Category: 91-00-9

Quality Control of Diphenylmethanamine. In 2019 ANGEW CHEM INT EDIT published article about INTERMOLECULAR ADDITION-REACTIONS; SULFONYL AZIDES; FUNCTIONALIZATION; SULFONAMIDES; DERIVATIVES; OXIDATION; BONDS; ACID in [Hernandez-Guerra, Daniel; Hlavackova, Anna; Pramthaisong, Chiranan; Vespoli, Ilaria; Pohl, Radek; Slanina, Tomas; Jahn, Ullrich] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Namesti 2, Prague 16610 6, Czech Republic in 2019, Cited 54. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A mild, atom-economic, and metal-free alpha-C-H amination of ethers using relatively stable nonafluorobutanesulfonyl (nonaflyl, Nf) azide as the aminating reagent to give N-sulfonyl hemiaminals is reported. This enables unprecedented C(sp(3)) difunctionalization reactions, leading to diverse functionalized amino group containing compounds starting from simple ethers in one pot.

Welcome to talk about 91-00-9, If you have any questions, you can contact Hernndez-Guerra, D; Hlavackov, A; Pramthaisong, C; Vespoli, I; Pohl, R; Slanina, T; Jahn, U or send Email.. Quality Control of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Micewicz, ED; Nguyen, C; Micewicz, A; Waring, AJ; McBrid, WH; Ruchala, P in [Micewicz, Ewa D.; Nguyen, Christine; McBrid, William H.] Univ Calif Los Angeles, Dept Radiat Oncol, 10833 Le Conte Ave, Los Angeles, CA 90095 USA; [Micewicz, Alina] Univ Calif Los Angeles, David Geffen Sch Med, Volunteering Program, 10833 Le Conte Ave, Los Angeles, CA 90095 USA; [Waring, Alan J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles Biomed Res Inst, 1000 West Carson St, Torrance, CA 90502 USA; [Ruchala, Piotr] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza, Los Angeles, CA 90024 USA; [Ruchala, Piotr] Jane & Terry Semel Inst Neurosci & Human Behav, Pasarow Mass Spectrometry Lab, 760 Westwood Plaza, Los Angeles, CA 90024 USA published Position of lipidation influences anticancer activity of Smac analogs in 2019.0, Cited 79.0. Name: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A small group of lipid-conjugated Smac mimetics was synthesized to probe the influence of the position of lipidation on overall anti-cancer activity. Specifically, new compounds were modified with lipid(s) in position 3 and C-terminus. Previously described position 2 lipidated analog M11 was also synthesized. The resulting mini library of Smacs lipidated in positions 2, 3 and C-terminus was screened extensively in vitro against a total number of 50 diverse cancer cell lines revealing that both the position of lipidation as well as the type of lipid, influence their anti-cancer activity and cancer type specificity. Moreover, when used in combination therapy with inhibitor of menin-MLL1 protein interactions, position 2 modified analog SM2 showed strong synergistic anti-cancer properties. The most promising lipid-conjugated analogs SM2 and SM6, showed favorable pharmacokinetics and in vivo activity while administered subcutaneously in the preclinical mouse model. Collectively, our findings suggest that lipid modification of Smacs may be a viable approach in the development of anti-cancer therapeutic leads.

Name: Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Computed Properties of C13H13N. Authors Sun, WN; Chen, XL; Huang, SZ; Li, WP; Tian, CY; Yang, SY; Li, LL in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Sun, Weining; Tian, Chenyu; Li, Linli] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu 610041, Sichuan, Peoples R China; [Chen, Xiuli; Huang, Shenzhen; Li, Wenpei; Yang, Shengyong] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China; [Chen, Xiuli; Huang, Shenzhen; Li, Wenpei; Yang, Shengyong] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China in 2020, Cited 14. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

SIRT6 is a deacetylase of histone H3 and inhibitors of SIRT6 have been thought as potential agents for treatment of diabetes. Herein we report the discovery of a series of new SIRT6 inhibitors containing the skeleton 1-phenylpiperazine. Among them, compound 5-(4-methylpiperazin-1-yl)-2-nitroaniline (6d) is the most potent one, which showed an IC50 value of 4.93 mu M against SIRT6 in the Fluor de Lys (FDL) assay. It displayed K-D values of 9.76 mu M and 10 mu M in surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) assays, respectively. In selectivity assay, 6d showed no activity against other members of the HDAC family (SIRT1-3 and HDAC1-11) at concentrations up to 200 mu M. In a mouse model of type 2 diabetes, 6d could significantly increase the level of glucose transporter GLUT-1, thereby reducing blood glucose. Overall, this study provides a promising lead compound for subsequent drug discovery targeting SIRT6.

Welcome to talk about 91-00-9, If you have any questions, you can contact Sun, WN; Chen, XL; Huang, SZ; Li, WP; Tian, CY; Yang, SY; Li, LL or send Email.. Computed Properties of C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Mild Iridium-Catalysed Isomerization of Epoxides. Computational Insights and Application to the Synthesis of beta-Alkyl Amines WOS:000474106100001 published article about MEINWALD REARRANGEMENT REACTIONS; PROMOTED REARRANGEMENT; SELECTIVE SYNTHESIS; CONVERSION; CYCLOPROPANES; CARBONYLATION; COMPLEXES; OXIDATION; ALDEHYDES in [Cabre, Albert; Cabezas-Gimenez, Juanjo; Verdaguer, Xavier; Riera, Antoni] Inst Res Biomed IRB Barcelona, Baldiri Reixac 10, Barcelona 08028, Spain; [Cabre, Albert; Cabezas-Gimenez, Juanjo; Verdaguer, Xavier; Riera, Antoni] Univ Barcelona, Dept Quim Inorgan & Organ, Seccio Organ, Marti i Franques 1, E-08028 Barcelona, Spain; [Sciortino, Giuseppe; Ujaque, Gregori; Lledos, Agusti] Univ Autonoma Barcelona, Dept Quim, Edifici Cn, Cerdanyola Del Valles 08193, Spain; [Sciortino, Giuseppe] Univ Sassari, Dipt Chim & Farm, Via Vienna 2, I-07017 Sassari, Italy in 2019.0, Cited 58.0. Safety of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The isomerization of epoxides to aldehydes using the readily available Crabtree’s reagent is described. The aldehydes were transformed into synthetically useful amines by a one-pot reductive amination using pyrrolidine as imine-formation catalyst. The reactions worked with low catalyst loadings in very mild conditions. The procedure is operationally simple and tolerates a wide range of functional groups. A DFT study of its mechanism is presented showing that the isomerization takes place via an iridium hydride mechanism with a low energy barrier, in agreement with the mild reaction conditions.

Welcome to talk about 91-00-9, If you have any questions, you can contact Cabre, A; Cabezas-Gimenez, J; Sciortino, G; Ujaque, G; Verdaguer, X; Lledos, A; Riera, A or send Email.. Safety of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: 91-00-9. In 2019.0 B CHEM SOC JPN published article about NITROSO-COMPOUNDS; OXIDATION; REDUCTION; COMPLEX; SYSTEM in [Matsukawa, Yuta; Hirashita, Tsunehisa; Araki, Shuki] Nagoya Inst Technol, Grad Sch Engn, Life Sci & Appl Chem, Showa Ku, Gokiso Cho, Nagoya, Aichi 4668555, Japan in 2019.0, Cited 35.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A series of reactions between 5-nitroso-1,3-diphenyltetrazolium tetrafluoroborate and methoxybenzenes, amines, thiols, sulfoxides, and sulfides, most of which are generally accepted as being inert to nitroso groups, is reported here. The tetrazolium-activated nitroso functionality is capable of oxidizing the aforementioned substrates to give the corresponding oxidized products, and the nitroso tetrazolium itself is transformed into the corresponding amide or hydroxyamide, depending on the nature of the reaction partners. In the case of thioanisole, an addition product was obtained.

Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Shelp, RA; Ciro, A; Pu, YG; Merchant, RR; Hughes, JME; Walsh, PJ in ROYAL SOC CHEMISTRY published article about in [Shelp, Russell A.; Ciro, Anthony; Pu, Youge; Walsh, Patrick J.] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, 231 South 34th St, Philadelphia, PA 19104 USA; [Merchant, Rohan R.] Merck & Co Inc, Dept Discovery Chem, San Francisco, CA 94080 USA; [Hughes, Jonathan M. E.] Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA in 2021, Cited 41. Computed Properties of C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

We report a 3-component reaction between N-benzyl ketimines, [1.1.1]propellane, and pinacol boronates to generate benzylamine bicyclo[1.1.1]pentane (BCP) pinacol boronates. These structures are analogous to highly sought diarylmethanamine cores, which are common motifs in bioactive molecules. We demonstrate the versatility of the boronate ester handle via downstream functionalization through a variety of reactions, including a challenging Pd-catalyzed (hetero)arylation that exhibits a broad substrate scope. Together, these methods enable the synthesis of high-value BCP benzylamines which are inaccessible by existing methods. Furthermore, we demonstrate the successful application of these newly developed (hetero)arylation conditions to a variety of challenging tertiary pinacol boronates, including nitrogen-containing heterocycles, 1,1-disubstituted cyclopropanes, and other BCP cores.

Computed Properties of C13H13N. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Application In Synthesis of Diphenylmethanamine. Wei, MJ; Liang, DC; Cao, XH; Luo, WJ; Ma, GJ; Liu, ZY; Li, L in [Wei, Mingjie; Liang, Dacheng; Luo, Wenjun; Ma, Guojian; Liu, Zeyuan; Li, Le] Sun Yat Sen Univ, Sch Chem, PCFM Lab, Guangzhou 510275, Peoples R China; [Wei, Mingjie; Liang, Dacheng; Luo, Wenjun; Ma, Guojian; Liu, Zeyuan; Li, Le] Sun Yat Sen Univ, Sch Chem, GDHPRC Lab, Guangzhou 510275, Peoples R China; [Cao, Xiaohui] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China published A Broad-Spectrum Catalytic Amidation of Sulfonyl Fluorides and Fluorosulfates** in 2021, Cited 144. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A broad-spectrum, catalytic method has been developed for the synthesis of sulfonamides and sulfamates. With the activation by the combination of a catalytic amount of 1-hydroxybenzotriazole (HOBt) and silicon additives, amidations of sulfonyl fluorides and fluorosulfates proceeded smoothly and excellent yields were generally obtained (87-99 %). Noticeably, this protocol is particularly efficient for sterically hindered substrates. Catalyst loading is generally low and only 0.02 mol % of catalyst is required for the multidecagram-scale synthesis of an amantadine derivative. In addition, the potential of this method in medicinal chemistry has been demonstrated by the synthesis of the marketed drug Fedratinib via a key intermediate sulfonyl fluoride 13. Since a large number of amines are commercially available, this route provides a facile entry to access Fedratinib analogues for biological screening.

Application In Synthesis of Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Wei, MJ; Liang, DC; Cao, XH; Luo, WJ; Ma, GJ; Liu, ZY; Li, L or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Micewicz, ED; Nguyen, C; Micewicz, A; Waring, AJ; McBrid, WH; Ruchala, P in [Micewicz, Ewa D.; Nguyen, Christine; McBrid, William H.] Univ Calif Los Angeles, Dept Radiat Oncol, 10833 Le Conte Ave, Los Angeles, CA 90095 USA; [Micewicz, Alina] Univ Calif Los Angeles, David Geffen Sch Med, Volunteering Program, 10833 Le Conte Ave, Los Angeles, CA 90095 USA; [Waring, Alan J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles Biomed Res Inst, 1000 West Carson St, Torrance, CA 90502 USA; [Ruchala, Piotr] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza, Los Angeles, CA 90024 USA; [Ruchala, Piotr] Jane & Terry Semel Inst Neurosci & Human Behav, Pasarow Mass Spectrometry Lab, 760 Westwood Plaza, Los Angeles, CA 90024 USA published Position of lipidation influences anticancer activity of Smac analogs in 2019.0, Cited 79.0. Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A small group of lipid-conjugated Smac mimetics was synthesized to probe the influence of the position of lipidation on overall anti-cancer activity. Specifically, new compounds were modified with lipid(s) in position 3 and C-terminus. Previously described position 2 lipidated analog M11 was also synthesized. The resulting mini library of Smacs lipidated in positions 2, 3 and C-terminus was screened extensively in vitro against a total number of 50 diverse cancer cell lines revealing that both the position of lipidation as well as the type of lipid, influence their anti-cancer activity and cancer type specificity. Moreover, when used in combination therapy with inhibitor of menin-MLL1 protein interactions, position 2 modified analog SM2 showed strong synergistic anti-cancer properties. The most promising lipid-conjugated analogs SM2 and SM6, showed favorable pharmacokinetics and in vivo activity while administered subcutaneously in the preclinical mouse model. Collectively, our findings suggest that lipid modification of Smacs may be a viable approach in the development of anti-cancer therapeutic leads.

Formula: C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Micewicz, ED; Nguyen, C; Micewicz, A; Waring, AJ; McBrid, WH; Ruchala, P or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Authors Sun, WN; Chen, XL; Huang, SZ; Li, WP; Tian, CY; Yang, SY; Li, LL in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Sun, Weining; Tian, Chenyu; Li, Linli] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu 610041, Sichuan, Peoples R China; [Chen, Xiuli; Huang, Shenzhen; Li, Wenpei; Yang, Shengyong] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China; [Chen, Xiuli; Huang, Shenzhen; Li, Wenpei; Yang, Shengyong] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China in 2020, Cited 14. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

SIRT6 is a deacetylase of histone H3 and inhibitors of SIRT6 have been thought as potential agents for treatment of diabetes. Herein we report the discovery of a series of new SIRT6 inhibitors containing the skeleton 1-phenylpiperazine. Among them, compound 5-(4-methylpiperazin-1-yl)-2-nitroaniline (6d) is the most potent one, which showed an IC50 value of 4.93 mu M against SIRT6 in the Fluor de Lys (FDL) assay. It displayed K-D values of 9.76 mu M and 10 mu M in surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) assays, respectively. In selectivity assay, 6d showed no activity against other members of the HDAC family (SIRT1-3 and HDAC1-11) at concentrations up to 200 mu M. In a mouse model of type 2 diabetes, 6d could significantly increase the level of glucose transporter GLUT-1, thereby reducing blood glucose. Overall, this study provides a promising lead compound for subsequent drug discovery targeting SIRT6.

Category: amides-buliding-blocks. Welcome to talk about 91-00-9, If you have any questions, you can contact Sun, WN; Chen, XL; Huang, SZ; Li, WP; Tian, CY; Yang, SY; Li, LL or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo WOS:000604903800017 published article about NEDD8-ACTIVATING ENZYME-INHIBITOR; PROTEIN NEDDYLATION; IDENTIFICATION; PATHWAY; DEGRADATION; DISCOVERY; APOPTOSIS; LIGASES in [Chen, Xin; Mao, Fei; Wei, Jinlian; Xu, Yixiang; Li, Baoli; Zhu, Jin; Li, Jian] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China; [Yang, Xi; Ni, Shuaishuai; Jia, Lijun] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst, Shanghai 200032, Peoples R China; [Li, Jian] Dali Univ, Coll Pharm & Chem, 5 Xue Ren Rd, Dali 671000, Yunnan, Peoples R China; [Li, Jian] East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, 130 Mei Long Rd, Shanghai 200237, Peoples R China in 2021.0, Cited 41.0. HPLC of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 mu M vs 16.43 mu M), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.

HPLC of Formula: C13H13N. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics