Category: 91-00-9

Recommanded Product: Diphenylmethanamine. Welker, A; Kersten, C; Muller, C; Madhugiri, R; Zimmer, C; Muller, P; Zimmermann, R; Hammerschmidt, S; Maus, H; Ziebuhr, J; Sotriffer, C; Schirmeister, T in [Welker, Armin; Sotriffer, Christoph] Justus Maximilians Univ Wurzburg, Inst Pharm & Food Chem, D-97074 Wurzburg, Germany; [Kersten, Christian; Zimmer, Collin; Mueller, Patrick; Zimmermann, Robert; Hammerschmidt, Stefan; Maus, Hannah; Schirmeister, Tanja] Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, Staudingerweg 5, D-55128 Mainz, Germany; [Mueller, Christin; Madhugiri, Ramakanth; Ziebuhr, John] Justus Liebig Univ Giessen, Inst Med Virol, Schubertstr 81, D-35392 Giessen, Germany published Deal;Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2 in 2021.0, Cited 29.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS-CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PL(pro)inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PL(pro)are valuable starting points for the development of new pan-coronaviral inhibitors.

Recommanded Product: Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Platinum-(phosphinito-phosphinous acid) complexes as bi-talented catalysts for oxidative fragmentation of piperidinols: an entry to primary amines WOS:000501604800016 published article about SECONDARY PHOSPHINE OXIDES; AEROBIC OXIDATION; N-ALKYLATION; PALLADIUM; FUNCTIONALIZATION; METHODOLOGY; CHEMISTRY; ALCOHOLS in [Membrat, Romain; Moraleda, Delphine; Michaud-Chevallier, Sabine; Martinez, Alexandre; Giordano, Laurent; Nuel, Didier] Aix Marseille Univ, CNRS, Cent Marseille, ISm2, F-ISM2 Marseille, France; [Vasseur, Alexandre] Univ Lorraine, CNRS, L2CM, F-54000 Nancy, France in 2019.0, Cited 31.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Recommanded Product: Diphenylmethanamine

Platinum-(phosphinito-phosphinous acid) complex catalyzes the oxidative fragmentation of hindered piperidinols according to a hydrogen transfer induced methodology. This catalyst acts successively as both a hydrogen carrier and soft Lewis acid in a one pot – two steps process. This method can be applied to the synthesis of a wide variety of primary amines in a pure form by a simple acid-base extraction without further purification.

Recommanded Product: Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Membrat, R; Vasseur, A; Moraleda, D; Michaud-Chevallier, S; Martinez, A; Giordano, L; Nuel, D or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Formula: C13H13N. I found the field of Chemistry very interesting. Saw the article Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification published in 2020.0, Reprint Addresses Cink, RD (corresponding author), AbbVie Inc, Proc Res & Dev, N Chicago, IL 60064 USA.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine.

Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical trials and subsequent commercial launch. The large-scale synthetic route to glecaprevir required the development of completely new synthetic approaches to the two key structural features: the 18-membered macrocycle 3 and the difluoromethyl-substituted cyclopropyl amino acid 4. In this first manuscript, we describe the route development for the macrocycle 3; the second manuscript will describe the development of a new synthetic route to the difluoromethyl-substituted cyclopropyl amino acid 4 and the final assembly of glecaprevir. The large-scale synthetic route to the macrocycle employed a unique intramolecular etherification reaction as the key step in the macrocycle synthesis, avoiding the scalability limitations of the ring-closing metathesis (RCM) reaction of the enabling route. The large-scale synthetic route to the macrocycle was successfully used to produce the amount of glecaprevir required to support the late-stage clinical development.

Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Kallemeyn, JM; Engstrom, KM; Pelc, MJ; Lukin, KA; Morrill, WH; Wei, HJ; Towne, TB; Henle, J; Nere, NK; Welch, DS; Shekhar, S; Ravn, MM; Zhao, G; Fickes, MG; Ding, C; Vinci, JC; Marren, J; Cink, RD or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Ambient Reductive Amination of Levulinic Acid to Pyrrolidones over Pt Nanocatalysts on Porous TiO2 Nanosheets WOS:000460996500037 published article about HIGHLY EFFICIENT CATALYST; NITROGEN-COMPOUNDS; PRECIOUS-METAL; PRIMARY AMINES; KETO ACIDS; BIOMASS; HYDROGENATION; AMINATION/CYCLIZATION; HYDRODEOXYGENATION; TRANSFORMATION in [Xie, Chao; Song, Jinliang; Wu, Haoran; Hu, Yue; Liu, Huizhen; Zhang, Zhanrong; Zhang, Pei; Chen, Bingfeng; Han, Buxing] Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,CAS Key Lab Colloid & In, Beijing 100190, Peoples R China; [Xie, Chao; Wu, Haoran; Hu, Yue; Liu, Huizhen; Han, Buxing] Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China in 2019.0, Cited 50.0. Product Details of 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Construction of N-substituted pyrrolidones from biomass-derived levulinic acid (LA) via reductive amination is a highly attractive route for biomass valorization. However, realizing this transformation using H-2 as the hydrogen source under mild conditions is still very challenging. Herein, we designed porous TiO2 nanosheets-supported Pt nanoparticles (Pt/P-TiO2) as the heterogeneous catalyst. The prepared Pt/P-TiO2 was highly efficient for reductive amination of LA to produce various N-substituted pyrrolidones (34 examples) at ambient temperature and H-2 pressure. Meanwhile, Pt/P-TiO2 showed good applicability for reductive amination of levulinic esters, 4-acetylbutyric acid, 2-acetylbenzoic acid, and 2-carboxybenzaldehyde. Systematic studies indicated that the strong acidity of P-TiO2 and the lower electron density of the Pt sites as well as the porous structure resulted in the excellent activity of Pt/P-TiO2.

Product Details of 91-00-9. Welcome to talk about 91-00-9, If you have any questions, you can contact Xie, C; Song, JL; Wu, HR; Hu, Y; Liu, HZ; Zhang, ZR; Zhang, P; Chen, BF; Han, BX or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about HOMOGENEOUS CATALYSIS; AEROBIC OXIDATION; CONVENIENT METHOD; FORMIC-ACID; HYDROGENATION; MILD; REAGENTS; OXYGEN; CO2, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21871183, 21631007, 21225103]; Doctoral Fund of Ministry of Education of ChinaMinistry of Education, China [20130002110042]; Tsinghua University Initiative Foundation Research Program [20131089204]; State Key Laboratory of Natural and Biomimetic Drugs [K20160202]; Shanghai Institute of Technology. COA of Formula: C13H13N. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Dan, DM; Chen, FB; Zhao, WS; Yu, H; Han, S; Wei, YG. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A simple and efficient protocol for the formylation of amines with formic acid, catalyzed by a polyoxometalate-based chromium catalyst, is described. Notably, this method shows excellent activity and chemo-selectivity for the formylation of primary amines; diamines have also been successfully employed. Importantly, the chromium catalyst is potentially non-toxic, environmentally benign and safer than the widely used high valence chromium catalysts such as CrO3 and K2Cr2O7. The catalyst can be recycled several times with a negligible impact on activity. Finally, a plausible mechanism is provided based on the observation of intermediate and control experiments.

Welcome to talk about 91-00-9, If you have any questions, you can contact Dan, DM; Chen, FB; Zhao, WS; Yu, H; Han, S; Wei, YG or send Email.. COA of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2019.0 SCI REP-UK published article about ACTIVATED RECEPTOR-ALPHA; PPAR-ALPHA; FENOFIBRATE; GROWTH; CELL; DRUGS; MELANOMA; METABOLISM; INHIBITION; PREDICTION in [Houser, Lisa; Reiss, Krzysztof; Jursic, Branko S.] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA; [Jursic, Branko S.] Stepharm llc, POB 24220, New Orleans, LA 70184 USA; [Stalinska, Joanna; Rak, Monika; Colley, Susan B.; Reiss, Krzysztof] LSU Hlth Sci Ctr, Dept Med, Stanley S Scott Canc Ctr, Neurol Canc Res, New Orleans, LA 70112 USA; [Stalinska, Joanna; Rak, Monika] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Cell Biol, Krakow, Poland in 2019.0, Cited 69.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. SDS of cas: 91-00-9

Structural variations of the benzylphenoxyacetamide (BPA) molecular skeleton were explored as a viable starting point for designing new anti-glioblastoma drug candidates. Hand-to-hand computational evaluation, chemical modifications, and cell viability testing were performed to explore the importance of some of the structural properties in order to generate, retain, and improve desired anti-glioblastoma characteristics. It was demonstrated that several structural features are required to retain the anti-glioblastoma activity, including a carbonyl group of the benzophenone moiety, as well as 4′-chloro and 2,2-dimethy substituents. In addition, the structure of the amide moiety can be modified in such a way that desirable anti-glioblastoma and physical properties can be improved. Via these structural modifications, more than 50 compounds were prepared and tested for anti-glioblastoma activity. Four compounds were identified (HR28, HR32, HR37, and HR46) that in addition to HR40 (PP1) from our previous study, have been determined to have desirable physical and biological properties. These include high glioblastoma cytotoxicity at low mu M concentrations, improved water solubility, and the ability to penetrate the blood brain barrier (BBB), which indicate a potential for becoming a new class of anti-glioblastoma drugs.

SDS of cas: 91-00-9. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Pd-catalyzed stereoselective tandem ring-opening amination/cyclization of vinyl gamma-lactones: access to caprolactam diversity WOS:000562597500014 published article about ENANTIOSELECTIVE SYNTHESIS; HIGHLY EFFICIENT; LACTAM SYNTHESIS; AMIDES; ACIDS; POLYMERIZATION; HYDROGENATION; HETEROCYCLES; SUBSTITUTION; CAPURAMYCIN in [Xie, Jianing; Li, Xuetong; Kleij, Arjan W.] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain; [Kleij, Arjan W.] Catalan Inst Res & Adv Studies ICREA, Pg Lluis Co 23, Barcelona 08010, Spain in 2020.0, Cited 68.0. Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A stereoselective amination/cyclization cascade process has been developed that allows for the preparation of a series of unsaturated and substituted caprolactam derivatives in good yields. This conceptually novel protocol takes advantage of the easy access and modular character of vinyl gamma-lactones that can be prepared from simple precursors. Activation of the lactone substrate in the presence of a suitable Pd precursor and newly developed phosphoramidite ligand offers a stereocontrolled ring-opening/allylic amination manifold under ambient conditions. The intermediate (E)-configured epsilon-amino acid can be cyclized using a suitable dehydrating agent in an efficient one-pot, two-step sequence. This overall highly chemo-, stereo- and regio-selective transformation streamlines the production of a wide variety of modifiable and valuable caprolactam building blocks in an operationally attractive way.

Formula: C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Xie, JN; Li, XT; Kleij, AW or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Quality Control of Diphenylmethanamine. Authors Harrison, D; Boutard, N; Brzozka, K; Bugaj, M; Chmielewski, S; Cierpich, A; Doedens, JR; Fabritius, CHRY; Gabel, CA; Galezowski, M; Kowalczyk, P; Levenets, O; Mroczkowska, M; Palica, K; Porter, RA; Schultz, D; Sowinska, M; Topolnicki, G; Urbanski, P; Woyciechowski, J; Watt, AP in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Harrison, David; Watt, Alan P.] NodThera Ltd, Suite 8,Chesterford Res Pk, Saffron Walden CB10 1XL, Essex, England; [Doedens, John R.; Gabel, Christopher A.] NodThera Inc, 454 N 34th St, Seattle, WA 98103 USA; [Boutard, Nicolas; Brzozka, Krzysztof; Bugaj, Marta; Chmielewski, Stefan; Cierpich, Anna; Fabritius, Charles-Henry R. Y.; Galezowski, Michal; Kowalczyk, Piotr; Levenets, Oleksandr; Mroczkowska, Magdalena; Palica, Katarzyna; Schultz, David; Sowinska, Marta; Topolnicki, Grzegorz; Urbanski, Piotr; Woyciechowski, Jakub] Ryvu Therapeut, Selvita SA, Pk Life Sci,Ul Bobrssynskiego 14, PL-30348 Krakow, Poland; [Porter, Roderick A.] Rod Porter Consultancy, 89 Back St, Baldock SG7 5PG, Herts, England in 2020.0, Cited 25.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The NLRP3 inflammasome is a component of the innate immune system involved in the production of proinflammatory cytokines. Aberrant activation by a wide range of exogenous and endogenous signals can lead to chronic, low-grade inflammation. It has attracted a great deal of interest as a drug target due to the association with diseases of large unmet medical need such as Alzheimer’s disease, Parkinson’s disease, arthritis, and cancer. To date, no drugs specifically targeting inhibition of the NLRP3 inflammasome have been approved. In this work, we used the known NLRP3 inflammasome inhibitor CP-456,773 (aka CRID3 or MCC 950) as our starting point and undertook a Structure-Activity Relationship (SAR) analysis and subsequent scaffold-hopping exercise. This resulted in the rational design of a series of novel ester-substituted urea compounds that are highly potent and selective NLRP3 inflammasome inhibitors, as exemplified by compounds 44 and 45. It is hypothesized that the ester moiety acts as a highly permeable delivery vehicle and is subsequently hydrolyzed to the carboxylic acid active species by carboxylesterase enzymes. These molecules are greatly differentiated from the state-of-the-art and offer potential in the treatment of NLRP3-driven diseases, particularly where tissue penetration is required.

Welcome to talk about 91-00-9, If you have any questions, you can contact Harrison, D; Boutard, N; Brzozka, K; Bugaj, M; Chmielewski, S; Cierpich, A; Doedens, JR; Fabritius, CHRY; Gabel, CA; Galezowski, M; Kowalczyk, P; Levenets, O; Mroczkowska, M; Palica, K; Porter, RA; Schultz, D; Sowinska, M; Topolnicki, G; Urbanski, P; Woyciechowski, J; Watt, AP or send Email.. Quality Control of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Name: Diphenylmethanamine. In 2020.0 ORG PROCESS RES DEV published article about HYDROGEN; BROMIDES; OLEFINS; ARYL in [Kallemeyn, Jeffrey M.; Engstrom, Kenneth M.; Pelc, Matthew J.; Lukin, Kirill A.; Morrill, Westin H.; Wei, Haojuan; Towne, Timothy B.; Henle, Jeremy; Nere, Nandkishor K.; Welch, Dennie S.; Shekhar, Shashank; Ravn, Matthew M.; Zhao, Gang; Fickes, Michael G.; Cink, Russell D.] AbbVie Inc, Proc Res & Dev, N Chicago, IL 60064 USA; [Ding, Chen; Vinci, John C.; Marren, James] AbbVie Inc, Analyt Res & Dev, N Chicago, IL 60064 USA in 2020.0, Cited 35.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical trials and subsequent commercial launch. The large-scale synthetic route to glecaprevir required the development of completely new synthetic approaches to the two key structural features: the 18-membered macrocycle 3 and the difluoromethyl-substituted cyclopropyl amino acid 4. In this first manuscript, we describe the route development for the macrocycle 3; the second manuscript will describe the development of a new synthetic route to the difluoromethyl-substituted cyclopropyl amino acid 4 and the final assembly of glecaprevir. The large-scale synthetic route to the macrocycle employed a unique intramolecular etherification reaction as the key step in the macrocycle synthesis, avoiding the scalability limitations of the ring-closing metathesis (RCM) reaction of the enabling route. The large-scale synthetic route to the macrocycle was successfully used to produce the amount of glecaprevir required to support the late-stage clinical development.

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Kallemeyn, JM; Engstrom, KM; Pelc, MJ; Lukin, KA; Morrill, WH; Wei, HJ; Towne, TB; Henle, J; Nere, NK; Welch, DS; Shekhar, S; Ravn, MM; Zhao, G; Fickes, MG; Ding, C; Vinci, JC; Marren, J; Cink, RD or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about HIGHLY ENANTIOSELECTIVE HYDROGENATION; REDUCTIVE AMINATION; CYCLIC AMINES; IMINES; BENZODIAZEPINONES; KETONES; ACCESS; ROUTE; SCOPE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672218, 21790332, 21521002]; Youth Innovation Promotion Association CAS [2017046]; CASChinese Academy of Sciences [QYZDJSSW-SLH023]. Recommanded Product: 91-00-9. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhang, SS; Chen, F; He, YM; Fan, QH. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

An efficient Ru-catalyzed asymmetric hydrogenation of dibenzo[c,e]azepines is reported. A series of seven-membered cyclic amines were obtained with moderate to excellent enantioselectivity. The catalyst counteranion played an important role in achieving high-level chiral induction. Moreover, a one-pot synthesis of chiral 6,7-dihydro-5H-dibenz[c,e]azepines via two-step reductive amination was also developed.

Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics