Category: 90-16-4

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 90-16-4 as follows. 90-16-4

General procedure: Propargyl bromide (1.2 mmol) was added to a solution of 1aa or 1bb or 1cc (1.0 mmol) and K2CO3 (3.0 mmol) in CH3CN (25 mL) under a nitrogen atmosphere. The mixture was stirred at room temperature for 3 h. After completion of the reaction (confirmed by TLC), the mixture was diluted with ice-water (60 mL) and extracted with EtOAc(3¡Á15 mL). The organic layers were collected, combined, dried over anhydrous Na2SO4, filtered and concentrated under low vacuum. The residue was purified by column chromatography using hexane- EtOAc as eluent to afford the title compound.

According to the analysis of related databases, 90-16-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Reddy, Gangireddy Sujeevan; Snehalatha, Ampalam Venkata; Edwin, Rebecca Kristina; Hossain, Kazi Amirul; Giliyaru, Varadaraj Bhat; Hariharapura, Raghu Chandrashekhar; Gautham Shenoy; Misra, Parimal; Pal, Manojit; Bioorganic Chemistry; vol. 91; (2019);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

90-16-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 90-16-4 as follows.

A solution of the alcohol from step 7 (0.050 g, 0.109 mmol), triphenylphosphine (0.057 g, 0.217 mmol) and benzo-1,2,3-triazin-4(3H)-one (0.034 g, 0.231 mmol) in THF (2.5 mL) was treated with diethyl azodicarboxylate (0.035mL, 0.222 mmol). The mixture was stirred at room temperature for 16 hrs., concentrated under reduced pressure and purified by MPLC (0-20% EtOAc-hexanes) to give the target compound (0.034g, 53%). TLC: Rf 0.16 (silica, 20% EtOAc-hexanes).

According to the analysis of related databases, 90-16-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer Corporation; EP923530; (2004); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 90-16-4, name is Benzo[d][1,2,3]triazin-4(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., 90-16-4

0.294 g (2.0 mmol) of benzo[d][1,2,3]triazin-4(3H)-one,0.418 g (2.0 mmol) of 5-(2-chloroethyl)-3-phenyl-1,2,4-oxadiazole,0.276 g (2.0 mmol) of potassium carbonate was added to 20 ml of acetone, and the temperature was raised to reflux.TLC tracks the progress of the reaction. After the reaction is completed, the solvent is distilled off under reduced pressure.50 ml of saturated sodium chloride was added to the residue, and extracted with dichloromethane (50 ml ¡Á 2).The organic phase is dried over anhydrous sodium sulfate, concentrated and purified by column chromatography.A white solid of 0.49 g was obtained in a yield of 77%.

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Reference:
Patent; East China University of Science and Technology; Xu Xiaoyong; Li Zhong; Chen Xiulei; Li Wei; Jia Haowu; Cao Xiaofeng; Shao Xusheng; Xu Zhiping; (70 pag.)CN108276352; (2018); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

90-16-4, A common compound: 90-16-4, name is Benzo[d][1,2,3]triazin-4(3H)-one, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

General procedure: A stirring suspension of 1,2,3-benzotriazin-4-one (6 mmol), 1,2-dibromoethane (18 mmol), potassium carbonate (12 mmol), and acetone (50 ml) was refluxed for 5-8 h and then cooled to room temperature. The reaction mixture was evaporated under reduced pressure, and water (100 mL) was added to the residue, which was extracted with CH2Cl2 (50 mL ¡Á 2). The organic layer was dried over anhydrous Na2SO4, concentrated, and purified with flash chromatography on silica gel, eluting with petroleum ether (60-90C)/EtOAc to afford compound 5 in yield of 62%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Benzo[d][1,2,3]triazin-4(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chen, Xiulei; Jia, Haowu; Li, Zhong; Xu, Xiaoyong; Chinese Chemical Letters; vol. 30; 6; (2019); p. 1207 – 1213;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics