1453-82-3 Archives - Page 9 of 9 - Amides-buliding-blocks

Aitipamula, Srinivasulu’s team published research in European Journal of Pharmaceutics and Biopharmaceutics in 149 | CAS: 1453-82-3

European Journal of Pharmaceutics and Biopharmaceutics published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application In Synthesis of 1453-82-3.

Aitipamula, Srinivasulu published the artcileCocrystal formulations: A case study of topical formulations consisting of ferulic acid cocrystals, Application In Synthesis of 1453-82-3, the publication is European Journal of Pharmaceutics and Biopharmaceutics (2020), 95-104, database is CAplus and MEDLINE.

Renaissance of cocrystals as alternative solid forms for fine-tuning physicochem. properties of active pharmaceutical ingredients (APIs) has paved way for development of marketable cocrystals. The current literature reveals established strategies for the design, synthesis and characterization of cocrystals. However, barring a few isolated case studies, strategies for development of cocrystal formulations have been underdeveloped. Herein we report topical formulations of an antioxidant, ferulic acid (FA), which contain the active in its cocrystal form. Cocrystals of FA with the coformers relevant to skin care such as urea, nicotinamide (NA) and isonicotinamide (INA) have been prepared and oleogel formulations of these have been developed. The cocrystal with urea and an anhydrous cocrystal with INA have been identified for the first time in this study. The novel cocrystals were structurally characterized by single crystal X-ray diffraction. Solubility and stability studies have revealed higher solubility of the cocrystals with NA and INA than the parent active and greater stability of FA in formulations that contained the cocrystals with INA and urea than the corresponding formulations containing phys. mixtures or parent active. In vitro membrane permeation tests have ascertained sustained release profile of active from the formulation that contained the FA·INA cocrystal. The higher solubility, greater stability and sustained active release profile of the FA·INA cocrystal formulation make it a promising topical formulation of FA.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sengupta, Manideepa’s team published research in Molecular Catalysis in 522 | CAS: 1453-82-3

Molecular Catalysis published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C10H15NO, Application of Isonicotinamide.

Sengupta, Manideepa published the artcileSustainable synthesis of drug intermediates via simultaneous utilization of carbon monoxide and ammonia over Pd@La-MOF, Application of Isonicotinamide, the publication is Molecular Catalysis (2022), 112212, database is CAplus.

Mitigation of carbon monoxide and ammonia to valuable primary aromatic amides is an imperative approach to control the environmentally harmful emissions thereby infusing towards sustainability. Designing of nanostructured catalyst for direct access to the synthetically valuable primary aromatic and heteroaromatic amides via carbonylative amination of aryl halides is always demanding since nano materials can bridge the gap between homogeneous and heterogeneous catalysis thus preserving the desirable attributes of both the systems towards sustainable catalysis. Herein, microwave assisted fabrication of highly uniform Pd NPs (3,4 nm) over La-MOFs has been performed and utilized efficiently for ligand free carbonylative amination of aryl iodides with carbon monoxide and ammonia. Moderate to high yields of benzamide derivatives, salicylamide, a drug having analgesic and antipyretic properties were achieved. The unsaturated metal sites in the MOF via synergistic mode of σ and π bonding binds with CO, which significantly enhances the catalytic activity of MOF-composite unlike other supported Pd NPs. DFT confirms the growth of pristine Pd₁₃ cluster within the framework, as active metal center for the carbonylative amination.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Chisca, Diana’s team published research in Inorganic Chemistry Communications in 132 | CAS: 1453-82-3

Inorganic Chemistry Communications published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application of Isonicotinamide.

Chisca, Diana published the artcileFour Cu(II) coordination polymers with biocompatible isonicotinamide and picolinate ligands in interplay with anionic and neutral linkers, Application of Isonicotinamide, the publication is Inorganic Chemistry Communications (2021), 108864, database is CAplus.

Four Cu(II)-based neutral coordination polymers, 1D {[Cu(isonia)₂(adi)(dmf)].0.5H₂adi}_n (1), 2D {[Cu(isonia)₂(adi)](H₂O.H₂adi)}_n (2), 1D {[Cu(pic)(CH₃COO)(bpe)].H₂O}_n (3), and 2D [Cu₂(pic)₂(CH₃COO)₂(bpy)]_n (4) with biocompatible mols.: isonicotinamide (isonia), pyridine-2-carboxylic (picolinic, Hpic) and adipic (H₂adi) acids and 1,2-bis(4-pyridyl)-ethane (bpe) and 4,4′-bipyridine (bpy) as neutral linkers are reported. The polymer extension in 1 and 2 is reached via bidentate bridging adi anions with isonia ligands as single 1 and double 2 pillars. 1D and 2D coordination arrays are associated in elegant 3D H-bonded networks via interplay of robust amide(isonia)…amide(isonia) homosynthon and NH…O(COO^–) side interactions. In 3 the pic residue coordinates in a chelate mode and forms the five-membered [Cu(pic)] corner fragment. The structure expansion occurs via bidentate-bridging bpe neutral linker registered in a coordination wire as different conformers thus providing long (Cu-bpe)₆ crystallog. unique chain fragment. Oppositely, in 4 the pic residue acts in a bidentate chelate bridging mode and gives rise to the 2D coordination array. The bpy trapping between each two Cu(II) atoms, does not participate in further structure extension. The decisive impact of amido-group of isonia ligand in structure rigidification and retention of protic H₂adi and water guest mols. is demonstrated. The gradual decrease of guest’s capacity correlates with an increased liphophilicity of 3 and 4 comparing with 1 and 2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Song, Liangliang’s team published research in Journal of Organic Chemistry in 85 | CAS: 1453-82-3

Journal of Organic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C19H34ClN, Safety of Isonicotinamide.

Song, Liangliang published the artcilePyridine-Enabled C-N Bond Activation for the Rapid Construction of Amides and 4-Pyridylglyoxamides by Cooperative Palladium/Copper Catalysis, Safety of Isonicotinamide, the publication is Journal of Organic Chemistry (2020), 85(12), 8045-8054, database is CAplus and MEDLINE.

A pyridine-enabled C-N bond activation of peptidomimetics employing cooperative palladium/copper catalysis in water is developed. Diverse amides and 4-pyridylglyoxamides are simultaneously synthesized through two steps from com. available materials in a rapid, environmentally friendly, and high atom-economical manner.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hussain, Muhammad Asif’s team published research in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 99 | CAS: 1453-82-3

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, HPLC of Formula: 1453-82-3.

Hussain, Muhammad Asif published the artcileAn efficient hydration of nitriles with ruthenium-supported heterogeneous catalyst in water under moderate conditions, HPLC of Formula: 1453-82-3, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2021), 187-195, database is CAplus.

A facile eco-friendly heterogeneous catalytic system has been developed for amide synthesis that further utilized in pharmaceutical and organic chem. The Ru/MnO₂ catalyst has shown outstanding and unprecedented activity for a wide range of aliphatic and benzylic nitriles in green solvent water at 60°C. The system has also exhibited a remarkable tolerance for selective hydration of heteroatom (e.g. nitrogen, oxygen and sulfur atoms) containing nitriles. Pharmaceutically important nicotinamides and pyrazinamide has been synthesized by hydration of the heteroat. nitriles with appreciable yields and selectivities. Moreover, the Ru/MnO₂ catalyst has employed water as a benign solvent, with more than 30,000 TONs and reusability five times after isolation from the reaction mixture by centrifugation and easy workup that established a path for green environmental and technol. acceptable protocol.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Nechaev, Ilya V.’s team published research in Journal of Organic Chemistry in 86 | CAS: 1453-82-3

Nechaev, Ilya V. published the artcileThree-Component Reaction of 3,3-Difluorocyclopropenes, s-Tetrazines, and (benzo) Pyridines, Related Products of amides-buliding-blocks, the publication is Journal of Organic Chemistry (2021), 86(1), 1037-1052, database is CAplus and MEDLINE.

A new three-component reaction leading to 1-α-(pyridyl-2-[1,2,4]triazolyl)-2-alkyl-ethanones has been discovered while studying the reactivity of monosubstituted 3,3-difluorocyclopropenes in an inverse electronic demand Diels-Alder (IEDDA) cycloaddition-cycloreversion sequence with s-tetrazines. The reaction involving the above-mentioned reactants and (benzo)pyridine as a third component results in a complex transformation proceeding in mild conditions in a stoichiometric ratio of reactants and has high functional group tolerance (phenols, amides, ethers, carboxylic acids, ketones, and acrylic esters). As a result, simple pyridines are selectively functionalized at the α-position in good isolated yields. The reaction mechanism includes a rare azaphilic [4 + 2]-cycloaddition step between s-tetrazine and intermediate 1-hydroxyindolizine, suggested after byproduct identification and tracked with a deuterium label. To date, it is only the third known example of skewed azaphilic cycloaddition of tetrazine. The reaction is truly three-component and cannot be effectively performed stepwise.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics