Category: 78191-00-1

Recommanded Product: 78191-00-1In 2021 ,《Regioselective Bromine/Magnesium Exchange for the Selective Functionalization of Polyhalogenated Arenes and Heterocycles》 appeared in Angewandte Chemie, International Edition. The author of the article were Desaintjean, Alexandre; Haupt, Tobias; Bole, Leonie J.; Judge, Neil R.; Hevia, Eva; Knochel, Paul. The article conveys some information:

Using the bimetallic combination sBu2Mg·2 LiOR (R = 2-ethylhexyl) in toluene enables efficient and regioselective Br/Mg exchanges with various dibromo-arenes and -heteroarenes under mild reaction conditions and provides bromo-substituted magnesium reagents. Assessing the role of Lewis donor additives in these reactions revealed that N,N,N’,N”,N”-pentamethyldiethylenetriamine (PMDTA) finely tunes the regioselectivity of the Br/Mg exchange on dibromo-pyridines and quinolines. Combining spectroscopic with X-ray crystallog. studies, light has been shed on the mixed Li/Mg constitution of the organometallic intermediates accomplishing these transformations. These systems reacted effectively with a broad range of electrophiles, including allyl bromides, ketones, aldehydes, and Weinreb amides in good yields. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Trabbic, Christopher J.; George, Sage M.; Alexander, Evan M.; Du, Shengnan; Offenbacher, Jennifer M.; Crissman, Emily J.; Overmeyer, Jean H.; Maltese, William A.; Erhardt, Paul W. published 《Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolyl-pyridinyl-propenones: effects on potency and mode of activity》.European Journal of Medicinal Chemistry published the findings.Recommanded Product: 78191-00-1 The information in the text is summarized as follows:

A series of [(pyridinylcarbonyl)vinyl]indoles I [R1 = 4-MeO, 6-MeO, 7-MeO, 5,6-(MeO)2, R2 = H, R3 = Me; R1 = 6-MeO, R2 = H, R3 = CF3; R1 = 5-MeO, R2 = R3 = Me; R4 = 4-pyridinyl] as well as their aroylvinyl analogs I [R1 = 5-MeO; R2 = H; R3 = Me; R4 = 2,4,6-(MeO)3C6H2, 3,4,5-(MeO)3C6H2] with methoxy groups on the indole ring have been synthesized and evaluated for anticancer activity. The location of the methoxy group was shown to alter both the potency and mechanism of cell death. Remarkably, changing the methoxy from the 5-position to the 6-position switched the biol. activity from induction of methuosis to disruption of microtubules. The latter may represent a prototype for a new class of mitotic inhibitors with potential therapeutic utility. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: 78191-00-1) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Akalezi, Chris O.; Oguzie, Emeka E. published 《Evaluation of anticorrosion properties of Chrysophyllum albidum leaves extract for mild steel protection in acidic media》.International Journal of Industrial Chemistry published the findings.Related Products of 78191-00-1 The information in the text is summarized as follows:

Background The inhibition efficiency of Chrysophyllum albidum extract in controlling corrosion of mild steel in 1 M HCl has been evaluated by weight loss, potentiodynamic polarization and electrochem. impedance techniques at 303 K. The effect of immersion time and temperature on inhibition efficiency of the extract was also studied. Results Inhibition was found to increase with increasing concentration of the extract but decrease with increasing time and temperature Data from electrochem. measurements suggest that the extract functioned by adsorption of the organic matter on the metal/corrodent interface, inhibiting both the anodic and cathodic half reactions of the corrosion process. The increase in concentration of the inhibitor causes an increase in the activation energy and a decrease in the exponential factor k. Conclusion The plant extracts follow Langmuir adsorption isotherm. Moreover, the process of adsorption is spontaneous, stable and considered to be phys. adsorption. The thermodn. properties recorded suggest that the process of film formation is higher than the destruction of the metal surface and that the adsorption process is exothermic.N-Methoxy-N-methylacetamide(cas: 78191-00-1Related Products of 78191-00-1) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Related Products of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Angewandte Chemie, International Edition included an article by Ziegler, Dorothee S.; Karaghiosoff, Konstantin; Knochel, Paul. Synthetic Route of C4H9NO2. The article was titled 《Generation of Aryl and Heteroaryl Magnesium Reagents in Toluene by Br/Mg or Cl/Mg Exchange》. The information in the text is summarized as follows:

The alkylmagnesium alkoxide sBuMgOR·LiOR (R = 2-ethylhexyl), which was prepared as a 1.5M solution in toluene, undergoes very fast Br/Mg exchange with aryl and heteroaryl bromides, producing aryl and heteroaryl magnesium alkoxides (ArMgOR·LiOR) in toluene. These Grignard reagents react with a broad range of electrophiles, including aldehydes, ketones, allyl bromides, acyl chlorides, epoxides, and aziridines, in good yields. Remarkably, the related reagent sBu2Mg·2LiOR (R = 2-ethylhexyl) undergoes Cl/Mg exchange with various electron-rich aryl chlorides in toluene, producing diorganomagnesium species of type Ar2Mg·2LiOR, which react well with aldehydes and allyl bromides. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Synthetic Route of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,de Jesus Cruz, Pedro; Cassels, William R.; Chen, Chun-Hsing; Johnson, Jeffrey S. published an article in Science (Washington, DC, United States). The title of the article was 《Doubly stereoconvergent crystallization enabled by asymmetric catalysis》.Synthetic Route of C4H9NO2 The author mentioned the following in the article:

Herein, discovery and development of a catalyst-mediated asym. Michael addition/crystallization-induced diastereomer transformation of broad scope was reported. The sequence controlled three stereogenic centers, two of which were stereochem. labile. The configurational instability of 1,3-dicarbonyls and nitroalkanes, typically considered a liability in stereoselective synthesis, was productively leveraged by merging enantioselective Bronsted base organocatalysis and thermodn. stereocontrol using a single convergent crystallization The synthesis of useful γ-nitro β-keto amides containing three contiguous stereogenic centers was thus achieved from Michael acceptors containing two prochiral centers. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Valderrey, Virginia; Bonasera, Aurelio; Fredrich, Sebastian; Hecht, Stefan published 《Light-Activated Sensitive Probes for Amine Detection》.Angewandte Chemie, International Edition published the findings.Recommanded Product: N-Methoxy-N-methylacetamide The information in the text is summarized as follows:

The authors’ new, simple, and accurate colorimetric method is based on diarylethenes (DAEs) for the rapid detection of a wide range of primary and secondary amines. The probes consist of aldehyde- or ketone-substituted diarylethenes, which undergo an amine-induced decoloration reaction, selectively to give the ring-closed isomer. Thus, these probes can be activated at the desired moment by light irradiation, with a sensitivity that allows the detection of amines at concentrations as low as 10-6 M in solution In addition, the practical immobilization of DAEs on paper makes it possible to detect biogenic amines, such as cadaverine, in the gas phase above a threshold of 12 ppbv within 30 s. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Fernandez, Jorge; Chicharro, Jesus; Bueno, Jose M.; Lorenzo, Milagros published 《Isoxazole mediated synthesis of 4-(1H)pyridones: improved preparation of antimalarial candidate GSK932121》.Chemical Communications (Cambridge, United Kingdom) published the findings.Formula: C4H9NO2 The information in the text is summarized as follows:

A new synthesis of the antimalarial clin. candidate GSK932121 is described. This approach has two key reactions, the selective acylation of an unprotected 3-hydroxymethyl-5-Me isoxazole and the reductive N-O bond cleavage of the previously functionalized isoxazole derivative, to give the 4-(1H)pyridone ring present in the final structure. The complete synthesis consists of 5 steps (vs. 10 steps in previously published reports) and has enabled the preparation of the material in kilogram scale to support clin. studies. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Computed Properties of C4H9NO2In 2016 ,《Screening of new antileukemic agents from essential oils of algae extracts and computational modeling of their interactions with intracellular signaling nodes》 was published in European Journal of Pharmaceutical Sciences. The article was written by Atasever-Arslan, Belkis; Yilancioglu, Kaan; Kalkan, Zeynep; Timucin, Ahmet Can; Gur, Hazal; Isik, Fatma Busra; Deniz, Emre; Erman, Batu; Cetiner, Selim. The article contains the following contents:

Microalgae are very rich in bioactive compounds, minerals, polysaccharides, poly-unsaturated fatty acids and vitamins, and these rich constituents make microalgae an important resource for the discovery of new bioactive compounds with applications in biotechnol. In this study, we studied the antileukemic activity of several chosen microalgae species at the mol. level and assessed their potential for drug development. Here we identified Stichococcus bacillaris, Phaeodactylum tricornutum, Microcystis aeruginosa and Nannochloropsis oculata microalgae extracts with possible antileukemic agent potentials. Specifically we studied the effects of these extracts on intracellular signal nodes and apoptotic pathways. We characterized the composition of essential oils of these fifteen different algae extracts using gas chromatog.-mass spectrometry (GC-MS). Finally, to identify potential mol. targets causing the phenotypic changes in leukemic cell lines, we docked a selected group of these essential oils to several key intracellular proteins. According to results of rank score algorithm, five of these essential oils analyzed might be considered as in silico plausible candidates to be used as antileukemic agents. The results came from multiple reactions, including the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Computed Properties of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Computed Properties of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of N-Methoxy-N-methylacetamideIn 2020 ,《Oral administration of royal jelly may improve the preservation of rooster spermatozoa》 was published in Journal of Animal Physiology and Animal Nutrition. The article was written by Rahnama, Golsomeh; Deldar, Hamid; Ansari Pirsaraei, Zarbakht; Kazemifard, Mohammad. The article contains the following contents:

The aim of the present study was to investigate the effect of dietary supplementation of royal jelly (RJ) on liquid and frozen storage of rooster spermatozoa. Twenty-five 30-wk-old of Mazandaran native breeder roosters were randomly divided into five treatments (n = 5 roosters/group). Exptl. treatments are designed to include a control group and various levels (0.0 (RJ0), 100 (RJ100), 200 (RJ200), 300 (RJ300) mg kg-1 BW-1) of royal jelly (RJ) that were fed to the roosters using force-feed method. The result of this study showed that the spermatozoa forward progressive motility, abnormality, membrane integrity, and viability were improved by the RJ100 group compared to the other groups after 24 and 48 h storage period at 4°C. The percentage of membrane integrity and forward progressive motility after freeze-thawing in the RJ100 group was significantly higher than the other groups, and the percentage of abnormal spermatozoa was lower. A significant decrease in semen quality parameters was seen after 24 and 48 h of refrigeration, but there was no observed change between 2 and 24 h in the RJ100. Moreover, after freeze-thawing, DNA integrity and mitochondrial activity in the RJ100 group were significantly higher than the other groups. According to our results, feeding of RJ at 100 mg kg-1 BW-1 to the roosters was improved spermatozoa characteristics during liquid and cryopreservation conditions. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Application In Synthesis of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application In Synthesis of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Wen, Juan Liang; Wen, Xin Wu; Lu, Zhen; Yun, Feng Bai; Feng, Feng; Wei, Jun Jin published an article in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The title of the article was 《Stimulus responsive luminescence and application of rotor type 1,1′-([2,2′-bithiophene]-3,3′-diyl)bis(ethan-1-one) and 3′-acetyl-[2,2′-bithiophene]-3-carbaldehyde as molecular rotors》.Safety of N-Methoxy-N-methylacetamide The author mentioned the following in the article:

Two dithiophene aldehyde/ketone derivatives are designed as luminescence mol. rotors, i.e., 1,1′-([2,2′-bithiophene]-3,3′-diyl)bis(ethan-1-one) (BTBE) and 3′-acetyl-[2,2′-bithiophene]-3-carbaldehyde (BTAC). Their absorption and luminescence properties, as well as the stimulus responsive luminescence characteristics of water spikes are studied in detail. In order to further explore relationship of luminescence and mol. structure, three reference compounds are also synthesized, named 1-(2-methylthiophen-3-yl)ethanone (MTE), 2-methylthiophene-3-carbaldehyde (MTC) and 4H-cyclohepta[1,2-b:7,6-b’]dithiophen-4-one (CDTO). BTBE and BTAC have two obvious absorption bands in the short wavelength region with peak wavelengths of about 212 nm and 260 nm, resp., while there is a weak trailing type absorption band in the range of about 300-400 nm. Their fluorescence spectra show two luminescence bands in the range of 280-350 nm and 400-600 nm, resp., and the latter is stronger. Compared with the absorption and luminescence spectra of the reference compounds, it is determined that two absorption bands of BTBE and BTAC in shorter wavelength region are derived from the single thiophene ring carbonyl planar unit, while the absorption band in longer region are derived from the integrated structure of dithiophene carbonyl. The fluorescence bands with peaks of about 300 nm and 470 nm originate resp. from the localized F-C vertical excited states (LE), i.e., the excited state from single planar thienyl-carbonyl unit, and integrated excited state (IE), i.e., the excited state from integrated di-thienyl-carbonyl rings linked covalently with less dihedral angle and greater degree of conjugation at excited state. The crystal structure data show that two thiophene rings possess larger dihedral angles in crystal states, 86.9° for BTBE and 60.8° for BTAC, resp. However, theor. calculation results prove the conformational stabilization energy changes little, less than 1.5 kcal/mol, as dihedral angle changes from 50° to 100°. Hydrogen bonding is sufficient to overcome the energy required for this conformational change. Therefore, both BTBE and BTAC can produce water stimulation response luminescence behavior. This stimulating response behavior of BTBE and BTAC can be applied to the preparation of water writable film materials.N-Methoxy-N-methylacetamide(cas: 78191-00-1Safety of N-Methoxy-N-methylacetamide) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Safety of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics