Song, Chao; Yang, Fan; Liu, Yun; Zhu, Jin] Nanjing Univ, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China in 2019.0, Cited 42.0. HPLC of Formula: C8H11NO. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

Transition metal-catalyzed directed C-H functionalization promises a straightforward route to polymerization but remains highly underexplored. We report herein the development of a polymer synthesis protocol based on Rh(III)-catalyzed N-nitroso-directed C-H olefination reaction. The single bifunctional monomer approach allows the high-yield generation of polymers with relatively narrow PDI under mild conditions. Further convenient denitrosation transformation furnishes responsive fluorescent polymers with metal ion-selective quenching behaviors. The high Hg2+ selectivity observed in one system provides a handy enabling tool for detecting this hazardous species.

Welcome to talk about 104-10-9, If you have any questions, you can contact Liu, ZS; Zeng, H; Zhang, WJ; Song, C; Yang, F; Liu, Y; Zhu, J or send Email.. HPLC of Formula: C8H11NO

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Recommanded Product: 104-10-9. In 2020 BIOCONJUGATE CHEM published article about CATALYZED AMINATION; BOND FORMATION; PALLADIUM; PD; SELECTION; DESIGN; DISCOVERY; LIGANDS; WATER in [Chen, Ying-Chu; Faver, John C.; Ku, Angela F.; Miklossy, Gabriella; Riehle, Kevin; Bohren, Kurt M.; Ucisik, Melek N.; Matzuk, Martin M.; Yu, Zhifeng; Simmons, Nicholas] Baylor Coll Med, Ctr Drug Discovery, Dept Pathol & Immunol, Houston, TX 77030 USA in 2020, Cited 54. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

DNA-encoded chemical library (DECL) screens are a rapid and economical tool to identify chemical starting points for drug discovery. As a robust transformation for drug discovery, palladium-catalyzed C-N coupling is a valuable synthetic method for the construction of DECL chemical matter; however, currently disclosed methods have only been demonstrated on DNA-attached (hetero)aromatic iodide and bromide electrophiles. We developed conditions utilizing an N-heterocyclic carbene-palladium catalyst that extends this reaction to the coupling of DNA-conjugated (hetero)aromatic chlorides with (hetero)aromatic and select aliphatic amine nucleophiles. In addition, we evaluated steric and electronic effects within this catalyst series, carried out a large substrate scope study on two representative (hetero)aryl bromides, and applied this newly developed method within the construction of a 63 million-membered DECL.

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Amide – Wikipedia,
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Recently I am researching about TOPOISOMERASE-I INHIBITOR; S-PHASE; DNA; ARREST; CAMPTOTHECIN; DOXORUBICIN; INDUCTION; EFFICIENT; APOPTOSIS; DERIVATIVES, Saw an article supported by the . Product Details of 104-10-9. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Ibric, A; Battisti, V; Deckardt, S; Haller, AV; Lee, C; Protsch, C; Langer, T; Heffeter, P; Schueffl, HH; Marian, B; Haider, N. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol

A series of new Luotonin A derivatives with substituents at rings A and E was synthesized, together with some E-ring-unsubstituted derivatives. Subsequently, the compound library was examined in silico for their binding into a previously proposed site in the DNA/topoisomerase I binary complex. Whereas no convincing correlation between docking scores and biological data from in vitro assays could be found, one novel 4,9-diamino Luotonin A derivative had strong antiproliferative activity based on massive G2/M phase arrest. As this biological activity clearly differs from the reference compound Camptothecin, this strongly indicates that at least some Luotonin A derivatives may be potent antiproliferative agents, however with a different mode of action.

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An article Decrease of Protein Vicinal Dithiols in Parkinsonism Disclosed by a Monoarsenical Fluorescent Probe WOS:000526563900028 published article about STRESS-MEDIATED APOPTOSIS; THIOREDOXIN REDUCTASE; ARSENIC-BINDING; CELLS; DESIGN; QUANTIFICATION; IDENTIFICATION; FLUOROGENS; CONVERSION; THIOLS in [Hu, Guodong; Jia, Huiyi; Hou, Yanan; Han, Xiao; Fang, Jianguo] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China; [Gan, Lu; Si, Jing; Zhang, Hong] Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Gansu, Peoples R China; [Cho, Dong-Hyung] Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea in 2020.0, Cited 53.0. Application In Synthesis of 2-(4-Aminophenyl)ethanol. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

Vicinal dithiol-containing proteins (VDPs) play an important role in maintaining the structures and functions of proteins mainly through the conversion between dithiols and disulfide bonds. The content of VDPs also reflects the redox status of an organism. To specifically and expediently detect VDPs, we developed a turn-on monoarsenical fluorescent probe (NEP) based on the intramolecular charge transfer mechanism. Naphthalimide was chosen as a fluorophore and linked with the receptor moiety (cyclic dithiarsolane) via carbamate segment. In the presence of VDPs, NEP displays a strong green fluorescence signal produced by the cyclic dithiarsolane cleavage and subsequent intramolecular cyclization to liberate the fluorophore. Furthermore, NEP exhibits high selectivity toward VDPs over other protein thiols and low molecular weight thiols. The favorable properties of NEP enable it readily to detect VDPs in live cells and in vivo. In addition, a remarkable decrease of VDPs in parkinsonism was disclosed for the first time, highlighting that regulating VDPs level has a therapeutic potential for parkinsonism.

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Computed Properties of C8H11NO. In 2019.0 ACS MED CHEM LETT published article about BINDING; MECHANISMS; INSIGHTS; ACID in [Giampietro, Letizia; Florio, Rosalba; Recinella, Lucia; Ammazzalorso, Alessandra; Bruno, Isabella; De Filippis, Barbara; Fantacuzzi, Marialuigia; Ferrante, Claudio; Maccallini, Cristina; Verginelli, Fabio; Brunetti, Luigi; Cama, Alessandro; Amoroso, Rosa] Univ G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Laghezza, Antonio; Tortorella, Paolo; Loiodice, Fulvio] Univ Bari Aldo Moro, Dept Pharm Drug Sci, Via E Orabona 4, I-70126 Bari, Italy; [Cerchia, Carmen; Capone, Fabio; Lavecchia, Antonio] Univ Napoli Federico II, Drug Discovery Lab, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy; [Florio, Rosalba; Verginelli, Fabio; Cama, Alessandro] Univ G dAnnunzio, Ctr Aging Sci & Translat Med CeSI MeT, Via Luigi Polacchi 11, I-66100 Chieti, Italy in 2019.0, Cited 30.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

The development of PPAR alpha/gamma dual or PPAR alpha/gamma/S pan-agonists could represent an efficacious approach for a simultaneous pharmacological intervention on carbohydrate and lipid metabolism. Two series of new phenyldiazenyl fibrate derivatives of GL479, a previously reported PPAR alpha/gamma dual agonist, were synthesized and tested. Compound 12a was identified as a PPAR pan-agonist with moderate and balanced activity on the three PPAR isoforms (alpha, gamma, delta). Moreover, docking experiments showed that 12a adopts a different binding mode in PPARy compared to PPARa or PPARS, providing a structural basis for further structure-guided design of PPAR pan-agonists. The beneficial effects of 12a were evaluated both in vitro, on the expression of PPAR target key metabolic genes, and ex vivo in two rat tissue inflammatory models. The obtained results allow considering this compound as an interesting lead for the development of a new class of PPAR pan-agonists endowed with an activation profile exploitable for therapy of metabolic syndrome.

Welcome to talk about 104-10-9, If you have any questions, you can contact Giampietro, L; Laghezza, A; Cerchia, C; Florio, R; Recinella, L; Capone, F; Ammazzalorso, A; Bruno, I; De Filippis, B; Fantacuzzi, M; Ferrante, C; Maccallini, C; Tortorella, P; Verginelli, F; Brunetti, L; Cama, A; Amoroso, R; Loiodice, F; Lavecchia, A or send Email.. Computed Properties of C8H11NO

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In 2020.0 EUR POLYM J published article about TRANSFER RADICAL POLYMERIZATION; CARBON NANOTUBES; CLICK CHEMISTRY; DISPERSED GRAPHENE; ORGANIC-SYNTHESIS; VISIBLE-LIGHT; SURFACE; NANOCOMPOSITES; NANOPARTICLES; BRUSHES in [Railian, Svitlana; Maes, Lowie; Junkers, Tanja] UHasselt Inst Mat Res, Polymer React Design Grp, Agoralaan, B-3590 Diepenbeek, Belgium; [Haven, Joris J.; Junkers, Tanja] Monash Univ, Sch Chem, 19 Rainforest Walk, Clayton, Vic 3800, Australia; [De Sloovere, Dries; Van Bael, Marlies K.; Hardy, An] UHasselt Inst Mat Res, Inorgan & Phys Chem, Agoralaan, B-3590 Diepenbeek, Belgium; [De Sloovere, Dries; Van Bael, Marlies K.; Hardy, An] Energyville, Thor Pk 8320, B-3600 Genk, Belgium; [De Sloovere, Dries; Adriaensens, Peter; Van Bael, Marlies K.; Hardy, An; Deferme, Wim] IMEC Vzw Div IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium; [Trouillet, Vanessa] Karlsruhe Inst Technol KIT, Inst Appl Mat IAM, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany; [Trouillet, Vanessa; Welle, Alexander] Karlsruhe Inst Technol KIT, Karlsruhe Nano Micro Facil KNMF, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany; [Welle, Alexander] Karlsruhe Inst Technol KIT, Inst Funct Interfaces, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany; [Adriaensens, Peter] UHasselt Inst Mat Res, Nucl Magnet Resonance Spect Grp, Agoralaan, B-3590 Diepenbeek, Belgium; [Deferme, Wim] UHasselt Inst Mat Res, Wetenschapspk 1, B-3590 Diepenbeek, Belgium in 2020.0, Cited 84.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Recommanded Product: 2-(4-Aminophenyl)ethanol

The preparation of well-dispersed graphene/polymer nanocomposites is challenging due to the poor miscibility of graphene sheets in a polymer matrix. To enhance the interaction between both phases, graphene sheets can be decorated with polymer chains. Herein, different strategies to graft poly(methyl methacrylate) (PMMA) and poly(di(ethylene glycol) ethyl ether acrylate) (PDEGA) chains at various positions on graphene oxide and reduced graphene oxide (GO/rGO) sheets are compared. Chain attachment was achieved by grafting-to and grafting-from methods. Grafting-to was performed by classical copper (I)-catalyzed alkyne azide cycloaddition. Using a grafting-from approach, PMMA and PDEGA brushes were grown from GO and rGO sheets via surface-initiated photo-induced copper-mediated polymerization (SI-photoCMP). SI-photoCMP is a robust and efficient method that allows polymerizations to be carried out under mild conditions and with reduced catalyst concentration. Moreover, the successful implementation of SI-photoCMP in a continuous-flow set-up enables easy upscaling of the system and is, therefore, a more efficient and environmentally friendly process for GO/rGO surface modification. By using the grafting-to approach, the grafting density of PMMA (M-n = 2,600 g/mol) was one chain per 990 carbons of graphene. In contrast, longer PMMA chains (M-n = 40,300 g/mol) and higher grafting density were obtained via the grafting-from method (one PMMA chain per 140 carbons of graphene).

Welcome to talk about 104-10-9, If you have any questions, you can contact Railian, S; Haven, JJ; Maes, L; De Sloovere, D; Trouillet, V; Welle, A; Adriaensens, P; Van Bael, MK; Hardy, A; Deferme, W; Junkers, T or send Email.. Recommanded Product: 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
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Quality Control of 2-(4-Aminophenyl)ethanol. Utsugi, Y; Kobuchi, H; Kawamura, Y; Atito, ASA; Nagao, M; Isoda, H; Miyamae, Y in [Utsugi, Yuki] Univ Tsukuba, Coll Agrobiol Resources Sci, Tsukuba, Ibaraki 3058572, Japan; [Utsugi, Yuki; Atito, Ahmed Salahelden Aboelhamd; Isoda, Hiroko; Miyamae, Yusaku] Univ Tsukuba, Sch Integrat & Global Majors, Masters Doctoral Program Life Sci Innovat, Tsukuba, Ibaraki 3058572, Japan; [Kobuchi, Hirona; Kawamura, Yukio] Kyoto Womens Univ, Fac Home Econ, Dept Food & Nutr, Kyoto 6058501, Japan; [Nagao, Masaya; Miyamae, Yusaku] Kyoto Univ, Grad Sch Biostudies, Kyoto 6068502, Japan; [Isoda, Hiroko] Univ Tsukuba, Alliance Res Mediterranean & North Africa, Tsukuba, Ibaraki 3058572, Japan; [Isoda, Hiroko; Miyamae, Yusaku] Univ Tsukuba, Fac Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan published Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPAR Agonists in 2019.0, Cited 27.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

Covalent agonists of PPAR cause unique receptor conformational changes and behave as selective PPAR modulators, whereas there are few covalent agonists other than endogenous unsaturated fatty acids metabolites. Previously, we established a cell-based strategy to identify new PPAR ligands and synthesized a new-type of covalent agonist that possesses the hybrid structure of a plant-derived cinnamic acid derivative and GW9662, a covalent antagonist. Herein, we report six analogues that differ in how the two fragments are linked together. Compounds with a simplified linker showed potent agonistic activity with improved EC50 values (less than 5 nM), indicating that close proximity between the two fragments improves binding affinity. When the position of cinnamic acid moiety was placed at 4 carbon of aniline ring, PPAR agonist activity was completely abolished. Docking studies suggested that the activation profile likely depends on interaction with the cavity around helix 3, -sheet, and -loop region in the ligand-binding domain. Furthermore, a cell-based assay revealed that agonist-type compounds activate PPAR transcription in a manner dependent on covalent linkage with the Cys285 residue leading to prolonged transactivation. This activation feature reflects pharmacological benefits of covalent drugs, suggesting that these hybrid compounds may serve as potential leads for a new-class of covalent PPAR ligands.

Quality Control of 2-(4-Aminophenyl)ethanol. Welcome to talk about 104-10-9, If you have any questions, you can contact Utsugi, Y; Kobuchi, H; Kawamura, Y; Atito, ASA; Nagao, M; Isoda, H; Miyamae, Y or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Quality Control of 2-(4-Aminophenyl)ethanol. Recently I am researching about WEAR BEHAVIOR; FRICTION; NANOCOMPOSITES; POLYIMIDE, Saw an article supported by the . Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Su, C; Xue, F; Xu, FL; Li, TS; Xin, YS; Wang, MM. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol

To improve the wear resistance of carbon fabric reinforced polyimide (CF/PI) composite, surface-modified graphene (MG) was synthesized and employed as a filler. The flexural strength, Rockwell hardness and thermal properties of the composites were tested. The composites were also evaluated for their tribological properties in a ring-on-block contact mode under dry sliding conditions. The results showed that the wear rate of MG reinforced CF/PI composites was reduced when compared to unfilled CF/PI composite. It was found that the 1 wt% MG filled CF/PI composites exhibited the optimal tribological properties. The worn surface, wear debris and transfer films were analyzed by scanning electron microscopy (SEM) and optical microscopy (OM) with the results helping to characterize the wear mechanism.

Quality Control of 2-(4-Aminophenyl)ethanol. Welcome to talk about 104-10-9, If you have any questions, you can contact Su, C; Xue, F; Xu, FL; Li, TS; Xin, YS; Wang, MM or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics