Category: 2447-79-2

Jaiswal, Yogesh published the artcileAcid-promoted palladium(II)-catalyzed ortho-halogenation of primary benzamides: En route to halo-arenes, Related Products of amides-buliding-blocks, the publication is Catalysis Communications (2019), 105784pp., database is CAplus.

Bronsted acid-promoted palladium(II)-catalyzed regioselective installation of halogens (Br, Cl, and I) to the aromatic ring of benzamide derivatives to afford the halogenated arenes I [R = H, 4-Me, 5-Cl, etc.; X = Cl, Br, I] was achieved using primary amides. Mild reaction conditions, use of primary amide as a directing group, external additive-free conditions and gram-scale reaction were some appealing features of this protocol.

Catalysis Communications published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Trush, Maria M. published the artcileIn silico and in vitro studies of a number PILs as new antibacterials against MDR clinical isolate Acinetobacter baumannii, Related Products of amides-buliding-blocks, the publication is Chemical Biology & Drug Design (2020), 95(6), 624-630, database is CAplus and MEDLINE.

QSAR anal. of a set of previously synthesized phosphonium ionic liquids (PILs) tested against Gram-neg. multidrug-resistant clin. isolate Acinetobacter baumannii was done using the Online Chem. Modeling Environment (OCHEM). To overcome the problem of overfitting due to descriptor selection, fivefold cross-validation with variable selection in each step of the model development was applied. The predictive ability of the classification models was tested by cross-validation, giving balanced accuracies (BA) of 76%-82%. The validation of the models using an external test set proved that the models can be used to predict the activity of newly designed compounds with a reasonable accuracy within the applicability domain (BA = 83%-89%). The models were applied to screen a virtual chem. library with expected activity of compounds against MDR Acinetobacter baumannii. The eighteen most promising compounds were identified, synthesized, and tested. Biol. testing of compounds was performed using the disk diffusion method in Mueller-Hinton agar. All tested mols. demonstrated high anti-A. baumannii activity and different toxicity levels. The developed classification SAR models are freely available online at and could be used by scientists for design of new more effective antibiotics.

Chemical Biology & Drug Design published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C4H12ClNO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bruun, L. published the artcileA quantitative enzyme-linked immunoassay for the detection of 2,6-dichlorobenzamide (BAM), a degradation product of the herbicide dichlobenil, Name: 2,4-Dichlorobenzamide, the publication is Journal of Immunological Methods (2000), 240(1-2), 133-142, database is CAplus and MEDLINE.

2,6-Dichlorobenzamide (BAM) is the dominant degradation product in soil of the widely used herbicide dichlobenil. To detect BAM in water, a highly sensitive and specific ELISA was developed. As an alternative to conventional coating of ELISA plates, the assay is based on direct covalent immobilization. A surface was achieved which requires a short time for the immobilization of ligand, is stable under dry storage, and which permits assays with a low CV. The performance of the assay was demonstrated by an inter-well CV that was generally less than 6%, a detection limit (DL₁₅) of 0.02 μg/l and an IC₅₀ of 0.19 μg/l. Cross-reactivity was measured against nine analytes with structural homol. to BAM. The highest degree of cross-reactivity (10.8%) was seen with 2,6-dichlorothiobenzamide (Chlorthiamid). Considering an EU-limit of 0.1 μg/l as the permissible maximum for the presence of pesticides in drinking water, this ELISA-procedure is suitable for large-scale screening of water samples suspected of being contaminated with BAM.

Journal of Immunological Methods published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Name: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ahmadi, Abbas published the artcileSynthesis and Investigating Hypoglycemic and Hypolipidemic Activities of Some Glibenclamide Analogues in Rats, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Mini-Reviews in Medicinal Chemistry (2014), 14(2), 208-213, database is CAplus and MEDLINE.

Glibenclamide (5-chloro-N-(4-[N-(cyclohexylcarbamoyl) sulfamoyl] phenethyl)-2-methoxybenzamide, Glyburide, E) is a well-known and potent second-generation of sulfonylurea oral hypoglycemic drug which is most widely used in type 2 diabetes recently. It acts upon pancreatic β -cells by stimulating insulin secretion in glucose and lipid-lowering activities. So far, many derivatives of E have been synthesized by adding new structural moieties to its structure while preserving its binding affinity to the receptor before their anti-hyperglycemic and anti hyperlipidemic activities being evaluated. In this study, new analogs of E after changing lipophilic side chain (5-chloro-2-methoxy benzamide) with 4- bromo-3, 5-dimethoxy benzamide and 2, 4-dichloro benzamide were synthesized. Also, their glucose and lipid-lowering activities were evaluated and compared to E and Tolbutamide (a famous first-generation of sulfonylurea oral hypoglycemic drug) by the known procedures. Findings showed that chloride substitution on lipophilic side chain of Glibenclamide could possibly increase the affinity of drug for receptor/or its half life time that resulted in more lasting anti-hyperglycemic and anti lipidemic activities in diabetic rats. However, bromide substitution with addnl. methoxy groups in benzamide ring could slightly improve the anti-hyperglycemic potency of the new drug compared to the root drug (E).

Mini-Reviews in Medicinal Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sathe, Pratima A. published the artcileTandem synthesis of aromatic amides from styrenes in water, SDS of cas: 2447-79-2, the publication is Tetrahedron Letters (2018), 59(29), 2820-2823, database is CAplus.

An expedient one-pot synthesis of aromatic amides from styrenes in the presence of N-bromosuccinimide and iodine by using aqueous ammonia in water is reported. The reaction proceeds through the formation of a α-bromoketone as an intermediate in the presence of NBS and water. The α-bromoketone on reaction with iodine forms bromodiiodoketone which on nucleophilic substitution with aqueous ammonia gives aromatic amide. Substituted aromatic amides were obtained in good yields with wide functional group compatibility.

Tetrahedron Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rajendar, K. published the artcileMolecular Iodine-Mediated Domino Reaction for the Synthesis of Benzamides, 2,2-Diazidobenzofuran-3(2H)-ones and Benzoxazolones, SDS of cas: 2447-79-2, the publication is Advanced Synthesis & Catalysis (2013), 355(18), 3591-3596, database is CAplus.

A simple and efficient domino protocol has been developed for the preparation of biol. important benzamides, e.g., I, 2,2-diazidobenzofuran-3(2H)-ones, e.g., II, and benzoxazolones, e.g., III, from various structurally and electronically divergent acetophenones and ortho-hydroxyacetophenones in the presence of mol. iodine, sodium azide and sodium bicarbonate at 100 ⁰C in good to excellent yields.

Advanced Synthesis & Catalysis published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Piskov, V. B. published the artcileConversion of carboxylic acids to amides, Related Products of amides-buliding-blocks, the publication is Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) (1973), 46(1), 220-1, database is CAplus.

Pelargonic, lauric, and (10) benzoic acid derivatives were converted to the resp. amides (≤99%) by heating with ≥2 equivalent of H2NSO3H in oleum or polyphosphoric acid at 100-20°; 3-02NC6H4CO2H and MeNHSO3H gave 89% 3-O2NC6H4CONHMe under similar conditions.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Broderius, Steven J. published the artcileUse of joint toxic response to define the primary mode of toxic action for diverse industrial organic chemicals, HPLC of Formula: 2447-79-2, the publication is Environmental Toxicology and Chemistry (1995), 14(9), 1591-605, database is CAplus.

We have explored the use of 96-h acute toxicity tests with juvenile fathead minnows and primarily binary chem. mixtures to define the primary acute mode of toxic action for diverse industrial organic chems. Our investigation mainly considered the two special cases of noninteractive joint action known as concentration (simple similar) and response (independent) addition The different forms of joint toxicity with binary mixtures were graphically illustrated by isobole diagrams. Designated as the mode of action-specific reference toxicants were 1-octanol, phenol, and 2,4-dinitrophenol. It was observed from binary isobole diagrams that a chem. with a similar primary mode of toxic action to that of a reference toxicant would display a concentration-addition type of joint action with the reference toxicant over the entire mixture ratio range. Dissimilar chems. with very steep concentration-response curves generally showed an interaction that was less-than-concentration additive, but consistently demonstrated a joint toxicity that was greater than predicted by the response-addition model. The more-than-concentration additive complex isoboles that are indicative of interactive toxicity were not commonly observed in our experiments

Environmental Toxicology and Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, HPLC of Formula: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

de Lipthay, Julia R. published the artcileBacterial diversity and community structure of a sub-surface aquifer exposed to realistic low herbicide concentrations, Synthetic Route of 2447-79-2, the publication is FEMS Microbiology Ecology (2004), 49(1), 59-69, database is CAplus and MEDLINE.

An increasing number of herbicides are found in our groundwater environments. This underlines the need for examining the effects of herbicide exposure on the indigenous groundwater microbial communities, as microbial degradation is the major process responsible for the complete removal of most contaminants. We examined the effect of in situ exposure to realistic low concentrations of herbicides on the microbial diversity and community structure of sub-surface sediments from a shallow aquifer near Vejen (Denmark). Three different community analyses were performed: colony morphol. typing, sole C source utilization in Biolog EcoPlates, and denaturing gradient gel electrophoresis. Cluster anal. demonstrated that the microbial communities of those aquifer sediments that acclimated to the herbicide exposure also had similar community structure. This observation was concurrent for all 3 community analyses. In contrast, no significant effect was found on the bacterial diversity, except for the culturable fraction where a significantly increased richness and Shannon index was found in the herbicide acclimated sediments. The results of this study show that in situ exposure of sub-surface aquifers to realistic low concentrations of herbicides may alter the overall structure of a natural bacterial community, although significant effects on the genetic diversity and C substrate usage cannot be detected. The observed impact was probably due to indirect effects. In future studies, the inclusion of methods that specifically detect relevant microbial sub-populations and functional genes is recommended.

FEMS Microbiology Ecology published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Synthetic Route of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ghosh, Santanu published the artcileAminofluorene-Mediated Biomimetic Domino Amination-Oxygenation of Aldehydes to Amides, Application of 2,4-Dichlorobenzamide, the publication is Organic Letters (2016), 18(22), 5788-5791, database is CAplus and MEDLINE.

A conceptually novel biomimetic strategy based on a domino amination-oxygenation reaction was developed for direct amidation of aldehydes under metal-free conditions employing mol. oxygen as the oxidant. 9-Aminofluorene derivatives acted as pyridoxamine-5′-phosphate equivalent for efficient, chemoselective, and operationally simple amine-transfer oxygenation reaction. Unprecedented RNH transfer involving secondary amines to produce secondary amides was achieved. In the presence of ¹⁸O₂, ¹⁸O-amide was formed with excellent (95%) isotopic purity.

Organic Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Application of 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics