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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ) is researched.Application In Synthesis of 3-(Chloromethyl)-1-methyl-1H-pyrazole.Bozhenkov, G. V.; Savosik, V. A.; Klyba, L. V.; Zhanchipova, E. R.; Mirskova, A. N.; Levkovskaya, G. G. published the article 《1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines》 about this compound( cas:84547-64-8 ) in Russian Journal of Organic Chemistry. Keywords: ketone chloro vinyl heterocyclization hydrazine dialkyl; pyrazole alkyl chloro preparation. Let’s learn more about this compound (cas:84547-64-8).

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 84547-64-8, is researched, SMILESS is CN1N=C(CCl)C=C1, Molecular C5H7ClN2Journal, Chungnam Kwahak Yonguchi called Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity, Author is Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun, the main research direction is antiulcer agent omeprazole analog preparation.SDS of cas: 84547-64-8.

For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Levkovskaya, G. G.; Bozhenkov, G. V.; Malyushenko, R. N.; Mirskova, A. N. researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Safety of 3-(Chloromethyl)-1-methyl-1H-pyrazole.They published the article 《Synthesis of pyrazole derivatives from 1,1-dimethylhydrazine and chlorovinyl ketones》 about this compound( cas:84547-64-8 ) in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). Keywords: chlorovinyl ketone cyclization methylhydrazine; pyrazol preparation; hydrazinium methyl chloride preparation. We’ll tell you more about this compound (cas:84547-64-8).

The reaction of accessible 2-chlorovinyl Me ketones with 1,1-dimethylhydrazine gave pyrazole derivatives in high yields. 1,1,1-Trimethylhydrazinium chloride was isolated as second product of this reaction in high yield.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Chungnam Kwahak Yonguchi called Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity, Author is Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun, which mentions a compound: 84547-64-8, SMILESS is CN1N=C(CCl)C=C1, Molecular C5H7ClN2, Quality Control of 3-(Chloromethyl)-1-methyl-1H-pyrazole.

For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ) is researched.Application of 84547-64-8.Perevalov, V. P.; Karim, A. Kh.; Andreeva, M. A.; Rumyantseva, E. G.; Stepanov, B. I. published the article 《1,3- And 1,5-dimethylpyrazole-based syntheses. VI. Stilbene and 1,4-distyrylbenzene analogs containing 3-, 4-, and 5-pyrazolyl radicals》 about this compound( cas:84547-64-8 ) in Zhurnal Obshchei Khimii. Keywords: pyrazolyl styrene IR fluorescence; aniline pyrazolylvinyl; nitrobenzene pyrazolylvinyl. Let’s learn more about this compound (cas:84547-64-8).

Condensation of 4-O2NC6H4CH2CO2H with pyrazolecarboxaldehydes, followed by reduction with SnCl2, gave I (R, R1 = H, H; Me, H; H, Me). Appropriate Wittig reactions gave II (R = 1-methyl-3-pyrazolyl, 4,5-dichloro-1-methyl-3-pyrazolyl, 1-methyl-5-pyrazolyl, 4-chloro-1-methyl-5-pyrazolyl), which showed intensive blue fluorescence in PhMe solution

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Recommanded Product: 3-(Chloromethyl)-1-methyl-1H-pyrazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of pyrazole derivatives from 1,1-dimethylhydrazine and chlorovinyl ketones.

The reaction of accessible 2-chlorovinyl Me ketones with 1,1-dimethylhydrazine gave pyrazole derivatives in high yields. 1,1,1-Trimethylhydrazinium chloride was isolated as second product of this reaction in high yield.

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Quality Control of 3-(Chloromethyl)-1-methyl-1H-pyrazole. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity. Author is Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun.

For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Levkovskaya, G. G.; Bozhenkov, G. V.; Malyushenko, R. N.; Mirskova, A. N. researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Recommanded Product: 3-(Chloromethyl)-1-methyl-1H-pyrazole.They published the article 《Synthesis of pyrazole derivatives from 1,1-dimethylhydrazine and chlorovinyl ketones》 about this compound( cas:84547-64-8 ) in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). Keywords: chlorovinyl ketone cyclization methylhydrazine; pyrazol preparation; hydrazinium methyl chloride preparation. We’ll tell you more about this compound (cas:84547-64-8).

The reaction of accessible 2-chlorovinyl Me ketones with 1,1-dimethylhydrazine gave pyrazole derivatives in high yields. 1,1,1-Trimethylhydrazinium chloride was isolated as second product of this reaction in high yield.

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Application of 84547-64-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about 1,3- And 1,5-dimethylpyrazole-based syntheses. VI. Stilbene and 1,4-distyrylbenzene analogs containing 3-, 4-, and 5-pyrazolyl radicals. Author is Perevalov, V. P.; Karim, A. Kh.; Andreeva, M. A.; Rumyantseva, E. G.; Stepanov, B. I..

Condensation of 4-O2NC6H4CH2CO2H with pyrazolecarboxaldehydes, followed by reduction with SnCl2, gave I (R, R1 = H, H; Me, H; H, Me). Appropriate Wittig reactions gave II (R = 1-methyl-3-pyrazolyl, 4,5-dichloro-1-methyl-3-pyrazolyl, 1-methyl-5-pyrazolyl, 4-chloro-1-methyl-5-pyrazolyl), which showed intensive blue fluorescence in PhMe solution

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For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

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