Category: 2447-79-2

Ghosh, Santanu published the artcileMetal-Free Thermal Activation of Molecular Oxygen Enabled Direct α-CH₂-Oxygenation of Free Amines, COA of Formula: C7H5Cl2NO, the publication is Journal of Organic Chemistry (2018), 83(1), 260-266, database is CAplus and MEDLINE.

Direct oxidation of α-CH₂ group of free amines is hard to achieve due to the higher reactivity of amine moiety. Therefore, oxidation of amines involves the use of sophisticated metallic reagents/catalyst in the presence or absence of hazardous oxidants under sensitive reaction conditions. A novel method for direct C-H oxygenation of aliphatic amines through a metal-free activation of mol. oxygen has been developed. Both activated and unactivated free amines were oxygenated efficiently to provide a wide variety of amides (primary, secondary) and lactams under operationally simple conditions without the aid of metallic reagents and toxic oxidants. The method has been applied to the synthesis of highly functionalized amide-containing medicinal drugs, such as O-Me-alibendol and -buclosamide.

Journal of Organic Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, COA of Formula: C7H5Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Eccles, Peter J. published the artcileOrganophosphorus compounds as potential fungicides. Part IV. The preparation and properties of some novel N-(1-substituted-2,2,2-trichloroethyl)phosphoramidates, Synthetic Route of 2447-79-2, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1995), 105(1-4), 33-44, database is CAplus.

A series of 20 di-Et N-(1-substituted-2,2,2-trichloroethyl)phosphoramidates (EtO)₂P(O)NHCH(CCl₃)X was prepared containing N-heterocyclic, carboxamide, phosphoramide, dithiocarbamate, xanthate, and hydroxyethylthio substituents X in the 1-position of the 2,2,2-trichloroethyl group. Screening in vitro at 500 ppm showed the dithiocarbamates (EtO)₂P(O)NHCH(CCl₃)SCSNR₂ (R = Me, Et) to be the most active, giving complete control of Fusarium spp., Helminthosporium spp., and Ophiobolus graminis under these conditions. High activity was also observed against Fusarium culmorum for the triazole, hydroxyethylthio, and xanthate derivatives, and for an imidazole analog in which one ethoxy and one dimethylamino group were attached to phosphorus. The carboxamide derivatives were the least active. The dithiocarbamates also gave ca. 50% control of Piricularia oryzae and Rhizoctonia solani at 300 ppm in vitro. Lower levels of activity were recorded when the compounds were applied to seeds infected with Drechslera teres and Septoria nodorum and slight inhibition of germination and plant development was observed The compounds were all weak inhibitors of acetylcholinesterase.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Synthetic Route of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Ning published the artcileDesign, synthesis, and insecticidal/acaricidal evaluation of novel pyrimidinamine derivatives containing phenyloxazole moiety, Synthetic Route of 2447-79-2, the publication is Chemical Papers (2020), 74(3), 963-970, database is CAplus.

A series of novel pyrimidinamine derivatives containing phenyloxazole moiety I (R¹ = H, 2-Cl, 4-CF₃, etc.; R² = Me, Et) was designed and synthesized, and their structures were characterized by ¹H NMR, MS, and elemental analyses. The bioassay results displayed that some compounds exhibited remarkable insecticidal activities against Aphis fabae and Tetranychus cinnabarinus. Especially, I (R¹ = 4-Me; R² = Et) showed potent activity against A. fabae, superior to that of the com. insecticide, imidacloprid. In addition, I (R¹ = 4-CF₃; R² = Et) showed potent activities against T. cinnabarinus, inferior to that of the com. insecticide spirotetramat. The structure-activity relationship study for the target compounds was also discussed.

Chemical Papers published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H13BrSi, Synthetic Route of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jagerovic, Nadine published the artcileDiscovery of 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a Novel in Vivo Cannabinoid Antagonist Containing a 1,2,4-Triazole Motif, Computed Properties of 2447-79-2, the publication is Journal of Medicinal Chemistry (2004), 47(11), 2939-2942, database is CAplus and MEDLINE.

A new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. The title compound, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole (I) showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist. Mol. modeling of I was carried out on Δ⁹-tetrahydrocannabinoic acid B.

Journal of Medicinal Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Computed Properties of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Reed, Kathryn L. published the artcileA mild and convenient oxidation of aryl nitriles to aryl amides by aqueous sodium perborate, Formula: C7H5Cl2NO, the publication is Synthetic Communications (1990), 20(4), 563-71, database is CAplus.

Treatment of aryl nitriles with NaBO₃.4H₂O in aqueous dioxane gives the corresponding benzamides in 13-85% yields. E.g., 3,5-Cl₂C₆H₃CN gives 74% 3,5-Cl₂C₆H₃CONH₂. The effect of substrate structure on yield is discussed.

Synthetic Communications published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Formula: C7H5Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rajca, Andrzej published the artcile5-Aryl-2-oxo-1,2,4-oxathiazoles as cyclocarbonylating agents for 2-aminoalcohols and 1,2-diamines, Synthetic Route of 2447-79-2, the publication is Synthesis (1983), 1032-3, database is CAplus.

Cyclocarbonylation of HOCH₂CH₂NHR (R = H, Me) with 2-oxo-5-phenyl- and 5-(2,4-dichlorophenyl)-2-oxo-1,3,4-oxathiazoles gave 68-82% I (X = O; R¹ = H). Similarly, RNHCHR¹CH₂NHR²(R, R¹, R² = H, Me) gave 65-88% I (X = NR²).

Synthesis published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Synthetic Route of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hernandez-Folgado, Laura published the artcileNovel derivatives of 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles and their pharmacological evaluation as CB₁ cannabinoid ligands, Name: 2,4-Dichlorobenzamide, the publication is Monatshefte fuer Chemie (2008), 139(9), 1073-1082, database is CAplus.

In a previous study, the authors identified 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles, e.g., I, to be a novel class of cannabinoid type-1 (CB₁) receptor antagonists. However, the synthesis yields for the ligands were low. An alternative synthesis pathway with improved yields is presented here. In addition, they have synthesized new structural derivatives and studied their results in competitive radioligand binding assays for cannabinoid receptors.

Monatshefte fuer Chemie published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Name: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ren, Shijin published the artcileAn exploratory study of the use of multivariate techniques to determine mechanisms of toxic action, Related Products of amides-buliding-blocks, the publication is Ecotoxicology and Environmental Safety (2003), 55(1), 86-97, database is CAplus and MEDLINE.

The most successful quant. structure-activity relationships have been developed by separating compounds by their mechanisms of toxic action (MOAs). However, to correctly determine the MOA of a compound is often not easy. The authors investigated the usefulness of discriminant anal. and logistic regression in determining MOAs. The discriminating variables used were the logarithm of octanol-water partition coefficients (log K_ow) and the exptl. toxicity data obtained from Pimephales promelas and Tetrahymena pyriformis assays. Small total error rates were obtained when separating nonpolar narcotic compounds from other compounds, however, relatively high total error rates were obtained when separating less reactive compounds (polar, ester, and amine narcotics) from more reactive compounds (electrophiles, proelectrophiles, and nucleophiles).

Ecotoxicology and Environmental Safety published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gilligan, Paul J. published the artcilePyrazolo-[1,5-a]-1,3,5-triazine corticotropin-releasing factor (CRF) receptor ligands, Product Details of C7H5Cl2NO, the publication is Bioorganic & Medicinal Chemistry (2003), 11(18), 4093-4102, database is CAplus and MEDLINE.

The syntheses and rat CRF receptor binding affinities of retro-pyrazolotriazine’ corticotropin-releasing factor (CRF) ligands are reported. Some have high affinity for rat CRF receptors (K_i≤10 nM). The data provide addnl. support for the hypothesis that it is possible to interchange isosteric cores with similar electronic properties in the design of high-affinity CRF receptor ligands, provided the peripheral pharmacophore elements are maintained in the same three-dimensional array.

Bioorganic & Medicinal Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Product Details of C7H5Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Markovskii, L. N. published the artcileIminothionyl chlorides. X. Synthesis from iminoester. Infrared spectra, Computed Properties of 2447-79-2, the publication is Zhurnal Organicheskoi Khimii (1974), 10(5), 992-7, database is CAplus.

RN:SCl2 [R = Cl3CCO (I), Bz (II), p-ClC6H4CO (III), p-BrC6H4CO (IV), 2,4-Cl2C6H3CO (V), p-O2NC6H4CO (VI), MeSO2 (VII), PhSO2 (VIII)] were prepared by different methods. II, V, VI, VII, and VIII were prepared (60-89%) by reaction of RNH2 with SCl2. I, II, III, IV, V and VI were prepared (57-90%) by reaction of the corresponding alkyl arenecarboximidate with SCl2. II and VI were prepared (59-95%) by reaction of SCl2 with PhC(:NCl)OR (R = alkyl) and p-O2NC6-H4C(:NCl)OR, resp. Reaction of p-O2NC6H4C(OEt):NSN:-C(OEt)C6H4NO2-p with SCl2 gave 62% VI. The ir spectra depended on R.

Zhurnal Organicheskoi Khimii published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Computed Properties of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics