Category: 70-55-3

Synthetic Route of C7H9NO2SIn 2020 ,《Enantioselective Hydroamination of Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer》 appeared in Journal of the American Chemical Society. The author of the article were Roos, Casey B.; Demaerel, Joachim; Graff, David E.; Knowles, Robert R.. The article conveys some information:

An enantioselective, radical-based method for the intramol. hydroamination of alkenes with sulfonamides to afford pyrrolidines I [R1 = Ph, 2-thienyl, 2,4,6-tri-MeC6H2, etc.; R2 = H, Me; R3 = Me, t-Bu, CH2CH2CH=CMe2; R2R3 = (CH2)2, (CH2)5, CH2CH2NBocCH2CH2] was reported. These reactions were proposed to proceed via N-centered radicals formed by proton-coupled electron transfer (PCET) activation of sulfonamide N-H bonds. Noncovalent interactions between the neutral sulfonamidyl radical and a chiral phosphoric acid generated in the PCET event were hypothesized to serve as the basis for asym. induction in a subsequent C-N bond forming step, achieving selectivities of up to 98:2 er. These results offer further supported for the ability of noncovalent interactions to enforce stereoselectivity in reactions of transient and highly reactive open-shell intermediates.4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《H-*BEA Zeolite-Catalyzed Nucleophilic Substitution in Allyl Alcohols Using Sulfonamides, Amides, and Anilines》 was written by Ohtsuki, Akimichi; Aoki, Shunsuke; Nishida, Ryo; Morita, Sachiko; Fujii, Takeshi; Okumura, Kazu. Computed Properties of C7H9NO2SThis research focused onzeolite catalyst nucleophilic substitution allyl alc sulfonamide amide aniline. The article conveys some information:

Herein, the authors report a novel zeolite-catalyzed nucleophilic substitution in allyl alcs. The product yield was improved upon the addition of NaOTf (0.05 mol-%) using the studied zeolites. The highest yields were observed using H-*BEA(Si/Al2 = 40)/NaOTf. The scope of the reaction with respect to the nucleophile was examined using 1,3-diphenylprop-2-ene-1-ol as a model substrate under optimized reaction conditions. p-Substituted aryl sulfonamides bearing electron-rich or electron-deficient substituents, alkyl sulfonamides, and heteroaryl sulfonamides undergo the amidation reaction to produce their corresponding allyl sulfonamides in good yield. Amides and anilines exhibited low activity under the optimized conditions, however, performing the reaction at 90° produced the target product. The scope of the allyl alc. was studied using p-toluenesulfonamide as the nucleophile and the reaction proceeded with a variety of allylic alcs. To probe the practical utility of the H-*BEA-catalyzed amidation reaction, a gram-scale reaction was performed using 1.01 g (4.8 mmol) of allyl alc., which afforded the target product in 88% yield. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Alkyne Versus Ynamide Reactivity: Regioselective Radical Cyclization of Yne-Ynamides》 was written by Dutta, Shubham; Mallick, Rajendra K.; Prasad, Rangu; Gandon, Vincent; Sahoo, Akhila K.. COA of Formula: C7H9NO2SThis research focused onyne tethered ynamide thiophenol regioselective radical cyclization; thioaryl pyrrole preparation; 4-thioaryl-pyrroles; 5-exo-dig cyclization; alkynes; radical cyclization; ynamides. The article conveys some information:

Ynamides are typically more reactive than simple alkynes and olefins. However, a serendipitous observation revealed a rare case where the reactivity of simple alkynes exceeds that of ynamides. This led to the development of a unique sulfur-radical-triggered cyclization of yne-tethered ynamides, which involves attack of the alkyne by a thiyl radical followed by cyclization with the ynamide. A wide range of novel 4-thioaryl pyrroles that could tolerate common functional moieties and N-protecting groups were expediently constructed by this strategy. The current method contrasts with the typical cyclization of yne-ynamides, which involves the attack of the alkyne moiety by the ynamide core. Control experiments and DFT calculations supported the participation of the sulfur radical in the reaction and the regioselective cyclization. The synthetic potential of the substituted pyrroles is also discussed. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Berthold, Dino; Geissler, Arne G. A.; Giofre, Sabrina; Breit, Bernhard. Recommanded Product: 70-55-3. The article was titled 《Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Allenes》. The information in the text is summarized as follows:

The rhodium-catalyzed asym. intramol. hydroamination of sulfonyl amides with terminal allenes was reported. It provided selective access to 5- and 6-membered N-heterocycles, scaffolds found in a large range of different bioactive compounds Moreover, gram scale reactions, as well as the application of suitable product transformations to natural products and key intermediates thereof were demonstrated. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of 4-MethylbenzenesulfonamideIn 2022 ,《Functionalized GO@ZIF-90-supported sulfuric acid and its application in the catalytic synthesis of sulfonamides》 was published in Research on Chemical Intermediates. The article was written by Ghazviniyan, Maryam; Masnabadi, Nasrin; Ghasemi, Mohammad Hadi. The article contains the following contents:

In this article, the sulfuric acid supported on the graphene oxide@ZIF-90 composite functionalized with ethylenediamine (GZAH) was synthesized and characterized with FTIR, SEM, TEM, EDS, BET, and TGA. Then, the synthesis of some sulfonamides was performed using the as-prepared nanocatalyst via N-acylation reaction. FTIR, 1HNMR, 13CNMR, and CHNS techniques were used to identify organic mols. The best results (93% yield) were obtained using a catalyst (0.1 g) in acetonitrile as a solvent and for 2 h at 60°C. The catalyst was recycled up to 5 times, maintaining efficiency. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Quality Control of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C7H9NO2SIn 2019 ,《Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides》 appeared in Angewandte Chemie, International Edition. The author of the article were Marcyk, Paul T.; Jefferies, Latisha R.; Abu Salim, Deyaa I.; Pink, Maren; Baik, Mu-Hyun; Cook, Silas P.. The article conveys some information:

A simple iron-based catalyst system for the mild, direct conversion of secondary and tertiary alcs. to sulfonamides was described. Starting from enantioenriched alcs., the intramol. variant proceeded with stereoinversion to produced enantioenriched 2- and 2,2-subsituted pyrrolidines I [R = Me, n-Pr, i-Bu, 4-MeOC6H4] and indolines II [R1 = i-Bu, n-hexyl, CH2(4-MeOC6H4), etc.; Y = H, F, MeO, CF3], without prior derivatization of the alc. or solvolytic conditions. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 70-55-3In 2020 ,《Highly Regio-, Diastereo- and Enantioselective Synthesis of Tetrahydroazepines and Benzo[b]oxepines through Palladium-Catalyzed [4+3] Cycloaddition Reactions》 was published in Angewandte Chemie, International Edition. The article was written by Trost, Barry M.; Zuo, Zhijun. The article contains the following contents:

A novel Pd0-catalyzed asym. [4+3] annulation reaction of two readily accessible starting materials was developed for building seven-membered heterocyclic architectures. The potential [3+2] side pathway could be suppressed though fine tuning of the conditions. A broad scope of cycloaddition donors and acceptors participated in the transformation with excellent chemo-, regio-, diastereo- and enantioselectivtities, leading to valuable tetrahydroazepines, e.g., I and benzo[b]oxepines, e.g., II. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3SDS of cas: 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.SDS of cas: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Synthesis of Sulfonyl Fluorides from Sulfonamides》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Perez-Palau, Marina; Cornella, Josep. Synthetic Route of C7H9NO2S The article mentions the following:

Aryl sulfonyl fluorides and selected alkylsulfonyl fluorides were prepared chemoselectively from the corresponding sulfonamides by treatment with pyrylium tetrafluoroborate, MgCl2, and KF in MeCN followed by quenching with H2O. Functionalized sulfonamides and sulfonamides derived from pharmaceutical agents underwent deamination and fluorination to sulfonyl fluorides. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Nickel-Catalyzed Cross-Coupling of Sulfonamides With (Hetero)aryl Chlorides》 was written by McGuire, Ryan T.; Simon, Connor M.; Yadav, Arun A.; Ferguson, Michael J.; Stradiotto, Mark. Product Details of 70-55-3 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

The development of Ni-catalyzed C-N cross-couplings of sulfonamides with (hetero)aryl chlorides is reported. These transformations, which were previously achievable only with Pd catalysis, are enabled using air-stable (L)NiCl(o-tol) pre-catalysts (L = PhPAd-DalPhos and PAd2-DalPhos), without photocatalysis. The collective scope of (pseudo)halide electrophiles (X = Cl, Br, I, OTs, and OC(O)NEt2) demonstrated herein is unprecedented for any reported catalyst system for sulfonamide C-N cross-coupling (Pd, Cu, Ni, or other). Preliminary competition experiments and relevant coordination chem. studies are also presented. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《CO2/N2-responsive nanoparticles for enhanced oil recovery during CO2 flooding》 was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2020. These research results belong to Lai, Nanjun; Zhu, Qingru; Qiao, Dongyu; Chen, Ke; Wang, Dongdong; Tang, Lei; Chen, Gang. HPLC of Formula: 70-55-3 The article mentions the following:

During CO2 flooding, serious gas channeling occurs in ultra-low permeability reservoirs due to the high mobility of CO2. The chief end of this work was to research the application of responsive nanoparticles for mobility control to enhance oil recovery. Responsive nanoparticles were developed based on the modification of nano-silica (SiO2) by 3-aminopropyltrimethoxysilane (KH540) via the Eschweiler-Clark reaction. The proof of concept for responsive nanoparticles was investigated by FT-IR, 1H-NMR, TEM, DLS, CO2/N2 response, wettability, plugging performance, and core flooding experiments The results indicated that responsive nanoparticles exhibited a good response to control nanoparticle dispersity due to electrostatic interaction. Subsequently, responsive nanoparticles showed a better plugging capacity of 93.3% to control CO2 mobility, and more than 26% of the original oil was recovered. Moreover, the proposed responsive nanoparticles could revert oil-wet surfaces to water-wet, depending on surface adsorption to remove the oil fromthe surface of the rocks. The results of this work indicated that responsive nanoparticles might have potential applications for improved oil recovery in ultra-low permeability reservoirs. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.HPLC of Formula: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics