Category: 91-00-9

I found the field of Chemistry very interesting. Saw the article Highly Active Chiral Dilithium(I) Binaphthyldisulfonate Catalysts for Enantio- and Chemoselective Strecker-Type Reactions published in 2019.0. HPLC of Formula: C13H13N, Reprint Addresses Ishihara, K (corresponding author), Nagoya Univ, Grad Sch Engn, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648603, Japan.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

An enantioselective Strecker-type reaction of aldimines and ketimines was developed by using a chiral dilithium(I) binaphthyldisulfonate as a chiral acid-base cooperative catalyst. The present catalytic system features an extremely short reaction time (10 min to 4 h), unlike conventional catalytic systems. Along with the design of stronger chiral Li(I) Lewis acid catalysts, a highly reactive pentacoordinate silicate generated in situ could promote the reactions. In particular, instead of unstable N-Bn Strecker products, more stable N-CH2 (9-anthryl) and N-CH2 (1-naphthyl) Strecker products could be obtained in high yields with high enantioselectivities. By a switch of the present and previous catalyst systems, chemoselective cyanation to a ketoaldimine could be performed, respectively. Moreover, mechanistic investigations provided useful information regarding the active catalysts, catalytic cycles, and possible transition states.

HPLC of Formula: C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Hatano, M; Nishio, K; Mochizuki, T; Nishikawa, K; Ishihara, K or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Scalable electrochemical oxidant-and metal-free dehydrogenative coupling of S-H/N-H published in 2019. Name: Diphenylmethanamine, Reprint Addresses Li, H; Yuan, BX (corresponding author), Zhengzhou Univ, Dept Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A practical and scalable electrochemical oxidation of S-H and N-H was developed. This oxidant-and catalyst-free electrochemical process enables S-N bond formation with inexpensive nickel electrodes in an undivided cell. This procedure exhibits broad substrate scopes and good functional-group compatibility. A 50 g scale oxidative coupling augurs well for industrial applications.

Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.. Name: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Pro-Phe Derivatives as Organocatalysts in Asymmetric Aldol Reaction WOS:000631153800009 published article about AQUEOUS-MEDIA; PROLINE; SOLVENT; DIPEPTIDES; CATALYSTS; ACETONE; WATER in [Karaoglu, Merve; Aydogan, Feray; Yolacan, Cigdem] Yildiz Tech Univ, Dept Chem, Davutpasa Campus, TR-34010 Istanbul, Turkey in 2021, Cited 53. Computed Properties of C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The aldol reaction which is the most important one among the C-C bond forming reactions, is widely used by synthetic organic chemists to obtain beta-hydroxycarbonyl compounds which are important starting components for biologically active compounds in optically pure form. In this research, five Pro-Phe derivatives were synthesized by simple amidation reactions and characterized by their spectral data. Their catalytic activities in asymmetric aldol reaction were investigated. The catalytic activity studies were performed with aliphatic ketones and various aromatic aldehydes. Especially, (S)methyl 3-mercapto-2-(S)-3-phenyl-2-((S)-pyrrolidine-2-carboxamido)propanamido)propanoate showed good catalytic activities in water at 0 degrees C in the presence of p-nitrobenzoic acid cocatalyst. The enantioselectivities were up to 90.4%, the diastereomeric ratios were up to 97/3 and yields were 99%. The results showed that these organocatalysts were promising organocatalysts for aldol reaction. Besides, this catalyst showed its best catalytic activities in water which is also an important contribution to green chemistry requirements.

Computed Properties of C13H13N. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Tertiary amine-directed and involved carbonylative cyclizations through Pd/Cu-cocatalyzed multiple C-X (X = H or N) bond cleavage WOS:000490984300010 published article about CATALYZED OXIDATIVE CARBONYLATION; DEALKYLATIVE CARBONYLATION; EFFICIENT SYNTHESIS; COUPLING REACTIONS; FUNCTIONALIZATION; PALLADIUM; ACTIVATION; ARYLATION; ACIDS; AMINOCARBONYLATION in [Mu, Qiu-Chao; Bai, Xing-Feng; Chen, Jing; Yang, Lei; Xia, Chun-Gu; Xu, Li-Wen] UCAS, LICP, SRI, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China; [Mu, Qiu-Chao; Nie, Yi-Xue; Bai, Xing-Feng; Yang, Lei; Xu, Zheng; Li, Li; Xu, Li-Wen] Hangzhou Normal Univ, Key Lab Organosilicon Mat Technol Zhejiang Prov, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 311121, Zhejiang, Peoples R China in 2019.0, Cited 97.0. Category: amides-buliding-blocks. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A novel Pd/Cu-cocatalyzed carbonylative cyclization by C-H activation and N-dealkylative C-N bond activation has been developed for the chemoselective construction of synthetically useful heterocycles. The N,N-dimethylamine group on o-indolyl-N,N-dimethylarylamines was found to act as both the directing group and reactive component in this C-H carbonylative cyclization reaction. Furthermore, a unique C-H oxidation/carbonylative lactonization of diarylmethylamines is firstly demonstrated under modified reaction conditions, which could be easily applicable to the one-step synthesis of multi-substituted phthalides bearing an N,O-ketal skeleton that is difficult to access by previously reported methods. Mechanistic studies implicate that Pd/Cu-cocatalyzed C-H oxidation/carbonylative lactonization is a sequential reaction system via Cu-catalyzed C(sp(3))-H oxidation and Pd-catalyzed oxidative carbonylation of the C(sp(2))-H bond. It was found that trace amounts of water are essential to promote the Cu-catalyzed C(sp(3))-H oxidation of diarylmethylamine for the formation of the hydroxyl group, which could act as an in situ-formed directing group in the intramolecular carbonylative lactonization step.

Welcome to talk about 91-00-9, If you have any questions, you can contact Mu, QC; Nie, YX; Bai, XF; Chen, J; Yang, L; Xu, Z; Li, L; Xia, CG; Xu, LW or send Email.. Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Dan, DM; Chen, FB; Zhao, WS; Yu, H; Han, S; Wei, YG in ROYAL SOC CHEMISTRY published article about HOMOGENEOUS CATALYSIS; AEROBIC OXIDATION; CONVENIENT METHOD; FORMIC-ACID; HYDROGENATION; MILD; REAGENTS; OXYGEN; CO2 in [Dan, Demin; Yu, Han; Han, Sheng] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; [Chen, Fubo] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Stomatol, Shanghai 200072, Peoples R China; [Zhao, Whenshu] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200000, Peoples R China; [Yu, Han; Wei, Yongge] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100081, Peoples R China; [Wei, Yongge] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China in 2021.0, Cited 52.0. Computed Properties of C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A simple and efficient protocol for the formylation of amines with formic acid, catalyzed by a polyoxometalate-based chromium catalyst, is described. Notably, this method shows excellent activity and chemo-selectivity for the formylation of primary amines; diamines have also been successfully employed. Importantly, the chromium catalyst is potentially non-toxic, environmentally benign and safer than the widely used high valence chromium catalysts such as CrO3 and K2Cr2O7. The catalyst can be recycled several times with a negligible impact on activity. Finally, a plausible mechanism is provided based on the observation of intermediate and control experiments.

Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Safety of Diphenylmethanamine. Tang, SY; Liu, Y; Li, LJ; Ren, XH; Li, J; Yang, GY; Li, H; Yuan, BX in [Tang, Shanyu; Li, Longjia; Ren, Xuanhe; Li, Jiao; Yang, Guanyu; Li, Heng; Yuan, Bingxin] Zhengzhou Univ, Dept Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China; [Liu, Yan] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China published Scalable electrochemical oxidant-and metal-free dehydrogenative coupling of S-H/N-H in 2019, Cited 44. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A practical and scalable electrochemical oxidation of S-H and N-H was developed. This oxidant-and catalyst-free electrochemical process enables S-N bond formation with inexpensive nickel electrodes in an undivided cell. This procedure exhibits broad substrate scopes and good functional-group compatibility. A 50 g scale oxidative coupling augurs well for industrial applications.

Safety of Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Tang, SY; Liu, Y; Li, LJ; Ren, XH; Li, J; Yang, GY; Li, H; Yuan, BX or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Product Details of 91-00-9. Recently I am researching about HUMAN BRAIN; ARECAIDINE; AGONIST; LOGP; OPPORTUNITIES; GUVACINE; SUBTYPES, Saw an article supported by the Medical University of Vienna; University of Vienna. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Ozenil, M; Pacher, K; Balber, T; Vraka, C; Roller, A; Holzer, W; Spreitzer, H; Mitterhauser, M; Wadsak, W; Hacker, M; Pichler, V. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Supported by their involvement in many neurodegenerative disorders, muscarinic acetylcholine receptors ( mAChRs) are an interesting target for PET imaging. Nevertheless, no radiotracer is established in clinical routine. Within this work we aim to develop novel PET tracers based on the structure of arecoline. Fifteen novel arecoline derivatives were synthesized, characterized and tested for their affinity to the mAChRs M1-M5 and the conceivable off-target acetylcholinesterase. Five arecoline derivatives and arecoline were labeled with carbon-11 in good yields. Arecaidine diphenylmethyl ester (3b), arecaidine bis(4-fluorophenyl)methyl ester (3c) and arecaidine (4-bromophenyl)(4-fluorophenyl)methyl ester (3e) showed a tremendous gain in mAChR affinity compared to arecoline and a pronounced subtype selectivity for M1. Metabolic stability and serum protein binding of [C-11] 3b and [C-11] 3c were in line with properties of established brain tracers. Nonspecific binding of [C-11]3c was prevalent in kinetic and endpoint experiment on living cells as well as in autoradiography on native mouse brain sections, which motivates us to decrease the lipophilicity of this substance class prior to in vivo experiments. (C) 2020 The Author(s). Published by Elsevier Masson SAS.

Welcome to talk about 91-00-9, If you have any questions, you can contact Ozenil, M; Pacher, K; Balber, T; Vraka, C; Roller, A; Holzer, W; Spreitzer, H; Mitterhauser, M; Wadsak, W; Hacker, M; Pichler, V or send Email.. Product Details of 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein WOS:000505633400021 published article about E3 UBIQUITIN LIGASE; 2 SH2 DOMAIN; SIGNAL TRANSDUCER; PEPTIDOMIMETIC INHIBITORS; SMALL MOLECULES; DESIGN; DEGRADATION; ACTIVATOR; OPTIMIZATION; VALIDATION in [Zhou, Haibin; Bai, Longchuan; Xu, Renqi; Zhao, Yujun; Chen, Jianyong; McEachern, Donna; Yang, Chao-Yie; Liu, Zhaomin; Wang, Mi; Liu, Liu; Yi, Han; Wang, Shaomeng] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA; [Zhou, Haibin; Bai, Longchuan; Xu, Renqi; Zhao, Yujun; Chen, Jianyong; McEachern, Donna; Yang, Chao-Yie; Liu, Zhaomin; Wang, Mi; Liu, Liu; Yi, Han; Wang, Shaomeng] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA; [Wang, Shaomeng] Univ Michigan, Dept Pharmacol, Med Sch, Ann Arbor, MI 48109 USA; [Wang, Shaomeng] Univ Michigan, Coll Pharm, Med Chem, 428 Church St, Ann Arbor, MI 48109 USA; [Chinnaswamy, Krishnapriya; Meagher, Jennifer L.; Stuckey, Jeanne A.] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA; [Wen, Bo; Dai, Lipeng; Kumar, Praveen; Sun, Duxin] Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, 428 Church St, Ann Arbor, MI 48109 USA in 2019.0, Cited 43.0. HPLC of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor and an attractive therapeutic target for cancer and other human diseases. Despite 20 years of persistent research efforts, targeting STAT3 has been very challenging. We report herein the structure-based discovery of potent small-molecule STAT3 degraders based upon the proteolysis targeting chimera (PROTAC) concept. We first designed SI-109 as a potent, small-molecule inhibitor of the STAT3 SH2 domain. Employing ligands for cereblon/cullin 4A E3 ligase and SI-109, we obtained a series of potent PROTAC STAT3 degraders, exemplified by SD-36. SD-36 induces rapid STAT3 degradation at low nanomolar concentrations in cells and fails to degrade other STAT proteins. SD-36 achieves nanomolar cell growth inhibitory activity in leukemia and lymphoma cell lines with high levels of phosphorylated STAT3. A single dose of SD-36 results in complete STAT3 protein degradation in xenograft tumor tissue and normal mouse tissues. SD-36 achieves complete and long-lasting tumor regression in the Molm-16 xenograft tumor model at well-tolerated dose-schedules. SD-36 is a potent, selective, and efficacious STAT3 degrader.

HPLC of Formula: C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Zhou, HB; Bai, LC; Xu, RQ; Zhao, YJ; Chen, JY; McEachern, D; Chinnaswamy, K; Wen, B; Dai, LP; Kumar, P; Yang, CY; Liu, ZM; Wang, M; Liu, L; Meagher, JL; Yi, H; Sun, DX; Stuckey, JA; Wang, SM or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Development and mechanistic investigation of the manganese(iii) salen-catalyzed dehydrogenation of alcohols WOS:000457342200020 published article about TRANSFER HYDROGENATION; SUBSTITUENT CONSTANTS; SUSTAINABLE SYNTHESIS; AMINES; LIGAND; KETONES; IRON; EPOXIDATION; ALKYLATION; EFFICIENT in [Samuelsen, SimoneV.; Santilli, Carola; Madsen, Robert] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark; [Ahlquist, Marten S. G.] KTH Royal Inst Technol, Dept Theoret Chem & Biol, Sch Engn Sci Chem Biotechnol & Hlth, S-10691 Stockholm, Sweden in 2019.0, Cited 64.0. Computed Properties of C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The first example of a manganese(III) catalyst for the acceptorless dehydrogenation of alcohols is presented. N,N’-Bis(salicylidene)-1,2-cyclohexanediaminomanganese(III) chloride (2) has been shown to catalyze the direct synthesis of imines from a variety of alcohols and amines with the liberation of hydrogen gas. The mechanism has been investigated experimentally with labelled substrates and theoretically with DFT calculations. The results indicate a metal-ligand bifunctional pathway in which both imine groups in the salen ligand are first reduced to form a manganese(III) amido complex as the catalytically active species. Dehydrogenation of the alcohol then takes place by a stepwise outer-sphere hydrogen transfer generating a manganese(III) salan hydride from which hydrogen gas is released.

Welcome to talk about 91-00-9, If you have any questions, you can contact Samuelsen, S; Santilli, C; Ahlquist, MSG; Madsen, R or send Email.. Computed Properties of C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Gunjal, VB; Reddy, DS in [Gunjal, Vidya B.; Reddy, D. Srinivasa] CSIR Natl Chem Lab, Organ Chem Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Gunjal, Vidya B.; Reddy, D. Srinivasa] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India published Total synthesis of Met(10)-teixobactin in 2019.0, Cited 41.0. Name: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The total synthesis of cyclic depsipeptide Met(10)-teixobactin in solution-phase is described. Teixobactin is a structurally and mechanistically novel antimicrobial peptidic natural product with very impressive activities against Gram-positive pathogens. It happens to possess an L-allo-enduracididine (End) residue as part of macrocyclic ring which is not readily accessible. In this report, we have used serine ligation strategy as the key step to prepare an analogue of teixobactin where End being replaced with a readily available amino acid methionine. (C) 2019 Elsevier Ltd. All rights reserved.

Name: Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Gunjal, VB; Reddy, DS or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics