Category: 1453-82-3

Kumar, Adarsh published the artcileBiocarbon Supported Nanoscale Ruthenium Oxide-Based Catalyst for Clean Hydrogenation of Arenes and Heteroarenes, Quality Control of 1453-82-3, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(41), 15740-15754, database is CAplus.

Despite considerable achievements in the hydrogenation of aromatic hydrocarbons over the past few years, the ability to hydrogenate arene or heteroarene rings in a highly selective manner in the presence of other reducible sites or without harming the remaining mol. structure has long been a major challenge. Such chemoselectivity and functional group tolerance is highly desirable for enabling direct access to key building blocks of polymers and pharmaceutical agents. For achieving such high selectivity, the development of suitable catalysts is of central importance. Herein, we report a convenient method for the scalable preparation of ruthenium oxide (RuO₂) nanoparticles supported on pine needle char (PNC) by simple impregnation of ruthenium salt on unactivated PNC, a solid byproduct (biochar) obtained in the slow pyrolysis of biomass pine needles. The resulting RuO₂-based nanocatalyst (RuO₂@PNC) exhibited remarkable activity and high selectivity for the hydrogenation of more than 50 challenging arenes and heteroarenes, including biomass-derived aromatic compounds (e.g., 4-n-propylphenol, furfuryl alc., and 2-Me furan). The synthetic value of this transformation is showcased for the hydrogenation of arene mixture present in petroleum refineries or coal tars as well as biomass-derived oils (bio-oils) with enriched furfural, ether, and phenol derivatives Under optimized conditions, the performance of this new catalyst was compared with state-of-the-art com. catalysts such as Ru/C, Pd/C, and Raney nickel and found that RuO₂@PNC is more superior and selective. Furthermore, the catalyst is easily recovered and reused up to four cycles. Biocarbon supported RuO₂-based catalyst exhibited remarkable activity and selectivity for clean hydrogenation of arenes and heteroarenes.

ACS Sustainable Chemistry & Engineering published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Quality Control of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dojer, Brina published the artcileIron(II) pyridinecarboxamide complexes: Synthesis, crystal structures and magnetic properties, Application In Synthesis of 1453-82-3, the publication is Journal of Molecular Structure (2022), 133393, database is CAplus.

Two new mononuclear complexes of iron(II) pyridinecarboxamides (picolinamide – pia, isonicotinamide – isn), [Fe(pia)₃]·(SO₄)·3H₂O (1) and (isnH)₂[Fe(isn)₂(SO₄)₂(H₂O)₂]·H₂O (2) were synthesized by the reaction of iron(II) sulfate heptahydrate and pyridinecarboxamides in different solvents by standard method under reflux. Both compounds were characterized by single-crystal x-ray diffraction structure anal., magnetic measurements and by FTIR spectroscopy. In the complex cation of 1 Fe²⁺ ion is six coordinated by three nitrogen and three oxygen atoms from three bidentate picolinamide ligands in mer mode. In complex anion of 2 central Fe²⁺ ion is six coordinated by two isonicotinamide ligands, two sulfate ligands and two water mols. in trans mode. In both structures complex ions are connected with counterions and crystal water mols. with intermol. hydrogen bonds. Magnetic properties of the compounds were measured between 2 K and 300 K giving the results: μ_eff = 4.5 μB for compound 1 and μ_eff = 4.7 μB for 2. Exptl. values of the IR spectra are comparable with literature data and are in good agreement with results of the structural anal.

Journal of Molecular Structure published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application In Synthesis of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pipalde, Amrit Kumar published the artcileStudies on chemical mediated induction of resistance in chickpea against dry root rot (Rhizoctonia bataticola), Related Products of amides-buliding-blocks, the publication is Pharma Innovation (2021), 10(7), 1068-1073, database is CAplus.

The present research work on, “Investigations on chem. mediated induction of resistance in chickpea against dry root rot (Rhizoctonia bataticola).” was carried out in the Section of Plant Pathol., College of Agriculture, Indore, during 2011-12 using variety JG-62. The object of the present investigation were evaluation of SAR inducing chems. against Rhizoctonia bataticola in vitro, evaluation of SAR inducing chems. for control of dry root rot in poly house and for control of dry root rot in the field at different concentrations The experiments were conducted with nine treatments in a Randomized Block Design with three replications and Completely Randomized Design with four replications; observations were recorded at different days after sowing. The typical symptoms of the disease and characterization of the pathogen were described to identify it as R. bataticola. Studies on control of dry root rot by seed treatments and foliar application of SAR compounds were undertaken. Among the tested treatments salicylic acid at 400ppm applied as seed treatment along with its foliar application at 30 DAS and seed treatment with 200ppm isonicotinamide and foliar application of isonicotinamide with 200ppm at 30 DAS were most effective. Seed treatments with 200ppm salicylic acid with 200ppm isonicotinamide was the least effective treatment against R. bataticola. Experiments carried out to evaluate the resistance through salicylic acid and isonicotinamide reduced disease incidence caused by R. bataticola by imparting resistance to the host rather than directly affecting the pathogen. Studies on effect of seed treatments and foliar application on the incidence of dry root rot in chickpea showed that the disease incidence was significantly reduced by combination seed treatment with 400ppm salicylic acid and foliar application of salicylic acid with 400ppm at 30 DAS and seed treatment with 200ppm isonicotinamide and foliar application of isonicotinamide with 200ppm at 30 DAS. But salicylic acid at 400ppm applied as seed treatment along with its foliar application at 30 DAS proved as the best with respect to other control measures.

Pharma Innovation published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Yuting published the artcileCrystal structure of five solid forms from isonicotinamide and carboxylic acids assembled by classical hydrogen bonds and other noncovalent interactions, Safety of Isonicotinamide, the publication is Journal of Molecular Structure (2021), 130048, database is CAplus.

Cocrystn. of the commonly available isonicotinamide, with carboxylic acids gave a total of 5 new anhydrous and hydrous multicomponent solid forms: (isonicotinamide)_2: (suberic acid) [(L)₂·(H₂sub), H₂sub = suberic acid] (1), (isonicotinamide)₂: (α-ketoglutaric acid): H₂O [(HL⁺)₂·(kga^2-)·H₂O, kga^2- = α-ketoglutarate] (2), (isonicotinamide): (1,2-phenylenediacetic acid) [(L)·(H₂pda), H₂pda = 1,2-phenylenediacetic acid] (3), (isonicotinamide): (4-nitrophthalic acid) [(HL⁺)·(Hnpta^–), Hnpta^– = 4-nitrohydrogenphthalate] (4) and (isonicotinamide)₄: (butane-1,2,3,4-tetracarboxylic acid) [(L)₄·(H₄bta), H₄bta = butane-1,2,3,4-tetracarboxylic acid] (5). The 5 solid forms were characterized by XRD, IR and EA and their m.ps. were also reported. Their structural and supramol. aspects are fully analyzed. 2 and 4 are organic salts with only the aryl N in L protonated, 1, 3 and 5 are co-crystals. The crystal packing is interpreted by the strong N-H···O, O-H···N and O-H···O H bonds. The carboxamide dimers were existed in all solid forms by a pair of N-H···O H bonds. Further inspection of the crystal packing told that a different set of addnl. CH-O/CH₂-O, CH-N, O-C, O-O, O-N, O-π and π-π associations contribute to the stabilization and expansion of the total high-dimensional (2D-3D) structures. For the delicate balance of the various weak nonbonding interactions these structures adopted homo/hetero supramol. synthons or both and the common R¹₂(7) and R²₂(8) graph sets were observed in all solid forms due to the interplay of H bonds and noncovalent associations

Journal of Molecular Structure published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C16H14O6, Safety of Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wang, Xiaojuan published the artcileCollecting the Molecular and Ionization States of Irbesartan in the Solid State, Computed Properties of 1453-82-3, the publication is Crystal Growth & Design (2020), 20(9), 5664-5669, database is CAplus.

An active pharmaceutical ingredient may exist in different solid forms, which are the products of the variation of mol. conformation and packing order stabilized through different intermol. interactions. Two special conditions, tautomerism and amphoterism, will make the solid-state landscape more abundant and diverse. Two known polymorphs of irbesartan (IBS) contain mols. in different tautomeric forms, resp. Here, one cationic salt and one anionic salt of IBS were successfully harvested. The NMR spectra demonstrated clear fingerprint features for these four different mol. and ionization states of IBS. The newly obtained crystalline forms also provide much better dissolution performance. Irbesartan can exist in 1H-tautomeric, 2H-tautomeric, cationic, and anionic states in different crystalline samples.

Crystal Growth & Design published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H12Br2, Computed Properties of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hoffmann, Johannes published the artcileThe unexpected dominance of secondary over primary nucleation, Safety of Isonicotinamide, the publication is Faraday Discussions (2021), 235(0), 109-131, database is CAplus and MEDLINE.

It is still a challenge to control the formation of particles in industrial crystallization processes. In such processes, new crystals can be generated either by primary or secondary nucleation. While in continuous stirred tank crystallization processes, secondary nucleation is thought to occur due to the shear or attrition of already present larger crystals; in antisolvent crystallization processes, where mixing at the inlets locally causes high supersaturations, primary nucleation is understood to be the main mechanism. We aim to show here that secondary nucleation is the dominant nucleation mechanism, even under conditions that are generally considered to be dominated by primary nucleation mechanisms. Measurements of primary and secondary nucleation rates under similar industrial crystallization conditions of sodium bromate in water, sodium chloride in water, glycine in water and isonicotinamide in ethanol show that the secondary nucleation rate is at least 6 orders of magnitude larger in all these systems. Furthermore, seeded fed-batch and continuous antisolvent crystallizations of sodium bromate under high local supersaturation, seeded with crystals of a specific handedness, result in a close to chirally pure crystalline product with the same handedness. This shows that indeed, enantioselective secondary nucleation is the dominant mechanism in these antisolvent crystallizations It is even possible to use the enantioselective secondary nucleation mechanism to control the product chirality in such a process, making antisolvent crystallization a viable crystallization-enhanced deracemization technique, having a superior productivity compared to other crystallization-enhanced deracemization methods. Our finding of a dominant secondary nucleation mechanism, rather than primary nucleation, will have a strong impact on nucleation control strategies in industrial crystallization processes.

Faraday Discussions published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Safety of Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bianchi, Federica published the artcileDevelopment of novel cocrystal-based active food packaging by a Quality by Design approach, Application In Synthesis of 1453-82-3, the publication is Food Chemistry (2021), 129051, database is CAplus and MEDLINE.

A way to reduce food waste is related to the increase of the shelf-life of food as a result of improving the package type. An innovative active food packaging material based on cocrystn. of microbiol. active compounds present in essential oils i.e. carvacrol, thymol and cinnamaldehyde was developed following the Quality by Design principles. The selected active components were used to produce antimicrobial plastic films with solidified active ingredients on their surface characterized by antimicrobial properties against four bacterial strains involved in fruit and vegetable spoilage. The developed packaging prototypes exhibited good antimicrobial activity in vitro providing inhibition percentage of 69 (±15)% by contact and inhibition diameters of 32 (±6) mm in the gas phase, along with a prolonged release of the active components. Finally, the prolonged shelf-life of grape samples up to 7 days at room temperature was demonstrated.

Food Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application In Synthesis of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Castineiras, Alfonso published the artcileMulticomponent Solids of DL-2-Hydroxy-2-phenylacetic Acid and Pyridinecarboxamides, Recommanded Product: Isonicotinamide, the publication is Crystals (2022), 12(2), 142, database is CAplus.

We prepared cocrystals of DL-2-Hydroxy-2-phenylacetic acid (D, L-H2ma) with the pyridinecarboxamide isomers, picolinamide (pic) and isonicotinamide (inam). They were characterized by elemental anal., single crystal and powder X-ray, IR spectroscopy and ¹H and ¹³C NMR. The crystal and mol. structures of (pic)-(D-H₂ma) (1), (nam)-(L-H₂ma) (2) and (inam)-(L-H₂ma) (3) were studied. The crystal packing is stabilized primarily by hydrogen bonding and in some cases through π-πstacking interactions. The anal. of crystal structures reveals the existence of the characteristic heterosynthons with the binding motif R²₂(8) (primary amide-carboxilic acid) between pyridinecarboxamide mols. and the acid. Other synthons involve hydrogen bonds such as O-H(carboxyl)···N(pyridine) and O-H(hydroxyl)···N(pyridine) depending on the isomer. The packing of 1 and 3 is formed by tetramers, for whose formation a crystallization mechanism based on two stages is proposed, involving an amide-acid (1) or amide-amide (3) mol. recognition in the first stage and the formation of others, and interdimeric hydrogen bonding interactions in the second. The thermal stability of the cocrystals was studied by differential scanning calorimetry and thermogravimetry. Further studies were conducted to evaluate other physicochem. properties of the cocrystals in comparison to the pure coformers. D.-functional theory (DFT) calculations (including NCIplot and QTAIM analyses) were performed to further characterize and rationalize the noncovalent interactions.

Crystals published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Recommanded Product: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhao, Yanbin published the artcileVanadium-catalyzed Oxidative Conversion of Primary Aromatic Alcohols into Amides and Nitriles with Molecular Oxygen, SDS of cas: 1453-82-3, the publication is Chemistry – An Asian Journal (2022), 17(11), e202200224, database is CAplus and MEDLINE.

Herein, a vanadium-based material V-N-C-700 was prepared via a simple and convenient method, and employed for liquid-phase catalytic ammoxidation of alcs. RCH₂OH (R = n-Bu, Ph, pyridin-2-yl, etc.) with mol. oxygen. By using V-N-C-700/2-picolinic acid, primary aromatic alcs. were smoothly converted into the amides RC(O)NH₂ and nitriles RCN in the presence of urea. The corresponding aldehydes RCHO are the key intermediates, and 2-picolinic acid could significantly enhance oxidation of alcs. into aldehydes. The amides were formed simultaneously along with nitriles, rather than only from nitriles via successive hydration. This work further expands non-noble metal catalysts for the preparation of amides and nitriles.

Chemistry – An Asian Journal published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C20H19NO4, SDS of cas: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Shiyuan published the artcileChitosan hydrogel for controlled crystallization of loaded drug: Role of interplay of assembly processes, Recommanded Product: Isonicotinamide, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2022), 128824, database is CAplus.

The utilization of natural polymer gel to achieve drug polymorph control is usually a challenging issue, and the interplay of gelation and crystallization has been neglected in many studies. In this work, a modified chitosan (Cs) hydrogel was used to encapsulate drug Isonicotinamide (IN), where competitive crystallization and gelation was constructed for a better control of different assembly processes. It was found that the crystalline outcome of drug (cocrystals or IN Form I) depends on different crosslinking agents used. Spectral anal. and MD simulation reveal that the interplay of crosslinking effect of Cs, dimerization of crosslinking agents and aggregation of IN determines the crystalline outcome, among which the affinity to crosslinking agents of Cs chain plays the significant role. To our knowledge, it is the first time that Cs hydrogel acts as a template to regulate polymorphism of drug. This work offers a promising way for drug delivery system design.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Recommanded Product: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics