Category: 5455-98-1

On August 31, 2010, Pace, Vittorio; Hoyos, Pilar; Fernandez, Maria; Sinisterra, Jose V.; Alcantara, Andres R. published an article.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was 2-Methyltetrahydrofuran as a suitable green solvent for phthalimide functionalization promoted by supported KF. And the article contained the following:

An efficient chemoselective nitrogen functionalization of phthalimides by using KF-Alumina in 2-methyltetrahydrofuran, a solvent obtained from renewable sources, is described. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to methyltetrahydrofuran green solvent alkylation phthalimide supported potassium fluoride, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ielo, Laura; Miele, Margherita; Pillari, Veronica; Senatore, Raffaele; Mirabile, Salvatore; Gitto, Rosaria; Holzer, Wolfgang; Alcantara, Andres R.; Pace, Vittorio published an article in 2021, the title of the article was Taking advantage of lithium monohalocarbenoid intrinsic α-elimination in 2-MeTHF: controlled epoxide ring-opening en route to halohydrins.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

A straightforward preparation of different β-halohydrins RCR1(OH)CH2X [R = Ph, 4-ClC6H4, 1,3-dioxoisoindolin-2-yl, etc.; R1 = H, Me, CF3, Ph; X = Cl, Br, I] through boosted Kirmse’s elimination of the corresponding lithium monohalocarbenoids starting from epoxide. Crucial for the development of the method was the use of the eco-friendly solvent 2-MeTHF, which forces the degradation of the incipient monohalolithium, due to the very limited stabilizing effect of this solvent on the chem. integrity of the carbenoid. The uniformly high-yield, the full preservation of the embodied stereochem. information and the high regiocontrol – deduced by selectively preparing variously decorated motifs further document the potential of this operationally simpleand intuitive methodol. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to halohydrin green preparation, epoxide lithium monohalocarbenoid ring opening elimination, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 1, 2014, Halimehjani, Azim Ziyaei; Hooshmand, Seyyed Emad; Shamiri, Elham Vali published an article.Formula: C11H9NO3 The title of the article was Synthesis of α-phthalimido-α’-dithiocarbamato propan-2-ols via a one-pot, three-component epoxide ring-opening in water. And the article contained the following:

Regioselective ring-opening of the N-(2,3-epoxypropyl)phthalimide with in situ prepared dithiocarbamic acid in water is reported for the synthesis of a new family of α-phthalimido-α’-dithiocarbamato propan-2-ols. The present method is simple, EtOAc is used for work-ups and affords excellent yield of products. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to phthalimido thiocarbamato propanol preparation, multicomponent phthalimido epoxide ring opening primary amine, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Le, Zhang-Gao; Zhong, Tao; Xie, Zong-Bo; Xu, Jian-Ping published an article in 2011, the title of the article was Solvent-free N-alkylation of phthalimide catalyzed by basic ionic liquids.SDS of cas: 5455-98-1 And the article contains the following content:

Solvent-free N-alkylation of phthalimide with alkyl halides catalyzed by basic ionic liquids is reported in this communication. With a comparative study, [Bmim]OH (1-butyl-3-methylimidazolium hydroxide) exhibited the highest catalytic activity among the selected basic ionic liquids, which afforded a convenient, efficient and general protocol for N-alkyl phthalimides exclusively. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).SDS of cas: 5455-98-1

The Article related to phthalimide n alkyl preparation solvent free condition, alkyl halide phthalimide n alkylation ionic liquid catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 19, 2012, Pace, Vittorio; Holzer, Wolfgang published an article.Related Products of 5455-98-1 The title of the article was A straightforward and general access to α-phthalimido-α’-substituted propan-2-ones. And the article contained the following:

The regioselective ring opening of the com. available N-(2,3-epoxypropyl)phthalimide with different nucleophiles, to obtain the corresponding phthalimidopropan-2-ols (including a challenging fluorohydrin) followed by the Dess-Martin periodinane oxidation, constitutes a general and widely applicable protocol for the preparation of differently functionalized α-phthalimido-α’-substituted propan-2-ones I [R = Cl, Br, F, etc.]. The incorporation of the substituent in the α’ position takes place in an early stage of the process, thus furnishing a divergent and valuable approach. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to regioselective ring opening epoxypropylphthalimide, phthalimidopropanol preparation dess martin oxidation, phthalimidopropanone preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 21, 2017, Mei, Congmin; Li, Xu; Liu, Lihuai; Cao, Changsheng; Pang, Guangsheng; Shi, Yanhui published an article.Related Products of 5455-98-1 The title of the article was Selectively synthesis of cyclic di- and trithiocarbonates by N-heterocyclic carbene/LiCl(Br) catalyzed addition of carbon disulfide to epoxides. And the article contained the following:

Carbon disulfide is an abundant, inexpensive and readily available material. One of the main challenges in the reaction of epoxides with CS2 is to control the chemoselectivity as a variety of compounds would be formed in the reaction. A simple and convenient method toward selectively synthesis of oxathiolane and trithiocarbonate from epoxides with CS2 catalyzed by NHC/LiCl(Br) under the neat conditions was developed. This catalytic system exhibits excellent activity and selectivity in cycloaddition reactions of carbon disulfide to terminal epoxides. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to heterocyclic carbene catalyst carbon disulfide epoxide cycloaddition, dithiocarbonate preparation, trithiocarbonate preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Related Products of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 23, 2016, Ombrato, Rosella; Garofalo, Barbara; Mangano, Giorgina; Capezzone de Joannon, Alessandra; Corso, Gaia; Cavarischia, Claudia; Furlotti, Guido; Iacoangeli, Tommaso published a patent.Formula: C11H9NO3 The title of the patent was Antibacterial compounds having broad spectrum of activity. And the patent contained the following:

The present invention relates to novel antibacterial compounds, I (R1 = H, halo, OH, C1-3 alkyl, C1-3 alkoxy, C1-3 alkyl-OH, carboxy, amido, etc.; L1 σ-bond, CH2, O, NH, etc.; Y = C1-6 alkylenyl, NH-C1-6 alkylenyl, C4-5 cycloaklenyl, etc.; L2 = σ-bond, NH, NH-C1-6 alkylenyl, etc.,; A = fused bicyclic group, etc.; B = fused bicyclic or tricyclic functional group, etc.; G1, G2 = CH, N, etc.), pharmaceutical compositions containing them and their use as antimicrobials. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to piperazine chromene derivative preparation antibacterial activity, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 13, 2012, Su, Wei-Guo; Deng, Wei; Ji, Jianguo published a patent.Application of 5455-98-1 The title of the patent was Preparation of pyridopyrazine derivatives for use as Syk inhibitors. And the patent contained the following:

Title compounds I [each R1 independently = H, halo, CN, OH, (un)substituted alkyl, etc.; R2 = NH2, OH, C(O)H, (un)substituted alkyl, etc.; R3 and R4 independently = H, (un)substituted alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; or together with the N to which they are attached form an (un)substituted monocyclic, fused bicyclic, or spirocyclic ring optionally containing 1-3 heteroatoms selected from n, o, or S], and their pharmaceutically acceptable salts, are prepared and disclosed as Syk inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in Syk kinase assays, e.g., II demonstrated an IC50 value in the range of 0.001 to <0.1 μM. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1

The Article related to pyridopyrazine derivative preparation syk inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2015, Huang, Min-yi; Xu, Wei; Huang, Jun-jun; Huang, Ya-jian; Yuan, Mu published an article.Formula: C11H9NO3 The title of the article was Synthesis, crystal structure and biological activity of N-(2-hydroxy-3-(4-(2-methoxyphenyl)-piperazin-1-yl)propyl)quinoxaline-2-methanamide. And the article contained the following:

The title compound N-(2-hydroxy-3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-quinoxaline-2-methanamide (I, C23H27N5O3, Mr = 421.50) was synthesized via a four-step reaction and characterized by 1H NMR, 13C NMR, ESIMS and single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 12.108(2), b = 12.639(3), c = 14.601(3) Å, β = 104.87(3)°, V = 2,159.6(8) Å3, Z = 4, Dc = 1.296 g/cm3, S = 1.023, μ = 0.088 mm-1, F(000) = 896, R = 0.0392 and wR = 0.0983 for 2,836 observed reflections with I>2σ (I). The single-crystal X-ray structural anal. reveals that I is stabilized by intramol. and intermol. hydrogen bonds together with π-π interactions. The bioassay showed that I exhibited high selective activity for α1A/D vs. α1B-adrenoceptors subtype. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to methoxyphenylpiperazinylpropyl quinoxalinecarboxamide preparation adrenoceptor antagonistic activity crystal mol structure, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 3, 2019, Bi, Yingzhi; Dorsey, Bruce D.; Fan, Yi; Moore, Christopher Brooks; Nguyen, Duyan published a patent.Product Details of 5455-98-1 The title of the patent was Preparation of substituted 1,1′-biphenyl compounds and analogues thereof, and methods for using them for treatment of HBV and HDV infections. And the patent contained the following:

The invention is related to the preparation of compounds I [X1 = CH, N; X2 = R2a = OCH2**, CH2O**, CONH**, NHCO**, wherein the bond marked with ** is to the Ph ring carbon marked with *; R1a, R1b = independently H, alkyl, alkoxy, CN, halo, haloalkyl; R1c = H, alkyl, OH, alkoxy optionally substituted; R2a = alkyl, alkoxy, (CH2)1-3(optionally substituted phenyl), etc.; R3a = CHO, COOH and derivatives, CONH2 and derivatives, etc.; R4a = halo, CN, alkyl], including substituted 3,3′-bis(phenoxymethyl)-1,1′-biphenyl compounds and their analogs, their salts, solvates, geometric isomers, stereoisomers, tautomers or any mixtures thereof, and compositions comprising them, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. Thus, II was prepared from (2-methyl-3-phenylphenyl)methanol using 2,4-dihydroxybenzaldehyde, 3-(bromomethyl)benzonitrile and ethane-1,2-diamine. II displayed an IC50 of 0.28 in a PD-L1 HTRF assay. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Product Details of 5455-98-1

The Article related to biphenyl analog preparation pd1 pdl1 inhibitor antiviral hbv hdv, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Product Details of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics