Category: 91-00-9

Product Details of 91-00-9. Authors Wang, WQ; Wang, ZQ; Sang, W; Zhang, R; Cheng, H; Chen, C; Peng, DY in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Wang, Wan-Qiang; Zhang, Rui; Cheng, Hua] Hubei Univ Arts & Sci, Dept Chem Engn & Food Sci, 296 Longzhong Rd, Xiangyang 441053, Peoples R China; [Wang, Zhi-Qin; Sang, Wei; Chen, Cheng] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Peoples R China; [Peng, Da-Yong] Jiangxi Agr Univ, Coll Sci, Nanchang 330045, Jiangxi, Peoples R China in 2021.0, Cited 63.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The metal-catalyzed dehydrogenative coupling of alcohols and amines to access amides has been recognized as an atom-economic and environmental-friendly process. Apart from the formation of the amide products, three other kinds of compounds (esters, imines and amines) may also be produced. Therefore, it is of vital importance to investigate product distribution in this transformation. Herein, N-heterocyclic carbene-based Ru (NHC/Ru) complexes [Ru-1]-[Ru-5] with different ancillary ligands were prepared and characterized. Based on these complexes, we selected condition A (without an added NHC precursor) and condition B (with an added NHC precursor) to comprehensively explore the selectivity and yield of the desired amides. After careful evaluation of various parameters, the Ru loadings, added NHC precursors and the electronic/steric properties of ancillary NHC ligands were found to have considerable influence on this catalytic process. (C) 2020 Elsevier Ltd. All rights reserved.

Welcome to talk about 91-00-9, If you have any questions, you can contact Wang, WQ; Wang, ZQ; Sang, W; Zhang, R; Cheng, H; Chen, C; Peng, DY or send Email.. Product Details of 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Ambient Reductive Amination of Levulinic Acid to Pyrrolidones over Pt Nanocatalysts on Porous TiO2 Nanosheets WOS:000460996500037 published article about HIGHLY EFFICIENT CATALYST; NITROGEN-COMPOUNDS; PRECIOUS-METAL; PRIMARY AMINES; KETO ACIDS; BIOMASS; HYDROGENATION; AMINATION/CYCLIZATION; HYDRODEOXYGENATION; TRANSFORMATION in [Xie, Chao; Song, Jinliang; Wu, Haoran; Hu, Yue; Liu, Huizhen; Zhang, Zhanrong; Zhang, Pei; Chen, Bingfeng; Han, Buxing] Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,CAS Key Lab Colloid & In, Beijing 100190, Peoples R China; [Xie, Chao; Wu, Haoran; Hu, Yue; Liu, Huizhen; Han, Buxing] Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China in 2019.0, Cited 50.0. Recommanded Product: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Construction of N-substituted pyrrolidones from biomass-derived levulinic acid (LA) via reductive amination is a highly attractive route for biomass valorization. However, realizing this transformation using H-2 as the hydrogen source under mild conditions is still very challenging. Herein, we designed porous TiO2 nanosheets-supported Pt nanoparticles (Pt/P-TiO2) as the heterogeneous catalyst. The prepared Pt/P-TiO2 was highly efficient for reductive amination of LA to produce various N-substituted pyrrolidones (34 examples) at ambient temperature and H-2 pressure. Meanwhile, Pt/P-TiO2 showed good applicability for reductive amination of levulinic esters, 4-acetylbutyric acid, 2-acetylbenzoic acid, and 2-carboxybenzaldehyde. Systematic studies indicated that the strong acidity of P-TiO2 and the lower electron density of the Pt sites as well as the porous structure resulted in the excellent activity of Pt/P-TiO2.

Recommanded Product: Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Xie, C; Song, JL; Wu, HR; Hu, Y; Liu, HZ; Zhang, ZR; Zhang, P; Chen, BF; Han, BX or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Formula: C13H13N. Recently I am researching about CYCLIC AMINOMETHYLPHOSPHINES; COMPLEXES, Saw an article supported by the . Published in MAIK NAUKA/INTERPERIODICA/SPRINGER in NEW YORK ,Authors: Musina, EI; Musin, LI; Litvinov, IA; Karasik, AA. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

New 1-aza-3,5-diphosphorinanes have been synthesized as a mixture of RR/SS- and RS-isomers via the reaction of bis(phenylphosphanyl)methane, paraformaldehyde, isopropylamine, of benzhydrylamine.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Authors Harrison, D; Boutard, N; Brzozka, K; Bugaj, M; Chmielewski, S; Cierpich, A; Doedens, JR; Fabritius, CHRY; Gabel, CA; Galezowski, M; Kowalczyk, P; Levenets, O; Mroczkowska, M; Palica, K; Porter, RA; Schultz, D; Sowinska, M; Topolnicki, G; Urbanski, P; Woyciechowski, J; Watt, AP in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Harrison, David; Watt, Alan P.] NodThera Ltd, Suite 8,Chesterford Res Pk, Saffron Walden CB10 1XL, Essex, England; [Doedens, John R.; Gabel, Christopher A.] NodThera Inc, 454 N 34th St, Seattle, WA 98103 USA; [Boutard, Nicolas; Brzozka, Krzysztof; Bugaj, Marta; Chmielewski, Stefan; Cierpich, Anna; Fabritius, Charles-Henry R. Y.; Galezowski, Michal; Kowalczyk, Piotr; Levenets, Oleksandr; Mroczkowska, Magdalena; Palica, Katarzyna; Schultz, David; Sowinska, Marta; Topolnicki, Grzegorz; Urbanski, Piotr; Woyciechowski, Jakub] Ryvu Therapeut, Selvita SA, Pk Life Sci,Ul Bobrssynskiego 14, PL-30348 Krakow, Poland; [Porter, Roderick A.] Rod Porter Consultancy, 89 Back St, Baldock SG7 5PG, Herts, England in 2020.0, Cited 25.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The NLRP3 inflammasome is a component of the innate immune system involved in the production of proinflammatory cytokines. Aberrant activation by a wide range of exogenous and endogenous signals can lead to chronic, low-grade inflammation. It has attracted a great deal of interest as a drug target due to the association with diseases of large unmet medical need such as Alzheimer’s disease, Parkinson’s disease, arthritis, and cancer. To date, no drugs specifically targeting inhibition of the NLRP3 inflammasome have been approved. In this work, we used the known NLRP3 inflammasome inhibitor CP-456,773 (aka CRID3 or MCC 950) as our starting point and undertook a Structure-Activity Relationship (SAR) analysis and subsequent scaffold-hopping exercise. This resulted in the rational design of a series of novel ester-substituted urea compounds that are highly potent and selective NLRP3 inflammasome inhibitors, as exemplified by compounds 44 and 45. It is hypothesized that the ester moiety acts as a highly permeable delivery vehicle and is subsequently hydrolyzed to the carboxylic acid active species by carboxylesterase enzymes. These molecules are greatly differentiated from the state-of-the-art and offer potential in the treatment of NLRP3-driven diseases, particularly where tissue penetration is required.

Category: amides-buliding-blocks. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli WOS:000480664100003 published article about EFFLUX PUMP INHIBITORS; PSEUDOMONAS-AERUGINOSA; RESISTANCE; LEVOFLOXACIN in [Blankson, Gifty; Parhi, Ajit K.; LaVoie, Edmond J.] Rutgers State Univ, Dept Med Chem, Piscataway, NJ 08820 USA; [Kaul, Malvika; Pilch, Daniel S.] Rutgers Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA; [Parhi, Ajit K.] TAXIS Pharmaceut Inc, Monmouth Jct, NJ 08552 USA in 2019.0, Cited 17.0. Quality Control of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Several studies that have identified agents that potentiate the antimicrobial activity of antibiotics, but there are limited insights into their structure-activity relationships (SAR). The SAR associated with select N-alkylaryl amide derivatives of ornithine was performed to establish those structural features that were associated with potentiation of the antimicrobial activity of clarithromycin against E. coli ATCC 25922. The data indicate that the N-propyl derivative was slightly more active in reducing the effective MIC of clarithromycin against E. coli ATCC 25922. In addition, the S-enantiomer of compound 9 was somewhat more potent than the R-enantiomer in potentiating clarithromycin activity. No significant enhancement in potentiation activity was observed with the conversion of these secondary amides to their N-methyl tertiary amides. Formation of the N-methyl or N,N-dimethyl derivatives of the primary amine of 9 was associated with the loss of potentiation activity. Conversion of this primary amine to a guanidine was also not associated with an increase in potentiation activity. Among the isomeric diamino pentamides, 15 potentiated the antibacterial activity of clarithromycin to the greatest extent In addition to these amide derivatives, the desoxy derivatives 16 and 18 were the more potent potentiators within this triamine series. The relative location of the primary amines, as indicated by the relative differences in the potentiation observed with 16 compared to 14, appears to be a critical factor in determining potentiation activity. Cell-based membrane permeabilization and efflux inhibition studies in E. coli ATCC 25922 suggest that the potentiation of clarithromycin activity by 16 reflects its ability to inhibit efflux pump activity and to a lesser extent its actions as a permeabilizer of the outer leaflet of the outer cell membrane. (C) 2019 Elsevier Masson SAS. All rights reserved.

Quality Control of Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Tertiary amine-directed and involved carbonylative cyclizations through Pd/Cu-cocatalyzed multiple C-X (X = H or N) bond cleavage WOS:000490984300010 published article about CATALYZED OXIDATIVE CARBONYLATION; DEALKYLATIVE CARBONYLATION; EFFICIENT SYNTHESIS; COUPLING REACTIONS; FUNCTIONALIZATION; PALLADIUM; ACTIVATION; ARYLATION; ACIDS; AMINOCARBONYLATION in [Mu, Qiu-Chao; Bai, Xing-Feng; Chen, Jing; Yang, Lei; Xia, Chun-Gu; Xu, Li-Wen] UCAS, LICP, SRI, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China; [Mu, Qiu-Chao; Nie, Yi-Xue; Bai, Xing-Feng; Yang, Lei; Xu, Zheng; Li, Li; Xu, Li-Wen] Hangzhou Normal Univ, Key Lab Organosilicon Mat Technol Zhejiang Prov, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 311121, Zhejiang, Peoples R China in 2019.0, Cited 97.0. Quality Control of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A novel Pd/Cu-cocatalyzed carbonylative cyclization by C-H activation and N-dealkylative C-N bond activation has been developed for the chemoselective construction of synthetically useful heterocycles. The N,N-dimethylamine group on o-indolyl-N,N-dimethylarylamines was found to act as both the directing group and reactive component in this C-H carbonylative cyclization reaction. Furthermore, a unique C-H oxidation/carbonylative lactonization of diarylmethylamines is firstly demonstrated under modified reaction conditions, which could be easily applicable to the one-step synthesis of multi-substituted phthalides bearing an N,O-ketal skeleton that is difficult to access by previously reported methods. Mechanistic studies implicate that Pd/Cu-cocatalyzed C-H oxidation/carbonylative lactonization is a sequential reaction system via Cu-catalyzed C(sp(3))-H oxidation and Pd-catalyzed oxidative carbonylation of the C(sp(2))-H bond. It was found that trace amounts of water are essential to promote the Cu-catalyzed C(sp(3))-H oxidation of diarylmethylamine for the formation of the hydroxyl group, which could act as an in situ-formed directing group in the intramolecular carbonylative lactonization step.

Quality Control of Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Mu, QC; Nie, YX; Bai, XF; Chen, J; Yang, L; Xu, Z; Li, L; Xia, CG; Xu, LW or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Product Details of 91-00-9. Recently I am researching about ONE-POT SYNTHESIS; CATALYZED KNOEVENAGEL CONDENSATION; METAL-ORGANIC FRAMEWORK; FACILE SYNTHESIS; CHEMOSELECTIVE REDUCTION; GREEN PROCEDURE; IONIC LIQUID; EFFICIENT; NITRILES; HYDRATION, Saw an article supported by the UGC-New DelhiUniversity Grants Commission, India. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Rupanawar, BD; Veetil, SM; Suryavanshi, G. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Formula: C13H13N. In 2019.0 CHEMMEDCHEM published article about MAO INHIBITORS; PROTEIN; DISCOVERY; DERIVATIVES; DOCKING; ANALOGS; TARGET; POTENT; CELLS; PC12 in [Dalla Via, Lisa] Univ Padua, Dipartimento Sci Farmaco, Via F Marzolo 5, I-35131 Padua, Italy; [Di Paolo, Maria L.] Univ Padua, Dipartimento Med Mol, Via G Colombo 3, I-35131 Padua, Italy; [Christodoulou, Michael S.] Univ Milan, DISFARM, Sez Chim Gen & Organ A Marchesini, Via Venezian 21, I-20133 Milan, Italy; [Calogero, Alessandra M.; Cappelletti, Graziella] Univ Milan, Dipartimento Biosci, Via Celoria 26, I-20133 Milan, Italy; [Pinzi, Luca; Rastelli, Giulio] Univ Modena & Reggio Emilia, Dipartimento Sci Vita, Via Campi 103, I-41125 Modena, Italy; [Passarella, Daniele] Univ Milan, Dipartimento Chim, Via C Golgi 19, I-20133 Milan, Italy in 2019.0, Cited 70.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (K-i) values in the sub-micromolar range and a good selectivity index (Ki MAO-A/Ki MAO-B>50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4 a) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of alpha-Tertiary Amino Ketones from Sulfonium Ylides WOS:000563079000043 published article about N-H BONDS; BRONSTED ACID; METAL CATALYSIS; AMINATION; INSERTION; DERIVATIVES; COMPLEXES; CARBENE; MODE in [Luo, Yuzheng; Li, Pingfan] Beijing Univ Chem Technol, Coll Chem, Dept Organ Chem, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China; [Guo, Wengang; Sung, Herman H-Y; Williams, Ian D.; Sun, Jianwei] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China in 2020.0, Cited 50.0. Name: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Herein we disclose a new catalytic asymmetric approach for the synthesis of chiral alpha-amino ketones, which is particularly useful for the less accessible acyclic alpha-tertiary cases. By a protonation-amination sequence, our approach represents a rare asymmetric H-heteroatom bond insertion by alpha-carbonyl sulfonium ylides, an attractive surrogate of diazocarbonyls. The mild intermolecular C-N bond formation was catalyzed by chiral phosphoric acids with excellent efficiency and enantioselectivity. The products are precursors to other important chiral amine derivatives, including drug molecules and chiral ligands. The enantioselectivity was controlled by dynamic kinetic resolution in the amination step, rather than the initial protonation. This process opens up a new platform for the development of other related insertion reactions.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about CARBONYL-COMPOUNDS; DEOXYGENATION; ALCOHOLS; HYDROGENOLYSIS; 1,2-DIOLS; AMINES; HYDROSILYLATION; ACTIVATION; CONVERSION; MECHANISM, Saw an article supported by the Alexander von Humboldt FoundationAlexander von Humboldt Foundation. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Fang, HQ; Oestreich, M. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Name: Diphenylmethanamine

The strong boron Lewis acid tris(pentafluorophenyl)borane B(C6F5)(3) is known to catalyze the dehydrogenative coupling of certain amines and hydrosilanes at elevated temperatures. At higher temperature, the dehydrogenation pathway competes with cleavage of the C-N bond and defunctionalization is obtained. This can be turned into a useful methodology for the transition-metal-free reductive deamination of a broad range of amines as well as heterocumulenes such as an isocyanate and an isothiocyanate.

Name: Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Fang, HQ; Oestreich, M or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics