Category: 70-55-3

Product Details of 70-55-3In 2020 ,《Solid Solubilities of Sulfonamides and Use of Rapid Expansion of Supercritical Solutions for Microparticle Production》 was published in Chemical Engineering & Technology. The article was written by Yang, Tsung-Mao; Li, Jin-Shuh; Yeh, Tsao-Fa; Su, Chie-Shaan. The article contains the following contents:

The solubility of solid active pharmaceutical ingredients in supercritical fluids is a major thermodn. criterion for selection and screening of microparticle generation processes. To develop an efficient method for solubility prediction, a solution model was adopted to establish the correlations of the solid solubilities of six sulfonamides in supercritical CO2. The model was capable of determining solubility correlations. Accordingly, it was attempted to simplify and generalize the model, yielding a predictive solution model, which provided order-consistent solubility predictions. A case study for model extrapolation was conducted. After understanding the mechanisms underlying the solubility of sulfonamides, the rapid expansion of supercritical solutions (RESS) process was applied to produce microparticles of p-toluenesulfonamide, an anticancer drug. The effects of RESS process parameters were investigated. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 70-55-3In 2019 ,《Rh(III)-Catalyzed Direct Amination of Aromatic Ketoximes Enabled by Potassium Acetate》 was published in European Journal of Organic Chemistry. The article was written by Liu, Lingling; Wang, Ning; Dai, Chenyang; Han, Yi; Yang, Shan; Huang, Zhibin; Zhao, Yingsheng. The article contains the following contents:

A method to achieve rhodium(III)-catalyzed, potassium acetate enabled intermol. C-H amination of ketoximes using various benzenesulfonamide, especially 4-nitrobenzenesulfonamide is reported. Various aryl ketoximes substituted with electron-withdrawing functional groups were all well tolerated and produced the corresponding products in moderate to good yields. A preliminary mechanistic study revealed that potassium acetate is essential to realizing intermol. amination. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Application of 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 4-MethylbenzenesulfonamideIn 2019 ,《Targeted Therapy for Interfacial Engineering Toward Stable and Efficient Perovskite Solar Cells》 was published in Advanced Materials (Weinheim, Germany). The article was written by Wang, Shuhui; Chen, Haiyang; Zhang, Jiandong; Xu, Guiying; Chen, Weijie; Xue, Rongming; Zhang, Moyao; Li, Yaowen; Li, Yongfang. The article contains the following contents:

The poor long-term stability of organic-inorganic hybrid halide perovskite solar cells (pero-SCs) remains a big challenge for their commercialization. Although strategies such as encapsulation, doping, and passivation have been reported, there remains a lack of understanding of the water resistance and thermal stability of pero-SCs. A fullerene derivative, [6,6]-phenyl-C61-butyric acid-N,N-dimethyl-3-(2-thienyl)propanam ester (PCBB-S-N) containing a functional S atom and C60, is synthesized and used as electron transporting layer (ETL)/intermediary layer to targetedly heal the multitype defects in pero-SCs or assist the growth of ETL, such as [6,6]-phenyl-C61-butyric acid Me ester (PCBM), in planar p-i-n pero-SCs. The repaired pero-SCs can not only dramatically improve their power conversion efficiencies, but also address stability issues under moisture and high temperature The corresponding mechanism of PCBB-S-N with targeted therapy effect in a device is systematically studied by both experiments and theor. calculation This work demonstrates that the proposed fullerene derivative with finely tuned chem. structure can be a promising ETL candidate or intermediary to approach stable and efficient planar p-i-n pero-SCs. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Solvent interception, heterocyclization and desilylation upon NBS-induced sulfamidation of trimethyl(vinyl)silane》 was written by Astakhova, Vera V.; Moskalik, Mikhail Yu.; Shainyan, Bagrat A.. Product Details of 70-55-3This research focused onthree component amidation bromination vinylsilane sulfonamide aziridine preparation; Ritter reaction acetonitrile vinylsilane bromosuccinimide sulfonamide preparation imidazole; oxazocine preparation Ritter reaction acetonitrile bromoalkylsilane. The article conveys some information:

Silylated N-bromoethylsulfonamides, aziridines, imidazoles and oxazocane were prepared by three-component reaction of vinylsilane with brominating agents and sulfonamides with participation of solvent acetonitrile. The reaction of trimethyl(vinyl)silane with sulfonamides in the presence of N-bromosuccinimide was shown to proceed regioselectively in methylene chloride under mild conditions and led to the products of bromosulfamidation in up to 88% yield. The obtained adducts undergo base-promoted dehydrobromination to give 2-trimethylsilyl-N-sulfonyl aziridines in a close to quant. yield. In the reaction with trifluoromethanesulfonamide in acetonitrile or THF, the Ritter-type (solvent-interception) products were obtained and converted to 1-triflyl-2-methyl-5-(trimethylsilyl)-2-imidazoline or 4-triflyl-3-(trimethylsilyl)-1,4-oxazocane in almost quant. yield. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Quality by Design (Qbd) Approach to Develop HPLC Method for Estimation of Gliclazide and its Impurity (Gliclazide Impurity A) in Bulk Drug》 were Vijayaraj, Surendran; Palei, Narahari N.; Katyayani, Thummala. And the article was published in Current Pharmaceutical Analysis in 2019. Safety of 4-Methylbenzenesulfonamide The author mentioned the following in the article:

Background: Gliclazide Impurity A (GI-A) is one of the gliclazide impurities, as described in the European Pharmacopoeia. Objective: The objective of this study was to develop and validate simple, robust and accurate Reverse- Phase High-Performance Liquid Chromatog. (RP-HPLC) method for estimation of gliclazide along with GI-A in bulk by optimizing chromatog. parameters using Box Behnken design in response surface methodol. Methods & Results: Box Behnken design was employed for optimizing flow rate, injection volume and strength of the buffer in order to minimize retention time of both gliclazide and GI-A. The optimized strength of orthophosphoric acid buffer in a mixture of Acetonitrile (50:50 volume/volume), flow rate and injection volume were found to be 25mM, 1mL/min, 20μL resp. Linearity was observed in concentration range of 25-150μg/mL (r2=0.999). The retention time of gliclazide and GI-A was found to be 5.799 min and 3.819 min, resp. The limit of detection for Gliclazide and GI-A was found to be 0.0066, and 0.0075μg/mL and the limit of quantification limit was found to be 0.0202, 0.0228μg/mL, resp. The developed method was validated as per the ICH guidelines. Conclusion: The proposed method is useful for best anal. of Gliclazide and GI-A in pharmaceutical dosage forms. QbD approach was found to be an effective tool for optimizing chromatog. conditions of the proposed method.4-Methylbenzenesulfonamide(cas: 70-55-3Safety of 4-Methylbenzenesulfonamide) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Safety of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Moutaoukil, Zakaria; Serrano-Diez, Emmanuel; Collado, Isidro G.; Jimenez-Tenorio, Manuel; Botubol-Ares, Jose Manuel published an article in 2022. The article was titled 《N-Alkylation of organonitrogen compounds catalyzed by methylene-linked bis-NHC half-sandwich ruthenium complexes》, and you may find the article in Organic & Biomolecular Chemistry.Synthetic Route of C7H9NO2S The information in the text is summarized as follows:

An efficient ruthenium-catalyzed N-alkylation of amines, amides and sulfonamides was developed employing novel pentamethylcyclopentadienylruthenium(II) complexes bearing the methylene linked bis(NHC) ligand bis(3-methylimidazol-2-ylidene)methane. The acetonitrile complex I was proved to be particularly effective with a broad range of substrates with low catalyst loading (0.1-2.5 mol%) and high functional group tolerance under mild conditions. A total of 52 N-alkylated organonitrogen compounds including biol. relevant scaffolds were synthesized from (hetero)aromatic and aliphatic amines, amides and sulfonamides using alcs. or diols as alkylating agents in up to 99% isolated yield, even on gram-scale reactions. In the case of sulfonamides, it was the first example of N-alkylation employing a transition-metal complex bearing NHC ligands. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Chemistry – A European Journal included an article by van Leest, Nicolaas P.; Grooten, Lars; van der Vlugt, Jarl Ivar; de Bruin, Bas. Category: amides-buliding-blocks. The article was titled 《Uncatalyzed Oxidative C-H Amination of 9,10-Dihydro-9-Heteroanthracenes: A Mechanistic Study》. The information in the text is summarized as follows:

A new method for the one-step C-H amination of xanthene and thioxanthene with sulfonamides is reported, without the need for any metal catalyst. A benzoquinone was employed as a hydride (or two-electron and one-proton) acceptor. Moreover, a previously unknown and uncatalyzed reaction between iminoiodanes and xanthene, thioxanthene and dihydroacridines (9,10-dihydro-9-heteroanthracenes or dihydroheteroanthracenes) is disclosed. The reactions proceed through hydride transfer from the heteroarene substrate to the iminoiodane or benzoquinone, followed by conjugate addition of the sulfonamide to the oxidized heteroaromatic compounds These findings may have important mechanistic implications for metal-catalyzed C-H amination processes involving nitrene transfer from iminoiodanes to dihydroheteroanthracenes. Due to the weak C-H bond, xanthene is an often-employed substrate in mechanistic studies of C-H amination reactions, which are generally proposed to proceed via metal-catalyzed nitrene insertion, especially for reactions involving nitrene or imido complexes that are less reactive (i.e., less strongly oxidizing). However, these substrates clearly undergo non-catalyzed (proton-coupled) redox coupling with amines, thus providing alternative pathways to the widely assumed metal-catalyzed pathways. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3Category: amides-buliding-blocks)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Journal of the American Chemical Society included an article by Chen, Pan-Pan; Lucas, Erika L.; Greene, Margaret A.; Zhang, Shuo-Qing; Tollefson, Emily J.; Erickson, Lucas W.; Taylor, Buck L. H.; Jarvo, Elizabeth R.; Hong, Xin. Product Details of 70-55-3. The article was titled 《A Unified Explanation for Chemoselectivity and Stereospecificity of Ni-Catalyzed Kumada and Cross-Electrophile Coupling Reactions of Benzylic Ethers: A Combined Computational and Experimental Study》. The information in the text is summarized as follows:

Ni-catalyzed C(sp3)-O bond activation provides a useful approach to synthesize enantioenriched products from readily available enantioenriched benzylic alc. derivatives The control of stereospecificity is key to the success of these transformations. To elucidate the reversed stereospecificity and chemoselectivity of Ni-catalyzed Kumada and cross-electrophile coupling reactions with benzylic ethers, a combined computational and exptl. study is performed to reach a unified mechanistic understanding. Kumada coupling proceeds via a classic cross-coupling mechanism. Initial rate-determining oxidative addition occurs with stereoinversion of the benzylic stereogenic center. Subsequent transmetalation with the Grignard reagent and syn-reductive elimination produce the Kumada coupling product with overall stereoinversion at the benzylic position. The cross-electrophile coupling reaction initiates with the same benzylic C-O bond cleavage and transmetalation to form a common benzylnickel intermediate. However, the presence of the tethered alkyl chloride allows a facile intramol. SN2 attack by the benzylnickel moiety. This step circumvents the competing Kumada coupling, leading to the excellent chemoselectivity of cross-electrophile coupling. These mechanisms account for the observed stereospecificity of the Kumada and cross-electrophile couplings, providing a rationale for double inversion of the benzylic stereogenic center in cross-electrophile coupling. The improved mechanistic understanding will enable design of stereoselective transformations involving Ni-catalyzed C(sp3)-O bond activation. The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols》 were Reed-Berendt, Benjamin G.; Morrill, Louis C.. And the article was published in Journal of Organic Chemistry in 2019. HPLC of Formula: 70-55-3 The author mentioned the following in the article:

An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed. This borrowing hydrogen approach employs a well-defined and bench-stable Mn(I) PNP pincer precatalyst, allowing benzylic and simple primary aliphatic alcs. to be employed as alkylating agents. A diverse range of aryl and alkyl sulfonamides undergoes mono-N-alkylation in excellent isolated yields (32 examples, 85% average yield). After reading the article, we found that the author used 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.HPLC of Formula: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 70-55-3In 2020 ,《Electrically-driven N(sp2)-C(sp2/3) bond cleavage of sulfonamides》 was published in ACS Sustainable Chemistry & Engineering. The article was written by Wetzel, Annica; Jones, Alan M.. The article contains the following contents:

The discovery and development of an unexpected elec.-driven N(sp2)-C(sp3) and N(sp2)-C(sp2) bond cleavage reaction alongside dehydrogenative C-O bond coupling reactions both in batch and flow conditions was reported. Intramol. trapping experiments with the diuretic hydrochlorothiazide, gave insight into the intermediacy of an N-sulfonyliminium ion en route to the related drug, chlorothiazide. Using only electrons as the oxidant, this was a green and sustainable technol. advance for sulfonamide deprotection chem. and drug metabolism studies.4-Methylbenzenesulfonamide(cas: 70-55-3SDS of cas: 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.SDS of cas: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics