Category: 18836-52-7

Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells was written by Rohm, Barbara;Riedel, Annett;Ley, Jakob P.;Widder, Sabine;Krammer, Gerhard E.;Somoza, Veronika. And the article was included in Food & Function in 2015.Synthetic Route of C14H25NO The following contents are mentioned in the article:

Red pepper and its major pungent component, capsaicin, have been associated with hypolipidemic effects in rats, although mechanistic studies on the effects of capsaicin and/or structurally related compounds on lipid metabolism are scarce. In this work, the effects of capsaicin and its structural analog nonivamide, the aliphatic alkamide trans-pellitorine and vanillin as the basic structural element of all vanilloids on the mechanisms of intestinal fatty acid uptake in differentiated intestinal Caco-2 cells were studied. Capsaicin and nonivamide were found to reduce fatty acid uptake, with IC₅₀ values of 0.49 μM and 1.08 μM, resp. trans-Pellitorine was shown to reduce fatty acid uptake by 14.0 ± 2.14% at 100 μM, whereas vanillin was not effective, indicating a pivotal role of the alkyl chain with the acid amide group in fatty acid uptake by Caco-2 cells. This effect was associated neither with the activation of the transient receptor potential cation channel subfamily V member 1 (TRPV1) or the epithelial sodium channel (ENaC) nor with effects on paracellular transport or glucose uptake. However, acetyl-CoA synthetase activity increased (p < 0.05) in the presence of 10 μM capsaicin, nonivamide or trans-pellitorine, pointing to an increased fatty acid biosynthesis that might counteract the decreased fatty acid uptake. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Synthetic Route of C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Extraction efficiency of water, ethanol and supercritical carbon dioxide for amide content from fruit of Piper sarmentosum using colorimetry and high performance liquid chromatography was written by Hussain, Khalid;Ismail, Zhari;Sadikun, Amirin;Ibrahim, Pazilah. And the article was included in Journal of the Chemical Society of Pakistan in 2010.COA of Formula: C14H25NO The following contents are mentioned in the article:

Extraction is important for both natural product research and preparation of extracts to be used as raw materials for phytopharmaceuticals. Selection of a suitable solvent as well as type of extraction is prerequisite to prepare extracts enriched with particular type of compounds with peculiar activities. Therefore, the present study aimed to evaluate the extraction efficiency of water, ethanol and supercritical CO₂ for amides from fruit of Piper sarmentosum using colorimetry and high performance liquid chromatog. (HPLC). The pulverized fruit material was extracted by reflux using water and ethanol, and supercritical CO₂ at 60 °C and operating pressure of 3000, 4000, 6000, 7000 and 8000 psi. The colorimetric anal. indicated that except the water extracts, total amide content in different extracts was not significantly different (P<0.05). Similarly, HPLC anal. using pellitorine, sarmentine and sarmentosine as markers indicated that except water extracts, total content of the markers in different extracts was not significantly different (P<0.05). These results indicate that extraction efficiency of ethanol for amides is comparable to that of supercritical CO₂. Hence, ethanol may be used to prepare amide enriched extracts without using costly equipment and operating expertise. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7COA of Formula: C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.COA of Formula: C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Scientific opinion on flavouring group evaluation 86, revision 2 (FGE.86Rev2): consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting) was written by Bolognesi, Claudia;Castle, Laurence;Cravedi, Jean-Pierre;Engel, Karl-Heinz;Fowler, Paul;Franz, Roland;Grob, Konrad;Gurtler, Rainer;Husoey, Trine;Mennes, Wim;Milana, Maria Rosaria;Penninks, Andre;Silano, Vittorio;Smith, Andrew;de Fatima Tavares Pocas, Maria;Tlustos, Christina;Toldra, Fidel;Wolfle, Detlef;Zorn, Holger. And the article was included in EFSA Journal in 2015.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

A review. The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 30 aliphatic and arylalkyl amines and amides evaluated by JECFA at the 65th meeting in 2005. This revision is required owing to addnl. available toxicity data on piperine [FL-no: 14.003] and deca-(2E,4E)-dienoic acid isobutyl-amide [FL-no: 16.091]. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicol. thresholds of concern and available data on metabolism and toxicity. The Panel agrees with JECFA’s conclusion “No safety concern at estimated levels of intake as flavouring substances” based on the Maximised Survey-derived Daily Intake (MSDI) approach for all substances considered in this FGE. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered and for all 30 substances, the information is adequate. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Utilization of Agro-Waste of Piper longum for a Potential Pancreatic Lipase Inhibitor was written by Gaur, Pooja;Tiwari, Neerja;Shanker, Karuna. And the article was included in ACS Agricultural Science & Technology in 2022.Reference of 18836-52-7 The following contents are mentioned in the article:

The present study demonstrates the alternative source for pseudoalkaloids as well as the utilization of the agricultural wastes of Piper longum (PiL) as possible antiobesity agents. HPLC-based bioactivity-guided micro-fractionation of PiL root has resulted in five known compounds, piplartine (1), piperlonguminine (2), piperine (3), piperanine (5), pellitorine (6), and a new compound, piperdardine (4). Isolated compounds (1-6) were evaluated for their pancreatic lipase (PL) inhibitory potential. Pellitorine (PTR) was the most active component with IC₅₀ = 3.35 μg/mL, which inhibited PL reversibly and in a mixed-type manner. The synergistic effect of PTR with orlistat (0.17 μM) was also observed at a concentration lower than 15.70 μM. The findings of Fourier transform IR spectral studies demonstrated the structural compactness of PL with PTR. The thermodn. studies have confirmed the binding interaction of PTR with PL as hydrophobic. Furthermore, mol. docking studies showed that PTR interacted in the catalytic active amino side residue (Ser153-Asp80-His264) of the protein (1ETH) by hydrogen bonds with affinity (ΔG = -7.0 kcal/mol). The findings of the study support PTR as a potential lead for further validation in animal studies to lead toward clin. translation as an anti-obesity supplement. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Reference of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Insilico binding studies of anti-MRSA compounds on Pencillin Binding Protein 2a was written by Alluraiah, G.;Sreenu Babu, A.;Hari babu, D.. And the article was included in Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences in 2019.COA of Formula: C14H25NO The following contents are mentioned in the article:

The study evaluates a few selected plant derived products including Sesamin, Pellitorine, Guineesine, Brachystamide B and Pipataline from piper longum for their binding with and inhibitory capacity on Penicillin Binding Protein 2a of Methicillin Resistant Staphylococcus aureus (MRSA) using computational methods. The crystal structure of Penicillin Binding Protein 2a was taken from the Protein Data Bank (PDB_ID:1VQQ). Possible binding sites of Penicillin Binding Protein 2a were searched with CASTP server. Mol. docking was performed using the Gold (Genetic Optimization of Ligand Docking) software which is based on genetic algorithm (GA), to study the binding orientation of compounds into the Penicillin Binding Protein 2a structure. The efficiency and drug-likeness of various plant compounds were identified by using pre-ADMET software. In this study, all docked compounds were found to have some interaction between an oxygen atom of the Compounds and Penicillin Binding Protein 2a. In the binding pocket, common H-bonding interactions were formed between all docked compounds and ASP-65, CYS-66, CYS-88. The docking results agreed well with the observed in vitro data, which showed that the Penicillin Binding Protein 2a inhibitory activity of pepataline was higher than those of other compounds This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7COA of Formula: C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.COA of Formula: C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Anticancer activities of Zanthoxylum bungeanum seed oil on malignant melanoma was written by Pang, Wenwen;Liu, Shan;He, Fangting;Li, Xinyang;Saira, Baloch;Zheng, Tianli;Chen, Jiayi;Dong, Ke;Pei, Xiao-fang. And the article was included in Journal of Ethnopharmacology in 2019.Application of 18836-52-7 The following contents are mentioned in the article:

Zanthoxylum bungeanum Maxim. (ZBM), a Chinese herb medicine and food additive, has been shown to have broad-spectrum beneficial effects. However, the anticancer activities of its seed have not been reported.for the first time investigated the anti-proliferation activity of seed oil of ZBM (ZBSO) on melanoma A375 cells as well as the underlying mechanisms. The chem. composition of ZBSO was analyzed by Ultra Performance Liquid Chromatog. A375 cells exposure at different concentrations of ZBSO to examine the selectivity vs. normal skin cells, invasion, apoptosis and cell cycle arrest. Furthermore, transcriptome anal. was employed to investigate potential anticancer mechanisms of ZBSO. Major compounds of ZBSO were identified and unsaturated fatty acid made up the major compound ZBSO-treated A375 cells showed more typical apoptotic morphol. features than normal cells. ZBSO can significantly inhibit invasion and proliferation of A375 cells by G1 phase arrest and induction of apoptosis. Transcriptome anal. showed that ZBSO may affect cell cycle and MAPK signaling pathway of A375 cells. ZBSO possessed anticancer activities that were selectively effective to A375 cells. This study support the hypothesis that ZBSO is a capable candidate for anti-melanoma agent, and provide new insights for future work on investigating the utilization of ZBSO in malignant melanoma treatment. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells was written by Shin, Dong-Mi;Choi, Kyeong-Mi;Lee, Youn-Sun;Kim, Wonkyun;Shin, Kyong-Oh;Oh, Seikwan;Jung, Jae-Chul;Lee, Mi Kyeong;Lee, Yong-Moon;Hong, Jin Tae;Yun, Yeo-Pyo;Yoo, Hwan-Soo. And the article was included in Archives of Pharmacal Research in 2014.Product Details of 18836-52-7 The following contents are mentioned in the article:

Echinacea purpurea has been shown to have anti-diabetic activities; for example, it activates peroxisome proliferator-activated receptor γ (PPARγ) and increases insulin-stimulated glucose uptake. Adipogenesis has been used to study the insulin signaling pathway and to screen anti-diabetic compounds The present study was conducted to investigate the effects of an ethanol extract of E. purpurea (EEEP) and its constituents on the insulin-induced adipocyte differentiation of 3T3-L1 preadipocytes. When adipocyte differentiation was induced with insulin plus 3-isobutyl-1-methylxanthine and dexamethasone, the accumulation of lipid droplets and the cellular triglyceride content were significantly increased by EEEP. The expressions of PPARγ and C/EBPα in adipocytes treated with EEEP were gradually increased as compared with control cells. Fat accumulation and triglyceride content of adipocytes treated with dodeca-2(E),4(E)-dienoic acid isobutylamide were significantly increased as compared with control cells. The expressions of PPARγ and C/EBPα in adipocytes treated with dodeca-2(E),4(E)-dienoic acid isobutylamide were significantly higher than in control cells. These results suggest EEEP promotes the adipogenesis that is partially induced by insulin and that dodeca-2(E),4(E)-dienoic acid isobutylamide appears to be responsible for EEEP-enhanced adipocyte differentiation. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Product Details of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Product Details of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Androgenic and Spermatogenic Activity of Alkylamide-Rich Ethanol Solution Extract of Anacyclus pyrethrum DC was written by Sharma, Vikas;Boonen, Jente;De Spiegeleer, Bart;Dixit, V. K.. And the article was included in Phytotherapy Research in 2013.Recommanded Product: 18836-52-7 The following contents are mentioned in the article:

Anacyclus pyrethrum (A. pyrethrum) has been used as Vajikaran Rasayana (aphrodisiac) in traditional Indian ayurvedic medicine to treat male sexual dysfunction, including infertility. Aphrodisiac activity may be due to an increase in the production or effect of androgens, so this study sought to evaluate the androgenic and spermatogenic potential of the alkylamide-rich ethanol solution extract Male Wistar strain rats weighing between 150 and 180 g were completely randomized divided into five groups. The ethanol solution extract of A. pyrethrum was administered to groups of rats in 50, 100, and 150 mg/kg doses for a period of 28 days, and the action was compared with control and testosterone-treated rats. Thirteen N-alkylamides were detected in the extract by using HPLC/UV/electrospray ionization mass spectrometry method. Extract administration at all the doses produced significant increase in body weight, sperm count, motility, and viability along with serum testosterone, LH, and FSH concentrations Histoarchitecture of testis revealed increased spermatogenic activities. Seminal fructose content was also significantly increased after 28 days of treatment. Our results suggest that the ethanol solution extract of the roots of A. pyrethrum has androgenic potential and may improve male fertility by enhancing spermatogenesis. Copyright © 2012 John Wiley & Sons, Ltd. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vascular barrier protective effects of pellitorine in LPS-induced inflammation in vitro and in vivo was written by Lee, Wonhwa;Ku, Sae-Kwang;Min, Byung-Woon;Lee, Sangkyu;Jee, Jun-Goo;Kim, Jeong Ah;Bae, Jong-Sup. And the article was included in Fitoterapia in 2014.Recommanded Product: 18836-52-7 The following contents are mentioned in the article:

Pellitorine (PT), an active amide compound, is well known to possess insecticidal, antibacterial and anticancer properties. In this study, we first investigated the possible barrier protective effects of pellitorine against pro-inflammatory responses induced by lipopolysaccharide (LPS) and the associated signaling pathways in vitro and in vivo. The barrier protective activities of PT were determined by measuring permeability, monocyte adhesion and migration, and activation of pro-inflammatory proteins in LPS-activated human umbilical vein endothelial cells (HUVECs) and in mice. We found that PT inhibited LPS-induced barrier disruption, expression of cell adhesion mols. (CAMs) and adhesion/transendothelial migration of monocytes to human endothelial cells. PT also suppressed LPS-induced hyperpermeability and leukocyte migration in vivo. Further studies revealed that PT suppressed the production of tumor necrosis factor-α (TNF-α) or Interleukin (IL)-6 and activation of nuclear factor-κB (NF-κB) or extracellular regulated kinases (ERK) 1/2 by LPS. Moreover, treatment with PT resulted in reduced LPS-induced lethal endotoxemia. These results suggest that PT protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Secondary metabolic profiles of two cultivars of Piper nigrum (Black Pepper) resulting from infection by Fusarium solani f. sp. piperis was written by da Luz, Shirlley F. M.;Yamaguchi, Lydia F.;Kato, Massuo J.;de Lemos, Oriel F.;Xavier, Luciana P.;Maia, Jose Guilherme S.;Ramos, Alessandra de R.;Setzer, William N.;da Silva, Joyce Kelly do R.. And the article was included in International Journal of Molecular Sciences in 2017.SDS of cas: 18836-52-7 The following contents are mentioned in the article:

Bragantina and Cingapura are the main black pepper (Piper nigrum L.) cultivars and the Pará state is the largest producer in Brazil with about 90% of national production, representing the third largest production in the world. The infection of Fusarium solani f. sp. piperis, the causal agent of Fusarium disease in black pepper, was monitored on the cultivars Bragantina (susceptible) and Cingapura (tolerant), during 45 days’ post infection (dpi). Gas Chromatog.-Mass spectrometry (GC-MS) anal. of the volatile concentrates of both cultivars showed that the Bragantina responded with the production of higher contents of α-bisabolol at 21 dpi and a decrease of elemol, mostly at 30 dpi; while Cingapura displayed an decrease of δ-elemene production, except at 15 dpi. The phenolic content determined by the Folin Ciocalteu method showed an increase in the leaves of plants inoculated at 7 dpi (Bragantina) and 7-15 dpi (Cingapura); in the roots, the infection caused a phenolic content decrease in Bragantina cultivar at 45 dpi and an increase in the Cingapura cultivar at 15, 30 and 45 dpi. High Performance Liquid Chromatog.-Mass spectrometry (HPLC-MS) anal. of the root extracts showed a qual. variation of alkamides during infection. The results indicated that there is a possible relationship between secondary metabolites and tolerance against phytopathogens. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7SDS of cas: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics