Category: 91-00-9

An article Effects of ruthenium hydride species on primary amine synthesis by direct amination of alcohols over a heterogeneous Ru catalyst WOS:000572262400009 published article about ONE-POT SYNTHESIS; REDUCTIVE AMINATION; N-ALKYLATION; SELECTIVE SYNTHESIS; SECONDARY ALCOHOLS; AMMONIA; EFFICIENT; HYDROTALCITE; ADSORPTION; COMPLEXES in [Kita, Yusuke; Kuwabara, Midori; Yamadera, Satoshi; Kamata, Keigo; Hara, Michikazu] Tokyo Inst Technol, Lab Mat & Struct, Inst Innovat Res, Midori Ku, 4259 Nagatsuta Cho, Yokohama, Kanagawa 2268503, Japan; [Hara, Michikazu] Japan Sci & Technol Agcy JST, Adv Low Carbon Technol Res & Dev Program ALCA, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan in 2020.0, Cited 51.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. COA of Formula: C13H13N

Heterogeneously catalysed synthesis of primary amines by direct amination of alcohols with ammonia has long been an elusive goal. In contrast to reported Ru-based catalytic systems, we report that Ru-MgO/TiO(2)acts as an effective heterogeneous catalyst for the direct amination of a variety of alcohols to primary amines at low temperatures ofca.100 degrees C without the introduction of H(2)gas. The present system could be applied to a variety of alcohols and provides an efficient synthetic route for 2,5-bis(aminomethyl)furan (BAMF), an attention-getting biomonomer. The high catalytic performance can be rationalized by the reactivity tuning of Ru-H species using MgO. Spectroscopic measurements suggest that MgO enhances the reactivity of hydride species by electron donation from MgO to Ru.

COA of Formula: C13H13N. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Hao, ZQ; Li, F; Gao, W in [Hao, Zhiqiang; Li, Feng; Gao, Wei] Jilin Univ, Coll Chem, Changchun 130012, Peoples R China; [Hao, Zhiqiang] Hebei Normal Univ, Coll Chem & Mat Sci, Hebei Key Lab Organ Funct Mol, Shijiazhuang 050024, Hebei, Peoples R China published o-Trityl phenoxy-imino vanadium (III) complexes: synthesis, characterization, and catalysis on ethylene (co)polymerization in 2020.0, Cited 56.0. COA of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Several phenoxy-imine ligands bearing o-trityl group in phenoxy moiety RN=CHArOH (Ar = C6H2(CPh3)Bu-t, R = 2,6-Me2C6H3 (L1H); 2,6-(Pr2C6H3)-Pr-i (L2H); 3,5-(CF3)(2)C6H3 (L3H); 3,5-(OMe)(2)C6H3 (L4H); CHPh2 (L5H); CPh3 (L6H)) were synthesized and characterized by H-1 NMR and C-13 NMR spectroscopy. The vanadium complexes based on these ligands LVCl2(THF)(2) (1-6) were synthesized via conventional transmetalation reaction in moderate to high yields. Complexes 1-6 were fully characterized by FT-IR, elemental analyses and the molecular structures of 1, 2 center dot H2O, (2 center dot H2O)(2)(mu-Cl)(2), 4, and 5 were confirmed by X-ray crystallographic analysis in which the six-coordinated vanadium centers are in a typical octahedral geometry. Upon activation with Et2AlCl in toluene, complexes 1-6 showed high activities in ethylene polymerization affording polymers with moderate molecular weight (5.9-11.8 x 10(4) Da). Moreover, in hexane or CH2Cl2, 1-6/Et2AlCl exhibited enhanced activities. When activated with MAO or MMAO in toluene, these complexes showed relatively low activities but afforded polymers with ultra-high molecular weight (up to 3.30 x 10(6) Da). 1-6/Et2AlCl also showed high activities in ethylene/1-hexene copolymerization at room temperature giving moderate molecular-weight polymers (6.5-11.4 x 10(4) Da) with co-monomer incorporation being of 6.0 similar to 7.8%.

COA of Formula: C13H13N. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Synthesis of New 1,3,5-Azadiphosphorinanes Based on Aliphatic Amines WOS:000522647800009 published article about CYCLIC AMINOMETHYLPHOSPHINES; COMPLEXES in [Musina, E. I.; Musin, L. I.; Litvinov, I. A.; Karasik, A. A.] Russian Acad Sci, Kazan Sci Ctr, Fed Res Ctr, AE Arbuzov Inst Organ & Phys Chem, Kazan 420088, Russia in 2020.0, Cited 25.0. COA of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

New 1-aza-3,5-diphosphorinanes have been synthesized as a mixture of RR/SS- and RS-isomers via the reaction of bis(phenylphosphanyl)methane, paraformaldehyde, isopropylamine, of benzhydrylamine.

COA of Formula: C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Musina, EI; Musin, LI; Litvinov, IA; Karasik, AA or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about TRANSFER HYDROGENATION; REVERSIBLE DEHYDROGENATION; AROMATIC-AMINES; IRON CATALYSTS; ACCEPTOR LESS; DIRECT ACCESS; N-ALKYLATION; COMPLEXES; KETONES; SECONDARY, Saw an article supported by the Villum Fonden [12380]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Bottaro, F; Madsen, R. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Application In Synthesis of Diphenylmethanamine

An in situ formed cobalt catalyst is developed from cobalt(II)bromide, bis[2-(diisopropylphosphino)-4-methylphenyl]amine and zinc metal. The catalyst mediates the acceptorless dehydrogenative coupling of alcohols and amines into imines with the release of hydrogen gas and the transformation is applied to the synthesis of a variety of imines from different alcohols and amines. The mechanism is investigated with labelled substrates and based on the results a cobalt(I) PNP complex is believed to be the catalytically active species which abstracts hydrogen gas from the alcohol through a metal ligand bifunctional pathway.

Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: Diphenylmethanamine. Recently I am researching about H BOND-CLEAVAGE; N-C CLEAVAGE; SECONDARY AMIDES; CARBOXAMIDES; ACTIVATION, Saw an article supported by the National Research Foundation of Korea (NRF) – Korea Government (MSIT) [NRF-2021R1A2C1005169]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Joseph, D; Park, MS; Lee, S. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.

Recommanded Product: Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Evaluation of Synthesized Ester or Amide Coumarin Derivatives on Aromatase Inhibitory Activity published in 2020.0. Category: amides-buliding-blocks, Reprint Addresses Yamaguchi, Y; Nishizono, N (corresponding author), Hlth Sci Univ Hokkaido, Sch Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Aromatase inhibitors are effective for the treatment of diseases such as breast cancer, which has led to an increase in their demand. However, only a limited number of aromatase inhibitor drugs are currently being marketed. In addition, considering the important aspect of drug resistance, the development of newer drug types is required. We have been developing inhibitors with backbone structures that differ from existing aromatase inhibitors. In this regard, we previously reported that diethylaminocoumarin dimers and thiazolyl coumarin derivatives possess strong aromatase inhibiting capabilities. In this study, we further examined the structure activity relationships of coumarin derivatives synthesized from thiazolyl coumarin derivatives and their aromatase inhibiting capabilities. Consequently, amide coumarin N-benzhydry1-7-(diethylamino)2-oxo-2H-chromene-3-carboxamide (IC50 values 4.5 mu M) is inhibitor of aromatase. This inhibitor was found to be comparable aromatase inhibitory activity to the 1st generation aromatase inhibitor aminoglutethimide (3.2 mu M). Substitution of the amide group on the amide coumarin derivative affects the aromatase inhibiting activity. Our findings suggest that the structure of each substituent changes the orientation of the compound in the active site of aromatase, thus creating a difference in their activities.

Welcome to talk about 91-00-9, If you have any questions, you can contact Yamaguchi, Y; Nishizono, N; Oda, K or send Email.. Category: amides-buliding-blocks

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein WOS:000505633400021 published article about E3 UBIQUITIN LIGASE; 2 SH2 DOMAIN; SIGNAL TRANSDUCER; PEPTIDOMIMETIC INHIBITORS; SMALL MOLECULES; DESIGN; DEGRADATION; ACTIVATOR; OPTIMIZATION; VALIDATION in [Zhou, Haibin; Bai, Longchuan; Xu, Renqi; Zhao, Yujun; Chen, Jianyong; McEachern, Donna; Yang, Chao-Yie; Liu, Zhaomin; Wang, Mi; Liu, Liu; Yi, Han; Wang, Shaomeng] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA; [Zhou, Haibin; Bai, Longchuan; Xu, Renqi; Zhao, Yujun; Chen, Jianyong; McEachern, Donna; Yang, Chao-Yie; Liu, Zhaomin; Wang, Mi; Liu, Liu; Yi, Han; Wang, Shaomeng] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA; [Wang, Shaomeng] Univ Michigan, Dept Pharmacol, Med Sch, Ann Arbor, MI 48109 USA; [Wang, Shaomeng] Univ Michigan, Coll Pharm, Med Chem, 428 Church St, Ann Arbor, MI 48109 USA; [Chinnaswamy, Krishnapriya; Meagher, Jennifer L.; Stuckey, Jeanne A.] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA; [Wen, Bo; Dai, Lipeng; Kumar, Praveen; Sun, Duxin] Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, 428 Church St, Ann Arbor, MI 48109 USA in 2019.0, Cited 43.0. Computed Properties of C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor and an attractive therapeutic target for cancer and other human diseases. Despite 20 years of persistent research efforts, targeting STAT3 has been very challenging. We report herein the structure-based discovery of potent small-molecule STAT3 degraders based upon the proteolysis targeting chimera (PROTAC) concept. We first designed SI-109 as a potent, small-molecule inhibitor of the STAT3 SH2 domain. Employing ligands for cereblon/cullin 4A E3 ligase and SI-109, we obtained a series of potent PROTAC STAT3 degraders, exemplified by SD-36. SD-36 induces rapid STAT3 degradation at low nanomolar concentrations in cells and fails to degrade other STAT proteins. SD-36 achieves nanomolar cell growth inhibitory activity in leukemia and lymphoma cell lines with high levels of phosphorylated STAT3. A single dose of SD-36 results in complete STAT3 protein degradation in xenograft tumor tissue and normal mouse tissues. SD-36 achieves complete and long-lasting tumor regression in the Molm-16 xenograft tumor model at well-tolerated dose-schedules. SD-36 is a potent, selective, and efficacious STAT3 degrader.

Computed Properties of C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Zhou, HB; Bai, LC; Xu, RQ; Zhao, YJ; Chen, JY; McEachern, D; Chinnaswamy, K; Wen, B; Dai, LP; Kumar, P; Yang, CY; Liu, ZM; Wang, M; Liu, L; Meagher, JL; Yi, H; Sun, DX; Stuckey, JA; Wang, SM or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about NEDD8-ACTIVATING ENZYME-INHIBITOR; PROTEIN NEDDYLATION; IDENTIFICATION; PATHWAY; DEGRADATION; DISCOVERY; APOPTOSIS; LIGASES, Saw an article supported by the Chinese Minister of Science and Technology grant [2016YFA0501800]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872747, 21702061, 81625018, 81820108022]; Innovative Research Team of High-level Local Universities in Shanghai; National Special Fund for State Key Laboratory of Bioreactor Engineering [2060204]; National Key R&D Programof China [2017YFB0202600]; Innovation Program of Shanghai Municipal Education CommissionInnovation Program of Shanghai Municipal Education Commission [2019-01-07-00-10-E00056]; Program of Shanghai Academic/Technology Research Leader [18XD1403800]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Name: Diphenylmethanamine

Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 mu M vs 16.43 mu M), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 91-00-9, If you have any questions, you can contact Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J or send Email.. Name: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections WOS:000466053900012 published article about DIHYDROFOLATE-REDUCTASE; THYMIDYLATE SYNTHASE; BINDING MODES; LEISHMANIA; IDENTIFICATION; ASSAY; DERIVATIVES; VALIDATION; SOLUBILITY; RESISTANCE in [Linciano, Pasquale; Luciani, Rosaria; Sesenna, Antony; Quotadamo, Antonio; Costantino, Luca; Costi, Maria Paola] Univ Modena & Reggio Emilia, Dipartimento Sci Vita, Via Campi 103, I-41125 Modena, Italy; [Pozzi, Cecilia; dello Iacono, Lucia; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Mangani, Stefano] Univ Siena, Dipartimento Biotecnol Chim & Farm, Via Aldo Moro 2, I-53100 Siena, Italy; [Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa] Fraunhofer Inst Mol Biol & Appl Ecol Screening Po, D-22525 Hamburg, Germany; [Santarem, Nuno; Baptista, Catarina] Inst Mol & Cell Biol, P-4150180 Porto, Portugal; [Santarem, Nuno; Baptista, Catarina] Univ Porto, Inst Invest & Inovacao Saude, P-4150180 Porto, Portugal; [Franco, Caio; Moraes, Carolina B.] CNPEM, Lab Nacl Biociencias LNBio, BR-13083100 Campinas, SP, Brazil; [Mueller, Wolfgang; Wittig, Ulrike] HITS, Sci Databases & Visualizat Grp, D-69118 Heidelberg, Germany; [Wittig, Ulrike] HITS, Mol & Cellular Modeling Grp, D-69118 Heidelberg, Germany; [Franco, Caio; Moraes, Carolina B.] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, BR-05508900 Sao Paulo, SP, Brazil in 2019.0, Cited 57.0. Name: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

2-Amino-benzo[d]thiazole was identified as a new scaffold for the development of improved pteridine reductase-1 (PTR1) inhibitors and anti-trypanosomatidic agents. Molecular docking and crystallography guided the design and synthesis of 42 new benzothiazoles. The compounds were assessed for Trypanosoma brucei and Leishmania major PTR1 inhibition and in vitro activity against T. brucei and amastigote Leishmania infantum. We identified several 2-amino-benzo[d]thiazoles with improved enzymatic activity (TbPTR1 IC50 = 0.35 mu M; LmPTR1 IC50 = 1.9 mu M) and low mu M antiparasitic activity against T. brucei. The ten most active compounds against TbPTR1 were able to potentiate the antiparasitic activity of methotrexate when evaluated in combination against T. brucei, with a potentiating index between 1.2 and 2.7. The compound library was profiled for early ADME toxicity, and 2-amino-N-benzylbenzo[d]thiazole-6-carboxamide (4c) was finally identified as a novel potent, safe, and selective anti-trypanocydal agent (EC50 = 7.0 mu M). Formulation of 4c with hydroxypropyl-beta-cyclodextrin yielded good oral bioavailability, encouraging progression to in vivo studies.

Welcome to talk about 91-00-9, If you have any questions, you can contact Linciano, P; Pozzi, C; dello Iacono, L; di Pisa, F; Landi, G; Bonucci, A; Gul, S; Kuzikov, M; Ellinger, B; Witt, G; Santarem, N; Baptista, C; Franco, C; Moraes, CB; Muller, W; Wittig, U; Luciani, R; Sesenna, A; Quotadamo, A; Ferrari, S; Pohner, I; Cordeiro-Da-Silva, A; Mangani, S; Costantino, L; Costi, MP or send Email.. Name: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

HPLC of Formula: C13H13N. Recently I am researching about SUFEX CLICK CHEMISTRY; NUCLEOPHILIC-SUBSTITUTION; N-ALKYLATION; SULFONAMIDES; ARYL; DISCOVERY; AMINES; ARYLATION; PEPTIDES; REAGENTS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21502241]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030313290]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Wei, MJ; Liang, DC; Cao, XH; Luo, WJ; Ma, GJ; Liu, ZY; Li, L. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A broad-spectrum, catalytic method has been developed for the synthesis of sulfonamides and sulfamates. With the activation by the combination of a catalytic amount of 1-hydroxybenzotriazole (HOBt) and silicon additives, amidations of sulfonyl fluorides and fluorosulfates proceeded smoothly and excellent yields were generally obtained (87-99 %). Noticeably, this protocol is particularly efficient for sterically hindered substrates. Catalyst loading is generally low and only 0.02 mol % of catalyst is required for the multidecagram-scale synthesis of an amantadine derivative. In addition, the potential of this method in medicinal chemistry has been demonstrated by the synthesis of the marketed drug Fedratinib via a key intermediate sulfonyl fluoride 13. Since a large number of amines are commercially available, this route provides a facile entry to access Fedratinib analogues for biological screening.

HPLC of Formula: C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Wei, MJ; Liang, DC; Cao, XH; Luo, WJ; Ma, GJ; Liu, ZY; Li, L or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics