Category: 70-55-3

《The effect of substituted benzene-sulfonamides and clinically licensed drugs on the catalytic activity of CynT2, a carbonic anhydrase crucial for Escherichia coli life cycle》 was published in International Journal of Molecular Sciences in 2020. These research results belong to Del Prete, Sonia; De Luca, Viviana; Bua, Silvia; Nocentini, Alessio; Carginale, Vincenzo; Supuran, Claudiu T.; Capasso, Clemente. Related Products of 70-55-3 The article mentions the following:

Proteins are relevant antimicrobial drug targets, and among them, enzymes represent a significant group, since most of them catalyze reactions essential for supporting the central metabolism, or are necessary for the pathogen vitality. Genomic exploration of pathogenic and non-pathogenic microorganisms has revealed genes encoding for a superfamily of metalloenzymes, known as carbonic anhydrases (CAs, EC 4.2.1.1). CAs catalyze the physiol. crucial reversible reaction of the carbon dioxide hydration to bicarbonate and protons. Herein, we investigated the sulfonamide inhibition profile of the recombinant β-CA (CynT2) identified in the genome of the Gram-neg. bacterium Escherichia coli. This biocatalyst is indispensable for the growth of the microbe at atm. pCO2. Surprisingly, this enzyme has not been investigated for its inhibition with any class of CA inhibitors. Here, we show that CynT2 was strongly inhibited by some substituted benzene-sulfonamides and the clin. used inhibitor sulpiride (KIs in the range of 82-97 nM). This study may be relevant for identifying novel CA inhibitors, as well as for another essential part of the drug discovery pipeline, such as the structure-activity relationship for this class of enzyme inhibitors. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

De Luca, Viviana; Angeli, Andrea; Mazzone, Valeria; Adelfio, Claudia; Carta, Fabrizio; Selleri, Silvia; Carginale, Vincenzo; Scaloni, Andrea; Supuran, Claudiu T.; Capasso, Clemente published an article in 2021. The article was titled 《Inhibitory Effects of Sulfonamide Derivatives on the β-Carbonic Anhydrase (MpaCA) from Malassezia pachydermatis, a Commensal, Pathogenic Fungus Present in Domestic Animals》, and you may find the article in International Journal of Molecular Sciences.Computed Properties of C7H9NO2S The information in the text is summarized as follows:

Fungi are exposed to various environmental variables during their life cycle, including changes in CO2 concentration CO2 has the potential to act as an activator of several cell signaling pathways. In fungi, the sensing of CO2 triggers cell differentiation and the biosynthesis of proteins involved in the metabolism and pathogenicity of these microorganisms. The mol. machineries involved in CO2 sensing constitute a promising target for the development of antifungals. Carbonic anhydrases (CAs, EC 4.2.1.1) are crucial enzymes in the CO2 sensing systems of fungi, because they catalyze the reversible hydration of CO2 to proton and HCO3-. Bicarbonate in turn boots a cascade of reactions triggering fungal pathogenicity and metabolism Accordingly, CAs affect microorganism proliferation and may represent a potential therapeutic target against fungal infection. Here, the inhibition of the unique β-CA (MpaCA) encoded in the genome of Malassezia pachydermatis, a fungus with substantial relevance in veterinary and medical sciences, was investigated using a series of conventional CA inhibitors (CAIs), namely aromatic and heterocyclic sulfonamides. This study aimed to describe novel candidates that can kill this harmful fungus by inhibiting their CA, and thus lead to effective anti-dandruff and anti-seborrheic dermatitis agents. In this context, current antifungal compounds, such as the azoles and their derivatives, have been demonstrated to induce the selection of resistant fungal strains and lose therapeutic efficacy, which might be restored by the concomitant use of alternative compounds, such as the fungal CA inhibitors. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Orooji, Yasin; Pakzad, Khatereh; Nasrollahzadeh, Mahmoud; Tajbakhsh, Mahmood published an article in 2021. The article was titled 《Novel magnetic lignosulfonate-supported Pd complex as an efficient nanocatalyst for N-arylation of 4-methylbenzenesulfonamide》, and you may find the article in International Journal of Biological Macromolecules.Recommanded Product: 4-Methylbenzenesulfonamide The information in the text is summarized as follows:

This study presented a novel and economical technique for synthesizing magnetic palladium complex conjugated to activated calcium lignosulfonate with triethylenetetramine (Fe3O4@lignosulfonate@triethylenetetramine@Pd complex (FLT-Pd complex)) as a practical and air-stable catalyst. FLT-Pd complex was used as a catalyst for the fabrication of 4-methyl-N-aryl-benzenesulfonamide derivatives I [Ar = Ph, 4-MeC6H4, 2-H2NC6H4, etc.] via N-arylation of 4-methylbenzenesulfonamide with aryl halides in good yields. Furthermore, because of the complex magnetic reparability and high stability, it could be removed easily from the reaction media using a magnet and reused 5 cycles without a remarkable loss of catalytic prowess. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C7H9NO2SIn 2019 ,《Selective Late-Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry-BF4》 was published in Angewandte Chemie, International Edition. The article was written by Gomez-Palomino, Alejandro; Cornella, Josep. The article contains the following contents:

Reported here is a simple and practical functionalization of primary sulfonamides, by a pyrylium salt (Pyry-BF4), with nucleophiles. This simple reagent activates the poorly nucleophilic NH2 group in a sulfonamide, enabling the formation of one of the best electrophiles in organic synthesis: a sulfonyl chloride. Because of the variety of primary sulfonamides in pharmaceutical contexts, special attention was focused on the direct conversion of densely functionalized primary sulfonamides by a late-stage formation of the corresponding sulfonyl chloride. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides, sulfonates, sulfides, sulfonyl fluorides, and sulfonic acids. The mild reaction conditions and the high selectivity of Pyry-BF4 towards NH2 groups permit the formation of sulfonyl chlorides in a late-stage fashion, tolerating a preponderance of sensitive functionalities. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of 4-MethylbenzenesulfonamideIn 2020 ,《Electrochemically generated N-iodoaminium species as key intermediates for selective methyl sulphonylimination of tertiary amines》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Huang, Binbin; Yang, Chao; Zhou, Jia; Xia, Wujiong. The article contains the following contents:

A straightforward protocol for approaching N-sulfonylamidines (E/Z)-RS(O)2N=CHN(R1)(R2) (R = Me, 2-fluorophenyl, thiophen-2-yl, etc.; R1 = Me; R2 = Et, cyclohexyl, benzyl, etc.; R1R2 = -(CH2)5-, -(CH2)2O(CH2)2-) and I via an electricity-driven, iodine-mediated cross dehydrogenative condensation (CDC) between sulfonamides RS(O)2NH2 and tertiary amines CH3N(R1)(R2), which features exclusive N-CH3 selectivity for the amine partners was reported. Mechanistic studies indicate that an in situ generated N-iodoaminium species serves as the key intermediate. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Quality Control of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Copper-catalyzed tandem cis-carbometalation/cyclization of imine-ynamides with arylboronic acids》 was written by Wang, Hao-Ran; Huang, En-He; Luo, Chen; Luo, Wen-Feng; Xu, Yin; Qian, Peng-Cheng; Zhou, Jin-Mei; Ye, Long-Wu. Related Products of 70-55-3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Indoles I (Ar1, Ar2 = Ph, substituted Ph; X = H, OMe, Me, Br) were prepared by copper(I) acetate-catalyzed tandem carboboration-cyclization of imino-ynamides 2-tBuN:CHC6H4N(PG)CCAr1 (PG = arenesulfonyl) with areneboronic acids Ar2B(OH)2. An efficient copper-catalyzed tandem regioselective cis-carbometalation/cyclization of imine-ynamides with arylboronic acids has been developed. This method leads to a facile and practical synthesis of valuable 2,3-disubstituted indolines in moderate to excellent yields and features a broad substrate scope and wide functional group tolerance. Other significant features of this protocol include the use of readily available starting materials, high flexibility, simple procedure and mild reaction conditions. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《One-pot aerobic oxidative sulfonamidation of aromatic thiols with ammonia by a dual-functional β-MnO2 nanocatalyst》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Hayashi, Eri; Yamaguchi, Yui; Kita, Yusuke; Kamata, Keigo; Hara, Michikazu. Electric Literature of C7H9NO2S The article mentions the following:

High-surface-area β-MnO2nanoparticles could act as effective heterogeneous catalysts for the one-pot oxidative sulfonamidation of various aromatic and heteroaromatic thiols to give corresponding sulfonamides ArSO2NH2 [Ar = Ph, 2-thienyl, 4-BrC6H4, etc.] using mol. oxygen and ammonia as resp. oxygen and nitrogen sources, without the need for any additives. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Electric Literature of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Electric Literature of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Bosnidou, Alexandra E.; Muniz, Kilian. Computed Properties of C7H9NO2S. The article was titled 《Intermolecular Radical C(sp3)-H Amination under Iodine Catalysis》. The information in the text is summarized as follows:

Alkanes and aryl alkanes such as ethylbenzene underwent regioselective amination with sulfonamides such as trifluoromethanesulfonamide in the presence of I2 using iodobenzene bis(4-bromobenzoate) as the stoichiometric oxidant in anhydrous dichloromethane under blue LED irradiation to yield N-sulfonyl benzylic and alkyl amines such as PhCH(NHTf)Me. The method was used to prepare aminated amino acids and racemic arylglycinates and β-aryl-β-alaninates as well as memantine, rasagiline, and racemic sertraline. The method was also used to prepare trans-2,5-disubstituted pyrrolidines by iodine-catalyzed photochem. amination of phenylalkanes with methanesulfonamide followed by intramol. amination in the presence of I2 using phenyliodine bis(3-chlorobenzoate) as the stoichiometric oxidant; the method was also used to prepare the dibenzoazabicyclooctane anticonvulsant MK-801. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Naccarato, Attilio; Tassone, Antonella; Martino, Maria; Elliani, Rosangela; Sprovieri, Francesca; Pirrone, Nicola; Tagarelli, Antonio published their research in Environmental Pollution (Oxford, United Kingdom) in 2021. The article was titled 《An innovative green protocol for the quantification of benzothiazoles, benzotriazoles and benzosulfonamides in PM10 using microwave-assisted extraction coupled with solid-phase microextraction gas chromatography tandem-mass spectrometry》.Computed Properties of C7H9NO2S The article contains the following contents:

Benzothiazoles (BTHs), benzotriazoles (BTRs), and benzenesulfonamides (BSAs) are chems. used in several industrial and household applications. Despite these compounds are emerging pollutants, there is still a lack of information about their presence in outdoor air samples. In this paper, we developed a new method for the quantification of BTHs, BTRs, and BSAs in airborne particulate matter (PM10). The extraction of fourteen analytes from PM10 was accomplished by microwave-assisted extraction (MAE) using an environmentally friendly mixture of water and ethanol. SPME was used to analyze the target compounds from the MAE extract by gas chromatog.-tandem mass spectrometry (SPME-GC-MS/MS), eliminating addnl. sample clean-up steps. The best working conditions for MAE and SPME were examined multivariately by exptl. design techniques. The target compounds were quantified in selected reaction monitoring acquisition mode. The proposed method was carefully validated, and the achieved results were satisfactory in terms of linearity, lower limit of quantification (picograms per cubic meter), intra- and inter-day accuracy (81-118% and 82-114%, resp.), and precision (repeatability and reproducibility in the range 2.3-17% and 7.4-19%, resp.). The application in a real monitoring campaign showed that the developed protocol is a valuable and eco-friendly alternative to the methods proposed so far. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors》 was written by Del Prete, Sonia; Bua, Silvia; Supuran, Claudiu T.; Capasso, Clemente. COA of Formula: C7H9NO2S And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. The article conveys some information:

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes involved in biosynthetic processes, transport, supply, and balance of CO2/HCO3- into the cell. In Bacteria, CAs avoid the depletion of the dissolved CO2/HCO3- from the cell, providing them to the central metabolism that is compromised without the CA activity. The involvement of CAs in the survival, pathogenicity, and virulence of several bacterial pathogenic species is recent. Here, we report the kinetic properties of the recombinant γ-CA (EcoCAγ) encoded in the genome of Escherichia coli. EcoCAγ is an excellent catalyst for the physiol. CO2 hydration reaction to bicarbonate and protons, with a kcat of 5.7 × 105 s-1 and kcat/Km of 6.9 × 106 M-1s-1. The EcoCAγ inhibition profile with a broad series of known CA inhibitors, the substituted benzene-sulfonamides, and clin. licensed drugs was explored. Benzolamide showed a KI lower than 100 nM. Our study reinforces the hypothesis that the synthesis of new drugs capable of interfering selectively with the bacterial CA activity, avoiding the inhibition of the human α -CAs, is achievable and may lead to novel antibacterials. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics