Category: 91-00-9

Recently I am researching about ONE-POT SYNTHESIS; CONJUGATED DIENES; HYDROGENATION; COMPLEXES; ELIMINATION; ALKYLATION; PORPHYRIN; LIGAND; SITE, Saw an article supported by the China Scholarship Council (CSC)China Scholarship Council; Technical University of Denmark; Independent Research Fund Denmark-Technology and Production Sciences. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Miao, YL; Samuelsen, SV; Madsen, R. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Application In Synthesis of Diphenylmethanamine

Vanadium(IV) tetraphenylporphyrin dichloride and chromium(III) tetraphenylporphyrin chloride have been developed as catalysts for the acceptorless dehydrogenation of alcohols. The catalysts have been applied to the direct synthesis of imines in overall good yields from a variety of alcohols and amines. The transformations are proposed to proceed by metal-ligand bifunctional pathways with an outer-sphere transfer of two hydrogen atoms from the alcohol to the metal porphyrin complexes. The results show that vanadium and chromium catalysts can also be employed for the dehydrogenation of alcohols with the release of hydrogen gas, and they may represent valuable alternatives to other catalysts based on Earth-abundant metals.

Application In Synthesis of Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. In 2019.0 CHEM SCI published article about CATALYZED OXIDATIVE CARBONYLATION; DEALKYLATIVE CARBONYLATION; EFFICIENT SYNTHESIS; COUPLING REACTIONS; FUNCTIONALIZATION; PALLADIUM; ACTIVATION; ARYLATION; ACIDS; AMINOCARBONYLATION in [Mu, Qiu-Chao; Bai, Xing-Feng; Chen, Jing; Yang, Lei; Xia, Chun-Gu; Xu, Li-Wen] UCAS, LICP, SRI, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China; [Mu, Qiu-Chao; Nie, Yi-Xue; Bai, Xing-Feng; Yang, Lei; Xu, Zheng; Li, Li; Xu, Li-Wen] Hangzhou Normal Univ, Key Lab Organosilicon Mat Technol Zhejiang Prov, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 311121, Zhejiang, Peoples R China in 2019.0, Cited 97.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A novel Pd/Cu-cocatalyzed carbonylative cyclization by C-H activation and N-dealkylative C-N bond activation has been developed for the chemoselective construction of synthetically useful heterocycles. The N,N-dimethylamine group on o-indolyl-N,N-dimethylarylamines was found to act as both the directing group and reactive component in this C-H carbonylative cyclization reaction. Furthermore, a unique C-H oxidation/carbonylative lactonization of diarylmethylamines is firstly demonstrated under modified reaction conditions, which could be easily applicable to the one-step synthesis of multi-substituted phthalides bearing an N,O-ketal skeleton that is difficult to access by previously reported methods. Mechanistic studies implicate that Pd/Cu-cocatalyzed C-H oxidation/carbonylative lactonization is a sequential reaction system via Cu-catalyzed C(sp(3))-H oxidation and Pd-catalyzed oxidative carbonylation of the C(sp(2))-H bond. It was found that trace amounts of water are essential to promote the Cu-catalyzed C(sp(3))-H oxidation of diarylmethylamine for the formation of the hydroxyl group, which could act as an in situ-formed directing group in the intramolecular carbonylative lactonization step.

Category: amides-buliding-blocks. Welcome to talk about 91-00-9, If you have any questions, you can contact Mu, QC; Nie, YX; Bai, XF; Chen, J; Yang, L; Xu, Z; Li, L; Xia, CG; Xu, LW or send Email.

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Amide – Wikipedia,
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SDS of cas: 91-00-9. Recently I am researching about NITRIC-OXIDE SYNTHASE; SELECTIVE-INHIBITION; DERIVATIVES; AGENT; IDENTIFICATION; ACETAMIDINES; AMIDOXIME; COMPONENT; THERAPY; AMIDINE, Saw an article supported by the MIURMinistry of Education, Universities and Research (MIUR) [FAR2018]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Maccallini, C; Marinelli, L; Indorf, P; Cacciatore, I; Fantacuzzi, M; Clement, B; Di Stefano, A; Amoroso, R. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Under different pathological conditions, aberrant induction of neuronal nitric oxide synthase (nNOS) generates overproduction of NO that can cause irreversible cell damage. The aim of this study was to develop an amidoxime prodrug of a potent nNOS inhibitor, the benzhydryl acetamidine. We synthesized the benzhydryl acetamidoxime, which was evaluatedin vitroto ascertain the potential NOS inhibitory activity, as well as conducting bioconversion into the parent acetamidine. The prodrug was also profiled forin vitrophysicochemical properties, by determining the lipophilicity, passive permeation through the human gastrointestinal tract and across the blood-brain barrier by PAMPA, and chemical, enzymatic, and plasma stability. The obtained data demonstrate that the amidoxime prodrug shows an improved pharmacokinetic profile with respect to the acetamidine nNOS inhibitor, thus suggesting that it could be a promising lead compound to treat all those pathological conditions in which nNOS activity is dysregulated.

Welcome to talk about 91-00-9, If you have any questions, you can contact Maccallini, C; Marinelli, L; Indorf, P; Cacciatore, I; Fantacuzzi, M; Clement, B; Di Stefano, A; Amoroso, R or send Email.. SDS of cas: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Application In Synthesis of Diphenylmethanamine. Recently I am researching about MECHANICALLY INTERLOCKED MOLECULES; ASYMMETRIC CATALYSIS; PEPTIDE-SYNTHESIS; MACHINES; COOPERATION; CATENANES; ALDEHYDES; SWITCHES; PYRIDYL, Saw an article supported by the Engineering and Physical Sciences Research Council (EPSRC)UK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/P027067/1]; EU (European Research Council (ERC))European Research Council (ERC) [786630, 642083]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Dommaschk, M; Echavarren, J; Leigh, DA; Marcos, V; Singleton, TA. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

We report on a switchable rotaxane molecular shuttle that features a pseudo-meso 2,5-disubstituted pyrrolidine catalytic unit on the axle whose local symmetry is broken according to the position of a threaded benzylic amide macrocycle. The macrocycle can be selectively switched (with light in one direction; with catalytic acid in the other) with high fidelity between binding sites located to either side of the pyrrolidine unit. The position of the macrocycle dictates the facial bias of the rotaxane-catalyzed conjugate addition of aldehydes to vinyl sulfones. The pseudo-meso non-interlocked thread does not afford significant selectivity as a catalyst (2-14 % ee), whereas the rotaxane affords selectivities of up to 40 % ee with switching of the position of the macrocycle changing the handedness of the product formed (up to 60 % Delta ee).

Welcome to talk about 91-00-9, If you have any questions, you can contact Dommaschk, M; Echavarren, J; Leigh, DA; Marcos, V; Singleton, TA or send Email.. Application In Synthesis of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Product Details of 91-00-9. Li, ML; Yu, JH; Li, YH; Zhu, SF; Zhou, QL in [Zhu, Shou-Fei; Zhou, Qi-Lin] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China; Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China published Highly enantioselective carbene insertion into N-H bonds of aliphatic amines in 2019, Cited 67. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Aliphatic amines strongly coordinate, and therefore easily inhibit, the activity of transition-metal catalysts, posing a marked challenge to nitrogen-hydrogen (N-H) insertion reactions. Here, we report highly enantioselective carbene insertion into N-H bonds of aliphatic amines using two catalysts in tandem: an achiral copper complex and chiral amino-thiourea. Coordination by a homoscorpionate ligand protects the copper center that activates the carbene precursor. The chiral amino-thiourea catalyst then promotes enantioselective proton transfer to generate the stereocenter of the insertion product. This reaction couples a wide variety of diazo esters and amines to produce chiral alpha-alkyl alpha-amino acid derivatives.

Product Details of 91-00-9. Welcome to talk about 91-00-9, If you have any questions, you can contact Li, ML; Yu, JH; Li, YH; Zhu, SF; Zhou, QL or send Email.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential published in 2020.0. Application In Synthesis of Diphenylmethanamine, Reprint Addresses Amoroso, R (corresponding author), Univ G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy.; Clement, B (corresponding author), Univ Kiel, Inst Pharmaceut, Gutenbergstr 76, D-24118 Kiel, Germany.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Under different pathological conditions, aberrant induction of neuronal nitric oxide synthase (nNOS) generates overproduction of NO that can cause irreversible cell damage. The aim of this study was to develop an amidoxime prodrug of a potent nNOS inhibitor, the benzhydryl acetamidine. We synthesized the benzhydryl acetamidoxime, which was evaluatedin vitroto ascertain the potential NOS inhibitory activity, as well as conducting bioconversion into the parent acetamidine. The prodrug was also profiled forin vitrophysicochemical properties, by determining the lipophilicity, passive permeation through the human gastrointestinal tract and across the blood-brain barrier by PAMPA, and chemical, enzymatic, and plasma stability. The obtained data demonstrate that the amidoxime prodrug shows an improved pharmacokinetic profile with respect to the acetamidine nNOS inhibitor, thus suggesting that it could be a promising lead compound to treat all those pathological conditions in which nNOS activity is dysregulated.

Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Blankson, G; Parhi, AK; Kaul, M; Pilch, DS; LaVoie, EJ in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about EFFLUX PUMP INHIBITORS; PSEUDOMONAS-AERUGINOSA; RESISTANCE; LEVOFLOXACIN in [Blankson, Gifty; Parhi, Ajit K.; LaVoie, Edmond J.] Rutgers State Univ, Dept Med Chem, Piscataway, NJ 08820 USA; [Kaul, Malvika; Pilch, Daniel S.] Rutgers Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA; [Parhi, Ajit K.] TAXIS Pharmaceut Inc, Monmouth Jct, NJ 08552 USA in 2019.0, Cited 17.0. SDS of cas: 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Several studies that have identified agents that potentiate the antimicrobial activity of antibiotics, but there are limited insights into their structure-activity relationships (SAR). The SAR associated with select N-alkylaryl amide derivatives of ornithine was performed to establish those structural features that were associated with potentiation of the antimicrobial activity of clarithromycin against E. coli ATCC 25922. The data indicate that the N-propyl derivative was slightly more active in reducing the effective MIC of clarithromycin against E. coli ATCC 25922. In addition, the S-enantiomer of compound 9 was somewhat more potent than the R-enantiomer in potentiating clarithromycin activity. No significant enhancement in potentiation activity was observed with the conversion of these secondary amides to their N-methyl tertiary amides. Formation of the N-methyl or N,N-dimethyl derivatives of the primary amine of 9 was associated with the loss of potentiation activity. Conversion of this primary amine to a guanidine was also not associated with an increase in potentiation activity. Among the isomeric diamino pentamides, 15 potentiated the antibacterial activity of clarithromycin to the greatest extent In addition to these amide derivatives, the desoxy derivatives 16 and 18 were the more potent potentiators within this triamine series. The relative location of the primary amines, as indicated by the relative differences in the potentiation observed with 16 compared to 14, appears to be a critical factor in determining potentiation activity. Cell-based membrane permeabilization and efflux inhibition studies in E. coli ATCC 25922 suggest that the potentiation of clarithromycin activity by 16 reflects its ability to inhibit efflux pump activity and to a lesser extent its actions as a permeabilizer of the outer leaflet of the outer cell membrane. (C) 2019 Elsevier Masson SAS. All rights reserved.

SDS of cas: 91-00-9. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Xie, JN; Li, XT; Kleij, AW in ROYAL SOC CHEMISTRY published article about ENANTIOSELECTIVE SYNTHESIS; HIGHLY EFFICIENT; LACTAM SYNTHESIS; AMIDES; ACIDS; POLYMERIZATION; HYDROGENATION; HETEROCYCLES; SUBSTITUTION; CAPURAMYCIN in [Xie, Jianing; Li, Xuetong; Kleij, Arjan W.] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain; [Kleij, Arjan W.] Catalan Inst Res & Adv Studies ICREA, Pg Lluis Co 23, Barcelona 08010, Spain in 2020.0, Cited 68.0. Name: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A stereoselective amination/cyclization cascade process has been developed that allows for the preparation of a series of unsaturated and substituted caprolactam derivatives in good yields. This conceptually novel protocol takes advantage of the easy access and modular character of vinyl gamma-lactones that can be prepared from simple precursors. Activation of the lactone substrate in the presence of a suitable Pd precursor and newly developed phosphoramidite ligand offers a stereocontrolled ring-opening/allylic amination manifold under ambient conditions. The intermediate (E)-configured epsilon-amino acid can be cyclized using a suitable dehydrating agent in an efficient one-pot, two-step sequence. This overall highly chemo-, stereo- and regio-selective transformation streamlines the production of a wide variety of modifiable and valuable caprolactam building blocks in an operationally attractive way.

Name: Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Vanadium- and Chromium-Catalyzed Dehydrogenative Synthesis of Imines from Alcohols and Amines WOS:000651063700017 published article about ONE-POT SYNTHESIS; CONJUGATED DIENES; HYDROGENATION; COMPLEXES; ELIMINATION; ALKYLATION; PORPHYRIN; LIGAND; SITE in [Miao, Yulong; Samuelsen, Simone, V; Madsen, Robert] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark in 2021.0, Cited 48.0. Product Details of 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Vanadium(IV) tetraphenylporphyrin dichloride and chromium(III) tetraphenylporphyrin chloride have been developed as catalysts for the acceptorless dehydrogenation of alcohols. The catalysts have been applied to the direct synthesis of imines in overall good yields from a variety of alcohols and amines. The transformations are proposed to proceed by metal-ligand bifunctional pathways with an outer-sphere transfer of two hydrogen atoms from the alcohol to the metal porphyrin complexes. The results show that vanadium and chromium catalysts can also be employed for the dehydrogenation of alcohols with the release of hydrogen gas, and they may represent valuable alternatives to other catalysts based on Earth-abundant metals.

Welcome to talk about 91-00-9, If you have any questions, you can contact Miao, YL; Samuelsen, SV; Madsen, R or send Email.. Product Details of 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Exploring anticancer activity of structurally modified benzylphenoxyacetamide (BPA); I: Synthesis strategies and computational analyses of substituted BPA variants with high anti-glioblastoma potential WOS:000497701200009 published article about ACTIVATED RECEPTOR-ALPHA; PPAR-ALPHA; FENOFIBRATE; GROWTH; CELL; DRUGS; MELANOMA; METABOLISM; INHIBITION; PREDICTION in [Houser, Lisa; Reiss, Krzysztof; Jursic, Branko S.] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA; [Jursic, Branko S.] Stepharm llc, POB 24220, New Orleans, LA 70184 USA; [Stalinska, Joanna; Rak, Monika; Colley, Susan B.; Reiss, Krzysztof] LSU Hlth Sci Ctr, Dept Med, Stanley S Scott Canc Ctr, Neurol Canc Res, New Orleans, LA 70112 USA; [Stalinska, Joanna; Rak, Monika] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Cell Biol, Krakow, Poland in 2019.0, Cited 69.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Application In Synthesis of Diphenylmethanamine

Structural variations of the benzylphenoxyacetamide (BPA) molecular skeleton were explored as a viable starting point for designing new anti-glioblastoma drug candidates. Hand-to-hand computational evaluation, chemical modifications, and cell viability testing were performed to explore the importance of some of the structural properties in order to generate, retain, and improve desired anti-glioblastoma characteristics. It was demonstrated that several structural features are required to retain the anti-glioblastoma activity, including a carbonyl group of the benzophenone moiety, as well as 4′-chloro and 2,2-dimethy substituents. In addition, the structure of the amide moiety can be modified in such a way that desirable anti-glioblastoma and physical properties can be improved. Via these structural modifications, more than 50 compounds were prepared and tested for anti-glioblastoma activity. Four compounds were identified (HR28, HR32, HR37, and HR46) that in addition to HR40 (PP1) from our previous study, have been determined to have desirable physical and biological properties. These include high glioblastoma cytotoxicity at low mu M concentrations, improved water solubility, and the ability to penetrate the blood brain barrier (BBB), which indicate a potential for becoming a new class of anti-glioblastoma drugs.

Application In Synthesis of Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Stalinska, J; Houser, L; Rak, M; Colley, SB; Reiss, K; Jursic, BS or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics