Category: 1453-82-3

Merlo, Thais Cardoso published the artcileRelationship between volatile organic compounds, free amino acids, and sensory profile of smoked bacon, Synthetic Route of 1453-82-3, the publication is Meat Science (2021), 108596, database is CAplus and MEDLINE.

Flavor is one of the most important characteristics of smoked bacon, strongly affecting its liking by consumers. The smoking process, lipid oxidation and proteolysis contribute to bacon quality through the generation of odors and flavor compounds In this study, the relationships between free amino acids (FAAs), volatile organic compounds (VOCs) and sensory characteristics of smoked bacon stored for 60 days at 5°C were investigated. Smoked bacon stored for 30 days was characterized by VOCs associated with the smoking process and lipid oxidation After 30 days of storage, the bacon samples presented an increase in FAAs produced mainly by proteolysis. Smoked bacon was characterized by the attributes smoky, crunchy, salty, soft and bright. This study demonstrated that VOCs, FAAs and their interactions are responsible for generating sensory attributes and increasing overall liking.

Meat Science published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Synthetic Route of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Hongji published the artcileBergenin-isonicotinamide (1:1) cocrystal with enhanced solubility and investigation of its solubility behavior, SDS of cas: 1453-82-3, the publication is Journal of Drug Delivery Science and Technology (2021), 102556, database is CAplus.

Bergenin (BER) is a bioactive compound used for the treatment of chronic bronchitis in China. However, its low solubility and permeation limits its oral bioavailability. In this study, a new BER: isonicotinamide (ISN) cocrystal (1: 1, molar ratio) was reported for the first time. BER-ISN shows better solubility and intrinsic dissolution rates (IDRs) in aqueous medias such as water, buffer solutions with pH = 1.2, 4.5, and 6.8 in comparison to BER monohydrate. For instance, the solubilities of BER-ISN and BER monohydrate in water were 3.72 ± 0.22 and 1.42 ± 0.006 mg/mL, resp., showing 2.62 times improvement. IDRs of BER-ISN and BER monohydrate were 29.90 ± 0.04 and 18.64 ± 0.27 mg/min/cm₂, resp., which was consistent with the solubility results. To explain the solubility behavior, phase solubility diagrams of BER monohydrate, ISN and BER-ISN in three pure organic solvents (ethanol, isopropanol and Et acetate) were performed according to the solubility product (Ksp) and complexes formation (K11) theory. The predicted solubilities are consistent with exptl. solubilities considering complexation effects. The Hildebrand solubility parameter (HSP) calculations support the results. Thus, BER-ISN cocrystal (1: 1) with improved solubility is a good candidate for further formulation development.

Journal of Drug Delivery Science and Technology published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, SDS of cas: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Li, Jianting published the artcileStructural landscape investigations on bendable plastic crystals of isonicotinamide polymorphs, Related Products of amides-buliding-blocks, the publication is Chinese Chemical Letters, database is CAplus.

Three polymorphs (forms I, II and V) of isonicotinamide (INA) were mech. flexible and exhibited 1-dimensional (1D) plasticity. Anisotropic intermol. interactions contribute to the plasticity of single crystals: weak dispersive interactions between slip planes such as 1D columns in forms I and II or 2D layers in form V were stabilized by strong H bonds, allowing the layer or column′s surface to glide smoothly without hindrance. The disparity of intermol. interactions on plastic properties of INA polymorphic crystals was confirmed by energy framework anal., nanoindentation tests and micro-Raman spectroscopy.

Chinese Chemical Letters published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Threlfall, T. published the artcileThe infrared spectra of amides. Part 1. The stretching vibrations of primary carboxamides, Category: amides-buliding-blocks, the publication is Vibrational Spectroscopy (2022), 103386, database is CAplus.

The IR spectra of more than 150 primarycarboxamides in the NH stretching and the carbonyl region have been measured. Comparison is made with Bellamys anal. of the stretching modes of amines. The offset to higher frequencies of amides compared with amines is attributed to the widening of the bond angle. The sym. and antisym. stretching of the NH₂ bonds is analyzed via a rearrangement of the Linnett equations. It is shown thereby that changes of bond strength vary the sym. and antisym. frequencies approx. proportionately while deviations from that relationship are due either to changes of the bond angle, steric hindrance or to hydrogen bonding. The spectral changes of m- and p-substituted amides are correlated with Hammett sigma functions, both in the carbonyl and the NH2 stretching region. Intensities and the influence of steric effects are also discussed.

Vibrational Spectroscopy published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C48H47FeP, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shiau, Lie-Ding published the artcileComparison of the Nucleation Kinetics Obtained from the Cumulative Distributions of the Metastable Zone Width and Induction Time Data, Product Details of C6H6N2O, the publication is Molecules (2022), 27(9), 3007, database is CAplus and MEDLINE.

A linearized integral model based on classical nucleation theory is applied in this work to determine the interfacial energy and pre-exponential factor using a linear plot from the cumulative distributions of the metastable zone width (MSZW) data for some systems reported in the literature, including isonicotinamide, Bu paraben, dicyandiamide, and salicylic acid. Based on the same criterion for the nucleation point, the interfacial energy and pre-exponential factor are determined using the conventional linear regression method from the cumulative distributions of the induction time data for the same systems. The results indicate that the interfacial energy and pre-exponential factor calculated from the MSZW data are consistent with those calculated from the induction time for the studied systems.

Molecules published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C16H23BO4, Product Details of C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Perlovich, German L. published the artcilePrediction of solubility of two-component molecular crystals, SDS of cas: 1453-82-3, the publication is CrystEngComm (2022), 24(12), 2217-2220, database is CAplus.

An approach which allows one to estimate the solubility of two-component mol. crystals in various solvents at different temperatures with an accuracy of 68% (an average absolute % deviation) without any information on their melting temperatures and enthalpies was proposed. The approach is based only on the information about the individual compounds in the co-crystal/salt: (a) melting temperatures and enthalpies and (b) activity coefficients in the investigated solvents at a given temperature

CrystEngComm published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, SDS of cas: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lemmerer, Andreas published the artcileThe 2-Chloro-4-nitrobenzoic acid as a coformer with pharmaceutical cocrystals and molecular salts, SDS of cas: 1453-82-3, the publication is Acta Crystallographica, Section C: Structural Chemistry (2020), 76(8), 746-752, database is CAplus and MEDLINE.

A series of five binary complexes, i.e. three cocrystals and two mol. salts, using 2-chloro-4-nitrobenzoic acid as a coformer have been produced with five commonly available compounds, some of pharmaceutical relevance, namely, 2-chloro-4-nitrobenzoic acid-isonicotinamide (1/1), C7H4ClNO4·C6H6N2O, 2-chloro-4-nitrobenzoic acid-3,3-diethylpyridine-2,4(1H,3H)-dione (2/1), 2C7H4ClNO4·C9H13NO2, 2-chloro-4-nitrobenzoic acid-pyrrolidin-2-one (1/1), C7H4ClNO4·C4H7NO, 2-carboxypiperidinium 2-chloro-4-nitrobenzoate, C6H12NO2-·C7H3ClNO4-, and (2-hydroxyethyl)ammonium 2-chloro-4-nitrobenzoate, C2H8NO+·C7H3ClNO4-. The coformer falls under the classification of a generally regarded as safe compound All five complexes make use of a number of different heteromeric hydrogen-bonded interactions. Intermol. potentials were evaluated using the CSD-Materials module.

Acta Crystallographica, Section C: Structural Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, SDS of cas: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Musalov, M. V. published the artcileOne-Pot Synthesis of Functionalized 1,1′-(9-Selenabicyclo[3.3.1]nonane-2,6-diyl)dipyridinium Dibromides, Quality Control of 1453-82-3, the publication is Russian Journal of Organic Chemistry (2021), 57(4), 668-670, database is CAplus.

Previously unknown functionally substituted 1,1′-(9-selenabicyclo[3.3.1]nonane-2,6-diyl)dipyridinium dibromides were synthesized in 90-98% yields by one-pot condensation of selenium dibromide, cycloocta-1,5-diene, and substituted pyridines.

Russian Journal of Organic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Quality Control of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wang, Pengfei published the artcileThe fingerprints of nifedipine/isonicotinamide cocrystal polymorph studied by terahertz time-domain spectroscopy, Product Details of C6H6N2O, the publication is International Journal of Pharmaceutics (Amsterdam, Netherlands) (2022), 121759, database is CAplus and MEDLINE.

Cocrystal is constructed to improve physicochem. properties of active pharmaceutical ingredient and prevent polymorphism via intermol. interactions. However, recent examples on cocrystal polymorphs display significantly different properties. Even though some anal. techniques have been used to characterize the cocrystal polymorphic system, it remains unclear how intermol. interactions drive and stabilize the structure. In this work, we study the cocrystal polymorphs of nifedipine (NFD) and isonicotinamide (INA) using terahertz (THz) spectroscopy. Form I and form II of NFD-INA cocrystals show spectral fingerprints in THz region. Temperature-dependent THz spectra display distinguished frequency shifts of each fingerprint. Combined with solid-state d. functional theory (DFT) calculations, the exptl. fingerprints and their distinct responses to temperature are elucidated by specific collective vibrational modes. The vibrations of hydrogen bonding between dihydropyridine ring of NFD and INA are generally distributed below 1.5 THz, which play important roles in stabilizing cocrystal and preventing the oxidation of NFD. The rotations of Me group in NFD are widely distributed in the range of 1.5-4.0 THz, which helps the steric recognition. The results demonstrate that THz spectroscopy is a sensitive tool to discriminate cocrystal polymorphs. It has the potential to be used as a non-invasive technique for pharmaceutical screening.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C15H20N2O2, Product Details of C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tu, Shun published the artcileN-(3-cyano-1H-indol-5-yl)isonicotinamide and N-(3-cyano-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamide derivatives: Novel amide-based xanthine oxidase inhibitors, Synthetic Route of 1453-82-3, the publication is Bioorganic Chemistry (2021), 105181, database is CAplus and MEDLINE.

Our previous work demonstrated that amide is an efficient linker to explore chem. space of xanthine oxidase (XO) inhibitors that are entirely different from febuxostat and topiroxostat. In this effort, with 3-cyano-1H-indol-5-yl as a key moiety, two series of amide-based XO inhibitors, N-(3-cyano-1H-indol-5-yl)isonicotinamides and N-(3-cyano-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamides, were designed and synthesized. The structure-activity relationship investigation identified N-(3-cyano-1-cyclopentyl-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamide (I, IC₅₀ = 0.62μM) as the most promising compound, with 14.4-fold higher in vitro inhibitory potency than allopurinol (IC₅₀ = 8.91μM). Mol. simulations provided reasonable interaction modes for the representative compounds Furthermore, in vivo activity evaluation demonstrated that compound I (oral dose of 12.8 mg/kg) has obviously hypouricemic effect on a potassium oxonate induced hyperuricemic rat model. Cytotoxicity assay and ADME prediction also supported that I is an excellent lead for further exploration of amide-based XO inhibitors.

Bioorganic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C17H28ClNO3, Synthetic Route of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics